Transcriptional regulation of Smad2 is required for enhancement of TGFbeta/Smad signaling by TGFbeta inducible early gene.

scientific article

Transcriptional regulation of Smad2 is required for enhancement of TGFbeta/Smad signaling by TGFbeta inducible early gene. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/JCB.10299
P698PubMed publication ID12244575

P50authorSteven A JohnsenQ54006767
P2093author name stringMalayannan Subramaniam
Thomas C Spelsberg
Ralf Janknecht
Takenobu Katagiri
P2860cites workFunctional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblastsQ43550271
Smad3 mutant mice develop metastatic colorectal cancerQ45345236
Xenopus Smad7 inhibits both the activin and BMP pathways and acts as a neural inducerQ47927154
Characterization of the MADH2/Smad2 gene, a human Mad homolog responsible for the transforming growth factor-beta and activin signal transduction pathwayQ48039568
Expression profile of agonistic Smads in human breast cancer cells: absence of regulation by estrogens.Q54102588
RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytesQ22008771
TGF-beta signaling by Smad proteinsQ22253317
Overexpression of a nuclear protein, TIEG, mimics transforming growth factor-beta action in human osteoblast cellsQ22254114
Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradationQ24290777
Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradationQ24291000
Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblastsQ24313343
A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3AQ24550902
Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cellsQ24561665
The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signalingQ24599753
Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2Q24645179
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cellsQ27860926
TGFbeta signaling in growth control, cancer, and heritable disordersQ28142605
The TGF-beta signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancerQ28145081
Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoterQ28208212
The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ SignalingQ28243202
Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signallingQ28251743
Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptorsQ28282476
Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 geneQ29616540
cDNA cloning and chromosomal mapping of rat Smad2 and Smad4 and their expression in cultured rat articular chondrocytesQ30838505
Signaling inputs converge on nuclear effectors in TGF-beta signalingQ33832063
Complex role of tumor cell transforming growth factor (TGF)-beta s on breast carcinoma progressionQ33962870
The Sp1-like protein BTEB3 inhibits transcription via the basic transcription element box by interacting with mSin3A and HDAC-1 co-repressors and competing with Sp1.Q34085341
TGFbeta inducible early gene enhances TGFbeta/Smad-dependent transcriptional responses.Q34144001
Direct binding of Smad1 and Smad4 to two distinct motifs mediates bone morphogenetic protein-specific transcriptional activation of Id1 geneQ38294929
Isolation and characterization of osteoblast precursor cells from human bone marrowQ38360786
Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation.Q38614636
The transforming growth factor beta(1)-inducible transcription factor TIEG1, mediates apoptosis through oxidative stressQ40916097
Overexpression of Smad2 and colocalization with TGF-beta1 in human pancreatic cancerQ40925831
A zinc-finger transcription factor induced by TGF-beta promotes apoptotic cell death in epithelial Mv1Lu cellsQ40931462
Induction of Smad6 mRNA by bone morphogenetic proteinsQ41056735
Smad6 suppresses TGF-beta-induced growth inhibition in COLO-357 pancreatic cancer cells and is overexpressed in pancreatic cancerQ41610166
P433issue2
P304page(s)233-241
P577publication date2002-01-01
P1433published inJournal of Cellular BiochemistryQ6294917
P1476titleTranscriptional regulation of Smad2 is required for enhancement of TGFbeta/Smad signaling by TGFbeta inducible early gene
P478volume87

