Shoc2/Sur8 protein regulates neurite outgrowth

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Shoc2/Sur8 protein regulates neurite outgrowth is …
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scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...9k4837L
P356DOI10.1371/JOURNAL.PONE.0114837
P932PMC publication ID4267731
P698PubMed publication ID25514808
P5875ResearchGate publication ID269679486

P50authorTeresa IglesiasQ57038769
Pilar Sánchez-GómezQ58788702
P2093author name stringMiguel Calero
Olga Calero
Natalia Martinez
Jose M Rojas
Natasha Zarich
Silvia Hernandez
Daniel Peña-Jimenez
Andrea Perez-Rodriguez
Berta Anta
Carlota A Garcia-Dominguez
Gonzalo Leon
Jose L Oliva
Judit Castro
Lara M Dura
Lucia Sanchez-Ruiloba
Teresa Gragera
P2860cites workERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGFQ24304344
SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegansQ24317576
A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activityQ24319503
soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signalingQ24323124
Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hairQ24336157
The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and RafQ24607066
Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinasesQ24680631
Grb2 is a negative modulator of the intrinsic Ras-GEF activity of hSos1Q24685178
Shoc2 is targeted to late endosomes and required for Erk1/2 activation in EGF-stimulated cellsQ27303629
Functional Integration of the Conserved Domains of Shoc2 ScaffoldQ27315483
Regulated segregation of kinase Dyrk1A during asymmetric neural stem cell division is critical for EGFR-mediated biased signaling.Q50562257
Cognitive profile of disorders associated with dysregulation of the RAS/MAPK signaling cascade.Q51942865
Nerve growth factor induces survival and differentiation through two distinct signaling cascades in PC12 cells.Q52177288
ras Genes and Human Cancer: Different Implications and Different RolesQ57375823
PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activityQ67542908
Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complexQ28282958
Mammalian sprouty proteins inhibit cell growth and differentiation by preventing ras activationQ28505657
Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fateQ28576088
Coordinating ERK/MAPK signalling through scaffolds and inhibitorsQ29618995
Sprouty2 binds Grb2 at two different proline-rich regions, and the mechanism of ERK inhibition is independent of this interactionQ30157899
Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II.Q30460881
Valproic acid induces differentiation and inhibition of proliferation in neural progenitor cells via the beta-catenin-Ras-ERK-p21Cip/WAF1 pathwayQ33391576
Ras and calcium signaling pathways converge at Raf1 via the Shoc2 scaffold proteinQ33721174
Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1.Q33966221
Rewiring MAP kinase pathways using alternative scaffold assembly mechanismsQ34168435
An MRAS, SHOC2, and SCRIB complex coordinates ERK pathway activation with polarity and tumorigenic growthQ34383929
Signaling pathways for PC12 cell differentiation: making the right connectionsQ34662640
Using engineered scaffold interactions to reshape MAP kinase pathway signaling dynamicsQ34761596
The leucine-rich repeat structure.Q34769694
Scaffolds: interaction platforms for cellular signalling circuits.Q34774526
Targeting the mitogen-activated protein kinase cascade to treat cancerQ35968411
SHOC2 and CRAF mediate ERK1/2 reactivation in mutant NRAS-mediated resistance to RAF inhibitorQ36451902
A branched signaling pathway for nerve growth factor is revealed by Src-, Ras-, and Raf-mediated gene inductionsQ36684518
Desmoglein-1/Erbin interaction suppresses ERK activation to support epidermal differentiationQ36733429
Scaffold proteins of MAP-kinase modules.Q36819386
MAP kinases and the control of nuclear eventsQ36819401
Protein scaffolds in MAP kinase signallingQ37156628
Scaffold proteins and immune-cell signallingQ37357014
The ERK Cascade: Distinct Functions within Various Subcellular OrganellesQ37903694
Grasping objects: the cortical mechanisms of visuomotor transformationQ38463051
Sur8/Shoc2 involves both inhibition of differentiation and maintenance of self-renewal of neural progenitor cells via modulation of extracellular signal-regulated kinase signaling.Q38472620
Endothelial SUR-8 acts in an ERK-independent pathway during atrioventricular cushion development.Q39692868
The scaffold protein Shoc2/SUR-8 accelerates the interaction of Ras and Raf.Q39763725
Sprouty-2 overexpression in C2C12 cells confers myogenic differentiation properties in the presence of FGF2Q40401260
p75 and Trk: a two-receptor systemQ40419805
Critical contribution of linker proteins to Raf kinase activationQ40763817
Palmitoylation of ERBIN is required for its plasma membrane localizationQ42812704
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectneuriteQ1534415
P304page(s)e114837
P577publication date2014-12-16
P1433published inPLOS OneQ564954
P1476titleShoc2/Sur8 protein regulates neurite outgrowth
P478volume9

Reverse relations

Q38755297SHOC2 subcellular shuttling requires the KEKE motif-rich region and N-terminal leucine-rich repeat domain and impacts on ERK signallingcites workP2860