| scholarly article | Q13442814 |
| P2093 | author name string | H Band | |
| S Miyake | |||
| N L Lill | |||
| P Douillard | |||
| K P Mullane-Robinson | |||
| P2860 | cites work | Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation | Q24336399 |
| Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl: implications for Cbl's function and oncogenicity | Q24645473 | ||
| Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase | Q27617539 | ||
| Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases | Q28267092 | ||
| The Cbl family of signal transduction molecules | Q28273358 | ||
| A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cells | Q28289338 | ||
| Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323 | Q28291812 | ||
| Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cells | Q28609046 | ||
| A role for Src in signal relay by the platelet-derived growth factor alpha receptor | Q28645730 | ||
| The structure of an antigenic determinant in a protein | Q29547829 | ||
| Regulation of neuronal survival by the serine-threonine protein kinase Akt | Q29614185 | ||
| Oncogenic forms of Cbl abrogate the anchorage requirement but not the growth factor requirement for proliferation | Q30176121 | ||
| D-Cbl, the Drosophila homologue of the c-Cbl proto-oncogene, interacts with the Drosophila EGF receptor in vivo, despite lacking C-terminal adaptor binding sites. | Q30176514 | ||
| EGF receptor binding and transformation by v-cbl is ablated by the introduction of a loss-of-function mutation from the Caenorhabditis elegans sli-1 gene | Q30176545 | ||
| Interactions of Drosophila Cbl with epidermal growth factor receptors and role of Cbl in R7 photoreceptor cell development. | Q30176591 | ||
| Similarity of sli-1 , a Regulator of Vulval Development in C. elegans , to the Mammalian Proto-Oncogene c- cbl | Q30193172 | ||
| The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70. | Q32170429 | ||
| Altered thymic positive selection and intracellular signals in Cbl-deficient mice | Q33596728 | ||
| Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice | Q33776192 | ||
| Activation of the Ras/mitogen-activated protein kinase pathway by kinase-defective epidermal growth factor receptors results in cell survival but not proliferation | Q33781714 | ||
| The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha | Q36164471 | ||
| Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation | Q36564274 | ||
| Oncogenes, growth factors, and signal transduction | Q38715382 | ||
| Signal transduction by the PDGF receptors | Q40760083 | ||
| Cbl: complex formation and functional implications | Q40844906 | ||
| Tyrosine kinase activity of the EGF receptor is enhanced by the expression of oncogenic 70Z-Cbl | Q41073646 | ||
| The cbl oncogene: a novel substrate of protein tyrosine kinases | Q41082091 | ||
| Cbl-mediated regulation of T cell receptor-induced AP1 activation. Implications for activation via the Ras signaling pathway | Q41655291 | ||
| Ras-dependent, Ca2+-stimulated activation of nuclear factor of activated T cells by a constitutively active Cbl mutant in T cells. | Q42528757 | ||
| Antisense repression of proto-oncogene c-Cbl enhances activation of the JAK-STAT pathway but not the ras pathway in epidermal growth factor receptor signaling | Q42802564 | ||
| Molecules in focus: The c-Cbl oncoprotein | Q56531398 | ||
| P433 | issue | 23 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 16619-16628 | |
| P577 | publication date | 1999-06-01 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. A critical role for Cbl tyrosine kinase-binding domain | |
| P478 | volume | 274 |
| Q33240362 | Activity of a novel PDGF beta-receptor enhancer during the cell cycle and upon differentiation of neuroblastoma |
| Q34044528 | Adapting to multiple personalities: Cbl is also a RING finger ubiquitin ligase |
| Q37527117 | Alix/AIP1 antagonizes epidermal growth factor receptor downregulation by the Cbl-SETA/CIN85 complex. |
| Q41547133 | An adenoviral vector encoding dominant negative Cbl lowers the threshold for T cell activation in post-thymic T cells |
| Q37460098 | An essential role of ubiquitination in Cbl-mediated negative regulation of the Src-family kinase Fyn. |
| Q34405560 | Beyond the RING: CBL proteins as multivalent adapters |
| Q40109529 | Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation |
| Q40750172 | C-Cbl binds the CSF-1 receptor at tyrosine 973, a novel phosphorylation site in the receptor's carboxy-terminus |
| Q64055875 | C-Cbl negatively regulates TRAF6-mediated NF-κB activation by promoting K48-linked polyubiquitination of TRAF6 |
| Q33528991 | CBL is frequently altered in lung cancers: its relationship to mutations in MET and EGFR tyrosine kinases |
