| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1003659648 |
| P356 | DOI | 10.1038/NCB1499 |
| P698 | PubMed publication ID | 17115033 |
| P2093 | author name string | Hyungjin Kim | |
| Gerard P Zambetti | |||
| John R Jeffers | |||
| Emily H-Y Cheng | |||
| Ho-Chou Tu | |||
| James J-D Hsieh | |||
| Mubina Rafiuddin-Shah | |||
| P2860 | cites work | PUMA induces the rapid apoptosis of colorectal cancer cells | Q24291462 |
| PUMA, a novel proapoptotic gene, is induced by p53 | Q24291463 | ||
| Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis | Q24291662 | ||
| Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function | Q24293924 | ||
| p53 has a direct apoptogenic role at the mitochondria | Q24298888 | ||
| Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins | Q24302494 | ||
| Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors | Q24310559 | ||
| Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis | Q24310597 | ||
| PUMA couples the nuclear and cytoplasmic proapoptotic function of p53 | Q24321694 | ||
| harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L) | Q24532147 | ||
| Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix | Q24537504 | ||
| Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis | Q24669892 | ||
| Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity | Q28138855 | ||
| Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1 | Q28142184 | ||
| Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis | Q28144256 | ||
| BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis | Q28189945 | ||
| p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa | Q28204059 | ||
| Direct addition of BimL to mitochondria does not lead to cytochrome c release | Q28208417 | ||
| Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis | Q28212224 | ||
| Puma is an essential mediator of p53-dependent and -independent apoptotic pathways | Q28213279 | ||
| Cell death: critical control points | Q28240722 | ||
| Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death | Q28363890 | ||
| Integral role of Noxa in p53-mediated apoptotic response | Q28510421 | ||
| Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis | Q28511080 | ||
| The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues | Q28512628 | ||
| Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim | Q28587387 | ||
| VDAC2 inhibits BAK activation and mitochondrial apoptosis | Q28594000 | ||
| An inhibitor of Bcl-2 family proteins induces regression of solid tumours | Q29547595 | ||
| Mitochondria and apoptosis | Q29547905 | ||
| The Bcl2 family: regulators of the cellular life-or-death switch | Q29614982 | ||
| BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly | Q29617135 | ||
| BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis | Q29620466 | ||
| Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics | Q29620467 | ||
| Bcl-X(L) affects Ca(2+) homeostasis by altering expression of inositol 1,4,5-trisphosphate receptors | Q34075849 | ||
| DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells | Q34278532 | ||
| BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak | Q35079498 | ||
| Bad-deficient mice develop diffuse large B cell lymphoma | Q35234507 | ||
| A decade of caspases | Q35591686 | ||
| Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death | Q36233254 | ||
| Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity. | Q37593642 | ||
| Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation | Q39895438 | ||
| WT1 induces apoptosis through transcriptional regulation of the proapoptotic Bcl-2 family member Bak. | Q40372880 | ||
| The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA. | Q40485961 | ||
| Molecular cloning of a novel polypeptide, DP5, induced during programmed neuronal death | Q42660594 | ||
| Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells | Q43514949 | ||
| Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. | Q43561629 | ||
| Critical role for DP5/Harakiri, a Bcl-2 homology domain 3-only Bcl-2 family member, in axotomy-induced neuronal cell death. | Q47763741 | ||
| Worms, life, and death (Nobel lecture). | Q48235550 | ||
| P433 | issue | 12 | |
| P921 | main subject | apoptotic process | Q14599311 |
| P304 | page(s) | 1348-1358 | |
| P577 | publication date | 2006-11-19 | |
| P1433 | published in | Nature Cell Biology | Q1574111 |
| P1476 | title | Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies | |
| P478 | volume | 8 |
| Q36572127 | 3-bromopyruvate and sodium citrate target glycolysis, suppress survivin, and induce mitochondrial-mediated apoptosis in gastric cancer cells and inhibit gastric orthotopic transplantation tumor growth |
| Q34311770 | A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway |
| Q39366387 | A Bax-mediated mechanism for obatoclax-induced apoptosis of cholangiocarcinoma cells |
| Q28909766 | A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis |
| Q47873934 | A critical role of PUMA in maintenance of genomic integrity of murine spermatogonial stem cell precursors after genotoxic stress |
| Q39971508 | A mitochondrial block and expression of XIAP lead to resistance to TRAIL-induced apoptosis during progression to metastasis of a colon carcinoma |
| Q41629130 | A natural chalcone induces apoptosis in lung cancer cells: 3D-QSAR, docking and an in vivo/vitro assay |
| Q27649579 | A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation |
| Q33309458 | A novel inhibitory mechanism of mitochondrion-dependent apoptosis by a herpesviral protein |
| Q37393924 | A simplified Bcl-2 network model reveals quantitative determinants of cell-to-cell variation in sensitivity to anti-mitotic chemotherapeutics. |
| Q30466831 | A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers. |
