Xylosyltransferase-1 expression is refractory to inhibition by the inflammatory cytokines tumor necrosis factor α and IL-1β in nucleus pulposus cells: novel regulation by AP-1, Sp1, and Sp3.

scientific article

Xylosyltransferase-1 expression is refractory to inhibition by the inflammatory cytokines tumor necrosis factor α and IL-1β in nucleus pulposus cells: novel regulation by AP-1, Sp1, and Sp3. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.AJPATH.2014.09.021
P932PMC publication ID4305180
P698PubMed publication ID25476526

P2093author name stringJun Li
Jie Zhou
Ye Tian
Wei Ye
Irving M Shapiro
D Greg Anderson
Makarand V Risbud
Dessislava Z Markova
P2860cites workModulation of xylosyltransferase I expression provides a mechanism regulating glycosaminoglycan chain synthesis during cartilage destruction and repairQ28573736
Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: implications in intervertebral disc degenerationQ28583559
TNF-α and IL-1β promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral discQ30423879
First isolation of human UDP-D-xylose: proteoglycan core protein beta-D-xylosyltransferase secreted from cultured JAR choriocarcinoma cellsQ30967075
Interleukin-1beta down-regulates the expression of glucuronosyltransferase I, a key enzyme priming glycosaminoglycan biosynthesis: influence of glucosamine on interleukin-1beta-mediated effects in rat chondrocytesQ32067938
Aggrecanases and aggrecanase-generated fragments in the human intervertebral disc at early and advanced stages of disc degenerationQ33304785
Xylosyltransferase-I regulates glycosaminoglycan synthesis during the pathogenic process of human osteoarthritisQ34221930
Tumor necrosis factor-α- and interleukin-1β-dependent matrix metalloproteinase-3 expression in nucleus pulposus cells requires cooperative signaling via syndecan 4 and mitogen-activated protein kinase-NF-κB axis: implications in inflammatory disc diQ34299937
Histology and pathology of the human intervertebral discQ34510523
Transforming growth factor beta1-regulated xylosyltransferase I activity in human cardiac fibroblasts and its impact for myocardial remodelingQ34652219
Regulation of CCN2/connective tissue growth factor expression in the nucleus pulposus of the intervertebral disc: role of Smad and activator protein 1 signalingQ34696270
BMP-2 and TGF-beta stimulate expression of beta1,3-glucuronosyl transferase 1 (GlcAT-1) in nucleus pulposus cells through AP1, TonEBP, and Sp1: role of MAPKsQ35157807
Oncoprotein c-Fos and c-Jun immunopositive cells and cell clusters in herniated intervertebral disc tissueQ36726151
Sp1 and Sp3 transcription factors mediate interleukin-1 beta down-regulation of human type II collagen gene expression in articular chondrocytes.Q38352099
Down-regulation of human type II collagen gene expression by transforming growth factor-beta 1 (TGF-beta 1) in articular chondrocytes involves SP3/SP1 ratioQ38363610
Identification and characterization of the human xylosyltransferase I gene promoter regionQ39798204
Effect of cell density on the rate of glycosaminoglycan accumulation by disc and cartilage cells in vitroQ39820220
Stability of the Sp3-DNA complex is promoter-specific: Sp3 efficiently competes with Sp1 for binding to promoters containing multiple Sp-sitesQ39922572
Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1 (ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-κB.Q41228270
Regulation of xylosyltransferase I gene expression by interleukin 1β in human primary chondrocyte cells: mechanism and impact on proteoglycan synthesisQ42798764
Activation of TonEBP by calcium controls {beta}1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral discQ42868510
The economic burden of back pain in the UK.Q43498681
Human xylosyltransferase-I - a new marker for myofibroblast differentiation in skin fibrosis.Q43917357
Nucleus pulposus cells express HIF-1 alpha under normoxic culture conditions: a metabolic adaptation to the intervertebral disc microenvironmentQ46891204
Magnetic resonance classification of lumbar intervertebral disc degeneration.Q48737575
Low back pain in relation to lumbar disc degenerationQ73522106
Sp3 represses the Sp1-mediated transactivation of the human COL2A1 gene in primary and de-differentiated chondrocytesQ74180488
TNF-alpha induces MMP2 gelatinase activity and MT1-MMP expression in an in vitro model of nucleus pulposus tissue degenerationQ80709304
Molecular changes in the degenerated goat intervertebral discQ81644470
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)485-495
P577publication date2014-12-02
P1433published inThe American Journal of PathologyQ4744259
P1476titleXylosyltransferase-1 expression is refractory to inhibition by the inflammatory cytokines tumor necrosis factor α and IL-1β in nucleus pulposus cells: novel regulation by AP-1, Sp1, and Sp3.
P478volume185

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cites work (P2860)
Q35944726Autophagy attenuates the catabolic effect during inflammatory conditions in nucleus pulposus cells, as sustained by NF-κB and JNK inhibition
Q26783031Disc in flames: Roles of TNF-α and IL-1β in intervertebral disc degeneration
Q41921012Effect of a low-frequency pulsed electromagnetic field on expression and secretion of IL-1β and TNF-α in nucleus pulposus cells
Q87947877Glycosaminoglycan synthesis in the nucleus pulposus: Dysregulation and the pathogenesis of disc degeneration
Q55422142MUTYH and ORAI1 polymorphisms are associated with susceptibility to osteoarthritis in the Chinese Han population.
Q51575900Regulation of a disintegrins and metalloproteinase with thrombospondin motifs 7 during inflammation in nucleus pulposus (NP) cells: role of AP-1, Sp1 and NF-κB signaling.
Q51533838SIRT1 expression is refractory to hypoxia and inflammatory cytokines in nucleus pulposus cells: Novel regulation by HIF-1α and NF-κB signaling.
Q39044506Surgical anatomy, radiological features, and molecular biology of the lumbar intervertebral discs.
Q52684314TSG-6 secreted by bone marrow mesenchymal stem cells attenuates intervertebral disc degeneration by inhibiting the TLR2/NF-κB signaling pathway.
Q60045578microRNA-29b mediates fibrotic induction of human xylosyltransferase-I in human dermal fibroblasts via the Sp1 pathway

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