Functional role of KLF10 in multiple disease processes

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Functional role of KLF10 in multiple disease processes is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1002/BIOF.67
P932PMC publication ID3104724
P698PubMed publication ID20087894
P5875ResearchGate publication ID41089968

P50authorJames N IngleQ89668737
P2093author name stringMalayannan Subramaniam
Thomas C Spelsberg
John R Hawse
Nalini M Rajamannan
P2860cites workOverexpression of a nuclear protein, TIEG, mimics transforming growth factor-beta action in human osteoblast cellsQ22254114
A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screeningQ24290201
Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblastsQ24313343
Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growthQ24316065
Signaling disrupts mSin3A binding to the Mad1-like Sin3-interacting domain of TIEG2, an Sp1-like repressorQ24536316
A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3AQ24550902
TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitroQ24557552
Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cellsQ24561665
MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancerQ24651422
Serological identification and bioinformatics analysis of immunogenic antigens in multiple myelomaQ28274681
Gene structure and evolution of Tieg3, a new member of the Tieg family of proteinsQ28513800
Identification of new Nerve Growth Factor-responsive immediate-early genesQ28576455
Elucidation of the substrate binding site of Siah ubiquitin ligaseQ28589749
Targeted disruption of Smad4 in cardiomyocytes results in cardiac hypertrophy and heart failureQ28591476
The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1Q28591890
The zinc finger transcription factor transforming growth factor beta-inducible early gene-1 confers myeloid-specific activation of the leukocyte integrin CD11d promoterQ31814879
Estrogen regulation of a transforming growth factor-beta inducible early gene that inhibits deoxyribonucleic acid synthesis in human osteoblastsQ32103237
Expression of early growth response genes in human prostate cancer.Q42456469
Transforming growth factor-beta and bone morphogenetic proteins: cooperative players in chick and murine programmed retinal cell deathQ42490012
Gene expression profiling of glucocorticoid-inhibited osteoblastsQ42826639
Identification of genes responsive to apoptosis in HL-60 cells.Q44786536
Expression profiling of insulin action in human myotubes: induction of inflammatory and pro-angiogenic pathways in relationship with glycogen synthesis and type 2 diabetesQ45060674
Down-regulation of stathmin is required for TGF-beta inducible early gene 1 induced growth inhibition of pancreatic cancer cellsQ46310536
Differential effects of diabetes induced by streptozotocin and that develops spontaneously on prostate growth in Bio Breeding (BB) ratsQ46489044
Bone morphogenetic protein 2 opposes Shh-mediated proliferation in cerebellar granule cells through a TIEG-1-based regulation of Nmyc.Q46939297
TGF beta 1 kills lymphoma cells using mitochondrial apoptotic pathway with the help of caspase-8.Q47847746
Characterization of the mouse TGFbeta-inducible early gene (TIEG): conservation of exon and transcriptional regulatory sequences with evidence of additional transcriptsQ48021384
TGFbeta-inducible early gene (TIEG) also codes for early growth response alpha (EGRalpha): evidence of multiple transcripts from alternate promotersQ48027582
Gene expression profiling of metastatic brain cancer.Q48115591
Balance of pro-apoptotic transforming growth factor-beta and anti-apoptotic insulin effects in the control of cell death in the postnatal mouse retina.Q52043873
TGFbeta inducible early gene-1 knockout mice display defects in bone strength and microarchitecture.Q53526849
Effect of TGF-beta inducible early gene deficiency on flexor tendon healing.Q54618998
Minor contribution of SMAD7 and KLF10 variants to genetic susceptibility of type 2 diabetesQ57249765
