| scholarly article | Q13442814 |
| P50 | author | Evripidis Gavathiotis | Q59661942 |
| Motoshi Suzuki | Q73270487 | ||
| Kenneth Pitter | Q79697463 | ||
| Loren D. Walensky | Q92710996 | ||
| P2093 | author name string | Hyungjin Kim | |
| Nico Tjandra | |||
| Emily H-Y Cheng | |||
| Ho-Chou Tu | |||
| Marguerite L Davis | |||
| Samuel G Katz | |||
| Gregory H Bird | |||
| P2860 | cites work | Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function | Q24293924 |
| Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak | Q24296478 | ||
| Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis | Q24296925 | ||
| Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins | Q24302494 | ||
| A stapled BID BH3 helix directly binds and activates BAX | Q24307663 | ||
| Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis | Q24307994 | ||
| Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade | Q24311006 | ||
| Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death | Q24312211 | ||
| BID: a novel BH3 domain-only death agonist | Q24320091 | ||
| Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members | Q24337108 | ||
| Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis | Q24533270 | ||
| Conformation of the Bax C-terminus regulates subcellular location and cell death | Q24534099 | ||
| Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix | Q24537504 | ||
| Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis | Q24669892 | ||
| Movement of Bax from the cytosol to mitochondria during apoptosis | Q24677881 | ||
| Structure of Bax: coregulation of dimer formation and intracellular localization | Q27628839 | ||
| X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death | Q27733156 | ||
| Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis | Q27734734 | ||
| BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis | Q28189945 | ||
| p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa | Q28204059 | ||
| Cell death: critical control points | Q28240722 | ||
| Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death | Q28363890 | ||
| The BCL-2 protein family: opposing activities that mediate cell death | Q29547380 | ||
| An inhibitor of Bcl-2 family proteins induces regression of solid tumours | Q29547595 | ||
| Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane | Q29616354 | ||
| ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor | Q29616727 | ||
| BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly | Q29617135 | ||
| Utilization of site-directed spin labeling and high-resolution heteronuclear nuclear magnetic resonance for global fold determination of large proteins with limited nuclear overhauser effect data | Q29617299 | ||
| Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics | Q29620467 | ||
| Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis | Q33854131 | ||
| BH3-Only proteins-essential initiators of apoptotic cell death | Q34117362 | ||
| The multidomain proapoptotic molecules Bax and Bak are directly activated by heat | Q34212713 | ||
| Cysteine 62 of Bax is critical for its conformational activation and its proapoptotic activity in response to H2O2-induced apoptosis | Q35674492 | ||
| Structural biology of the Bcl-2 family of proteins | Q35680498 | ||
| Caspase cleavage of BimEL triggers a positive feedback amplification of apoptotic signaling | Q36017432 | ||
| Regulated targeting of BAX to mitochondria. | Q36255507 | ||
| Conformational control of Bax localization and apoptotic activity by Pro168. | Q36321947 | ||
| BCL-2 in the crosshairs: tipping the balance of life and death | Q36501184 | ||
| Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes | Q36799170 | ||
| Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity. | Q37593642 | ||
| Differential regulation of Bax and Bak by anti-apoptotic Bcl-2 family proteins Bcl-B and Mcl-1. | Q39646171 | ||
| Bcl-2 changes conformation to inhibit Bax oligomerization | Q40287064 | ||
| The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA. | Q40485961 | ||
| Involvement of the N-terminus of Bax in its intracellular localization and function. | Q45711449 | ||
| Dissection of the BCL-2 family signaling network with stabilized alpha-helices of BCL-2 domains | Q46500385 | ||
| The importance of not saturating water in protein NMR. Application to sensitivity enhancement and NOE measurements | Q57080265 | ||
| Nonionic detergents induce dimerization among members of the Bcl-2 family | Q73343305 | ||
| Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies | Q79370601 | ||
| Synthesis and biophysical characterization of stabilized alpha-helices of BCL-2 domains | Q81584715 | ||
| P433 | issue | 7216 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 1076-1081 | |
| P577 | publication date | 2008-10-01 | |
