| scholarly article | Q13442814 |
| P2093 | author name string | K M Galvin | |
| J N Lorenz | |||
| M A Gimbrone | |||
| D Huszar | |||
| V Fairchild-Huntress | |||
| M J Donovan | |||
| R J Paul | |||
| C A Lynch | |||
| K L Dixon | |||
| D Falb | |||
| J H Dunmore | |||
| R I Meyer | |||
| P2860 | cites work | TGF-beta signal transduction | Q22003891 |
| Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart | Q22009087 | ||
| Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor | Q24321977 | ||
| Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium | Q24322926 | ||
| Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells | Q28142906 | ||
| Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members | Q28280195 | ||
| Targeted ablation of the phospholamban gene is associated with a marked decrease in sensitivity in aortic smooth muscle | Q28594459 | ||
| The mouse Pgk-1 gene promoter contains an upstream activator sequence | Q35788889 | ||
| Mechanisms of cell transformation in the embryonic heart. | Q40528479 | ||
| Bone and cartilage differentiation | Q40588385 | ||
| Atherosclerotic calcification: relation to developmental osteogenesis | Q40598040 | ||
| Induction of Smad6 mRNA by bone morphogenetic proteins | Q41056735 | ||
| Role of TGF-beta in vascular development and vascular reactivity. | Q41731277 | ||
| Smad6 inhibits signalling by the TGF-beta superfamily | Q48044158 | ||
| The dopamine β-hydroxylase gene promoter directs expression of E. coli lacZ to sympathetic and other neurons in adult transgenic mice | Q48634015 | ||
| Application of LacZ gene fusions to postimplantation development. | Q54042034 | ||
| P433 | issue | 2 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | circulatory system | Q11068 |
| SMAD family member 6 | Q14904341 | ||
| P304 | page(s) | 171-4 | |
| P577 | publication date | 2000-02-01 | |
| P1433 | published in | Nature Genetics | Q976454 |
| P1476 | title | A role for smad6 in development and homeostasis of the cardiovascular system | |
| P478 | volume | 24 |
| Q50769739 | A 7.1 kbp beta-myosin heavy chain promoter, efficient for green fluorescent protein expression, probably induces lethality when overexpressing a mutated transforming growth factor-beta type II receptor in transgenic mice. |
| Q24634134 | A Runx1-Smad6 rheostat controls Runx1 activity during embryonic hematopoiesis |
| Q36820985 | A Three-Way Interaction among Maternal and Fetal Variants Contributing to Congenital Heart Defects |
| Q64289639 | A generally conserved response to hypoxia in iPSC-derived cardiomyocytes from humans and chimpanzees |
| Q34042368 | A genetic blueprint for cardiac development |
| Q35097446 | A locus on chromosome 7 determines dramatic up-regulation of osteopontin in dystrophic cardiac calcification in mice |
| Q38072446 | A molecular and genetic outline of cardiac morphogenesis. |
| Q62016886 | A novel SMAD6 variant in a patient with severely calcified bicuspid aortic valve and thoracic aortic aneurysm |
| Q40768248 | A nuclear antagonistic mechanism of inhibitory Smads in transforming growth factor-beta signaling |
| Q33737421 | ADAM-17: the enzyme that does it all. |
| Q46377767 | Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation |
| Q34588824 | Advances towards understanding heart valve response to injury. |
| Q35618803 | Altered versican cleavage in ADAMTS5 deficient mice; a novel etiology of myxomatous valve disease |
| Q40883914 | An allelic series of miR-17 ∼ 92-mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron |
| Q28586261 | An essential role of Bmp4 in the atrioventricular septation of the mouse heart |
| Q33370427 | An in vivo reporter of BMP signaling in organogenesis reveals targets in the developing kidney |
| Q35147157 | Animal models of calcific aortic valve disease |
| Q35746931 | Aortic valve endothelial cells undergo transforming growth factor-beta-mediated and non-transforming growth factor-beta-mediated transdifferentiation in vitro |
| Q37293900 | Arterial calcifications |
| Q34988392 | Association of two variants in SMAD7 with the risk of congenital heart disease in the Han Chinese population |
| Q90567461 | Atheroprone flow enhances the endothelial-to-mesenchymal transition |
| Q37176133 | Atherosclerosis and osteoporosis: age-dependent degenerative processes or related entities? |
| Q28507415 | Atrioventricular cushion transformation is mediated by ALK2 in the developing mouse heart |
