3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling

scientific article published on 20 September 2018

3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.STEM.2018.08.009
P932PMC publication ID6282026
P698PubMed publication ID30244870

P50authorRevathi BalasubramanianQ57055572
Monika BialeckaQ59312337
Munemasa MoriQ84071470
P2093author name stringSijie Lin
Ying Yang
Ming Jiang
Xin Zhang
Wellington V Cardoso
Eugene Kim
Jianwen Que
Ya-Wen Chen
Hans-Willem Snoeck
Susana M Chuva de Sousa Lopes
Denise Al Alam
Yongchun Zhang
Wanwei Zhang
Carlos Serra
Paul N Riccio
Ana Luisa Rodrigues Toste de Carvalho
Soula Danopoulos
Sarah Xuelian Huang
P2860cites workNoggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somiteQ24602347
Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movementsQ27313892
Generation of functional human pancreatic β cells in vitroQ28249536
Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identitiesQ28277481
Lung epithelial branching program antagonizes alveolar differentiationQ28504589
Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-/-) mouse embryosQ28505450
Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregutQ28509406
The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells.Q41877949
Transitional basal cells at the squamous-columnar junction generate Barrett's oesophagusQ41919300
Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like propertiesQ42030667
Efficient derivation of purified lung and thyroid progenitors from embryonic stem cellsQ42057076
Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells.Q42065869
Overexpression of Kruppel-like factor 5 in esophageal epithelia in vivo leads to increased proliferation in basal but not suprabasal cellsQ42510390
KLF4 transcriptionally activates non-canonical WNT5A to control epithelial stratificationQ42783866
Prox1 is an early specific marker for the developing liver and pancreas in the mammalian foregut endodermQ44154968
Mesodermal Wnt2b signalling positively regulates liver specification.Q45995605
Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells.Q47719385
The cut-homeodomain transcriptional activator HNF-6 is coexpressed with its target gene HNF-3 beta in the developing murine liver and pancreasQ48040924
Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic Interaction with GATA4 in Human Pancreatic DevelopmentQ50455898
The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear.Q52040186
Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling.Q52884838
Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decisionQ74211426
Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner earQ28510001
Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endodermQ28510560
Wnt/beta-catenin signaling is required for development of the exocrine pancreasQ28510840
Sox9 plays multiple roles in the lung epithelium during branching morphogenesisQ28585673
Morphogenesis of the trachea and esophagus: current players and new roles for noggin and BmpsQ28588087
beta-Catenin promotes respiratory progenitor identity in mouse foregutQ28593614
The canonical Notch signaling pathway: unfolding the activation mechanismQ29547725
Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities.Q32024327
An in vivo reporter of BMP signaling in organogenesis reveals targets in the developing kidneyQ33370427
A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specificationQ33387191
Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2.Q33818155
The Krüppel-like transcriptional factors Zf9 and GKLF coactivate the human keratin 4 promoter and physically interactQ33901164
Wnt/β-catenin promotes gastric fundus specification in mice and humansQ33926430
Generation of multipotent lung and airway progenitors from mouse ESCs and patient-specific cystic fibrosis iPSCsQ34031395
Efficient generation of lung and airway epithelial cells from human pluripotent stem cellsQ34039177
Hedgehog signaling regulates FOXA2 in esophageal embryogenesis and Barrett's metaplasia.Q34117556
Isolation and characterization of mouse and human esophageal epithelial cells in 3D organotypic cultureQ34125957
Cellular heterogeneity in the mouse esophagus implicates the presence of a nonquiescent epithelial stem cell populationQ34470310
Generation of mice with a conditional null allele of the Jagged2 geneQ35044217
Residual embryonic cells as precursors of a Barrett's-like metaplasia.Q35073657
BMP-driven NRF2 activation in esophageal basal cell differentiation and eosinophilic esophagitisQ35408666
KeyGenes, a Tool to Probe Tissue Differentiation Using a Human Fetal Transcriptional AtlasQ35754919
Genetic and cellular mechanisms regulating anterior foregut and esophageal developmentQ36131001
The initial establishment and epithelial morphogenesis of the esophagus: a new model of tracheal-esophageal separation and transition of simple columnar into stratified squamous epithelium in the developing esophagusQ38366427
Prospective isolation of NKX2-1-expressing human lung progenitors derived from pluripotent stem cells.Q38688592
Pluripotent stem cells progressing to the clinicQ38747535
Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR proteinQ38865602
A NOTCH3-mediated squamous cell differentiation program limits expansion of EMT-competent cells that express the ZEB transcription factors.Q38905550
Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia.Q38979614
Development and stem cells of the esophagusQ39051019
NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional networkQ39662272
Long-lived keratin 15+ esophageal progenitor cells contribute to homeostasis and regeneration.Q40211146
A three-dimensional model of human lung development and disease from pluripotent stem cells.Q40230465
Distribution of the titf2/foxe1 gene product is consistent with an important role in the development of foregut endoderm, palate, and hair.Q40707542
Sox2 cooperates with inflammation-mediated Stat3 activation in the malignant transformation of foregut basal progenitor cellsQ41260832
BMP signaling in the development of the mouse esophagus and forestomachQ41591432
Modelling human development and disease in pluripotent stem-cell-derived gastric organoidsQ41680408
Directed differentiation of human pluripotent stem cells into intestinal tissue in vitroQ41770080
The human squamous oesophagus has widespread capacity for clonal expansion from cells at diverse stages of differentiation.Q41847010
P4510describes a project that usesImageJQ1659584
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)516-529.e5
P577publication date2018-09-20
P1433published inCell Stem CellQ2943975
P1476title3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling
P478volume23

Reverse relations

cites work (P2860)
Q93137039Biologically inspired approaches to enhance human organoid complexity
Q90261702Human induced pluripotent stem cell-derived vocal fold mucosa mimics development and responses to smoke exposure
Q97418936Human organoids: model systems for human biology and medicine
Q90110358Multi-lineage Human iPSC-Derived Platforms for Disease Modeling and Drug Discovery
Q89882676Organoid models of gastrointestinal cancers in basic and translational research
Q92997188Targeting SOX2 Protein with Peptide Aptamers for Therapeutic Gains against Esophageal Squamous Cell Carcinoma
Q102141773The promise of human organoids in the digestive system
Q99631269Translating Embryogenesis to Generate Organoids: Novel Approaches to Personalized Medicine

Search more.