| P1433 | published in | Nature | Q180445 |
| P1476 | title | BAX activation is initiated at a novel interaction site | |
| P478 | volume | 455 |
| Q55243328 | (-)-Gochnatiolide B, synthesized from dehydrocostuslactone, exhibits potent anti-bladder cancer activity in vitro and in vivo. |
| Q39366387 | A Bax-mediated mechanism for obatoclax-induced apoptosis of cholangiocarcinoma cells |
| Q37720808 | A Short Double-Stapled Peptide Inhibits Respiratory Syncytial Virus Entry and Spreading. |
| Q31100573 | A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival |
| Q30538270 | A myosin-Va tail fragment sequesters dynein light chains leading to apoptosis in melanoma cells |
| Q54548513 | A new i, i + 3 peptide stapling system for α-helix stabilization. |
| Q33855651 | A phospho-BAD BH3 helix activates glucokinase by a mechanism distinct from that of allosteric activators |
| Q34407579 | A screening strategy for trapping the inactive conformer of a dimeric enzyme with a small molecule inhibitor |
| Q98293355 | A small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy |
| Q30466831 | A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers. |
| Q39632109 | A stapled p53 helix overcomes HDMX-mediated suppression of p53. |
| Q33842900 | APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction |
| Q34364547 | ARID3B induces tumor necrosis factor alpha mediated apoptosis while a novel ARID3B splice form does not induce cell death |
| Q92596486 | Activating the Intrinsic Pathway of Apoptosis Using BIM BH3 Peptides Delivered by Peptide Amphiphiles with Endosomal Release |
| Q46920040 | Activation of Bax by joint action of tBid and mitochondrial outer membrane: Monte Carlo simulations |
| Q37713569 | Activation of the proapoptotic Bcl-2 protein Bax by a small molecule induces tumor cell apoptosis |
| Q28749082 | Active fragments from pro- and antiapoptotic BCL-2 proteins have distinct membrane behavior reflecting their functional divergence |
| Q37727610 | After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization. |
| Q36012325 | Allosteric inhibition of antiapoptotic MCL-1. |
| Q49261983 | Allosteric sensitization of proapoptotic BAX. |
| Q53424475 | Allostery in BAX protein activation. |
| Q50077375 | An Akt3 Splice Variant Lacking the Serine 472 Phosphorylation Site Promotes Apoptosis and Suppresses Mammary Tumorigenesis |
| Q39593727 | An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway. |
| Q38387363 | An enhanced functional interrogation/manipulation of intracellular signaling pathways with the peptide 'stapling' technology |
| Q36109186 | An interconnected hierarchical model of cell death regulation by the BCL-2 family |
| Q47964693 | Anthocyanins/anthocyanidins and colorectal cancer: What is behind the scenes? |
| Q37828794 | Apoptosis and oncogenesis: give and take in the BCL-2 family |
| Q26750639 | Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies |
| Q38181031 | Apoptosis regulation at the mitochondrial outer membrane |
| Q43023126 | Apoptosis: Stabbed in the BAX. |
| Q35088734 | Apoptotic cell signaling in cancer progression and therapy |
| Q39384348 | Apoptotic foci at mitochondria: in and around Bax pores |
| Q37151053 | Assembly of the Bak apoptotic pore: a critical role for the Bak protein α6 helix in the multimerization of homodimers during apoptosis |
| Q38854924 | Assessing the Efficacy of Mdm2/Mdm4-Inhibiting Stapled Peptides Using Cellular Thermal Shift Assays. |
| Q35229082 | Asymmetric triplex metallohelices with high and selective activity against cancer cells. |
| Q34990137 | BAD dephosphorylation and decreased expression of MCL-1 induce rapid apoptosis in prostate cancer cells |
| Q37566231 | BAD: undertaker by night, candyman by day. |
| Q49725642 | BAK α6 permits activation by BH3-only proteins and homooligomerization via the canonical hydrophobic groove |
| Q36941147 | BAK/BAX activation and cytochrome c release assays using isolated mitochondria |
| Q42115161 | BAX and BAK caught in the act. |
| Q39073674 | BAX to basics: How the BCL2 gene family controls the death of retinal ganglion cells |
| Q27002044 | BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore |
| Q64245128 | BCL-2 Protein Family Interaction Analysis by Nuclear Magnetic Resonance Spectroscopy |
| Q47155532 | BCL-2 family proteins: changing partners in the dance towards death |
| Q24305138 | BH3 domains other than Bim and Bid can directly activate Bax/Bak |
| Q34363841 | BH3 helix-derived biophotonic nanoswitches regulate cytochrome c release in permeabilised cells |
| Q26828031 | BH3 profiling--measuring integrated function of the mitochondrial apoptotic pathway to predict cell fate decisions |