| Q35917067 | A three-helix homo-oligomerization domain containing BH3 and BH1 is responsible for the apoptotic activity of Bax. |
| Q39292731 | A unified model of mammalian BCL-2 protein family interactions at the mitochondria. |
| Q42868172 | ABT-737 and/or folate reverse the PDGF-induced alterations in the mitochondrial apoptotic pathway in low-grade glioma patients |
| Q37133945 | Acetylation of FoxO1 activates Bim expression to induce apoptosis in response to histone deacetylase inhibitor depsipeptide treatment |
| Q39659332 | Actinomycin D synergistically enhances the efficacy of the BH3 mimetic ABT-737 by downregulating Mcl-1 expression |
| Q36841281 | Activation of the calcium-sensing receptor promotes apoptosis by modulating the JNK/p38 MAPK pathway in focal cerebral ischemia-reperfusion in mice |
| Q33295311 | Activation of the mitochondrial death pathway is commonly mediated by a preferential engagement of Bak. |
| Q37713569 | Activation of the proapoptotic Bcl-2 protein Bax by a small molecule induces tumor cell apoptosis |
| Q24293539 | Active Bax and Bak are functional holins |
| Q40077983 | Ad-PUMA sensitizes drug-resistant choriocarcinoma cells to chemotherapeutic agents |
| Q33569857 | Adjuvant-specific regulation of long-term antibody responses by ZBTB20 |
| Q36012325 | Allosteric inhibition of antiapoptotic MCL-1. |
| Q85154129 | Alternative Functions of the BCL-2 Protein Family at the Endoplasmic Reticulum |
| Q33789426 | An anti-apoptotic peptide improves survival in lethal total body irradiation |
| Q36109186 | An interconnected hierarchical model of cell death regulation by the BCL-2 family |
| Q38621581 | Analysis of endogenous Bax complexes during apoptosis using blue native PAGE: implications for Bax activation and oligomerization |
| Q36482941 | Anoikis, initiated by Mcl-1 degradation and Bim induction, is deregulated during oncogenesis |
| Q30895657 | Anthrax lethal toxin induced lysosomal membrane permeabilization and cytosolic cathepsin release is Nlrp1b/Nalp1b-dependent |
| Q42909041 | Anti-apoptotic Bcl-2 fails to form efficient complexes with pro-apoptotic Bak to protect from Celecoxib-induced apoptosis |
| Q42063420 | Anti-apoptotic molecule Bcl-2 regulates the differentiation, activation, and survival of both osteoblasts and osteoclasts |
| Q37352687 | Antigen-affinity controls pre-germinal centser B cell selection by promoting Mcl-1 induction through BAFF receptor signaling. |
| Q37815428 | Apoptosis and autophagy in the regulation of T lymphocyte function |
| Q38228349 | Apoptosis and molecular targeting therapy in cancer |
| Q37828794 | Apoptosis and oncogenesis: give and take in the BCL-2 family |
| Q37028788 | Apoptosis commitment--translating survival signals into decisions on mitochondria |
| Q39553881 | Apoptosis induced by overall metabolic stress converges on the Bcl-2 family proteins Noxa and Mcl-1 |
| Q36960721 | Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax. |
| Q36963811 | Apoptosis regulators as targets for cancer therapy |
| Q42820807 | Apoptotic actions of p53 require transcriptional activation of PUMA and do not involve a direct mitochondrial/cytoplasmic site of action in postnatal cortical neurons. |
| Q27016160 | Apoptotic agents |
| Q36546746 | Application of functional vincristine plus dasatinib liposomes to deletion of vasculogenic mimicry channels in triple-negative breast cancer |
| Q61453566 | Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-κB-mediated induction of XIAP |
| Q39867690 | Assembly and mobility of exon-exon junction complexes in living cells |
| Q37169502 | Assembly of the mitochondrial apoptosis-induced channel, MAC. |
| Q38845451 | Autophagy capacity and sub-mitochondrial heterogeneity shape Bnip3-induced mitophagy regulation of apoptosis. |
| Q55213455 | Autophagy inhibition enhances radiosensitivity of Eca‑109 cells via the mitochondrial apoptosis pathway. |
| Q90271568 | Autophagy, apoptosis, and mitochondria: molecular integration and physiological relevance in skeletal muscle |
| Q39633320 | Axl promotes cutaneous squamous cell carcinoma survival through negative regulation of pro-apoptotic Bcl-2 family members. |
| Q37566231 | BAD: undertaker by night, candyman by day. |
| Q24295530 | BAK multimerization for apoptosis, but not bid binding, is inhibited by negatively charged residue in the BAK hydrophobic groove |
| Q46349808 | BAK regulates catalase release from peroxisomes |
| Q27652635 | BAX activation is initiated at a novel interaction site |
| Q34082489 | BAX/BAK-independent mitoptosis during cell death induced by proteasome inhibition? |
| Q36935301 | BCL-2 family regulation by the 20S proteasome inhibitor bortezomib |
| Q24305138 | BH3 domains other than Bim and Bid can directly activate Bax/Bak |
| Q24655483 | BH3 mimetics to improve cancer therapy; mechanisms and examples |
| Q24337209 | BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents |
| Q36948615 | BH3 response profiles from neuroblastoma mitochondria predict activity of small molecule Bcl-2 family antagonists |
| Q58573059 | BH3-Dependent and Independent Activation of BAX and BAK in Mitochondrial Apoptosis |
| Q37797387 | BH3-Only Proteins and Their Effects on Cancer |
| Q33394363 | BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets |
| Q34227850 | BH3-only molecule Bim mediates β-cell death in IRS2 deficiency. |
| Q37301019 | BH3-only protein Noxa contributes to apoptotic control of stress-erythropoiesis |
| Q39947763 | BH3-only protein mimetic obatoclax sensitizes cholangiocarcinoma cells to Apo2L/TRAIL-induced apoptosis |
| Q36658048 | BH3-only proteins Noxa, Bmf, and Bim are necessary for arsenic trioxide-induced cell death in myeloma |
| Q37566201 | BH3-only proteins and their roles in programmed cell death |
| Q36000128 | BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α. |