| Q24304461 | CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases |
| Q33558284 | Cbl-b is a novel physiologic regulator of glycoprotein VI-dependent platelet activation |
| Q38935044 | Cbl-family ubiquitin ligases and their recruitment of CIN85 are largely dispensable for epidermal growth factor receptor endocytosis. |
| Q24296414 | Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation |
| Q34205572 | Cbl: many adaptations to regulate protein tyrosine kinases |
| Q33273613 | Chemically diverse toxicants converge on Fyn and c-Cbl to disrupt precursor cell function |
| Q30168118 | Differential interaction of Cbl with Grb2 and CrkL in CD2-mediated NK cell activation |
| Q40266580 | Direct binding of Cbl to Tyr568 and Tyr936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation. |
| Q33292370 | Distinct turnover of alternatively spliced isoforms of the RET kinase receptor mediated by differential recruitment of the Cbl ubiquitin ligase |
| Q27936947 | Domains of the Rsp5 ubiquitin-protein ligase required for receptor-mediated and fluid-phase endocytosis |
| Q38074797 | E3 ubiquitin ligase-mediated regulation of bone formation and tumorigenesis |
| Q36783457 | Endocytosis of receptor tyrosine kinases |
| Q37447644 | Endothelial and smooth muscle-derived neuropilin-like protein regulates platelet-derived growth factor signaling in human vascular smooth muscle cells by modulating receptor ubiquitination |
| Q42081863 | Epidermal growth factor receptor fate is controlled by Hrs tyrosine phosphorylation sites that regulate Hrs degradation |
| Q30164745 | Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalization |
| Q42829472 | F604S exchange in FIP1L1-PDGFRA enhances FIP1L1-PDGFRA protein stability via SHP-2 and SRC: a novel mode of kinase inhibitor resistance |
| Q28574938 | Fibroblast Growth Factor-2 Represses Platelet-derived Growth Factor Receptor-α (PDGFR-α) Transcription via ERK1/2-dependent Sp1 Phosphorylation and an Atypical cis-Acting Element in the Proximal PDGFR-α Promoter |
| Q24537487 | Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling |
| Q62884236 | GPCRs in Cancer: Protease-Activated Receptors, Endocytic Adaptors and Signaling |
| Q35563158 | Grb10 adapter protein as regulator of insulin‐like growth factor receptor signaling |
| Q37954724 | Imatinib mesylate for the treatment of pulmonary arterial hypertension |
| Q54667187 | Immunohistochemical study of the growth factors, aFGF, bFGF, PDGF-AB, VEGF-A and its receptor (Flk-1) during arteriogenesis. |
| Q43982351 | Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor |
| Q37459881 | Injury-induced platelet-derived growth factor receptor-alpha expression mediated by interleukin-1beta (IL-1beta) release and cooperative transactivation by NF-kappaB and ATF-4: IL-1beta facilitates HDAC-1/2 dissociation from promoter. |
| Q47756210 | Involvement of platelet-derived growth factor ligands and receptors in tumorigenesis |
| Q40729416 | Isolation and characterization of a novel, transforming allele of the c-Cbl proto-oncogene from a murine macrophage cell line |
| Q37216064 | LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies |
| Q37454255 | Leukocyte Ig-like receptor B4 (LILRB4) is a potent inhibitor of FcgammaRI-mediated monocyte activation via dephosphorylation of multiple kinases |
| Q28146026 | Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7 |
| Q40449433 | Low density lipoprotein receptor-related protein 1 (LRP1) controls endocytosis and c-CBL-mediated ubiquitination of the platelet-derived growth factor receptor beta (PDGFR beta). |
| Q33912823 | Lymphocyte signaling: Cbl sets the threshold for autoimmunity |
| Q33940384 | Lysine methylation promotes VEGFR-2 activation and angiogenesis |
| Q28207560 | Membrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular transformation |
| Q34228160 | Molecular controls of antigen receptor clustering and autoimmunity |
| Q28210330 | Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein |
| Q24291166 | N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8 |
| Q53622019 | Nef enhances c-Cbl phosphorylation in HIV-infected CD4+ T lymphocytes. |
| Q40714708 | Negative regulation of EphA2 receptor by Cbl. |
| Q36197104 | Neuronal Cbl controls biosynthesis of insulin-like peptides in Drosophila melanogaster. |
| Q35901705 | Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia |
| Q24322037 | PI3-kinase/Akt-dependent antiapoptotic signaling by the PDGF alpha receptor is negatively regulated by Src family kinases |
| Q39484324 | Potentiation of platelet-derived growth factor receptor-β signaling mediated by integrin-associated MFG-E8. |