| Q52003936 | Atrioventricular valve development during late embryonic and postnatal stages involves condensation and extracellular matrix remodeling. |
| Q52018487 | BMP and FGF regulatory pathways control cell lineage diversification of heart valve precursor cells. |
| Q53568871 | BMP and FGF regulatory pathways in semilunar valve precursor cells. |
| Q37850773 | BMP signaling in congenital heart disease: new developments and future directions |
| Q37776859 | BMP signaling in vascular development and disease |
| Q28512717 | BMP type II receptor regulates positioning of outflow tract and remodeling of atrioventricular cushion during cardiogenesis |
| Q35082302 | BMP-2 and TGFβ2 shared pathways regulate endocardial cell transformation |
| Q36816511 | BMP-2 induces cell migration and periostin expression during atrioventricular valvulogenesis |
| Q35643930 | BMP-2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cells |
| Q36159603 | BMP-SMAD signalling output is highly regionalized in cardiovascular and lymphatic endothelial networks |
| Q30497098 | BMP/SMAD signaling regulates the cell behaviors that drive the initial dorsal-specific regional morphogenesis of the otocyst. |
| Q35791889 | BMPER Promotes Epithelial-Mesenchymal Transition in the Developing Cardiac Cushions |
| Q92455821 | Bicuspid aortic valve-associated aortopathy: Where do we stand? |
| Q34512444 | Bone Morphogenetic Protein (BMP) signaling in development and human diseases |
| Q37033822 | Bone Morphogenetic Protein Signaling Is Required for Aortic Valve Calcification. |
| Q38733364 | Bone Morphogenetic Protein-Based Therapeutic Approaches |
| Q38872877 | Bone Morphogenetic Proteins in Vascular Homeostasis and Disease |
| Q52141297 | Bone morphogenetic protein function is required for terminal differentiation of the heart but not for early expression of cardiac marker genes. |
| Q35464101 | Bone morphogenetic protein signaling transcription factor (SMAD) function in granulosa cells. |
| Q34418714 | Bone: a new endocrine organ at the heart of chronic kidney disease and mineral and bone disorders. |
| Q35060426 | Building a heart: implications for congenital heart disease |
| Q38215191 | Building and repairing the heart: what can we learn from embryonic development? |
| Q36826515 | Cadherin-11 coordinates cellular migration and extracellular matrix remodeling during aortic valve maturation |
| Q50420240 | Calcific Aortic Valve Disease: a Developmental Biology Perspective. |
| Q30503246 | Calcific aortic valve stenosis: methods, models, and mechanisms |
| Q36160498 | Calcification in atherosclerosis: bone biology and chronic inflammation at the arterial crossroads. |
| Q44142868 | Calcineurin and NFAT4 induce chondrogenesis |
| Q33792221 | Candidate Gene Resequencing in a Large Bicuspid Aortic Valve-Associated Thoracic Aortic Aneurysm Cohort: SMAD6 as an Important Contributor. |
| Q35541868 | Cardiac chamber formation: development, genes, and evolution. |
| Q36083465 | Cell biology of cardiac cushion development. |
| Q61927929 | Chapter 6 Vascular Calcification Inhibitors In Relation To Cardiovascular Disease With Special Emphasis On Fetuin‐A In Chronic Kidney Disease |
| Q37083019 | Characterization of human bone morphogenetic protein gene variants for possible roles in congenital heart disease |
| Q48286499 | Characterization of new bone morphogenetic protein (Bmp)-2 regulatory alleles. |
| Q38171918 | Cilia and coordination of signaling networks during heart development |
| Q36837874 | Clinical, cellular, and molecular aspects of arterial calcification |
| Q38060591 | Co-ordinating Notch, BMP, and TGF-β signaling during heart valve development |
| Q91844857 | Confirmation of the role of pathogenic SMAD6 variants in bicuspid aortic valve-related aortopathy |
| Q30475786 | Congenital semilunar valvulogenesis defect in mice deficient in phospholipase C epsilon. |
| Q35025212 | Consequences of knocking out BMP signaling in the mouse |
| Q35563823 | Control of endocardial cushion and cardiac valve maturation by BMP signaling pathways |
| Q28205077 | Cordon-bleu is a conserved gene involved in neural tube formation |
| Q28581449 | Decreased Smad 7 expression contributes to cardiac fibrosis in the infarcted rat heart |
| Q35032897 | Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling |
| Q44910199 | Development of heart valve leaflets and supporting apparatus in chicken and mouse embryos |
| Q57462387 | Developmental SMAD6 loss leads to blood vessel hemorrhage and disrupted endothelial cell junctions |
| Q32079308 | Developmentally regulated expression of Smad3, Smad4, Smad6, and Smad7 involved in TGF-beta signaling |
| Q28508533 | Differential expression and function of Tbx5 and Tbx20 in cardiac development |
| Q34654975 | Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7 |
| Q52141299 | Dissection of inhibitory Smad proteins: both N- and C-terminal domains are necessary for full activities of Xenopus Smad6 and Smad7. |
| Q89914653 | Dullard-mediated Smad1/5/8 inhibition controls mouse cardiac neural crest cells condensation and outflow tract septation |
| Q24292399 | Early endosomal regulation of Smad-dependent signaling in endothelial cells |
| Q52846786 | Ehlers-Danlos syndrome with lethal cardiac valvular dystrophy in males carrying a novel splice mutation in FLNA. |
| Q26830155 | Endocardial and epicardial epithelial to mesenchymal transitions in heart development and disease |
| Q38943396 | Endocardial cell epithelial-mesenchymal transformation requires Type III TGFβ receptor interaction with GIPC. |
| Q39692868 | Endothelial SUR-8 acts in an ERK-independent pathway during atrioventricular cushion development. |
| Q36756262 | Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults |
| Q33163160 | Epicardial calcineurin-NFAT signals through Smad2 to direct coronary smooth muscle cell and arterial wall development |
| Q24303956 | Epicardial-myocardial signaling directing coronary vasculogenesis |
| Q28594617 | Essential role for ADAM19 in cardiovascular morphogenesis |
| Q81297429 | Essential role of Smad4 in maintaining cardiomyocyte proliferation during murine embryonic heart development |
| Q28509327 | Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa |
| Q35792899 | FOG-2 attenuates endothelial-to-mesenchymal transformation in the endocardial cushions of the developing heart |
| Q53228041 | Familial cardiac valvulopathy due to filamin A mutation. |
| Q35162957 | Form and function of developing heart valves: coordination by extracellular matrix and growth factor signaling |
| Q28302331 | Frzb modulates Wnt-9a-mediated beta-catenin signaling during avian atrioventricular cardiac cushion development |
| Q37625175 | Gene expression and genetic variation in human atria |
| Q30724640 | Gene profiling techniques and their application in angiogenesis and vascular development |
| Q92011318 | Genes Associated with Thoracic Aortic Aneurysm and Dissection: 2019 Update and Clinical Implications |
| Q33352008 | Genetics in arterial calcification: pieces of a puzzle and cogs in a wheel |
| Q27014805 | Genetics of valvular heart disease |
| Q34013514 | Genome-wide identification of mouse congenital heart disease loci |
| Q34699441 | Heart development: learning from mistakes |
| Q33607338 | Heart valve development: endothelial cell signaling and differentiation |
| Q37421779 | Heart valve development: regulatory networks in development and disease |
| Q33840844 | Hepatic deletion of Smad7 in mouse leads to spontaneous liver dysfunction and aggravates alcoholic liver injury |
| Q44512715 | Hepatic gene expression profiling reveals perturbed calcium signaling in a mouse model lacking both LDL receptor and Apobec1 genes |
| Q24645017 | Hereditary haemorrhagic telangiectasia: current views on genetics and mechanisms of disease |
| Q36391104 | Heterogeneity in the Segmental Development of the Aortic Tree: Impact on Management of Genetically Triggered Aortic Aneurysms |
| Q29619993 | How cells read TGF-beta signals |
| Q33607348 | Human pulmonary valve endothelial cells express functional adhesion molecules for leukocytes |
| Q42527108 | Inducible and selective transgene expression in murine vascular endothelium |
| Q35105653 | Inhibitory SMADs: potential regulators of ovarian function |
| Q53802661 | Insights into the mechanism of vascular calcification. |
| Q47264301 | Kinetic analysis of cardiac transcriptome regulation during chronic high-fat diet in dogs. |
| Q38358459 | Krüppel-like factor 4 (KLF4/GKLF) is a target of bone morphogenetic proteins and transforming growth factor beta 1 in the regulation of vascular smooth muscle cell phenotype. |
| Q28586742 | Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease |
| Q42444833 | Ligand- and stage-dependent divergent functions of BMP signaling in the differentiation of embryonic skeletogenic progenitors in vitro |
| Q38709824 | Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function |
| Q39030652 | Loss of Axin2 results in impaired heart valve maturation and subsequent myxomatous valve disease. |
| Q34500736 | Loss of β2-spectrin prevents cardiomyocyte differentiation and heart development |
| Q36027711 | Mapping Breakpoints of Complex Chromosome Rearrangements Involving a Partial Trisomy 15q23.1-q26.2 Revealed by Next Generation Sequencing and Conventional Techniques |
| Q38793075 | MicroRNAs 223-3p and 93-5p in patients with chronic kidney disease before and after renal transplantation. |
| Q36982749 | Models of aortic valve calcification |
| Q38361465 | Modulation of thrombomodulin-dependent activation of human protein C through differential expression of endothelial Smads |
| Q52096947 | Molecular markers of cardiac endocardial cushion development. |
| Q37259252 | Molecular mechanisms underlying the onset of degenerative aortic valve disease |
| Q37383073 | Mouse models of congenital cardiovascular disease |
| Q34156745 | Myocardial deletion of Smad4 using a novel α skeletal muscle actin Cre recombinase transgenic mouse causes misalignment of the cardiac outflow tract |
| Q41833592 | Negative autoregulation of BMP dependent transcription by SIN3B splicing reveals a role for RBM39. |
| Q35064303 | Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes development |
| Q28507662 | Nf1 has an essential role in endothelial cells |
| Q35095178 | Nfatc1 coordinates valve endocardial cell lineage development required for heart valve formation |
| Q39406800 | Nonsynonymous variants in the SMAD6 gene predispose to congenital cardiovascular malformation |
| Q35753562 | Osteogenic regulation of vascular calcification: an early perspective |
| Q24684936 | Osteopontin inhibits mineral deposition and promotes regression of ectopic calcification |
| Q30478829 | Outflow tract cushions perform a critical valve-like function in the early embryonic heart requiring BMPRIA-mediated signaling in cardiac neural crest |
| Q36178682 | Partitioning the heart: mechanisms of cardiac septation and valve development |
| Q39390979 | Pathophysiology of Aortic Stenosis and Mitral Regurgitation |
| Q30234828 | Pathophysiology of Aortic Valve Stenosis: Is It Both Fibrocalcific and Sex Specific? |
| Q42537904 | Periostin Expression is Altered in Aortic Valves in Smad6 Mutant Mice |
| Q33968020 | Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents. |
| Q37222921 | Periostin as a heterofunctional regulator of cardiac development and disease |
| Q41807478 | Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart |
| Q33915818 | Periostin promotes a fibroblastic lineage pathway in atrioventricular valve progenitor cells |
| Q30305991 | Positive- and negative-acting Kruppel-like transcription factors bind a transforming growth factor beta control element required for expression of the smooth muscle cell differentiation marker SM22alpha in vivo. |
| Q33941107 | Preferential activation of SMAD1/5/8 on the fibrosa endothelium in calcified human aortic valves--association with low BMP antagonists and SMAD6 |
| Q44945249 | Prenatal genetic diagnosis using microarray analysis in fetuses with congenital heart defects |
| Q37255043 | Prospective surface marker-based isolation and expansion of fetal endothelial colony-forming cells from human term placenta |
| Q37214425 | Protective Role of Smad6 in Inflammation-Induced Valvular Cell Calcification. |
| Q36313076 | Ras-related signaling pathways in valve development: ebb and flow. |
| Q35757916 | Re-employment of developmental transcription factors in adult heart disease |
| Q39029996 | Regulation of TGF-β Family Signaling by Inhibitory Smads. |
| Q35699827 | Regulation of cardiovascular calcification |
| Q38465654 | Regulators and effectors of bone morphogenetic protein signalling in the cardiovascular system. |
| Q35031614 | Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells |
| Q90631576 | Research Models for Studying Vascular Calcification |
| Q38269616 | Review of molecular and mechanical interactions in the aortic valve and aorta: implications for the shared pathogenesis of aortic valve disease and aortopathy |
| Q35090135 | Roles of TGFbeta signaling in epidermal/appendage development |