| Q90262608 | BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis |
| Q37629756 | BH3-only proteins: the death-puppeteer's wires |
| Q41884328 | BH3-triggered structural reorganization drives the activation of proapoptotic BAX. |
| Q34182014 | BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy response |
| Q38269004 | BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program |
| Q47254152 | BIM Binding Remotely Regulates BAX Activation: Insights from the Free Energy Landscapes |
| Q24304086 | BNIP3 and NIX mediate Mieap-induced accumulation of lysosomal proteins within mitochondria |
| Q41819191 | Bad targets the permeability transition pore independent of Bax or Bak to switch between Ca2+-dependent cell survival and death |
| Q35749559 | Bak Conformational Changes Induced by Ligand Binding: Insight into BH3 Domain Binding and Bak Homo-Oligomerization |
| Q39617756 | Bax activation by engagement with, then release from, the BH3 binding site of Bcl-xL. |
| Q37237621 | Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members |
| Q33569749 | Bax contains two functional mitochondrial targeting sequences and translocates to mitochondria in a conformational change- and homo-oligomerization-driven process |
| Q24313049 | Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis |
| Q33885192 | Bax forms an oligomer via separate, yet interdependent, surfaces |
| Q35512551 | Bax forms two types of channels, one of which is voltage-gated |
| Q30492381 | Bax shuttling after neonatal hypoxia-ischemia: hyperoxia effects |
| Q37589942 | Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes |
| Q37482805 | Bax/Bak activation in the absence of Bid, Bim, Puma, and p53. |
| Q60907777 | Bcl-2 Inhibition to Overcome Resistance to Chemo- and Immunotherapy |
| Q34121322 | Bcl-2 and Bax interact via the BH1-3 groove-BH3 motif interface and a novel interface involving the BH4 motif |
| Q36880621 | Bcl-2-regulated apoptosis: mechanism and therapeutic potential |
| Q37112029 | Bcl-X(L) is the primary mediator of p21 protection against hyperoxia-induced cell death |
| Q33343021 | Bcl-XL inhibits membrane permeabilization by competing with Bax. |
| Q30495553 | Bcl-XL represents a druggable molecular vulnerability during aurora B inhibitor-mediated polyploidization |
| Q24298758 | Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol |
| Q36914292 | Bcl-xL Is Essential for the Survival and Function of Differentiated Neurons in the Cortex That Control Complex Behaviors |
| Q38256367 | Bcl-xL in neuroprotection and plasticity. |
| Q34802591 | Bcl-xL is necessary for neurite outgrowth in hippocampal neurons |
| Q38626077 | Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase. |
| Q36293251 | Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax. |
| Q28473237 | Bid participates in genotoxic drug-induced apoptosis of HeLa cells and is essential for death receptor ligands' apoptotic and synergistic effects |
| Q37566240 | Bid: a Bax-like BH3 protein. |
| Q27317352 | Bim and Bmf synergize to induce apoptosis in Neisseria gonorrhoeae infection |
| Q37451892 | Bim upregulation by histone deacetylase inhibitors mediates interactions with the Bcl-2 antagonist ABT-737: evidence for distinct roles for Bcl-2, Bcl-xL, and Mcl-1. |
| Q33648236 | Bim, Bak, and Bax regulate osteoblast survival |
| Q36118310 | BimS-induced apoptosis requires mitochondrial localization but not interaction with anti-apoptotic Bcl-2 proteins |
| Q41436188 | Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions |
| Q34493785 | Blockade of the BAK hydrophobic groove by inhibitory phosphorylation regulates commitment to apoptosis |
| Q28300914 | Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis |
| Q35579307 | CHCHD2 inhibits apoptosis by interacting with Bcl-x L to regulate Bax activation. |
| Q33705126 | CXCL12 chemokine expression and secretion regulates colorectal carcinoma cell anoikis through Bim-mediated intrinsic apoptosis. |
| Q58699828 | Cantharidin Inhibits Anti-Apoptotic Bcl-2 Family Proteins and Induces Apoptosis in Human Osteosarcoma Cell Lines MG-63 and MNNG/HOS via Mitochondria-Dependent Pathway |
| Q39600380 | Caspase cleavage of HER-2 releases a Bad-like cell death effector |
| Q38827694 | Caspase-3 feedback loop enhances Bid-induced AIF/endoG and Bak activation in Bax and p53-independent manner |
| Q37446194 | Caspase-9 activation by the apoptosome is not required for fas-mediated apoptosis in type II Jurkat cells |
| Q37379411 | Caspase-cleaved arrestin-2 and BID cooperatively facilitate cytochrome C release and cell death |
| Q43227837 | Caspase-mediated Bak activation and cytochrome c release during intrinsic apoptotic cell death in Jurkat cells |
| Q89706468 | Cell Death and Recovery in Traumatic Brain Injury |
| Q34019760 | Cell death |
| Q34003160 | Cell death and inflammatory bowel diseases: apoptosis, necrosis, and autophagy in the intestinal epithelium |
| Q26823103 | Cell death disguised: The mitochondrial permeability transition pore as the c-subunit of the F(1)F(O) ATP synthase |
| Q90481728 | Cell-based high-throughput screen for small molecule inhibitors of Bax translocation |
| Q28553025 | Characterization and Inducing Melanoma Cell Apoptosis Activity of Mannosylerythritol Lipids-A Produced from Pseudozyma aphidis |
| Q36704147 | Chelerythrine induces apoptosis through a Bax/Bak-independent mitochondrial mechanism |
| Q39688681 | Chemotherapeutic drugs sensitize human renal cell carcinoma cells to ABT-737 by a mechanism involving the Noxa-dependent inactivation of Mcl-1 or A1. |
| Q37725770 | Chlamydia trachomatis-containing vacuole serves as deubiquitination platform to stabilize Mcl-1 and to interfere with host defense. |
| Q41128070 | Cholesterol effects on BAX pore activation |