Three Conserved Transcriptional Repressor Domains Are a Defining Feature of the TIEG Subfamily of Sp1-like Zinc Finger ProteinsQ61135523
Nitric oxide-mediated upregulation of the TGF-beta-inducible early response gene-1 (TIEG1) in human fibroblasts by mRNA stabilization independent of TGF-betaQ73483852
Age-dependent changes in the mechanical properties of tail tendons in TGF-beta inducible early gene-1 knockout miceQ79774604
Tieg3/Klf11 induces apoptosis in OLI-neu cells and enhances the TGF-beta signaling pathway by transcriptional repression of Smad7Q80480476
EGR1 predicts PTEN and survival in patients with non-small-cell lung cancerQ81538352
TIEG proteins join the Smads as TGF-beta-regulated transcription factors that control pancreatic cell growth.Q33890489
Absence of mutations in the transforming growth factor-beta inducible early gene 1, TIEG1, in pancreatic cancerQ34133360
Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven in absentia homologueQ34134107
TGFbeta inducible early gene enhances TGFbeta/Smad-dependent transcriptional responses.Q34144001
15‐hydroxy‐eicosatetraenoic acid arrests growth of colorectal cancer cells via a peroxisome proliferator‐activated receptor gamma‐dependent pathwayQ34270983
Dual functions of transcription factors, transforming growth factor-beta-inducible early gene (TIEG)2 and Sp3, are mediated by CACCC element and Sp1 sites of human monoamine oxidase (MAO) B geneQ34306237
Differential gene expression of TGF beta inducible early gene (TIEG), Smad7, Smad2 and Bard1 in normal and malignant breast tissue.Q34329206
The leukocyte integrin gene CD11d is repressed by gut-enriched Kruppel-like factor 4 in myeloid cellsQ34370628
Characterization of an early growth response gene, which encodes a zinc finger transcription factor, potentially involved in cell cycle regulationQ34373431
Tissue, cell type, and breast cancer stage-specific expression of a TGF-beta inducible early transcription factor geneQ34453776
TIEG1 induces apoptosis through mitochondrial apoptotic pathway and promotes apoptosis induced by homoharringtonine and velcadeQ34656839
Role of TIEG1 in biological processes and disease states.Q34668861
A binding motif for Siah ubiquitin ligase.Q34866593
Candidate gene analysis of femoral neck trabecular and cortical volumetric bone mineral density in older men.Q35156255
TIEG1-NULL OSTEOCYTES DISPLAY DEFECTS IN THEIR MORPHOLOGY, DENSITY AND SURROUNDING BONE MATRIX.Q35569802
TGFbeta-mediated signaling and transcriptional regulation in pancreatic development and cancer.Q36619111
Effect of acute physiological hyperinsulinemia on gene expression in human skeletal muscle in vivoQ36635727
Quinazoline-based alpha 1-adrenoceptor antagonists induce prostate cancer cell apoptosis via TGF-beta signalling and I kappa B alpha inductionQ36648945
Two novel VHL targets, TGFBI (BIGH3) and its transactivator KLF10, are up-regulated in renal clear cell carcinoma and other tumors.Q36699730
Estrogen receptor beta isoform-specific induction of transforming growth factor beta-inducible early gene-1 in human osteoblast cells: an essential role for the activation function 1 domainQ36756456
TGFbeta regulated gene expression by Smads and Sp1/KLF-like transcription factors in cancer.Q37217589
Kruppel-like factor KLF10 targets transforming growth factor-beta1 to regulate CD4(+)CD25(-) T cells and T regulatory cellsQ37375680
TIEG-null mice display an osteopenic gender-specific phenotypeQ37391168
TGFbeta inducible early gene-1 (TIEG1) and cardiac hypertrophy: Discovery and characterization of a novel signaling pathwayQ37590787
Modulation of the TGFbeta/Smad signaling pathway in mesangial cells by CTGF/CCN2.Q38325122
Gene expression profiling of leiomyoma and myometrial smooth muscle cells in response to transforming growth factor-betaQ38333036
Transcriptional regulation of Smad2 is required for enhancement of TGFbeta/Smad signaling by TGFbeta inducible early gene.Q38362711
