| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1008874395 |
| P356 | DOI | 10.1007/S13238-012-2105-7 |
| P932 | PMC publication ID | 3888511 |
| P698 | PubMed publication ID | 23136067 |
| P5875 | ResearchGate publication ID | 233334358 |
| P2093 | author name string | Yi Sun | |
| Hua Li | |||
| P2860 | cites work | Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-kappaB activation in mouse embryonic stem cells. | Q39678874 |
| Knockdown of sensitive to apoptosis gene by small interfering RNA enhances the sensitivity of PC3 cells toward actinomycin D and etoposide | Q39696218 | ||
| Inhibition of NEDD8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia. | Q39732225 | ||
| Validation of SAG/RBX2/ROC2 E3 ubiquitin ligase as an anticancer and radiosensitizing target | Q39747521 | ||
| Restriction of Src activity by Cullin-5 | Q39894835 | ||
| Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1. | Q39911661 | ||
| Regulation of heat shock-induced apoptosis by sensitive to apoptosis gene protein | Q39985624 | ||
| SAG/ROC2/RBX2 E3 ligase promotes UVB-induced skin hyperplasia, but not skin tumors, by simultaneously targeting c-Jun/AP-1 and p27. | Q40015382 | ||
| SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1 alpha ubiquitination and degradation | Q40082905 | ||
| SAG protects human neuroblastoma SH-SY5Y cells against 1-methyl-4-phenylpyridinium ion (MPP+)-induced cytotoxicity via the downregulation of ROS generation and JNK signaling | Q40180555 | ||
| Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras | Q40424687 | ||
| Elevated expression of SAG/ROC2/Rbx2/Hrt2 in human colon carcinomas: SAG does not induce neoplastic transformation, but antisense SAG transfection inhibits tumor cell growth | Q40820258 | ||
| Oxygen free radicals and metallothionein | Q40889930 | ||
| p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells | Q40918524 | ||
| SAG/ROC2/Rbx2 is a novel activator protein-1 target that promotes c-Jun degradation and inhibits 12-O-tetradecanoylphorbol-13-acetate-induced neoplastic transformation | Q42511244 | ||
| MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-{kappa}B-dependent lymphoma | Q43043795 | ||
| Attenuation of ischemia-induced mouse brain injury by SAG, a redox-inducible antioxidant protein | Q44470615 | ||
| Targeting NEDD8-activated cullin-RING ligases for the treatment of cancer. | Q45976197 | ||
| The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase | Q46603785 | ||
| HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin | Q47965199 | ||
| Transduced Tat-SAG fusion protein protects against oxidative stress and brain ischemic insult | Q48333769 | ||
| Basic Medical Research Award. The ubiquitin system | Q48372080 | ||
| Effects of sensitive to apoptosis gene protein on cell proliferation, neuroblast differentiation, and oxidative stress in the mouse dentate gyrus | Q48806453 | ||
| SAG attenuates apoptotic cell death caused by simulated ischaemia/reoxygenation in rat cardiomyocytes | Q51679003 | ||
| Analysis of RING finger genes required for embryogenesis in C. elegans | Q52094097 | ||
| The Nedd8-activating enzyme inhibitor MLN4924 induces autophagy and apoptosis to suppress liver cancer cell growth | Q53170777 | ||
| Regulation of nitric oxide-induced apoptosis by sensitive to apoptosis gene protein | Q53603673 | ||
| CK2 phosphorylation of SAG at Thr10 regulates SAG stability, but not its E3 ligase activity | Q53608479 | ||
| Induction of glutathione synthetase by 1,10-phenanthroline | Q73407821 | ||
| Proteases to die for | Q74630246 | ||
| Expression of the sensitive to apoptosis gene, SAG, as a prognostic marker in nonsmall cell lung cancer | Q74826250 | ||
| Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies | Q79370601 | ||
| Cell signalling: mTOR targets its own inhibitor | Q82433565 | ||
| Expanding the substantial interactome of NEMO using protein microarrays | Q21142672 | ||
| Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling | Q21144354 | ||
| SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents | Q22009063 | ||
| ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity | Q22009487 | ||
| The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis | Q22009936 | ||
| HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing | Q24291102 | ||
| Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function | Q24293924 | ||
| I kappa B: a specific inhibitor of the NF-kappa B transcription factor | Q24296774 | ||
| ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes | Q24297841 | ||
| DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival | Q24311448 | ||
| VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases | Q24322407 | ||
| Systematic analysis and nomenclature of mammalian F-box proteins | Q24561715 | ||
| Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34 | Q24602536 | ||
| The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro | Q24608829 | ||
| Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence | Q24627126 | ||
| Tumor microenvironment and neurofibromatosis type I: connecting the GAPs | Q24654681 | ||
| Cullin 5 regulates Dab1 protein levels and neuron positioning during cortical development | Q24672124 | ||
| RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis | Q26853207 | ||
| SPRY domain-containing SOCS box protein 2: crystal structure and residues critical for protein binding | Q27653472 | ||
| Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ | Q27659474 | ||
| Targeting HIF-1 for cancer therapy | Q27860504 | ||
| RING domain E3 ubiquitin ligases | Q27860546 | ||
| The ubiquitin system | Q27860803 | ||
| Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation | Q27860876 | ||
| CDK inhibitors: positive and negative regulators of G1-phase progression | Q27860983 | ||
| Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction | Q28131789 | ||
| p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27 | Q28137813 | ||
| SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27 | Q28137860 | ||
| Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell growth, but not for germination: chip profiling implicates its role in cell cycle regulation | Q28138144 | ||
| Mammalian caspases: structure, activation, substrates, and functions during apoptosis | Q28139429 | ||
| Expression, purification, and biochemical characterization of SAG, a ring finger redox-sensitive protein | Q28141895 | ||
| Alterations of SAG mRNA in human cancer cell lines: requirement for the RING finger domain for apoptosis protection | Q28145344 | ||
| Protein kinase CKII interacts with and phosphorylates the SAG protein containing ring-H2 finger motif | Q28145580 | ||
| NF1 tumor suppressor gene function: narrowing the GAP | Q28203741 | ||
| Phosphorylation of threonine 10 on CKBBP1/SAG/ROC2/Rbx2 by protein kinase CKII promotes the degradation of IkappaBalpha and p27Kip1 | Q28204190 | ||
| Promotion of S-phase entry and cell growth under serum starvation by SAG/ROC2/Rbx2/Hrt2, an E3 ubiquitin ligase component: association with inhibition of p27 accumulation | Q28205253 | ||
| Human sensitive to apoptosis gene protein inhibits peroxynitrite-induced DNA damage | Q28207047 | ||
| Induction of APOBEC3G Ubiquitination and Degradation by an HIV-1 Vif-Cul5-SCF Complex | Q28210666 | ||
| SAG/ROC2/Rbx2/Hrt2, a component of SCF E3 ubiquitin ligase: genomic structure, a splicing variant, and two family pseudogenes | Q28212932 | ||
| Thiol-linked peroxidase activity of human sensitive to apoptosis gene (SAG) protein | Q28216992 | ||
| The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling | Q28240232 | ||
| mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR | Q28251026 | ||
| DEPTOR, an mTOR Inhibitor, Is a Physiological Substrate of SCFβTrCP E3 Ubiquitin Ligase and Regulates Survival and Autophagy | Q28251037 | ||
| mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTOR | Q28251047 | ||
| The SOCS2 ubiquitin ligase complex regulates growth hormone receptor levels | Q28477287 | ||
| The E3 ubiquitin ligase specificity subunit ASB2beta is a novel regulator of muscle differentiation that targets filamin B to proteasomal degradation | Q28512761 | ||
| Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays | Q28566104 | ||
| Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-kappa B transcription factor | Q28615489 | ||
| Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex | Q29041391 | ||
| The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation | Q29400446 | ||
| Inhibitors of mammalian G1 cyclin-dependent kinases | Q29547907 | ||
| MAP kinase signalling pathways in cancer | Q29615542 | ||
| FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation | Q29616127 | ||
| AP-1 as a regulator of cell life and death | Q29616558 | ||
| An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer | Q29616732 | ||
| Complementation Cloning of NEMO, a Component of the IκB Kinase Complex Essential for NF-κB Activation | Q29617419 | ||
| Ubiquitin ligases: cell-cycle control and cancer | Q29617992 | ||
| A hitchhiker's guide to the cullin ubiquitin ligases: SCF and its kin | Q29618006 | ||
| The ubiquitin-proteasome pathway: on protein death and cell life | Q29619270 | ||
| Thiol-based antioxidants. | Q30326876 | ||
| NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cells | Q30429284 | ||
| Cullin 5 regulates cortical layering by modulating the speed and duration of Dab1-dependent neuronal migration | Q30494388 | ||
| Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis | Q30525356 | ||
| EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressors | Q33261811 | ||
| Identifying determinants of cullin binding specificity among the three functionally different Drosophila melanogaster Roc proteins via domain swapping | Q33359573 | ||
| Antioxidant defenses and lipid peroxidation in human blood plasma | Q33688237 | ||
| Antioxidant role of metallothioneins: a comparative overview | Q33896346 | ||
| The SCF(HOS/beta-TRCP)-ROC1 E3 ubiquitin ligase utilizes two distinct domains within CUL1 for substrate targeting and ubiquitin ligation | Q33962019 | ||
| Identification and characterization of genes responsive to apoptosis: application of DNA chip technology and mRNA differential display | Q34045284 | ||
| Inactivation of SAG E3 ubiquitin ligase blocks embryonic stem cell differentiation and sensitizes leukemia cells to retinoid acid | Q34081767 | ||
| The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy | Q34202686 | ||
| The p21-Dependent Radiosensitization of Human Breast Cancer Cells by MLN4924, an Investigational Inhibitor of NEDD8 Activating Enzyme | Q34212168 | ||
| Small RING Finger Proteins RBX1 and RBX2 of SCF E3 Ubiquitin Ligases: The Role in Cancer and as Cancer Targets | Q34318259 | ||
| Cullins and Cancer | Q34365216 | ||
| SAG/ROC/Rbx/Hrt, a zinc RING finger gene family: molecular cloning, biochemical properties, and biological functions | Q34367608 | ||
| Induction of p21-Dependent Senescence by an NAE Inhibitor, MLN4924, as a Mechanism of Growth Suppression | Q35042995 | ||
| E3 ubiquitin ligases as cancer targets and biomarkers | Q35082710 | ||
| Cdk5 targets active Src for ubiquitin-dependent degradation by phosphorylating Src(S75) | Q35199261 | ||
| Prognostic role of sensitive-to-apoptosis gene expression in rectal cancer | Q35606935 | ||
| Targeting E3 ubiquitin ligases for cancer therapy. | Q35612694 | ||
| SAG/ROC-SCF beta-TrCP E3 ubiquitin ligase promotes pro-caspase-3 degradation as a mechanism of apoptosis protection | Q35613215 | ||
| The NEDD8-activating enzyme inhibitor, MLN4924, cooperates with TRAIL to augment apoptosis through facilitating c-FLIP degradation in head and neck cancer cells | Q35613406 | ||
| SAG/RBX2/ROC2 E3 Ubiquitin Ligase Is Essential for Vascular and Neural Development by Targeting NF1 for Degradation | Q35621518 | ||
| Radiosensitization of Human Pancreatic Cancer Cells by MLN4924, an Investigational NEDD8-Activating Enzyme Inhibitor | Q35653286 | ||
| Stimulation of angiogenesis by Ras proteins | Q35676047 | ||
| Oxidative stress, redox, and the tumor microenvironment | Q35837045 | ||
| SCF E3 Ubiquitin Ligases as Anticancer Targets | Q35880315 | ||
| Targeting the mTOR-DEPTOR Pathway by CRL E3 Ubiquitin Ligases: Therapeutic Application | Q36062128 | ||
| SAG/ROC2 E3 ligase regulates skin carcinogenesis by stage-dependent targeting of c-Jun/AP1 and IkappaB-alpha/NF-kappaB. | Q36119281 | ||
| NF-kappa B-mediated adaptive resistance to ionizing radiation | Q36493029 | ||