Reverse relations

cites work (P2860)
Q42092525Chronic fluoxetine treatment induces brain region-specific upregulation of genes associated with BDNF-induced long-term potentiation
Q40081365Different regulatory elements are required for response of hepcidin to interleukin-6 and bone morphogenetic proteins 4 and 9.
Q34329206Differential gene expression of TGF beta inducible early gene (TIEG), Smad7, Smad2 and Bard1 in normal and malignant breast tissue.
Q33873532Drosophila TIEG is a modulator of different signalling pathways involved in wing patterning and cell proliferation
Q36046827Effector ExoU from the type III secretion system is an important modulator of gene expression in lung epithelial cells in response to Pseudomonas aeruginosa infection
Q36025687Estrogen-TGFbeta cross-talk in bone and other cell types: role of TIEG, Runx2, and other transcription factors
Q35015610Functional role of KLF10 in multiple disease processes
Q28511137Functional study of transcription factor KLF11 by targeted gene inactivation
Q25257668HER-2 overexpression differentially alters transforming growth factor-beta responses in luminal versus mesenchymal human breast cancer cells
Q39652309Histone demethylase JARID1B/KDM5B is a corepressor of TIEG1/KLF10
Q38735918Hunting complex differential gene interaction patterns across molecular contexts
Q36162864Impact of TIEG1 Deletion on the Passive Mechanical Properties of Fast and Slow Twitch Skeletal Muscles in Female Mice
Q50335047Impact of TIEG1 on the structural properties of fast- and slow-twitch skeletal muscle
Q54321250Impaired cutaneous wound healing in transforming growth factor-β inducible early gene1 knockout mice.
Q34611035Interleukin-10 regulates transforming growth factor-beta signaling in cultured human bronchial epithelial cells
Q34185182Klf10 and Klf11 as mediators of TGF-beta superfamily signaling
Q37220966Klf10 regulates odontoblast differentiation and mineralization via promoting expression of dentin matrix protein 1 and dentin sialophosphoprotein genes
Q41845530Krüppel-like Transcription Factor KLF10 Suppresses TGFβ-Induced Epithelial-to-Mesenchymal Transition via a Negative Feedback Mechanism
Q24612560Mammalian Krüppel-Like Factors in Health and Diseases
Q48438626Molecular characterization of adult mouse subventricular zone progenitor cells during the onset of differentiation
Q33863032Progression of diet induced nonalcoholic steatohepatitis is accompanied by increased expression of Kruppel-like-factor 10 in mice
Q35930608Selective Inhibition of SIN3 Corepressor with Avermectins as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer
Q44636860Sequential Gonadotropin Treatment of Immature Mice Leads to Amplification of Transforming Growth Factor β Action, Via Upregulation of Receptor-Type 1, Smad 2 and 4, and Downregulation of Smad 6
Q35504587Social Defeat during Adolescence and Adulthood Differentially Induce BDNF-Regulated Immediate Early Genes
Q37707669Synergistic effects of overexpression of BMP‑2 and TGF‑β3 on osteogenic differentiation of bone marrow mesenchymal stem cells
Q37590787TGFbeta inducible early gene-1 (TIEG1) and cardiac hypertrophy: Discovery and characterization of a novel signaling pathway
Q33640377TGFβ inducible early gene-1 plays an important role in mediating estrogen signaling in the skeleton
Q36391354TGFβ-inducible early gene-1 (TIEG1) mutations in hypertrophic cardiomyopathy
Q35555559TGFβ2 regulates hypothalamic Trh expression through the TGFβ inducible early gene-1 (TIEG1) during fetal development
Q47606161TIEG and estrogen modulate SOST expression in the murine skeleton.
Q37391168TIEG-null mice display an osteopenic gender-specific phenotype
Q36563503TIEG1 enhances Osterix expression and mediates its induction by TGFβ and BMP2 in osteoblasts
Q33701577TIEG1 modulates β-catenin sub-cellular localization and enhances Wnt signaling in bone
Q24557552TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro
Q35547034TIEG1-null tenocytes display age-dependent differences in their gene expression, adhesion, spreading and proliferation properties
Q36544024Targeting the SIN3A-PF1 interaction inhibits epithelial to mesenchymal transition and maintenance of a stem cell phenotype in triple negative breast cancer
Q40096089The role of STAT, AP-1, E-box and TIEG motifs in the regulation of hepcidin by IL-6 and BMP-9: lessons from human HAMP and murine Hamp1 and Hamp2 gene promoters
Q31814879The zinc finger transcription factor transforming growth factor beta-inducible early gene-1 confers myeloid-specific activation of the leukocyte integrin CD11d promoter
Q37477447WOUND-HEALING PROPERTIES OF TRANSFORMING GROWTH FACTOR β (TGF-β) INDUCIBLE EARLY GENE 1 (TIEG1) KNOCKOUT MICE.
Q35911349Zinc finger transcription factors in skeletal development

Search more.