Differential regulation of the proapoptotic multidomain protein Bak by p53 and p73 at the promoter level

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Differential regulation of the proapoptotic multidomain protein Bak by p53 and p73 at the promoter level is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1022400548
P356DOI10.1038/CDD.2010.179
P932PMC publication ID3131957
P698PubMed publication ID21233848
P5875ResearchGate publication ID49754338

P2093author name stringP T Daniel
F Essmann
K Schulze-Osthoff
B F Gillissen
E Alexander
O Rothfuss
T Overkamp
V De Laurenzi
V Graupner
P2860cites workPUMA induces the rapid apoptosis of colorectal cancer cellsQ24291462
PUMA, a novel proapoptotic gene, is induced by p53Q24291463
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or BakQ24296478
A novel response element confers p63- and p73-specific activation of the WNT4 promoterQ24298536
Adenovirus-mediated overexpression of p14(ARF) induces p53 and Bax-independent apoptosisQ24300313
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteinsQ24302494
Sp1 and p73 activate PUMA following serum starvationQ24655353
FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawalQ24676637
Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathwayQ24681629
WAF1, a potential mediator of p53 tumor suppressionQ27861121
Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosisQ28144256
Definition of a consensus binding site for p53Q28207794
Cell death: critical control pointsQ28240722
Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivoQ28253554
Regulation of apoptosis by alternative pre-mRNA splicingQ28259246
Tumor suppressor p53 is a direct transcriptional activator of the human bax geneQ28306186
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and deathQ28363890
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasiaQ29615437
Transcriptional control of human p53-regulated genesQ29617650
Role of BAX in the apoptotic response to anticancer agentsQ31523620
Irradiation-induced translocation of p53 to mitochondria in the absence of apoptosisQ33222943
Bak functionally complements for loss of Bax during p14ARF-induced mitochondrial apoptosis in human cancer cellsQ33250477
Mcl-1 determines the Bax dependency of Nbk/Bik-induced apoptosisQ33306334
PUMA is directly activated by NF-kappaB and contributes to TNF-alpha-induced apoptosisQ33857705
A novel member of the IkappaB family, human IkappaB-zeta, inhibits transactivation of p65 and its DNA bindingQ34499168
A functional p53-responsive intronic promoter is contained within the humanmdm2geneQ34761984
The functional domains in p53 family proteins exhibit both common and distinct propertiesQ36423942
Transcriptional down-regulation of Bcl-2 by vinorelbine: identification of a novel binding site of p53 on Bcl-2 promoterQ38352839
Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repairQ39823278
Functional characterization of p53beta and p53gamma, two isoforms of the tumor suppressor p53.Q39869719
Upregulation of BAK by butyrate in the colon is associated with increased Sp3 binding.Q40274243
WT1 induces apoptosis through transcriptional regulation of the proapoptotic Bcl-2 family member Bak.Q40372880
p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocationQ40614201
Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site.Q42487048
A novel form of Epstein-Barr virus latency in normal B cells in vivoQ45789413
VP22-mediated intercellular transport of p53 in hepatoma cells in vitro and in vivoQ45886319
Comparative binding of p53 to its promoter and DNA recognition elements.Q51503955
Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53.Q53393697
Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamiliesQ79370601
Upgrading the BCL-2 networkQ79397659
p21 blocks irradiation-induced apoptosis downstream of mitochondria by inhibition of cyclin-dependent kinase-mediated caspase-9 activationQ79405060
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)1130-1139
P577publication date2011-01-14
P1433published inCell Death & DifferentiationQ2943974
P1476titleDifferential regulation of the proapoptotic multidomain protein Bak by p53 and p73 at the promoter level
P478volume18

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cites work (P2860)
Q35535592Apoptosis resistance, mitotic catastrophe, and loss of ploidy control in Burkitt lymphoma.
Q36763830Astaxanthin Inhibits Acetaldehyde-Induced Cytotoxicity in SH-SY5Y Cells by Modulating Akt/CREB and p38MAPK/ERK Signaling Pathways
Q53022205BIRC6 promotes hepatocellular carcinogenesis: interaction of BIRC6 with p53 facilitating p53 degradation.
Q26829232Caloric restriction: is mammalian life extension linked to p53?
Q36907168Caspase-1 is a novel target of p63 in tumor suppression
Q34104165ERBB3 knockdown induces cell cycle arrest and activation of Bak and Bax-dependent apoptosis in colon cancer cells
Q61445366Eukaryotic initiation factor 5B (eIF5B) provides a critical cell survival switch to glioblastoma cells via regulation of apoptosis
Q35441339Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells
Q37530290GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation
Q33425096HTLV-1-associated adult T cell leukemia is highly susceptible to Navitoclax due to enhanced Bax expression
Q54110583Hey1- and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth.
Q38184518How the TP53 family proteins TP63 and TP73 contribute to tumorigenesis: regulators and effectors
Q34863536Levels of pro-apoptotic regulator Bad and anti-apoptotic regulator Bcl-xL determine the type of the apoptotic logic gate
Q39493955Mcl-1 and YY1 inhibition and induction of DR5 by the BH3-mimetic Obatoclax (GX15-070) contribute in the sensitization of B-NHL cells to TRAIL apoptosis
Q97904873Mithramycin selectively attenuates DNA-damage-induced neuronal cell death
Q83228165NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress
Q93129152NR2E3 is a key component in p53 activation by regulating a long noncoding RNA DINO in acute liver injuries
Q46606403Nol12 is a multifunctional RNA binding protein at the nexus of RNA and DNA metabolism.
Q38064995Nutrient availability links mitochondria, apoptosis, and obesity
Q34453986Overexpression of ankyrin repeat domain 1 enhances cardiomyocyte apoptosis by promoting p53 activation and mitochondrial dysfunction in rodents
Q36736367P73 and age-related diseases: is there any link with Parkinson Disease?
Q49714600TP53 is required for BECN1- and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition
Q53089642Terfenadine induces anti-proliferative and apoptotic activities in human hormone-refractory prostate cancer through histamine receptor-independent Mcl-1 cleavage and Bak up-regulation.
Q37066512The Atypical Inhibitor of NF-κB, IκBζ, Controls Macrophage Interleukin-10 Expression
Q24273295The transcription factor p53: not a repressor, solely an activator
Q36556362Tissue-specific expression of p73 C-terminal isoforms in mice.
Q35708113Translational approaches targeting the p53 pathway for anti-cancer therapy
Q50054365Trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine induces lipid peroxidation-associated apoptosis via the intrinsic and extrinsic apoptosis pathways in a first-trimester placental cell line
Q36655752Yin Yang 1 Promotes Thymocyte Survival by Downregulating p53.
Q89805472p53-Related Transcription Targets of TAp73 in Cancer Cells-Bona Fide or Distorted Reality?
Q36581663p63 the guardian of human reproduction
Q42492256p73 gene in dopaminergic neurons is highly susceptible to manganese neurotoxicity

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