| RBX1/ROC1 disruption results in early embryonic lethality due to proliferation failure, partially rescued by simultaneous loss of p27 | Q37159057 | ||
| The cullin protein family | Q37873586 | ||
| Free radicals, antioxidant enzymes, and carcinogenesis | Q37936921 | ||
| MLN4924: a novel first-in-class inhibitor of NEDD8-activating enzyme for cancer therapy | Q38026589 | ||
| Radiosensitization of Cancer Cells by Inactivation of Cullin-RING E3 Ubiquitin Ligases | Q38052131 | ||
| Activation of p53 transcriptional activity by 1,10-phenanthroline, a metal chelator and redox sensitive compound | Q38349183 | ||
| Inhibition of NEDD8-Activating Enzyme Induces Rereplication and Apoptosis in Human Tumor Cells Consistent with Deregulating CDT1 Turnover | Q39559719 | ||
| Sensitive to apoptosis gene protein regulates ionizing radiation-induced apoptosis | Q39646381 | ||
| P433 | issue | 2 | |
| P304 | page(s) | 103-116 | |
| P577 | publication date | 2012-11-08 | |
| P1433 | published in | Protein & Cell | Q26854012 |
| P1476 | title | Functional characterization of SAG/RBX2/ROC2/RNF7, an antioxidant protein and an E3 ubiquitin ligase | |
| P478 | volume | 4 |
| Q26822657 | Cullin family proteins and tumorigenesis: genetic association and molecular mechanisms |
| Q50316561 | Delineating Crosstalk Mechanisms of the Ubiquitin Proteasome System That Regulate Apoptosis |
| Q37497812 | Depletion of SAG/RBX2 E3 ubiquitin ligase suppresses prostate tumorigenesis via inactivation of the PI3K/AKT/mTOR axis |
| Q33594656 | Endothelial deletion of Sag/Rbx2/Roc2 E3 ubiquitin ligase causes embryonic lethality and blocks tumor angiogenesis |
| Q35697259 | Erbin is a novel substrate of the Sag-βTrCP E3 ligase that regulates KrasG12D-induced skin tumorigenesis |
| Q27027897 | Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases |
| Q33850029 | Identification of RING-box 2 as a potential target for combating colorectal cancer growth and metastasis |
| Q38634986 | Impact of physiological, pathological and environmental factors on the expression and activity of human cytochrome P450 2D6 and implications in precision medicine |
| Q64078530 | Inactivation of SAG or ROC1 E3 Ligase Inhibits Growth and Survival of Renal Cell Carcinoma Cells: Effect of BIM |
| Q30569769 | Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis |
| Q35023926 | Inactivation of Sag/Rbx2/Roc2 e3 ubiquitin ligase triggers senescence and inhibits kras-induced immortalization |
| Q40293672 | MLN4924 and 2DG combined treatment enhances the efficiency of radiotherapy in breast cancer cells. |
| Q38570362 | MLN4924 therapy as a novel approach in cancer treatment modalities |
| Q36785312 | Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells. |
| Q38645501 | Oxidative Stress Gene Expression Profile Correlates with Cancer Patient Poor Prognosis: Identification of Crucial Pathways Might Select Novel Therapeutic Approaches. |
| Q37676275 | RNF7 knockdown inhibits prostate cancer tumorigenesis by inactivation of ERK1/2 pathway |
| Q38984879 | Really interesting new gene finger protein 121 is a novel Golgi-localized membrane protein that regulates apoptosis |
| Q34987659 | Regulation of T cell receptor complex-mediated signaling by ubiquitin and ubiquitin-like modifications |
| Q37388126 | Role of SKP1-CUL1-F-Box-Protein (SCF) E3 Ubiquitin Ligases in Skin Cancer |
| Q92569854 | SAG expression associates with COPB2-related signaling and a poorer prognosis in breast cancer |
| Q60046080 | SAG/RBX2 E3 Ubiquitin Ligase Differentially Regulates Inflammatory Responses of Myeloid Cell Subsets |
| Q28818138 | SAG/RBX2 E3 ligase complexes with UBCH10 and UBE2S E2s to ubiquitylate β-TrCP1 via K11-linkage for degradation |
| Q42237216 | SAG/RBX2 is a novel substrate of NEDD4-1 E3 ubiquitin ligase and mediates NEDD4-1 induced chemosensitization |
| Q34563129 | Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy |
| Q46250292 | The E3 Ubiquitin Ligase RNF7 Negatively Regulates CARD14/CARMA2sh Signaling |
| Q34610533 | The association of apoptotic protein expressions sensitive to apoptosis gene, p73 and p53 with the prognosis of cervical carcinoma |
| Q38229325 | Ubiquitination involved enzymes and cancer |
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