Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

scientific article

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1101/GAD.12.2.186
P3181OpenCitations bibliographic resource ID613408
P932PMC publication ID316444
P698PubMed publication ID9436979
P5875ResearchGate publication ID13793512

P50authorAli Hemmati-BrivanlouQ67158924
P2093author name stringJ Massagué
A Hata
G Lagna
P2860cites workActivation of signalling by the activin receptor complexQ24308084
MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signalingQ24310282
Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexesQ24310852
Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4Q24314569
MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinomaQ24315119
The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4Q24315313
MADR1, a MAD-related protein that functions in BMP2 signaling pathwaysQ24317247
Receptor-associated Mad homologues synergize as effectors of the TGF-beta responseQ24318330
Serine phosphorylation, chromosomal localization, and transforming growth factor-beta signal transduction by human bsp-1Q24322007
Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endotheliumQ24322926
Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genesQ24607900
A structural basis for mutational inactivation of the tumour suppressor Smad4Q27740172
Cloning and characterization of a novel member of the human Mad gene family (MADH6)Q28242476
The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ SignalingQ28243202
Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signallingQ28251743
The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinaseQ28628494
DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1Q29616726
Bone morphogenetic proteins: multifunctional regulators of vertebrate developmentQ29618986
Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fateQ29619008
A transcriptional partner for MAD proteins in TGF-beta signallingQ29622823
Serine/threonine kinase receptors: mediators of transforming growth factor beta family signals.Q34406617
Concentration-dependent patterning of the Xenopus ectoderm by BMP4 and its signal transducer Smad1.Q34437048
A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo.Q35844444
TGF-beta signalling through the Smad pathwayQ36914476
Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growthQ37378595
GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complexQ37697197
Smad5 induces ventral fates in Xenopus embryoQ38346792
Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptorsQ41099665
The tumor suppressor Smad4/DPC 4 as a central mediator of Smad functionQ41119639
Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.Q41157114
A human Mad protein acting as a BMP-regulated transcriptional activatorQ41192122
Embryonic patterning: to BMP or not to BMP, that is the questionQ41434992
Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivoQ41436510
Vertebrate neural induction: inducers, inhibitors, and a new synthesisQ41496834
Activin-like factor from a Xenopus laevis cell line responsible for mesoderm inductionQ41730591
Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A.Q41730594
Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in XenopusQ43411996
Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryosQ44061010
Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing centerQ45071731
Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4Q45345228
A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathwayQ46482720
Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structuresQ46821460
Cephalic expression and molecular characterization of Xenopus En-2Q46880356
Daughters against dpp modulates dpp organizing activity in Drosophila wing developmentQ47070119
Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-beta responsive cellsQ47072372
Mesodermal induction in early amphibian embryos by activin A (erythroid differentiation factor).Q47679683
Smad6 inhibits signalling by the TGF-beta superfamilyQ48044158
Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor.Q48061850
Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamilyQ48064097
Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activityQ48083210
Frequency of Smad gene mutations in human cancers.Q48676822
Induction of epidermis and inhibition of neural fate by Bmp-4Q52508863
A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryosQ59061571
A Dominant Negative Bone Morphogenetic Protein 4 Receptor Causes Neuralization in Xenopus EctodermQ71880118
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectI-SMAD bindingQ14902704
P304page(s)186-97
P577publication date1998-01-15
P1433published inGenes & DevelopmentQ1524533
P1476titleSmad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
P478volume12