| Q43144632 | Cleavage of Bid by executioner caspases mediates feed forward amplification of mitochondrial outer membrane permeabilization during genotoxic stress-induced apoptosis in Jurkat cells |
| Q36487244 | Cleavage of anti-apoptotic Bcl-2 family members after TCR stimulation contributes to the decision between T cell activation and apoptosis |
| Q35163097 | Clic4, a novel protein that sensitizes β-cells to apoptosis |
| Q37258521 | Context-dependent Bcl-2/Bak interactions regulate lymphoid cell apoptosis. |
| Q38163284 | Contributions of Bcl-xL to acute and long term changes in bioenergetics during neuronal plasticity |
| Q38172752 | Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. |
| Q37385623 | Control of mitochondrial apoptosis by the Bcl-2 family |
| Q36293800 | Conversion of cell-survival activity of Akt into apoptotic death of cancer cells by two mutations on the BIM BH3 domain. |
| Q37638544 | Coxiella burnetii exploits host cAMP-dependent protein kinase signalling to promote macrophage survival |
| Q40093022 | Crosstalk among Bcl-2 family members in B-CLL: seliciclib acts via the Mcl-1/Noxa axis and gradual exhaustion of Bcl-2 protection. |
| Q39191694 | Cytokine-dependent and cytokine-independent roles for Mcl-1: genetic evidence for multiple mechanisms by which Mcl-1 promotes survival in primary T lymphocytes |
| Q28579310 | Cytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activation |
| Q39406288 | Cytosolic Bax: does it require binding proteins to keep its pro-apoptotic activity in check? |
| Q35815150 | DNA-damage response network at the crossroads of cell-cycle checkpoints, cellular senescence and apoptosis |
| Q34671696 | Data-driven modeling of SRC control on the mitochondrial pathway of apoptosis: implication for anticancer therapy optimization |
| Q36339591 | Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis |
| Q42104592 | Deletion of the BH3-only protein Noxa alters electrographic seizures but does not protect against hippocampal damage after status epilepticus in mice |
| Q37059647 | Diagnosing and exploiting cancer's addiction to blocks in apoptosis |
| Q33793136 | Differential regulation of the proapoptotic multidomain protein Bak by p53 and p73 at the promoter level |
| Q38942011 | Differential retrotranslocation of mitochondrial Bax and Bak. |
| Q30353924 | Direct Activation of Bax Protein for Cancer Therapy |
| Q36692849 | Direct activation of full-length proapoptotic BAK |
| Q36741892 | Direct and selective small-molecule activation of proapoptotic BAX |
| Q34306986 | Disruption of the VDAC2-Bak interaction by Bcl-x(S) mediates efficient induction of apoptosis in melanoma cells |
| Q46500385 | Dissection of the BCL-2 family signaling network with stabilized alpha-helices of BCL-2 domains |
| Q41762088 | Distinct cellular and therapeutic effects of obatoclax in rituximab-sensitive and -resistant lymphomas. |
| Q35153790 | Distribution of Bim determines Mcl-1 dependence or codependence with Bcl-xL/Bcl-2 in Mcl-1-expressing myeloma cells |
| Q37786022 | Drugs targeting Bcl-2 family members as an emerging strategy in cancer |
| Q39277476 | Dying to protect: cell death and the control of T-cell homeostasis. |
| Q33363105 | Dynamical systems analysis of mitochondrial BAK activation kinetics predicts resistance to BH3 domains |
| Q46529662 | EGL-1 BH3 mutants reveal the importance of protein levels and target affinity for cell-killing potency. |
| Q35054988 | Electrical stimuli are anti-apoptotic in skeletal muscle via extracellular ATP. Alteration of this signal in Mdx mice is a likely cause of dystrophy |
| Q90654735 | Electroacupuncture Alleviated Neuronal Apoptosis Following Ischemic Stroke in Rats via Midkine and ERK/JNK/p38 Signaling Pathway |
| Q38398064 | Emerging understanding of Bcl-2 biology: Implications for neoplastic progression and treatment. |
| Q42100332 | Endogenous Noxa Determines the Strong Proapoptotic Synergism of the BH3-Mimetic ABT-737 with Chemotherapeutic Agents in Human Melanoma Cells. |
| Q39926659 | Enhanced killing of androgen-independent prostate cancer cells using inositol hexakisphosphate in combination with proteasome inhibitors. |
| Q34104845 | Epithelial ablation of Bcl-XL increases sensitivity to oxygen without disrupting lung development |
| Q34914561 | Epithelial cell death is an important contributor to oxidant-mediated acute lung injury. |
| Q28740916 | Estrogen-mediated upregulation of Noxa is associated with cell cycle progression in estrogen receptor-positive breast cancer cells |
| Q28569153 | Evaluating cytochrome c diffusion in the intermembrane spaces of mitochondria during cytochrome c release |
| Q27665695 | Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX |
| Q36936532 | Flavokawain B, a kava chalcone, induces apoptosis in synovial sarcoma cell lines |
| Q33925625 | Flavokawain B, a kava chalcone, induces apoptosis via up-regulation of death-receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growth |
| Q36117059 | Flavokawain B, a novel, naturally occurring chalcone, exhibits robust apoptotic effects and induces G2/M arrest of a uterine leiomyosarcoma cell line |
| Q33283940 | Frequent loss of expression of the pro-apoptotic protein Bim in renal cell carcinoma: evidence for contribution to apoptosis resistance. |
| Q24299330 | From death receptor to reactive oxygen species and c-Jun N-terminal protein kinase: the receptor-interacting protein 1 odyssey |
| Q38058483 | Functional characterization of SAG/RBX2/ROC2/RNF7, an antioxidant protein and an E3 ubiquitin ligase |
| Q24302321 | GRP78 and Raf-1 cooperatively confer resistance to endoplasmic reticulum stress-induced apoptosis |
| Q37765824 | Gene polymorphisms and their role in epilepsy treatment and prognosis |
| Q42576111 | Genetically defining the mechanism of Puma- and Bim-induced apoptosis |
