Understanding the native nucleus pulposus cell phenotype has important implications for intervertebral disc regeneration strategies.

scientific article published on January 2013

Understanding the native nucleus pulposus cell phenotype has important implications for intervertebral disc regeneration strategies. is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.2217/RME.12.108
P8608Fatcat IDrelease_6nozdrst5ffl5fwwsgashv2wfu
P698PubMed publication ID23259807
P5875ResearchGate publication ID233973112

P50authorStephen M RichardsonQ40727008
P2093author name stringJudith A Hoyland
Kanna Gnanalingham
Francesca E Ludwinski
P2860cites workDetection and distribution of the carbohydrate binding protein galectin-3 in human notochord, intervertebral disc and chordomaQ24324165
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Tumor necrosis factor-alpha modulates matrix production and catabolism in nucleus pulposus tissueQ28270050
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Collagen II is essential for the removal of the notochord and the formation of intervertebral discsQ28512869
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Prevalence of low back pain in the community: implications for service provision in Bradford, UK.Q30492369
Osteogenic protein-1 injection into a degenerated disc induces the restoration of disc height and structural changes in the rabbit anular puncture modelQ31035667
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Matrix metalloproteinase 28, a novel matrix metalloproteinase, is constitutively expressed in human intervertebral disc tissue and is present in matrix of more degenerated discsQ33517863
Differential expression level of cytokeratin 8 in cells of the bovine nucleus pulposus complicates the search for specific intervertebral disc cell markersQ33873717
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Disc cell clusters in pathological human intervertebral discs are associated with increased stress protein immunostainingQ33972062
Intervertebral disc repair by autologous mesenchymal bone marrow cells: a pilot studyQ33972441
Sensitivity of notochordal disc cells to mechanical loading: an experimental animal studyQ33973651
Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation toward a young nucleus pulposus phenotypeQ33999475
Shh signaling from the nucleus pulposus is required for the postnatal growth and differentiation of the mouse intervertebral discQ34256955
Expression of acid-sensing ion channel 3 (ASIC3) in nucleus pulposus cells of the intervertebral disc is regulated by p75NTR and ERK signalingQ42517459
The economic burden of back pain in the UK.Q43498681
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Hypoxia reduces the inhibitory effect of IL-1beta on chondrogenic differentiation of FCS-free expanded MSC.Q47741014
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Evidence for skeletal progenitor cells in the degenerate human intervertebral disc.Q50872079
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Human nucleus pulposus cells react to IL-6: independent actions and amplification of response to IL-1 and TNF-α.Q54395973
Characterization of the human nucleus pulposus cell phenotype and evaluation of novel marker gene expression to define adult stem cell differentiation.Q54414958
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Degeneration of the cervical disc: histology compared with radiography and magnetic resonance imagingQ56483343
Notochordal Cell Produce and Assemble Extracellular Matrix in a Distinct Manner, Which May Be Responsible for the Maintenance of Healthy Nucleus PulposusQ57192572
Immunohistochemical identification of notochordal markers in cells in the aging human lumbar intervertebral discQ34337940
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Nuclei pulposi formation from the embryonic notochord occurs normally in GDF-5-deficient miceQ35022188
Hedgehog signaling is required for formation of the notochord sheath and patterning of nuclei pulposi within the intervertebral discsQ35034959
The notochordal cell in the nucleus pulposus: a review in the context of tissue engineeringQ35294166
Notochordal conditioned media from tissue increases proteoglycan accumulation and promotes a healthy nucleus pulposus phenotype in human mesenchymal stem cells.Q35557848
Regenerative potential of TGFβ3 + Dex and notochordal cell conditioned media on degenerated human intervertebral disc cellsQ35691009
Notochordal cells protect nucleus pulposus cells from degradation and apoptosis: implications for the mechanisms of intervertebral disc degenerationQ35907855
Comparison of animal discs used in disc research to human lumbar disc: torsion mechanics and collagen contentQ36040849
Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degenerationQ36392322
Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ zymographic and gene therapy studyQ36392408
Nutrient supply and intervertebral disc metabolismQ36440797
Pain and disability correlated with disc degeneration via magnetic resonance imaging in scoliosis patientsQ36627574
Toward an understanding of the role of notochordal cells in the adult intervertebral disc: from discord to accordQ36790063
'Rumours of my death may have been greatly exaggerated': a brief review of cell death in human intervertebral disc disease and implications for cell transplantation therapyQ36883854
Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degeneration.Q36955390
Interleukin-1beta and tumor necrosis factor alpha inhibit chondrogenesis by human mesenchymal stem cells through NF-kappaB-dependent pathwaysQ37208217
The cellular pathobiology of the degenerate intervertebral disc and discogenic back pain.Q37293616
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Human mesenchymal stem cell differentiation to NP-like cells in chitosan-glycerophosphate hydrogelsQ39329306
Development and degeneration of the intervertebral discsQ39457825
Hypoxia activates the notch signaling pathway in cells of the intervertebral disc: implications in degenerative disc diseaseQ39475834
2001 Volvo Award Winner in Basic Science Studies: Effect of nutrient supply on the viability of cells from the nucleus pulposus of the intervertebral discQ39586800
The effect of extracellular pH on matrix turnover by cells of the bovine nucleus pulposusQ39656019
Exogenous and autocrine growth factors stimulate human intervertebral disc cell proliferation via the ERK and Akt pathways.Q39684345
Age-related variation in cell density of human lumbar intervertebral discQ39852121
Notochordal intervertebral disc cells: sensitivity to nutrient deprivationQ39879588
A phenotypic comparison of proteoglycan production of intervertebral disc cells isolated from rats, rabbits, and bovine tails; which animal model is most suitable to study tissue engineering and biological repair of human disc disorders?Q39896926
The influence of serum, glucose and oxygen on intervertebral disc cell growth in vitro: implications for degenerative disc diseaseQ39941958
Injury-induced sequential transformation of notochordal nucleus pulposus to chondrogenic and fibrocartilaginous phenotype in the mouse.Q39994862
Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degenerationQ40006569
A phenotypic comparison of intervertebral disc and articular cartilage cells in the rat.Q40177444
Molecular phenotypes of notochordal cells purified from immature nucleus pulposusQ40341786
Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypesQ40726927
The development of fibrocartilage in the rat intervertebral discQ40981860
Degeneration and the chemical composition of the human lumbar intervertebral discQ41455931
The structure and degradation of aggrecan in human intervertebral discQ41854830
P433issue1
P921main subjectphenotypeQ104053
P304page(s)75-87
P577publication date2013-01-01
P1433published inRegenerative MedicineQ19921466
P1476titleUnderstanding the native nucleus pulposus cell phenotype has important implications for intervertebral disc regeneration strategies
P478volume8

