An in vivo reporter of BMP signaling in organogenesis reveals targets in the developing kidney

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An in vivo reporter of BMP signaling in organogenesis reveals targets in the developing kidney is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1026891361
P356DOI10.1186/1471-213X-8-86
P932PMC publication ID2561030
P698PubMed publication ID18801194

P50authorUlrika BlankQ122700029
Leif OxburghQ54280533
P2093author name stringDon M Wojchowski
Derek C Adams
Michele J Karolak
Marianne L Seto
P2860cites workGenetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesisQ21145242
TGF-beta signal transductionQ22003891
Heart specific expression of mouse BMP-10 a novel member of the TGF-beta superfamilyQ22009012
OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathwaysQ22011195
Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cellsQ24309588
Regulation of BMP7 expression during kidney developmentQ24321655
Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivoQ24555732
Bone morphogenetic protein-9 is a circulating vascular quiescence factorQ24657942
Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteinsQ24677861
A role for smad6 in development and homeostasis of the cardiovascular systemQ28143788
Endogenous patterns of BMP signaling during early chick developmentQ28207797
Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoterQ28208212
Human Smad3 and Smad4 are sequence-specific transcription activatorsQ28276193
BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesisQ28289169
Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroupQ28506935
BMP4 substitutes for loss of BMP7 during kidney developmentQ28507463
Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammationQ28507809
Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in BMP7 deficient embryosQ28507860
A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eyeQ28508005
Bmp in podocytes is essential for normal glomerular capillary formationQ28511751
Differential requirements for Smad4 in TGFbeta-dependent patterning of the early mouse embryoQ28513265
Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac developmentQ28513337
TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor populationQ28513547
Dynamic regulation of Smad expression during mesenchyme to epithelium transition in the metanephric kidneyQ28570315
Smad expression during kidney developmentQ28585087
BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardiumQ28586500
Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal developmentQ28586643
Evidence that autocrine signaling through Bmpr1a regulates the proliferation, survival and morphogenetic behavior of distal lung epithelial cellsQ28587721
Expression of bone morphogenetic protein receptors in the developing mouse metanephrosQ77149595
Morphogenesis during mouse embryonic kidney explant cultureQ78630765
Patterning the embryonic kidney: BMP signaling mediates the differentiation of the pronephric tubules and duct in Xenopus laevisQ80171752
Essential role of Smad4 in maintaining cardiomyocyte proliferation during murine embryonic heart developmentQ81297429
Control of kidney, eye and limb expression of Bmp7 by an enhancer element highly conserved between speciesQ28754463
BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3Q29614624
A highly efficient recombineering-based method for generating conditional knockout mutationsQ29615157
In vivo enhancer analysis of human conserved non-coding sequencesQ29616554
Immunohistochemical expression of Smads 1-6 in the 15-day gestation mouse embryo: signaling by BMPs and TGF-betasQ31911425
Functional redundancy of TGF-beta family type I receptors and receptor-Smads in mediating anti-Mullerian hormone-induced Mullerian duct regression in the mouseQ33621021
Developmental expression of mouse Follistatin-like 1 (Fstl1): Dynamic regulation during organogenesis of the kidney and lungQ33705583
Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3Q34014910
Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repressionQ34316282
Requirement for BMP signaling in interdigital apoptosis and scale formation.Q34377113
Interaction between FGF and BMP signaling pathways regulates development of metanephric mesenchymeQ35199256
Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in miceQ36421055
BMP signaling in dermal papilla cells is required for their hair follicle-inductive propertiesQ36453561
BMP receptor ALK3 controls collecting system developmentQ36667155
Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine developmentQ36686718
Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureterQ37176177
The pro-osteogenic action of beta-catenin requires interaction with BMP signaling, but not Tcf/Lef transcriptional activityQ37265057
Essential pro-Bmp roles of crossveinless 2 in mouse organogenesisQ38308645
Enhancer analysis of the mouse HNF-3 beta gene: regulatory elements for node/notochord and floor plate are independent and consist of multiple sub-elementsQ38363013
Spatio-temporal activation of Smad1 and Smad5 in vivo: monitoring transcriptional activity of Smad proteinsQ40521999
p38MAPK acts in the BMP7-dependent stimulatory pathway during epithelial cell morphogenesis and is regulated by Smad1.Q40600202
Transcriptional regulation of BMP4 synexpression in transgenic XenopusQ40734215
BMP-2 and OP-1 exert direct and opposite effects on renal branching morphogenesisQ41070912
Inducible expression of an hsp68-lacZ hybrid gene in transgenic miceQ44484787
TGF-beta superfamily members modulate growth, branching, shaping, and patterning of the ureteric bud.Q44738676
BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signalingQ45065876
Phylogenetic footprinting and genome scanning identify vertebrate BMP response elements and new target genes.Q45965916
Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesisQ46255940
De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestineQ47961996
Real time monitoring of BMP Smads transcriptional activity during mouse development.Q50628619
Localization of TGF-beta signaling intermediates Smad2, 3, 4, and 7 in developing and mature human and mouse kidney.Q52000197
BMP receptor type IA in limb bud mesenchyme regulates distal outgrowth and patterning.Q52019997
In vivo evidence that BMP signaling is necessary for apoptosis in the mouse limb.Q52115127
Endogenous patterns of TGFbeta superfamily signaling during early Xenopus development.Q52167679
Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development.Q52174962
Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects.Q52178711
Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation.Q54588887
Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injuryQ57936785
Physical and functional interaction of SMADs and p300/CBPQ64381971
BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterningQ71817916
Mechanism of the pleiotropic effects of the short-ear mutant gene in the mouseQ72137415
P304page(s)86
P577publication date2008-09-18
P1433published inBMC Developmental BiologyQ15761839
P1476titleAn in vivo reporter of BMP signaling in organogenesis reveals targets in the developing kidney
P478volume8