| Q37783548 | Genomic profiles in B cell lymphoma |
| Q47555333 | Getting the "Kill" into "Shock and Kill": Strategies to Eliminate Latent HIV. |
| Q34987519 | HBx sensitizes cells to oxidative stress-induced apoptosis by accelerating the loss of Mcl-1 protein via caspase-3 cascade |
| Q34809043 | Hepatic deficiency of COP9 signalosome subunit 8 induces ubiquitin-proteasome system impairment and Bim-mediated apoptosis in murine livers. |
| Q34742600 | Hepatitis B virus X protein enhances cisplatin-induced hepatotoxicity via a mechanism involving degradation of Mcl-1. |
| Q24305060 | Heterodimerization of BAK and MCL-1 activated by detergent micelles |
| Q38785390 | High CIP2A levels correlate with an antiapoptotic phenotype that can be overcome by targeting BCL-XL in chronic myeloid leukemia. |
| Q37169993 | Histone deacetylase inhibitors prevent p53-dependent and p53-independent Bax-mediated neuronal apoptosis through two distinct mechanisms |
| Q34435161 | Holins in bacteria, eukaryotes, and archaea: multifunctional xenologues with potential biotechnological and biomedical applications |
| Q37100016 | How do BCL-2 proteins induce mitochondrial outer membrane permeabilization? |
| Q36879036 | How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression? |
| Q24300623 | Human Bop is a novel BH3-only member of the Bcl-2 protein family |
| Q24302151 | Human nuclear clusterin mediates apoptosis by interacting with Bcl-XL through C-terminal coiled coil domain |
| Q37137685 | Hypoxia ischemia-mediated cell death in neonatal rat brain |
| Q60912252 | IFNγ and TNFα synergistically induce apoptosis of mesenchymal stem/stromal cells via the induction of nitric oxide |
| Q37269154 | IMB-6G, a novel N-substituted sophoridinic acid derivative, induces endoplasmic reticulum stress-mediated apoptosis via activation of IRE1α and PERK signaling. |
| Q24323069 | Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation |
| Q35641400 | Identification of the Essential Role of Viral Bcl-2 for Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication. |
| Q34205786 | Implication of TAp73 in the p53-independent pathway of Puma induction and Puma-dependent apoptosis in primary cortical neurons |
| Q39037754 | Implications of Epigenetic Mechanisms and their Targets in Cerebral Ischemia Models |
| Q54518992 | In cancer drug resistance, germline matters too. |
| Q37848658 | In vivo contributions of BH3-only proteins to neuronal death following seizures, ischemia, and traumatic brain injury |
| Q36823954 | Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane |
| Q41771527 | Inhibition of Antiapoptotic BCL-XL, BCL-2, and MCL-1 Proteins by Small Molecule Mimetics |
| Q36057887 | Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process |
| Q36352337 | Inhibition of FOXO1 by small interfering RNA enhances proliferation and inhibits apoptosis of papillary thyroid carcinoma cells via Akt/FOXO1/Bim pathway |
| Q37959963 | Inhibition of germinal centre apoptotic programmes by epstein-barr virus |
| Q34118004 | Inhibitors of Bcl-2 protein family deplete ER Ca2+ stores in pancreatic acinar cells. |
| Q31151393 | Interdependence of Bad and Puma during ionizing-radiation-induced apoptosis |
| Q37383229 | Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis |
| Q42085320 | Intramitochondrial recruitment of endolysosomes mediates Smac degradation and constitutes a novel intrinsic apoptosis antagonizing function of XIAP E3 ligase. |
| Q90161935 | Involvement of Metabolic Lipid Mediators in the Regulation of Apoptosis |
| Q34806907 | IκΒα inhibits apoptosis at the outer mitochondrial membrane independently of NF-κB retention. |
| Q35579660 | JAK2V617F drives Mcl-1 expression and sensitizes hematologic cell lines to dual inhibition of JAK2 and Bcl-xL. |
| Q37446730 | JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis |
| Q37379488 | Jolkinolide B induces apoptosis and inhibits tumor growth in mouse melanoma B16F10 cells by altering glycolysis. |
| Q33712835 | KLF6-SV1 is a novel antiapoptotic protein that targets the BH3-only protein NOXA for degradation and whose inhibition extends survival in an ovarian cancer model. |
| Q37848690 | Kidney and urinary tract development: an apoptotic balancing act. |
| Q28550350 | Knockout Serum Replacement Promotes Cell Survival by Preventing BIM from Inducing Mitochondrial Cytochrome C Release |
| Q41661616 | Lipogenic transcription factor ChREBP mediates fructose-induced metabolic adaptations to prevent hepatotoxicity. |
| Q39619596 | Long-term exposure of INS-1 rat insulinoma cells to linoleic acid and glucose in vitro affects cell viability and function through mitochondrial-mediated pathways |
| Q28595056 | Loss of the Birt-Hogg-Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription |
| Q33796094 | Lysosome dysfunction triggers Atg7-dependent neural apoptosis |
| Q46629439 | MAC inhibitors antagonize the pro-apoptotic effects of tBid and disassemble Bax / Bak oligomers. |
| Q35990714 | MEK1/2 inhibitors potentiate UCN-01 lethality in human multiple myeloma cells through a Bim-dependent mechanism |
| Q38185804 | Many players in BCL-2 family affairs |
| Q59136340 | Mass Action Kinetic Model of Apoptosis by TRAIL-Functionalized Leukocytes |
| Q38451839 | Mcl-1 is vital for neutrophil survival. |
| Q33838448 | Mcl-1 promotes survival of thymocytes by inhibition of Bak in a pathway separate from Bcl-2. |
| Q83968238 | Mcl1 becomes ubiquitin-ous: new opportunities to antagonize a pro-survival protein |
| Q37068553 | Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins |
| Q34805885 | Mechanisms and biology of B-cell leukemia/lymphoma 2/adenovirus E1B interacting protein 3 and Nip-like protein X. |
| Q36932838 | Mechanisms of action of Bcl-2 family proteins |
| Q24323186 | Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax |
| Q36101583 | MiR-125b protects against ethanol-induced apoptosis in neural crest cells and mouse embryos by targeting Bak 1 and PUMA. |
| Q36163240 | MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells. |
| Q37566211 | Mimicking the BH3 domain to kill cancer cells |
| Q38760561 | Mitochondria-Judges and Executioners of Cell Death Sentences |
| Q37347485 | Mitochondria: gatekeepers of response to chemotherapy |
| Q36546659 | Mitochondrial ATF2 translocation contributes to apoptosis induction and BRAF inhibitor resistance in melanoma through the interaction of Bim with VDAC1. |
| Q37466054 | Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia. |
| Q33869857 | Mitochondrial dysfunction links ceramide activated HRK expression and cell death |
| Q36118156 | Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak. |
| Q37517187 | Mitochondrial targeting of tBid/Bax: a role for the TOM complex? |
| Q28474253 | Modeling a snap-action, variable-delay switch controlling extrinsic cell death |
| Q33471807 | Modeling the role of p53 pulses in DNA damage- induced cell death decision. |
| Q26800081 | Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and β-Cell Dysfunction |
| Q47843948 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. |
| Q37430520 | Molecular participants in mitochondrial cell death channel formation during neuronal ischemia |
| Q38012566 | Molecular pathogenesis of malignant mesothelioma |
| Q38918113 | Mouse cytotoxic T cell-derived granzyme B activates the mitochondrial cell death pathway in a Bim-dependent fashion |
| Q33819193 | Mst1 promotes cardiac myocyte apoptosis through phosphorylation and inhibition of Bcl-xL |
| Q38843835 | Multi-parametric imaging of cell heterogeneity in apoptosis analysis |
| Q37620684 | Multiple components of the spliceosome regulate Mcl1 activity in neuroblastoma |
| Q24322798 | Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis |
| Q34233598 | Mutual regulation of Bcl-2 proteins independent of the BH3 domain as shown by the BH3-lacking protein Bcl-x(AK). |
| Q29614484 | NIX is required for programmed mitochondrial clearance during reticulocyte maturation |
| Q39958561 | Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa |
| Q35668914 | Natural diterpenoid compound elevates expression of Bim protein, which interacts with antiapoptotic protein Bcl-2, converting it to proapoptotic Bax-like molecule. |
| Q64110798 | Natural gypenosides: targeting cancer through different molecular pathways |
| Q28578213 | Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion via regulation of Bim |
| Q39749589 | Neuroglobin protects nerve cells from apoptosis by inhibiting the intrinsic pathway of cell death |
| Q35886625 | Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling |
| Q101455784 | Neuronal cell life, death, and axonal degeneration as regulated by the BCL-2 family proteins |
| Q37399624 | Neurotoxic lipid peroxidation species formed by ischemic stroke increase injury |
| Q41375785 | Nipping at cardiac remodeling. |
| Q33505312 | Nitric oxide induces cell death by regulating anti-apoptotic BCL-2 family members |
| Q36140862 | Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL. |
| Q33502518 | Novel Bcl-2 homology-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival Bcl-2 proteins. |
| Q37691759 | Novel agents for B-cell non-Hodgkin lymphoma: science and the promise |
| Q38866647 | Noxa and cancer therapy: Tuning up the mitochondrial death machinery in response to chemotherapy |
| Q24296352 | Noxa is necessary for hydrogen peroxide-induced caspase-dependent cell death |
| Q47649146 | Noxa/HSP27 complex delays degradation of ubiquitylated IkBα in airway epithelial cells to reduce pulmonary inflammation. |
| Q37184726 | Oxidative stress and mitochondrial dysfunction as determinants of ischemic neuronal death and survival |
| Q37121933 | PUMA and BIM are required for oncogene inactivation-induced apoptosis. |
| Q40021264 | PUMA inactivation protects against oxidative stress through p21/Bcl-XL inhibition of bax death |
| Q24631776 | PUMA, a potent killer with or without p53 |
| Q48272590 | Pancortin-2 interacts with WAVE1 and Bcl-xL in a mitochondria-associated protein complex that mediates ischemic neuronal death. |
| Q58702444 | Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes |
| Q33832757 | Perturbation of the Bcl-2 network and an induced Noxa/Bcl-xL interaction trigger mitochondrial dysfunction after DNA damage |
| Q42789241 | Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice |
| Q39659313 | Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint |
| Q24631299 | Phosphorylation of Puma modulates its apoptotic function by regulating protein stability |
| Q35252479 | Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53 |
| Q64229946 | Photocrosslinking Approach to Investigate Protein Interactions in the BCL-2 Family |
| Q42363155 | Physiological roles of the mitochondrial permeability transition pore |
| Q36892623 | Piercing the armor of hepatobiliary cancer: Bcl-2 homology domain 3 (BH3) mimetics and cell death. |
| Q39627618 | Platinum resistant cancer cells conserve sensitivity to BH3 domains and obatoclax induced mitochondrial apoptosis |
| Q28572255 | Postnatal developmental regulation of Bcl-2 family proteins in brain mitochondria |
| Q92946992 | Potential Roles of NIX/BNIP3L Pathway in Rat Traumatic Brain Injury |
| Q26771601 | Potential of apoptotic pathway-targeted cancer therapeutic research: Where do we stand? |
| Q28573853 | Potential role of PUMA in delayed death of hippocampal CA1 neurons after transient global cerebral ischemia |
| Q39188578 | Pramanicin analog induces apoptosis in human colon cancer cells: critical roles for Bcl-2, Bim, and p38 MAPK signaling. |
