scholarly article | Q13442814 |
P819 | ADS bibcode | 2008Sci...319.1539B |
P356 | DOI | 10.1126/SCIENCE.1151153 |
P698 | PubMed publication ID | 18339942 |
P5875 | ResearchGate publication ID | 5512287 |
P2093 | author name string | Wendell A Lim | |
Shude Yan | |||
Caleb J Bashor | |||
Noah C Helman | |||
P2860 | cites work | Differential regulation of FUS3 MAP kinase by tyrosine-specific phosphatases PTP2/PTP3 and dual-specificity phosphatase MSG5 in Saccharomyces cerevisiae | Q27930148 |
Functional characterization of the interaction of Ste50p with Ste11p MAPKKK in Saccharomyces cerevisiae | Q27931575 | ||
Differential input by Ste5 scaffold and Msg5 phosphatase route a MAPK cascade to multiple outcomes | Q27935204 | ||
The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway. | Q27935451 | ||
Signaling through scaffold, anchoring, and adaptor proteins | Q28131792 | ||
Robustness in simple biochemical networks | Q29617496 | ||
The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes | Q29619826 | ||
Signal transduction: hanging on a scaffold. | Q33860503 | ||
Negative autoregulation speeds the response times of transcription networks | Q33962256 | ||
Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms | Q34168435 | ||
Regulated cell-to-cell variation in a cell-fate decision system | Q34451943 | ||
Scaffolding protein INAD regulates deactivation of vision by promoting phosphorylation of transient receptor potential by eye protein kinase C in Drosophila | Q35051082 | ||
Scaffold proteins confer diverse regulatory properties to protein kinase cascades. | Q35941359 | ||
MAPK signal specificity: the right place at the right time | Q36444123 | ||
The where's and when's of kinase anchoring | Q36475672 | ||
Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits. | Q36498348 | ||
Graded mode of transcriptional induction in yeast pheromone signalling revealed by single-cell analysis | Q39580394 | ||
Acquisition of chemoresistance following discontinuous exposures to cisplatin is associated in ovarian carcinoma cells with progressive alteration of FAK, ERK and p38 activation in response to treatment | Q40334868 | ||
Role of ERK activation in cisplatin-induced apoptosis in A172 human glioma cells. | Q40505995 | ||
Positive-feedback loops as a flexible biological module | Q42128441 | ||
Untangling the signalling wires | Q43107612 | ||
Assembly of the Drosophila phototransduction cascade into a signalling complex shapes elementary responses | Q46057937 | ||
MAPK-mediated bimodal gene expression and adaptive gradient sensing in yeast. | Q51063630 | ||
Role of scaffolds in MAP kinase pathway specificity revealed by custom design of pathway-dedicated signaling proteins. | Q52935984 | ||
P433 | issue | 5869 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 1539-1543 | |
P577 | publication date | 2008-03-01 | |
P1433 | published in | Science | Q192864 |
P1476 | title | Using engineered scaffold interactions to reshape MAP kinase pathway signaling dynamics | |
P478 | volume | 319 |
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