| Q26852269 | Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases |
| Q26853207 | RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis |
| Q40601255 | Regulation of CXCR4-mediated chemotaxis and chemoinvasion of breast cancer cells |
| Q29619145 | Regulation of Membrane Protein Transport by Ubiquitin and Ubiquitin-Binding Proteins |
| Q32029952 | Regulation of receptor tyrosine kinase signaling by endocytic trafficking |
| Q28513277 | Regulation of synaptic growth and maturation by a synapse-associated E3 ubiquitin ligase at the neuromuscular junction |
| Q21263140 | Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk |
| Q40756969 | Role for adapter proteins in costimulatory signals of CD2 and IL-2 on NK cell activation |
| Q35107707 | Role of ubiquitination in Na,K-ATPase regulation during lung injury |
| Q33781079 | Roles of E3 ubiquitin ligases in cell adhesion and migration |
| Q46025873 | Shear stress and VEGF activate IKK via the Flk-1/Cbl/Akt signaling pathway |
| Q33954578 | Sorting in the endosomal system in yeast and animal cells. |
| Q22253382 | Src family kinases negatively regulate platelet-derived growth factor alpha receptor-dependent signaling and disease progression |
| Q43670938 | Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins |
| Q26829546 | Structural and functional properties of platelet-derived growth factor and stem cell factor receptors |
| Q34506190 | Systemic perturbation of the ERK signaling pathway by the proteasome inhibitor, MG132. |
| Q45263240 | TGF-beta, c-Cbl, and PDGFR-alpha the in mammary stroma |
| Q30164133 | TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin |
| Q34393461 | Targeting the PDGF signaling pathway in tumor treatment |
| Q42800790 | The APS adapter protein couples the insulin receptor to the phosphorylation of c-Cbl and facilitates ligand-stimulated ubiquitination of the insulin receptor |
| Q30160093 | The Cbl RING finger C-terminal flank controls epidermal growth factor receptor fate downstream of receptor ubiquitination |
| Q24682781 | The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor |
| Q58179986 | The RING Finger Domain of Cbl Is Essential for Negative Regulation of the Syk Tyrosine Kinase |
| Q42818177 | The Src-like adaptor protein regulates PDGF-induced actin dorsal ruffles in a c-Cbl-dependent manner |
| Q42757567 | The Ubiquitin Ligases c-Cbl and Cbl-b Negatively Regulate Platelet-derived Growth Factor (PDGF) BB-induced Chemotaxis by Affecting PDGF Receptor β (PDGFRβ) Internalization and Signaling |
| Q28143185 | The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction |
| Q33734632 | The carboxyl terminus of VEGFR-2 is required for PKC-mediated down-regulation |
| Q39818667 | The fusion proteins TEL-PDGFRbeta and FIP1L1-PDGFRalpha escape ubiquitination and degradation |
| Q38294657 | The kinase-null EphB6 receptor undergoes transphosphorylation in a complex with EphB1. |
| Q35036574 | The role of ubiquitylation in signaling by growth factors: implications to cancer |
| Q39016533 | The tyrosine phosphatase SHP2 is required for cell transformation by the receptor tyrosine kinase mutants FIP1L1-PDGFRα and PDGFRα D842V. |
| Q24306128 | Ubiquitin ligase activity of c-Cbl guides the epidermal growth factor receptor into clathrin-coated pits by two distinct modes of Eps15 recruitment |
| Q39617513 | Ubiquitin ligase c-Cbl is involved in tamoxifen-induced apoptosis of MCF-7 cells by downregulating the survival signals |
| Q33910576 | Ubiquitin-mediated proteolysis: biological regulation via destruction |
| Q42917525 | Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies |
| Q39033646 | Ubiquitination and the Regulation of Membrane Proteins |
| Q34365210 | Ubiquitination-dependent regulation of signaling receptors in cancer |
| Q28201688 | c-Cbl associates directly with the C-terminal tail of the receptor for the macrophage colony-stimulating factor, c-Fms, and down-modulates this receptor but not the viral oncogene v-Fms |
| Q37672284 | c-Cbl inhibits angiogenesis and tumor growth by suppressing activation of PLCγ1 |
| Q24294848 | c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2 |
| Q42831849 | c-Cbl-facilitated cytoskeletal effects in v-Abl-transformed fibroblasts are regulated by membrane association of c-Cbl |
| Q38363746 | p73 independent of c-Myc represses transcription of platelet-derived growth factor beta-receptor through interaction with NF-Y. |
| Q24303919 | The Casitas B lineage lymphoma (Cbl) mutant G306E enhances osteogenic differentiation in human mesenchymal stromal cells in part by decreased Cbl-mediated platelet-derived growth factor receptor alpha and fibroblast growth factor receptor 2 ubiquiti |
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