Reverse relations

cites work (P2860)
Q570254613D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling
Q42324689A Bmp reporter with ultrasensitive characteristics reveals that high Bmp signaling is not required for cortical hem fate
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Q35035999Adult-specific systemic over-expression reveals novel in vivo effects of the soluble forms of ActRIIA, ActRIIB and BMPRII.
Q37330620An interdigit signalling centre instructs coordinate phalanx-joint formation governed by 5'Hoxd-Gli3 antagonism.
Q51933152Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment.
Q34343116Anti-inflammatory activity of bone morphogenetic protein signaling pathways in stomachs of mice
Q50678241BMP antagonism by Noggin is required in presumptive notochord cells for mammalian foregut morphogenesis.
Q38161819BMP signaling and its modifiers in kidney development
Q41591432BMP signaling in the development of the mouse esophagus and forestomach
Q37849623BMP signaling in the nephron progenitor niche
Q36159603BMP-SMAD signalling output is highly regionalized in cardiovascular and lymphatic endothelial networks
Q35408666BMP-driven NRF2 activation in esophageal basal cell differentiation and eosinophilic esophagitis
Q37385501BMP7 promotes proliferation of nephron progenitor cells via a JNK-dependent mechanism
Q26822802Bone morphogenetic protein signaling in nephron progenitor cells
Q30431055Cadherin 6B induces BMP signaling and de-epithelialization during the epithelial mesenchymal transition of the neural crest
Q38275152Cell signaling pathways involved in hematopoietic stem cell specification
Q35096652Chondrocyte-specific microRNA-140 regulates endochondral bone development and targets Dnpep to modulate bone morphogenetic protein signaling.
Q50525535Direct visualization of Smad1/5/8-mediated transcriptional activity identifies podocytes and collecting ducts as major targets of BMP signalling in healthy and diseased kidneys.
Q33792073Disruption of mitotic arrest precedes precocious differentiation and transdifferentiation of pregranulosa cells in the perinatal Wnt4 mutant ovary
Q35498717Distinct bone morphogenetic proteins activate indistinguishable transcriptional responses in nephron epithelia including Notch target genes.
Q34870630Dynamic analysis of BMP-responsive smad activity in live zebrafish embryos
Q64951976Expression of BMP-4 and Smad1 in patients with Hirschsprung disease and its clinical significance.
Q36309205Inactivation of the dual Bmp/Wnt inhibitor Sostdc1 enhances pancreatic islet function
Q35111241Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron
Q33573554Lrp4 regulates initiation of ureteric budding and is crucial for kidney formation--a mouse model for Cenani-Lenz syndrome
Q38649803On signaling pathways: hematopoietic stem cell specification from hemogenic endothelium.
Q96954768RIPK3: A New Player in Renal Fibrosis
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Q35626101SMAD1 and SMAD5 Expression Is Coordinately Regulated by FLI1 and GATA2 during Endothelial Development
Q52669131Stromal β-catenin overexpression contributes to the pathogenesis of renal dysplasia.
Q52703607TGF-β Family Signaling in Ductal Differentiation and Branching Morphogenesis.
Q35533843TGFβ superfamily signaling in the neural crest lineage

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