Endothelial SUR-8 acts in an ERK-independent pathway during atrioventricular cushion development.

scientific article published on July 2010

Endothelial SUR-8 acts in an ERK-independent pathway during atrioventricular cushion development. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/DVDY.22343
P932PMC publication ID3138404
P698PubMed publication ID20549726
P5875ResearchGate publication ID44674854

P50authorXiao YangQ52359342
Jing YiQ38523246
P2093author name stringYuan Zhuang
Tian Xu
Min Han
Xiaohui Wu
Rener Xu
Muyun Chen
P2860cites workGATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5Q24307366
SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegansQ24317576
A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activityQ24319503
soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signalingQ24323124
Bone morphogenetic protein-2 can mediate myocardial regulation of atrioventricular cushion mesenchymal cell formation in miceQ24338200
ADAM10 is essential for proteolytic activation of Notch during thymocyte development.Q51952311
Haemodynamics determined by a genetic programme govern asymmetric development of the aortic arch.Q51972715
Temporal and distinct TGFbeta ligand requirements during mouse and avian endocardial cushion morphogenesis.Q52116730
A novel role for VEGF in endocardial cushion formation and its potential contribution to congenital heart defects.Q52137184
Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression.Q52165853
Essential functions of Alk3 during AV cushion morphogenesis in mouse embryonic hearts.Q53600682
Migratory behavior of cardiac cushion tissue cells in a collagen-lattice culture systemQ70400076
The development of the atrioventricular junction in the human heartQ71006297
Invasion of mesenchyme into three-dimensional collagen gels: a regional and temporal analysis of interaction in embryonic heart tissueQ71664314
Localization of transcription factor GATA-4 to regions of the mouse embryo involved in cardiac developmentQ72093904
Expression of smooth muscle alpha-actin in mesenchymal cells during formation of avian endocardial cushion tissue: A role for transforming growth factor β3Q73494345
A gene atlas of the mouse and human protein-encoding transcriptomesQ24568043
The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and RafQ24607066
Epithelial-mesenchymal transitions in development and diseaseQ27860630
Development of heart valves requires Gata4 expression in endothelial-derived cellsQ27863348
A role for smad6 in development and homeostasis of the cardiovascular systemQ28143788
Erbin suppresses the MAP kinase pathwayQ28207608
Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complexQ28282958
A null mutation of Hhex results in abnormal cardiac development, defective vasculogenesis and elevated Vegfa levelsQ28285594
Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart functionQ28505013
A critical role for the EphA3 receptor tyrosine kinase in heart developmentQ28506094
Nf1 has an essential role in endothelial cellsQ28507662
Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformationQ28589469
ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient miceQ28590176
Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervationQ28591836
The incidence of congenital heart diseaseQ29614195
Heart valve development: endothelial cell signaling and differentiationQ33607338
GATA transcription factors and cardiac developmentQ33650760
Mechanisms involved in valvuloseptal endocardial cushion formation in early cardiogenesis: roles of transforming growth factor (TGF)-beta and bone morphogenetic protein (BMP).Q33823445
Epidemiology of cardiovascular malformations: prevalence and risk factorsQ34263615
Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signalingQ35032897
Form and function of developing heart valves: coordination by extracellular matrix and growth factor signalingQ35162957
A novel GATA4 mutation completely segregated with atrial septal defect in a large Japanese familyQ35446305
Control of endocardial cushion and cardiac valve maturation by BMP signaling pathwaysQ35563823
Cell biology of cardiac cushion development.Q36083465
Cardiac neural crestQ36212774
Ras-related signaling pathways in valve development: ebb and flow.Q36313076
Essential role of endothelial Smad4 in vascular remodeling and integrity.Q36315610
Heart valve development: regulatory networks in development and diseaseQ37421779
Incidence of congenital heart disease: II. Prenatal incidenceQ40417373
Incidence of congenital heart disease: I. Postnatal incidence.Q40448489
Critical contribution of linker proteins to Raf kinase activationQ40763817
Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus.Q40875075
Structural analysis of cell: Matrix association during the morphogenesis of atrioventricular cushion tissueQ41558496
Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formationQ46377767
The timing of emergence of muscle progenitors is controlled by an FGF/ERK/SNAIL1 pathway.Q47791335
P433issue7
P921main subjectendotheliumQ111140
P304page(s)2005-2013
P577publication date2010-07-01
P1433published inDevelopmental DynamicsQ59752
P1476titleEndothelial SUR-8 acts in an ERK-independent pathway during atrioventricular cushion development
P478volume239

Reverse relations

cites work (P2860)
Q37725186Erbin is a negative modulator of cardiac hypertrophy
Q27315483Functional Integration of the Conserved Domains of Shoc2 Scaffold
Q34298040HUWE1 is a molecular link controlling RAF-1 activity supported by the Shoc2 scaffold
Q57457543Hematopoietic and neural crest defects in zebrafish shoc2 mutants: a novel vertebrate model for Noonan-like syndrome
Q28585805Mst1 and mst2 are essential regulators of trophoblast differentiation and placenta morphogenesis
Q92642505SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers
Q26765993Scaffold Proteins Regulating Extracellular Regulated Kinase Function in Cardiac Hypertrophy and Disease
Q36677993Shoc2-tranduced ERK1/2 motility signals--Novel insights from functional genomics
Q34712536Shoc2/Sur8 protein regulates neurite outgrowth
Q36462466Spatial control of Shoc2-scaffold-mediated ERK1/2 signaling requires remodeling activity of the ATPase PSMC5.
Q38472620Sur8/Shoc2 involves both inhibition of differentiation and maintenance of self-renewal of neural progenitor cells via modulation of extracellular signal-regulated kinase signaling.
Q58605081Systematic identification of celastrol-binding proteins reveals that Shoc2 is inhibited by celastrol
Q37183275The function of Shoc2: A scaffold and beyond
Q92038741VCP/p97 controls signals of the ERK1/2 pathway transmitted via the Shoc2 scaffolding complex: novel insights into IBMPFD pathology

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