| Q35748569 | Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1's inhibitory effect on Bak. |
| Q82420849 | Prevention of apoptosis by the interaction between FIH1 and Bax |
| Q34545350 | Pro-apoptotic Bax is the major and Bak an auxiliary effector in cytokine deprivation-induced mast cell apoptosis |
| Q34168039 | Proapoptotic Bad and Bid protein expression predict survival in stages II and III colon cancers |
| Q37247458 | Proapoptotic Noxa is required for particulate matter-induced cell death and lung inflammation. |
| Q35374719 | Proapoptotic role of nuclear clusterin in brain |
| Q36670900 | Prognostic impact of expression of Bcl-2 and Bax genes in circulating immune cells derived from patients with head and neck carcinoma |
| Q34328597 | Programming biological models in Python using PySB |
| Q38088109 | Programming cancer cells for high expression levels of Mcl1. |
| Q39268374 | Promotion of Caspase Activation by Caspase-9-mediated Feedback Amplification of Mitochondrial Damage |
| Q35983626 | Prosurvival Bcl-2 proteins stabilize pancreatic mitochondria and protect against necrosis in experimental pancreatitis |
| Q24294703 | Proteasome inhibitors evoke latent tumor suppression programs in pro-B MLL leukemias through MLL-AF4 |
| Q38076413 | Protecting and rescuing the effectors: roles of differentiation and survival in the control of memory T cell development |
| Q38946419 | Proteinase-activated receptor 2 (PAR2) decreases apoptosis in colonic epithelial cells. |
| Q41868050 | Proteomic analysis of enriched lysosomes at early phase of camptothecin-induced apoptosis in human U-937 cells |
| Q46886447 | Puma is a dominant regulator of oxidative stress induced Bax activation and neuronal apoptosis. |
| Q43107803 | Puma strikes Bax. |
| Q33807797 | Quantitative analysis of pathways controlling extrinsic apoptosis in single cells |
| Q41009828 | Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of complexes for apoptosis regulation. |
| Q30503448 | Rapid induction of apoptosis during Kinesin-5 inhibitor-induced mitotic arrest in HL60 cells. |
| Q34692159 | Reconstitution of the anti-apoptotic Bcl-2 protein into lipid membranes and biophysical evidence for its detergent-driven association with the pro-apoptotic Bax protein |
| Q37324058 | Redefining the BH3 Death Domain as a 'Short Linear Motif'. |
| Q91100188 | Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins |
| Q42918078 | Regulation of bim in glucocorticoid-mediated osteoblast apoptosis. |
| Q35483598 | Regulation of memory B-cell survival by the BH3-only protein Puma |
| Q39639146 | Reovirus infection or ectopic expression of outer capsid protein micro1 induces apoptosis independently of the cellular proapoptotic proteins Bax and Bak. |
| Q36762412 | Resistance to HSP90 inhibition involving loss of MCL1 addiction. |
| Q63408376 | Response to Callus et al on ‘Cytoplasmic p53 is not required for PUMA-induced apoptosis’ |
| Q34948698 | Role of BNIP3 and NIX in cell death, autophagy, and mitophagy |
| Q37826384 | Role of Bcl-2 family proteins and caspases in the regulation of apoptosis. |
| Q39810072 | Role of FK506-binding protein 51 in the control of apoptosis of irradiated melanoma cells |
| Q36790564 | Role of cardiolipin in cytochrome c release from mitochondria |
| Q39798291 | Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family |
| Q39627698 | SRC directly phosphorylates Bif-1 and prevents its interaction with Bax and the initiation of anoikis |
| Q28487858 | STL-based analysis of TRAIL-induced apoptosis challenges the notion of type I/type II cell line classification |
| Q36846076 | Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis |
| Q43159511 | Selective glucocorticoid receptor translational isoforms reveal glucocorticoid-induced apoptotic transcriptomes. |
| Q34146431 | Selective induction of cell death in melanoma cell lines through targeting of Mcl-1 and A1. |
| Q42714125 | Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways |
| Q84285839 | Signaling by IL-1beta+IFN-gamma and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic beta-cell apoptosis |
| Q90239351 | Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX |
| Q36203280 | Small PARP inhibitor PJ-34 induces cell cycle arrest and apoptosis of adult T-cell leukemia cells |
| Q24646161 | Small-molecule Bcl-2 antagonists as targeted therapy in oncology |
| Q37799747 | Small-molecule inhibitors reveal a new function for Bcl-2 as a proangiogenic signaling molecule. |
| Q38268983 | Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis. |
| Q37773789 | Still embedded together binding to membranes regulates Bcl-2 protein interactions. |
| Q27680461 | Structural Insights of tBid, the Caspase-8-activated Bid, and Its BH3 Domain |
| Q27649776 | Structural and Biochemical Bases for the Inhibition of Autophagy and Apoptosis by Viral BCL-2 of Murine γ-Herpesvirus 68 |
| Q36857420 | Structure-based design of flavonoid compounds as a new class of small-molecule inhibitors of the anti-apoptotic Bcl-2 proteins. |
| Q38262165 | Subcellular localization of PUMA regulates its pro-apoptotic activity in Burkitt's lymphoma B cells |
| Q41766825 | Suppression of p38 MAPK and JNK via Akt-mediated inhibition of apoptosis signal-regulating kinase 1 constitutes a core component of the beta-cell pro-survival effects of glucose-dependent insulinotropic polypeptide |
| Q33564558 | Systematic genetic dissection of p14ARF-mediated mitochondrial cell death signaling reveals a key role for p21CDKN1 and the BH3-only protein Puma/bbc3. |
| Q36946967 | TGF beta-mediated BIM expression and apoptosis are regulated through SMAD3-dependent expression of the MAPK phosphatase MKP2 |
| Q50875899 | TGFbeta-mediated apoptosis of Burkitt's lymphoma BL41 cells is associated with the relocation of mitochondrial BimEL. |
| Q38190369 | TMBIM protein family: ancestral regulators of cell death |