Reverse relations

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Q34121672TGFbeta/BMP type I receptors ALK1 and ALK2 are essential for BMP9-induced osteogenic signaling in mesenchymal stem cells
Q35172304TGFβ superfamily signaling regulators are differentially expressed in the developing and adult mouse testis
Q38325146Temporal analysis of the early BMP functions identifies distinct anti-organizer and mesoderm patterning phases
Q36682952Temporal control of BMP signalling determines neuronal subtype identity in the dorsal neural tube.
Q28771732Tenascin-C upregulation by transforming growth factor-beta in human dermal fibroblasts involves Smad3, Sp1, and Ets1
Q39871283Tgf-Beta superfamily receptors-targets for antiangiogenic therapy?
Q39295657The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites
Q28276556The Discovery and Early Days of TGF-β: A Historical Perspective
Q42638343The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-beta receptors.
Q36294196The N domain of Smad7 is essential for specific inhibition of transforming growth factor-beta signaling
Q35691527The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture
Q92446155The Role of Ubiquitination in Regulating Embryonic Stem Cell Maintenance and Cancer Development
Q35612296The SCL transcriptional network and BMP signaling pathway interact to regulate RUNX1 activity
Q38319514The Smad6-histone deacetylase 3 complex silences the transcriptional activity of the glucocorticoid receptor: potential clinical implications
Q33857580The Smads: transcriptional regulation and mouse models
Q34511224The TGF-beta--Smad network: introducing bioinformatic tools
Q52172698The Xvex-1 antimorph reveals the temporal competence for organizer formation and an early role for ventral homeobox genes.
Q35037659The evolution of signalling pathways in animal development
Q37109638The homing and inhibiting effects of hNSCs-BMP4 on human glioma stem cells
Q36862425The murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized mice.
Q46338473The neural plate specifies somite size in the Xenopus laevis gastrula
Q33222328The role of Smad signaling in hematopoiesis
Q54696020The role of endogenous bone morphogenetic proteins in normal skeletal repair.
Q39171149Therapeutic Potential for Bone Morphogenetic Protein 4 in Human Malignant Glioma
Q37128066To (TGF)beta or not to (TGF)beta: fine-tuning of Smad signaling via post-translational modifications
Q36737268Tob genes in development and homeostasis
Q28208130Tob proteins enhance inhibitory Smad-receptor interactions to repress BMP signaling
Q29618985Transcriptional control by the TGF-beta/Smad signaling system
Q34684392Transcriptome analysis of newt lens regeneration reveals distinct gradients in gene expression patterns.
Q28083526Transforming Growth Factor-Beta and Oxidative Stress Interplay: Implications in Tumorigenesis and Cancer Progression
Q33930282Transforming growth factor beta signaling mediators and modulators
Q28286474Transforming growth factor beta1 induces nuclear export of inhibitory Smad7
Q24793265Transforming growth factor-beta and breast cancer: Transforming growth factor-beta/SMAD signaling defects and cancer
Q34438032Transforming growth factor-beta signal transduction in epithelial cells.
Q37103999Transforming growth factor-beta signaling in thoracic aortic aneurysm development: a paradox in pathogenesis
Q35177514Transforming growth factor-beta stimulates epithelial-mesenchymal transformation in the proepicardium
Q42100860Transgenic analysis of the Smad family of TGF-beta signal transducers in Drosophila melanogaster suggests new roles and new interactions between family members
Q33853415Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice
Q34017313Trigenic neural crest-restricted Smad7 over-expression results in congenital craniofacial and cardiovascular defects.
Q41259219Two locus inheritance of non-syndromic midline craniosynostosis via rare SMAD6 and common BMP2 alleles
Q45981141Two models of Smad4 and Hoxa9 complex are proposed: structural and interactional perspective.
Q24305427USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma
Q28752508Unexpected activities of Smad7 in Xenopus mesodermal and neural induction
Q36717858Valproic acid suppresses collagen by selective regulation of Smads in conjunctival fibrosis
Q35066911Vascularization of the developing chick limb bud: role of the TGFbeta signalling pathway
Q30421569miR-26a is required for skeletal muscle differentiation and regeneration in mice
Q35475330miR-367 promotes epithelial-to-mesenchymal transition and invasion of pancreatic ductal adenocarcinoma cells by targeting the Smad7-TGF-β signalling pathway
Q28140333Participation of Smad2, Smad3, and Smad4 in transforming growth factor beta (TGF-beta)-induced activation of Smad7. THE TGF-beta response element of the promoter requires functional Smad binding element and E-box sequences for transcriptional regula

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