scholarly article | Q13442814 |
P50 | author | Ali Hemmati-Brivanlou | Q67158924 |
P2093 | author name string | J Massagué | |
A Hata | |||
G Lagna | |||
P2860 | cites work | Activation of signalling by the activin receptor complex | Q24308084 |
MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling | Q24310282 | ||
Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes | Q24310852 | ||
Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4 | Q24314569 | ||
MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma | Q24315119 | ||
The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4 | Q24315313 | ||
MADR1, a MAD-related protein that functions in BMP2 signaling pathways | Q24317247 | ||
Receptor-associated Mad homologues synergize as effectors of the TGF-beta response | Q24318330 | ||
Serine phosphorylation, chromosomal localization, and transforming growth factor-beta signal transduction by human bsp-1 | Q24322007 | ||
Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium | Q24322926 | ||
Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genes | Q24607900 | ||
A structural basis for mutational inactivation of the tumour suppressor Smad4 | Q27740172 | ||
Cloning and characterization of a novel member of the human Mad gene family (MADH6) | Q28242476 | ||
The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling | Q28243202 | ||
Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling | Q28251743 | ||
The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase | Q28628494 | ||
DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1 | Q29616726 | ||
Bone morphogenetic proteins: multifunctional regulators of vertebrate development | Q29618986 | ||
Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate | Q29619008 | ||
A transcriptional partner for MAD proteins in TGF-beta signalling | Q29622823 | ||
Serine/threonine kinase receptors: mediators of transforming growth factor beta family signals. | Q34406617 | ||
Concentration-dependent patterning of the Xenopus ectoderm by BMP4 and its signal transducer Smad1. | Q34437048 | ||
A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo. | Q35844444 | ||
TGF-beta signalling through the Smad pathway | Q36914476 | ||
Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth | Q37378595 | ||
GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex | Q37697197 | ||
Smad5 induces ventral fates in Xenopus embryo | Q38346792 | ||
Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors | Q41099665 | ||
The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function | Q41119639 | ||
Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways. | Q41157114 | ||
A human Mad protein acting as a BMP-regulated transcriptional activator | Q41192122 | ||
Embryonic patterning: to BMP or not to BMP, that is the question | Q41434992 | ||
Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo | Q41436510 | ||
Vertebrate neural induction: inducers, inhibitors, and a new synthesis | Q41496834 | ||
Activin-like factor from a Xenopus laevis cell line responsible for mesoderm induction | Q41730591 | ||
Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A. | Q41730594 | ||
Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus | Q43411996 | ||
Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos | Q44061010 | ||
Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center | Q45071731 | ||
Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4 | Q45345228 | ||
A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway | Q46482720 | ||
Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures | Q46821460 | ||
Cephalic expression and molecular characterization of Xenopus En-2 | Q46880356 | ||
Daughters against dpp modulates dpp organizing activity in Drosophila wing development | Q47070119 | ||
Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-beta responsive cells | Q47072372 | ||
Mesodermal induction in early amphibian embryos by activin A (erythroid differentiation factor). | Q47679683 | ||
Smad6 inhibits signalling by the TGF-beta superfamily | Q48044158 | ||
Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor. | Q48061850 | ||
Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamily | Q48064097 | ||
Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity | Q48083210 | ||
Frequency of Smad gene mutations in human cancers. | Q48676822 | ||
Induction of epidermis and inhibition of neural fate by Bmp-4 | Q52508863 | ||
A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos | Q59061571 | ||
A Dominant Negative Bone Morphogenetic Protein 4 Receptor Causes Neuralization in Xenopus Ectoderm | Q71880118 | ||
P433 | issue | 2 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | I-SMAD binding | Q14902704 |
P304 | page(s) | 186-97 | |
P577 | publication date | 1998-01-15 | |
P1433 | published in | Genes & Development | Q1524533 |
P1476 | title | Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor | |
P478 | volume | 12 |
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Q28141283 | A Smad transcriptional corepressor |
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Q40768248 | A nuclear antagonistic mechanism of inhibitory Smads in transforming growth factor-beta signaling |
Q28143788 | A role for smad6 in development and homeostasis of the cardiovascular system |
Q47938281 | A role for the homeobox gene Xvex-1 as part of the BMP-4 ventral signaling pathway |
Q74671626 | A short amino-acid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3 |
Q28144663 | Activation of Smad1-mediated transcription by p300/CBP |
Q39548366 | Activation of c-Jun NH(2)-terminal kinase 1 increases cellular responsiveness to BMP-2 and decreases binding of inhibitory Smad6 to the type 1 BMP receptor |
Q46377767 | Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation |
Q46500539 | Activin/TGFbeta and BMP crosstalk determines digit chondrogenesis |
Q24307781 | Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium |
Q50002288 | Alteration of Epigenetic Regulation by Long Noncoding RNAs in Cancer |
Q24815989 | An Oct-1 binding site mediates activation of the gata2 promoter by BMP signaling |
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Q24634424 | Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7 |
Q24315751 | Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia |
Q36050423 | BMP receptor-activated Smads confer diverse functions during the development of the dorsal spinal cord. |
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Q36659526 | BMP signaling in the cartilage growth plate. |
