TNF-α promotes nuclear enrichment of the transcription factor TonEBP/NFAT5 to selectively control inflammatory but not osmoregulatory responses in nucleus pulposus cells

scientific article published on 25 August 2017

TNF-α promotes nuclear enrichment of the transcription factor TonEBP/NFAT5 to selectively control inflammatory but not osmoregulatory responses in nucleus pulposus cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M117.790378
P932PMC publication ID5655530
P698PubMed publication ID28842479

P2093author name stringIrving M Shapiro
Makarand V Risbud
Zariel I Johnson
Alexandra C Doolittle
Joseph W Snuggs
Christine L Le Maitre
P2860cites workTonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicityQ22008847
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The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-1alphaQ40296392
Expression of taurine transporter is regulated through the TonE (tonicity-responsive element)/TonEBP (TonE-binding protein) pathway and contributes to cytoprotection in HepG2 cellsQ40556250
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Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1 (ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-κB.Q41228270
Physiological tonicity improves human chondrogenic marker expression through nuclear factor of activated T-cells 5 in vitroQ42262285
Activation of TonEBP by calcium controls {beta}1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral discQ42868510
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Substance P stimulates production of inflammatory cytokines in human disc cellsQ47967373
Inflammatory signals induce the expression of tonicity-responsive enhancer binding protein (TonEBP) in microgliaQ48709772
RNA Sequencing Reveals a Role of TonEBP Transcription Factor in Regulation of Pro-inflammatory Genes in Response to Hyperosmolarity in Healthy Nucleus Pulposus Cells: A HOMEOSTATIC RESPONSE?Q49411461
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IN VIVO MEASUREMENTS OF INTRADISCAL PRESSURE. DISCOMETRY, A METHOD FOR THE DETERMINATION OF PRESSURE IN THE LOWER LUMBAR DISCSQ76915569
Sodium chloride inhibits cytokine production by lipopolysaccharide-stimulated human neutrophils and mononuclear cellsQ79436719
TonEBP/OREBP is a regulator of nucleus pulposus cell function and survival in the intervertebral discQ83986148
TNF-α and IL-1β promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral discQ30423879
Osmoprotective transcription factor NFAT5/TonEBP modulates nuclear factor-kappaB activityQ30496797
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Regulation of Mycobacterium tuberculosis-dependent HIV-1 transcription reveals a new role for NFAT5 in the toll-like receptor pathwayQ34229621
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Tumor necrosis factor-α- and interleukin-1β-dependent matrix metalloproteinase-3 expression in nucleus pulposus cells requires cooperative signaling via syndecan 4 and mitogen-activated protein kinase-NF-κB axis: implications in inflammatory disc diQ34299937
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Extracellular osmolarity regulates matrix homeostasis in the intervertebral disc and articular cartilage: evolving role of TonEBPQ35323760
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Gene expression induced by Toll-like receptors in macrophages requires the transcription factor NFAT5Q35760842
Cytokine inhibition and time-related influence of inflammatory stimuli on the hyperalgesia induced by the nucleus pulposusQ35812708
Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1α activity in hypoxiaQ35956449
High-Salt Enhances the Inflammatory Response by Retina Pigment Epithelium Cells following Lipopolysaccharide StimulationQ36401004
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Fat-specific protein 27 modulates nuclear factor of activated T cells 5 and the cellular response to stressQ36744115
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LPS-induced NFκB enhanceosome requires TonEBP/NFAT5 without DNA bindingQ36841546
Syndecan-4 in intervertebral disc and cartilage: Saint or synner?Q36923621
Cellular response to hyperosmotic stressesQ36967681
Reactive oxygen species regulate context-dependent inhibition of NFAT5 target genesQ37064902
NF-κB and STAT1 control CXCL1 and CXCL2 gene transcriptionQ37575397
Hyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of toll-like receptor 2 signalling pathwaysQ37690081
The cytokine and chemokine expression profile of nucleus pulposus cells: implications for degeneration and regeneration of the intervertebral disc.Q37691242
A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation.Q38320987
High mechanical strain of primary intervertebral disc cells promotes secretion of inflammatory factors associated with disc degeneration and pain.Q38652746
The xanthine oxidase-NFAT5 pathway regulates macrophage activation and TLR-induced inflammatory arthritisQ38973610
Osmolarity determines the in vitro chondrogenic differentiation capacity of progenitor cells via nuclear factor of activated T-cells 5.Q39230938
Swelling pressure of the inervertebral disc: influence of proteoglycan and collagen contentsQ39316010
A role for TNFα in intervertebral disc degeneration: a non-recoverable catabolic shift.Q39461994
P4510describes a project that usesImageQuantQ112270642
P433issue42
P407language of work or nameEnglishQ1860
P304page(s)17561-17575
P577publication date2017-08-25
P1433published inJournal of Biological ChemistryQ867727
P1476titleTNF-α promotes nuclear enrichment of the transcription factor TonEBP/NFAT5 to selectively control inflammatory but not osmoregulatory responses in nucleus pulposus cells
P478volume292

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cites work (P2860)
Q88487617COX-2 expression mediated by calcium-TonEBP signaling axis under hyperosmotic conditions serves osmoprotective function in nucleus pulposus cells
Q91891461Differential regulation of TRP channel gene and protein expression by intervertebral disc degeneration and back pain
Q64068657Discogenic Back Pain: Literature Review of Definition, Diagnosis, and Treatment
Q91846231NFAT5/TonEBP controls early acquisition of notochord phenotypic markers, collagen composition, and sonic hedgehog signaling during mouse intervertebral disc embryogenesis
Q90351514PACT-mediated PKR activation acts as a hyperosmotic stress intensity sensor weakening osmoadaptation and enhancing inflammation
Q100513942Role of AP-2α/TGF-β1/Smad3 axis in rats with intervertebral disc degeneration
Q64238723Role of NFAT5 in the Immune System and Pathogenesis of Autoimmune Diseases
Q64085327TLR4/NF-κB axis signaling pathway-dependent up-regulation of miR-625-5p contributes to human intervertebral disc degeneration by targeting
Q60949502Transgenic mice overexpressing human TNF-α experience early onset spontaneous intervertebral disc herniation in the absence of overt degeneration
Q90642801Ulipristal Acetate Mediates Decreased Proteoglycan Expression Through Regulation of Nuclear Factor of Activated T-Cells (NFAT5)

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