| Q39197893 | Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation. |
| Q41077849 | Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy |
| Q24603213 | Taspase1 functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosis |
| Q35568029 | The BCL-2 family reunion |
| Q29547380 | The BCL-2 protein family: opposing activities that mediate cell death |
| Q41878505 | The BCL2 rheostat in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia |
| Q34685414 | The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner |
| Q37420518 | The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways |
| Q49458182 | The Bcl-2 Homology-3 Domain (BH3)-Only Proteins, Bid, DP5/Hrk, and BNip3L, Are Upregulated in Reactive Astrocytes of End-Stage Mutant SOD1 Mouse Spinal Cord |
| Q24620437 | The Bcl-2 apoptotic switch in cancer development and therapy |
| Q37233959 | The Bcl-2 homology domain 3 (BH3)-only proteins Bim and bid are functionally active and restrained by anti-apoptotic Bcl-2 family proteins in healthy liver. |
| Q48290361 | The C-terminal Domains of Apoptotic BH3-only Proteins Mediate Their Insertion into Distinct Biological Membranes. |
| Q33285445 | The N-terminus and alpha-5, alpha-6 helices of the pro-apoptotic protein Bax, modulate functional interactions with the anti-apoptotic protein Bcl-xL. |
| Q38717426 | The VDAC2-BAK axis regulates peroxisomal membrane permeability. |
| Q37347133 | The VDAC2-BAK rheostat controls thymocyte survival |
| Q37370350 | The antiapoptotic protein Bcl-xL negatively regulates the bone-resorbing activity of osteoclasts in mice |
| Q30368405 | The functional differences between pro-survival and pro-apoptotic B cell lymphoma 2 (Bcl-2) proteins depend on structural differences in their Bcl-2 homology 3 (BH3) domains. |
| Q38254507 | The molecular mechanisms between autophagy and apoptosis: potential role in central nervous system disorders. |
| Q35140947 | The novel anti-MEK small molecule AZD6244 induces BIM-dependent and AKT-independent apoptosis in diffuse large B-cell lymphoma |
| Q37079047 | The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage |
| Q80352679 | The proapoptotic BCL-2 family member BIM mediates motoneuron loss in a model of amyotrophic lateral sclerosis |
| Q36792997 | The promise of TRAIL--potential and risks of a novel anticancer therapy |
| Q26827928 | The role of BH3-mimetic drugs in the treatment of pediatric hepatoblastoma |
| Q37309119 | The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins |
| Q35710492 | The role of calcineurin signaling in microcystin-LR triggered neuronal toxicity |
| Q36602674 | The role of mitochondria in apoptosis*. |
| Q38041423 | The selective BH4-domain biology of Bcl-2-family members: IP3Rs and beyond |
| Q39028789 | The use of a neutral peptide aptamer scaffold to anchor BH3 peptides constitutes a viable approach to studying their function |
| Q40125495 | Therapeutic window for melanoma treatment provided by selective effects of the proteasome on Bcl-2 proteins |
| Q54226578 | Tirofiban counteracts endothelial cell apoptosis through the VEGF/VEGFR2/pAkt axis. |
| Q35320797 | Transforming growth factor beta (TGFbeta)-induced apoptosis: the rise & fall of Bim |
| Q36620902 | Transforming growth factor-β directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas. |
| Q42800693 | Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization |
| Q34400731 | Trichonomas vaginalis metalloproteinase induces apoptosis of SiHa cells through disrupting the Mcl-1/Bim and Bcl-xL/Bim complexes |
| Q36288668 | Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition. |
| Q40393121 | Tumor suppressor BLU promotes TRAIL-induced apoptosis by downregulating NF-κB signaling in nasopharyngeal carcinoma |
| Q21562302 | Two independent positive feedbacks and bistability in the Bcl-2 apoptotic switch |
| Q33344919 | Unravelling the bcl-2 apoptosis code with a simple model system |
| Q28478856 | Up-regulation of Mcl-1 and Bak by coronavirus infection of human, avian and animal cells modulates apoptosis and viral replication |
| Q79397659 | Upgrading the BCL-2 network |
| Q103027729 | Viral Bcl2s' transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis |
| Q86506057 | WITHDRAWN: IRE1α-TRAF2-ASK1 complex-mediated endoplasmic reticulum stress and mitochondrial dysfunction contribute to CXC195-induced apoptosis in human bladder carcinoma T24 cells |
| Q36629743 | Where killers meet--permeabilization of the outer mitochondrial membrane during apoptosis |
| Q33758493 | Why anti-Bcl-2 clinical trials fail: a solution |
| Q47159040 | Why do BCL-2 inhibitors work and where should we use them in the clinic? |
| Q33883278 | eIF2alpha phosphorylation tips the balance to apoptosis during osmotic stress |
| Q36905867 | microRNAs: innovative targets for cerebral ischemia and stroke. |
| Q39802136 | p16INK4A sensitizes human leukemia cells to FAS- and glucocorticoid-induced apoptosis via induction of BBC3/Puma and repression of MCL1 and BCL2. |
| Q37074474 | p21(Cip1) protects against oxidative stress by suppressing ER-dependent activation of mitochondrial death pathways |
| Q33819250 | p53 and mitochondrial function in neurons |
| Q24338796 | p53 opens the mitochondrial permeability transition pore to trigger necrosis |
| Q28580759 | p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress |
| Q38817198 | uPAR peptide antagonist alters regulation of MAP kinases and Bcl-2 family members in favor of apoptosis in MDA-MB-231 cell line |
| Q47323308 | ΔNp63 Inhibits Oxidative Stress-Induced Cell Death, Including Ferroptosis, and Cooperates with the BCL-2 Family to Promote Clonogenic Survival |
| Q34577504 | α-TEA cooperates with MEK or mTOR inhibitors to induce apoptosis via targeting IRS/PI3K pathways |
Search more.