| Q54396322 | Screening of TGFBR1, TGFBR2, and FLNA in familial mitral valve prolapse. |
| Q33674328 | Smad signaling in skeletal development and regeneration |
| Q34599300 | Smad signalling in the ovary |
| Q35243103 | Smad6 is essential to limit BMP signaling during cartilage development |
| Q38351441 | Smad6 is induced by BMP-2 and modulates chondrocyte differentiation |
| Q35122982 | Smad6 promotes neuronal differentiation in the intermediate zone of the dorsal neural tube by inhibition of the Wnt/beta-catenin pathway |
| Q36322115 | Smad6/Smurf1 overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopenia |
| Q34395261 | Smad6s regulates plasminogen activator inhibitor-1 through a protein kinase C-beta-dependent up-regulation of transforming growth factor-beta |
| Q24309082 | Smad7 is required for the development and function of the heart |
| Q40806167 | Smads, TAK1, and their common target ATF-2 play a critical role in cardiomyocyte differentiation. |
| Q37413451 | T-box 2, a mediator of Bmp-Smad signaling, induced hyaluronan synthase 2 and Tgfbeta2 expression and endocardial cushion formation. |
| Q34421804 | TGF-beta signaling in cancer--a double-edged sword |
| Q37359962 | TGF-beta signaling in vascular biology and dysfunction |
| Q37628211 | TGF-beta-dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome |
| Q87681974 | TGF-β Signaling in Control of Cardiovascular Function |
| Q28142605 | TGFbeta signaling in growth control, cancer, and heritable disorders |
| Q37976673 | TGFβ signaling and cardiovascular diseases |
| Q28590974 | Tbx2 and Tbx3 regulate the dynamics of cell proliferation during heart remodeling |
| Q36083442 | Tgf-beta superfamily and mouse craniofacial development: interplay of morphogenetic proteins and receptor signaling controls normal formation of the face. |
| Q36242266 | The BMP signaling and in vivo bone formation |
| Q59136506 | The Genetic Regulation of Aortic Valve Development and Calcific Disease |
| Q35612296 | The SCL transcriptional network and BMP signaling pathway interact to regulate RUNX1 activity |
| Q38319514 | The Smad6-histone deacetylase 3 complex silences the transcriptional activity of the glucocorticoid receptor: potential clinical implications |
| Q24805956 | The Smads |
| Q39008931 | The expression of Smad signaling pathway in myocardium and potential therapeutic effects |
| Q38233054 | The living aortic valve: From molecules to function. |
| Q37616278 | The role of secondary heart field in cardiac development |
| Q35013304 | The roles of the skeleton and phosphorus in the CKD mineral bone disorder |
| Q53819472 | The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium. |
| Q34562988 | Transcription factors in cardiogenesis: the combinations that unlock the mysteries of the heart |
| Q34096014 | Transcriptional regulation of cardiac development: implications for congenital heart disease and DiGeorge syndrome |
| Q37663819 | Transcriptional regulation of heart valve progenitor cells. |
| Q38988997 | Transforming Growth Factor β Superfamily Signaling in Development of Colorectal Cancer |
| Q35209142 | Transforming growth factor beta in cardiovascular development and function |
| Q34438032 | Transforming growth factor-beta signal transduction in epithelial cells. |
| Q35177514 | Transforming growth factor-beta stimulates epithelial-mesenchymal transformation in the proepicardium |
| Q24548354 | Trichloroethylene exposure during cardiac valvuloseptal morphogenesis alters cushion formation and cardiac hemodynamics in the avian embryo |
| Q37296203 | Up-regulation of BMP-2 antagonizes TGF-β1/ROCK-enhanced cardiac fibrotic signalling through activation of Smurf1/Smad6 complex |
| Q36849680 | Valvulogenesis: the moving target |
| Q36676122 | Vascular calcification and osteoporosis--from clinical observation towards molecular understanding |
| Q37356863 | Vascular calcification in middle age and long-term risk of hip fracture: the Framingham Study |
| Q36570771 | Vascular smooth muscle cell phenotypic plasticity and the regulation of vascular calcification. |
| Q37871555 | What chick and mouse models have taught us about the role of the endocardium in congenital heart disease |
| Q38853714 | Where do we stand on vascular calcification? |
| Q34988841 | c-Myc is essential to prevent endothelial pro-inflammatory senescent phenotype |
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