Altered expression of novel genes in the cerebral cortex following experimental brain injuryQ38363044
GDNF signaling in embryonic midbrain neurons in vitroQ40118913
Smad signal and TGFbeta induced apoptosis in human lymphoma cellsQ40414971
Cell and tissue specific expression of human Krüppel-like transcription factors in human ocular surface.Q40486659
TIEG1 facilitates transforming growth factor-beta-mediated apoptosis in the oligodendroglial cell line OLI-neuQ40595636
The transforming growth factor beta(1)-inducible transcription factor TIEG1, mediates apoptosis through oxidative stressQ40916097
A zinc-finger transcription factor induced by TGF-beta promotes apoptotic cell death in epithelial Mv1Lu cellsQ40931462
Effects of gonadal and adrenal androgens in a novel androgen-responsive human osteoblastic cell lineQ41009217
Cloning and characterization of murine glial cell-derived neurotrophic factor inducible transcription factor (MGIF).Q41082876
TGF-beta regulation of nuclear proto-oncogenes and TGF-beta gene expression in normal human osteoblast-like cellsQ41396369
Chronic fluoxetine treatment induces brain region-specific upregulation of genes associated with BDNF-induced long-term potentiationQ42092525
Quantitative real-time RT-PCR analysis of eight novel estrogen-regulated genes in breast cancerQ42165700
P433issue1
P304page(s)8-18
P577publication date2010-01-01
P1433published inBioFactorsQ15767404
P1476titleFunctional role of KLF10 in multiple disease processes
P478volume36

Reverse relations

cites work (P2860)
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Q64241260Fluorine-Modified Rutaecarpine Exerts Cyclooxygenase-2 Inhibition and Anti-inflammatory Effects in Lungs
Q34845804Gene set signature of reversal reaction type I in leprosy patients
Q37455310Impact of visceral fat on gene expression profile in peripheral blood cells in obese Japanese subjects.
Q49948350Impaired epidermal Langerhans cell maturation in TGFβ-inducible early gene 1 (TIEG1) knockout mice
Q39528324KLF10 Mediated Epigenetic Dysregulation of Epithelial CD40/CD154 Promotes Endometriosis.
Q64124046KLF10 transcription factor regulates hepatic glucose metabolism in mice
Q37220966Klf10 regulates odontoblast differentiation and mineralization via promoting expression of dentin matrix protein 1 and dentin sialophosphoprotein genes
Q42231919Knockout of krüppel-like factor 10 suppresses hepatic cell proliferation in a partially hepatectomized mouse model
Q55386014Krüppel-Like Factor 10 participates in cervical cancer immunoediting through transcriptional regulation of Pregnancy-Specific Beta-1 Glycoproteins.
Q90348812Krüppel-like factor 10 (KLF10) is transactivated by the transcription factor C/EBPβ and involved in early 3T3-L1 preadipocyte differentiation
Q36345914Krüppel-like factor KLF10 deficiency predisposes to colitis through colonic macrophage dysregulation
Q35138456Krüppel-like factor KLF10 regulates transforming growth factor receptor II expression and TGF-β signaling in CD8+ T lymphocytes
Q30424246Leptin protects host cells from Entamoeba histolytica cytotoxicity by a STAT3-dependent mechanism
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Q97652812MCD diet-induced steatohepatitis generates a diurnal rhythm of associated biomarkers and worsens liver injury in Klf10 deficient mice
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Q33863032Progression of diet induced nonalcoholic steatohepatitis is accompanied by increased expression of Kruppel-like-factor 10 in mice
Q33646069Reexpression of LSAMP inhibits tumor growth in a preclinical osteosarcoma model
Q35838903SUMOylation of sPRDM16 promotes the progression of acute myeloid leukemia
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Q47606161TIEG and estrogen modulate SOST expression in the murine skeleton.
Q36563503TIEG1 enhances Osterix expression and mediates its induction by TGFβ and BMP2 in osteoblasts
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