Using engineered scaffold interactions to reshape MAP kinase pathway signaling dynamics

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Using engineered scaffold interactions to reshape MAP kinase pathway signaling dynamics is …
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scholarly articleQ13442814

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P819ADS bibcode2008Sci...319.1539B
P356DOI10.1126/SCIENCE.1151153
P698PubMed publication ID18339942
P5875ResearchGate publication ID5512287

P2093author name stringWendell A Lim
Shude Yan
Caleb J Bashor
Noah C Helman
P2860cites workDifferential regulation of FUS3 MAP kinase by tyrosine-specific phosphatases PTP2/PTP3 and dual-specificity phosphatase MSG5 in Saccharomyces cerevisiaeQ27930148
Functional characterization of the interaction of Ste50p with Ste11p MAPKKK in Saccharomyces cerevisiaeQ27931575
Differential input by Ste5 scaffold and Msg5 phosphatase route a MAPK cascade to multiple outcomesQ27935204
The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway.Q27935451
Signaling through scaffold, anchoring, and adaptor proteinsQ28131792
Robustness in simple biochemical networksQ29617496
The biochemical basis of an all-or-none cell fate switch in Xenopus oocytesQ29619826
Signal transduction: hanging on a scaffold.Q33860503
Negative autoregulation speeds the response times of transcription networksQ33962256
Rewiring MAP kinase pathways using alternative scaffold assembly mechanismsQ34168435
Regulated cell-to-cell variation in a cell-fate decision systemQ34451943
Scaffolding protein INAD regulates deactivation of vision by promoting phosphorylation of transient receptor potential by eye protein kinase C in DrosophilaQ35051082
Scaffold proteins confer diverse regulatory properties to protein kinase cascades.Q35941359
MAPK signal specificity: the right place at the right timeQ36444123
The where's and when's of kinase anchoringQ36475672
Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits.Q36498348
Graded mode of transcriptional induction in yeast pheromone signalling revealed by single-cell analysisQ39580394
Acquisition of chemoresistance following discontinuous exposures to cisplatin is associated in ovarian carcinoma cells with progressive alteration of FAK, ERK and p38 activation in response to treatmentQ40334868
Role of ERK activation in cisplatin-induced apoptosis in A172 human glioma cells.Q40505995
Positive-feedback loops as a flexible biological moduleQ42128441
Untangling the signalling wiresQ43107612
Assembly of the Drosophila phototransduction cascade into a signalling complex shapes elementary responsesQ46057937
MAPK-mediated bimodal gene expression and adaptive gradient sensing in yeast.Q51063630
Role of scaffolds in MAP kinase pathway specificity revealed by custom design of pathway-dedicated signaling proteins.Q52935984
P433issue5869
P407language of work or nameEnglishQ1860
P304page(s)1539-1543
P577publication date2008-03-01
P1433published inScienceQ192864
P1476titleUsing engineered scaffold interactions to reshape MAP kinase pathway signaling dynamics
P478volume319

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