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Q35082302 | BMP-2 and TGFβ2 shared pathways regulate endocardial cell transformation |
Q92602914 | BMP-4 enhances epithelial mesenchymal transition and cancer stem cell properties of breast cancer cells via Notch signaling |
Q40346961 | BMP-4 induces a Smad-dependent apoptotic cell death of mouse embryonic stem cell-derived neural precursors. |
Q38364243 | BMP/Smad signaling and embryonic cerebellum development: stem cell specification and heterogeneity of anterior rhombic lip. |
Q28140674 | BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6 |
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Q46956041 | BMPs, Smads and metalloproteases: extracellular and intracellular modes of negative regulation |
Q36003520 | BRCA1 regulates follistatin function in ovarian cancer and human ovarian surface epithelial cells |
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Q36227044 | Bmp indicator mice reveal dynamic regulation of transcriptional response |
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Q26746964 | Bone Morphogenetic Protein 4 Signalling in Neural Stem and Progenitor Cells during Development and after Injury |
Q41783158 | Bone Morphogenetic Protein Signaling: Implications in Urology |
Q38872877 | Bone Morphogenetic Proteins in Vascular Homeostasis and Disease |
Q48464668 | Bone mesenchymal stem cell-conditioned medium induces the upregulation of Smad6, which inhibits the BMP-4/Smad1/5/8 signaling pathway |
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Q35376245 | Bone morphogenetic protein 4 (BMP-4) and epidermal growth factor (EGF) inhibit metalloproteinase-9 (MMP-9) expression in cancer cells |
Q36324476 | Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of preadipocytes |
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Q73376498 | Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells |
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Q36263679 | CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor beta transcriptional responses in endothelial cells |
Q30431055 | Cadherin 6B induces BMP signaling and de-epithelialization during the epithelial mesenchymal transition of the neural crest |
Q44142868 | Calcineurin and NFAT4 induce chondrogenesis |
Q52164935 | Calmodulin differentially modulates Smad1 and Smad2 signaling. |
Q33665042 | Can't get no SMADisfaction: Smad proteins as positive and negative regulators of TGF-beta family signals |
Q33792221 | Candidate Gene Resequencing in a Large Bicuspid Aortic Valve-Associated Thoracic Aortic Aneurysm Cohort: SMAD6 as an Important Contributor. |
Q36083465 | Cell biology of cardiac cushion development. |
Q48236427 | Cerebellar deficits and hyperactivity in mice lacking Smad4. |
Q35080458 | Characterization of negative feedback network motifs in the TGF-β signaling pathway |
Q47919138 | Characterization of zebrafish smad1, smad2 and smad5: the amino-terminus of smad1 and smad5 is required for specific function in the embryo. |
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Q40459372 | Cloning of Smad2, Smad3, Smad4, and Smad7 from the goldfish pituitary and evidence for their involvement in activin regulation of goldfish FSHbeta promoter activity. |
Q21284175 | Cloning of a novel signaling molecule, AMSH-2, that potentiates transforming growth factor beta signaling |
Q42147850 | Computational modelling of Smad-mediated negative feedback and crosstalk in the TGF-β superfamily network |
Q33722414 | Concise Review: The Potential Use of Intestinal Stem Cells to Treat Patients with Intestinal Failure |
Q38332721 | Conditional BMP inhibition in Xenopus reveals stage-specific roles for BMPs in neural and neural crest induction |
Q91844857 | Confirmation of the role of pathogenic SMAD6 variants in bicuspid aortic valve-related aortopathy |
Q35541207 | Connective tissue disorders and cardiovascular complications: the indomitable role of transforming growth factor-beta signaling |
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Q24337748 | Control of prostate cell growth: BMP antagonizes androgen mitogenic activity with incorporation of MAPK signals in Smad1 |
Q39791091 | Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads |
Q34769120 | Cross-species comparison of human and mouse intestinal polyps reveals conserved mechanisms in adenomatous polyposis coli (APC)-driven tumorigenesis |
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Q28581449 | Decreased Smad 7 expression contributes to cardiac fibrosis in the infarcted rat heart |
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Q57462387 | Developmental SMAD6 loss leads to blood vessel hemorrhage and disrupted endothelial cell junctions |
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Q35969690 | Dynamics of BMP and Hes1/Hairy1 signaling in the dorsal neural tube underlies the transition from neural crest to definitive roof plate |
Q24649140 | Effect of interleukin-1beta on osteogenic protein 1-induced signaling in adult human articular chondrocytes |
Q42488929 | Efficient TGF-beta induction of the Smad7 gene requires cooperation between AP-1, Sp1, and Smad proteins on the mouse Smad7 promoter |
Q36106667 | Elevating CLIC4 in Multiple Cell Types Reveals a TGF- Dependent Induction of a Dominant Negative Smad7 Splice Variant |
Q38943396 | Endocardial cell epithelial-mesenchymal transformation requires Type III TGFβ receptor interaction with GIPC. |
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Q33820694 | Epigenetic regulation of cancer stem cell marker CD133 by transforming growth factor-beta |
Q43710307 | Expression of TGF-beta superfamily growth factors, their receptors, the associated SMADs and antagonists in five isolated size-matched populations of pre-antral follicles from normal human ovaries |
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Q24682784 | GATA- and Smad1-dependent enhancers in the Smad7 gene differentially interpret bone morphogenetic protein concentrations |
Q35799605 | Gene expression in the normal adult human kidney assessed by complementary DNA microarray |
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Q38484478 | Smad3 regulates Rho signaling via NET1 in the transforming growth factor-beta-induced epithelial-mesenchymal transition of human retinal pigment epithelial cells |
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Q24303055 | Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane |
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