Reverse relations

cites work (P2860)
Q92860073Higenamine inhibits IL-1β-induced inflammation in human nucleus pulposus cells
Q42056281Identifying molecular phenotype of nucleus pulposus cells in human intervertebral disc with aging and degeneration
Q33613461Long-term load duration induces N-cadherin down-regulation and loss of cell phenotype of nucleus pulposus cells in a disc bioreactor culture
Q35258641N-Cadherin-Mediated Signaling Regulates Cell Phenotype for Nucleus Pulposus Cells of the Intervertebral Disc
Q28542740Protective effects of cannabidiol on lesion-induced intervertebral disc degeneration
Q55669959Quality Assessment of Surgical Disc Samples Discriminates Human Annulus Fibrosus and Nucleus Pulposus on Tissue and Molecular Level.
Q49606797Static compression down-regulates N-cadherin expression and facilitates loss of cell phenotype of nucleus pulposus cells in a disc perfusion culture
Q38162814Stem cell regeneration of degenerated intervertebral discs: current status (update).
Q38728066TGF-β Stimulates Expression of Chondroitin Polymerizing Factor in Nucleus Pulposus Cells Through the Smad3, RhoA/ROCK1, and MAPK Signaling Pathways.
Q92970304Therapeutic potential of growth differentiation factors in the treatment of degenerative disc diseases

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