pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase

scientific article published on 22 May 2017

pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase is …
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scholarly articleQ13442814

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P819ADS bibcode2017NatCo...815398A
P6179Dimensions Publication ID1085460780
P356DOI10.1038/NCOMMS15398
P932PMC publication ID5458144
P698PubMed publication ID28530236

P50authorKatherine A DonovanQ64355331
Eric S. FischerQ43073160
P2093author name stringJian An
Michael B Stadler
Jan Seebacher
Ragna Sack
Charles M Ponthier
P2860cites workAn Atypical E3 Ligase Zinc Finger Protein 91 Stabilizes and Activates NF-κB-inducing Kinase via Lys63-linked UbiquitinationQ24294345
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Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomideQ27684738
Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogsQ27694755
Structural basis of lenalidomide-induced CK1α degradation by the CRL4(CRBN) ubiquitin ligaseQ27704179
Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosomeQ27704406
A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligaseQ27713259
RING domain E3 ubiquitin ligasesQ27860546
A comparison of normalization methods for high density oligonucleotide array data based on variance and biasQ27860710
The ubiquitin systemQ27860803
Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomicsQ28131742
Global quantification of mammalian gene expression controlQ28238103
The ubiquitin codeQ28265104
The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteinsQ28303081
Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cellsQ28303091
A novel pulse-chase SILAC strategy measures changes in protein decay and synthesis rates induced by perturbation of proteostasis with an Hsp90 inhibitorQ28535467
DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradationQ28830958
MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantificationQ29547200
Proteomics. Tissue-based map of the human proteomeQ29617248
limma powers differential expression analyses for RNA-sequencing and microarray studiesQ29617988
Analysis of intronic and exonic reads in RNA-seq data characterizes transcriptional and post-transcriptional regulation.Q30975976
Quantitative temporal viromics: an approach to investigate host-pathogen interactionQ33722378
Antitumor activity of thalidomide in refractory multiple myelomaQ33880642
Options and considerations when selecting a quantitative proteomics strategyQ34125509
Tandem Mass Tags: A Novel Quantification Strategy for Comparative Analysis of Complex Protein Mixtures by MS/MSQ34192662
MultiNotch MS3 enables accurate, sensitive, and multiplexed detection of differential expression across cancer cell line proteomes.Q34434094
Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4.Q34479551
HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion ProteinsQ34480529
Catalytic in vivo protein knockdown by small-molecule PROTACs.Q34480735
Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS.Q34483086
Cancerous inhibitor of PP2A is targeted by natural compound celastrol for degradation in non-small-cell lung cancer.Q35055737
Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.).Q35064910
Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic TaggingQ35666096
A quantitative spatial proteomics analysis of proteome turnover in human cellsQ35863277
Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variationQ36044823
Understanding cullin-RING E3 biology through proteomics-based substrate identificationQ36455676
Neutron-encoded mass signatures for multiplexed proteome quantificationQ36728847
Ubiquitin proteasome system (UPS): what can chromatin do for you?Q36741709
The thalidomide sagaQ36763353
Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor CereblonQ36956452
Identification of long-lived proteins reveals exceptional stability of essential cellular structuresQ37210826
Lenalidomide: deciphering mechanisms of action in myeloma, myelodysplastic syndrome and beyondQ38619028
Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover.Q38681448
Ubiquitin ligase trapping identifies an SCF(Saf1) pathway targeting unprocessed vacuolar/lysosomal proteins.Q39900436
A set of baculovirus transfer vectors for screening of affinity tags and parallel expression strategiesQ39908030
Hyperplexing: a method for higher-order multiplexed quantitative proteomics provides a map of the dynamic response to rapamycin in yeastQ42131449
Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicityQ42696060
QuasR: quantification and annotation of short reads in R.Q43213442
The evolution of thalidomide and its IMiD derivatives as anticancer agentsQ44824886
Zinc-finger protein 91 plays a key role in LIGHT-induced activation of non-canonical NF-κB pathway.Q45924445
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that useslimmaQ112236343
P407language of work or nameEnglishQ1860
P304page(s)15398
P577publication date2017-05-22
P1433published inNature CommunicationsQ573880
P1476titlepSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase
P478volume8

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