| Q36948615 | BH3 response profiles from neuroblastoma mitochondria predict activity of small molecule Bcl-2 family antagonists |
| Q58573059 | BH3-Dependent and Independent Activation of BAX and BAK in Mitochondrial Apoptosis |
| Q37797387 | BH3-Only Proteins and Their Effects on Cancer |
| Q33394363 | BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets |
| Q41865581 | BH3-only protein BIM mediates heat shock-induced apoptosis |
| Q37566201 | BH3-only proteins and their roles in programmed cell death |
| Q39394965 | BH3-only proteins are tail-anchored in the outer mitochondrial membrane and can initiate the activation of Bax |
| Q34085370 | BH3-only proteins in apoptosis and beyond: an overview |
| Q90262608 | BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis |
| Q37629756 | BH3-only proteins: the death-puppeteer's wires |
| Q41884328 | BH3-triggered structural reorganization drives the activation of proapoptotic BAX. |
| Q34182014 | BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy response |
| Q38269004 | BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program |
| Q27677468 | BID-induced structural changes in BAK promote apoptosis |
| Q47254152 | BIM Binding Remotely Regulates BAX Activation: Insights from the Free Energy Landscapes |
| Q35588268 | BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors. |
| Q41885064 | BIM-mediated membrane insertion of the BAK pore domain is an essential requirement for apoptosis |
| Q33642685 | BIMEL is a key effector molecule in oxidative stress-mediated apoptosis in acute myeloid leukemia cells when combined with arsenic trioxide and buthionine sulfoximine |
| Q35851632 | Baicalein inhibits prostate cancer cell growth and metastasis via the caveolin-1/AKT/mTOR pathway |
| Q35749559 | Bak Conformational Changes Induced by Ligand Binding: Insight into BH3 Domain Binding and Bak Homo-Oligomerization |
| Q43156404 | Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains |
| Q37531911 | Bax activation by Bim? |
| Q37237621 | Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members |
| Q39033533 | Bax and Bak Pores: Are We Closing the Circle? |
| Q50542236 | Bax and calpain mediate excitotoxic oligodendrocyte death induced by activation of both AMPA and kainate receptors. |
| Q33569749 | Bax contains two functional mitochondrial targeting sequences and translocates to mitochondria in a conformational change- and homo-oligomerization-driven process |
| Q24313049 | Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis |
| Q35840528 | Bax dimerizes via a symmetric BH3:groove interface during apoptosis |
| Q33885192 | Bax forms an oligomer via separate, yet interdependent, surfaces |
| Q35512551 | Bax forms two types of channels, one of which is voltage-gated |
| Q28506109 | Bax regulates primary necrosis through mitochondrial dynamics |
| Q47305952 | Bax, Bak and beyond - mitochondrial performance in apoptosis |
| Q37482805 | Bax/Bak activation in the absence of Bid, Bim, Puma, and p53. |
| Q36298500 | BaxΔ2 is a novel bax isoform unique to microsatellite unstable tumors |
| Q34121322 | Bcl-2 and Bax interact via the BH1-3 groove-BH3 motif interface and a novel interface involving the BH4 motif |
| Q42802217 | Bcl-2 delays cell cycle through mitochondrial ATP and ROS. |
| Q37807748 | Bcl-2 proteins and mitochondria—Specificity in membrane targeting for death |
| Q42083057 | Bcl-2 turns deadly |
| Q35737865 | Bim and Bmf in tissue homeostasis and malignant disease |
| Q37451892 | Bim upregulation by histone deacetylase inhibitors mediates interactions with the Bcl-2 antagonist ABT-737: evidence for distinct roles for Bcl-2, Bcl-xL, and Mcl-1. |
| Q39885694 | Bim-Bcl-2 homology 3 mimetic therapy is effective at suppressing inflammatory arthritis through the activation of myeloid cell apoptosis |
| Q24309169 | BimL directly neutralizes Bcl-xL to promote Bax activation during UV-induced apoptosis |
| Q36108890 | Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices |
| Q34493785 | Blockade of the BAK hydrophobic groove by inhibitory phosphorylation regulates commitment to apoptosis |
| Q39661214 | Born to be alive: a role for the BCL-2 family in melanoma tumor cell survival, apoptosis, and treatment |
| Q28300914 | Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis |
| Q42911031 | Can the analysis of BH3-only protein knockout mice clarify the issue of 'direct versus indirect' activation of Bax and Bak? |
| Q36927134 | Cdk2 phosphorylation of Bcl-xL after stress converts it to a pro-apoptotic protein mimicking Bax/Bak |
| Q38151753 | Cell death and the mitochondria: therapeutic targeting of the BCL-2 family-driven pathway |
| Q38855898 | Cellular Uptake and Ultrastructural Localization Underlie the Pro-apoptotic Activity of a Hydrocarbon-stapled BIM BH3 Peptide. |
| Q36137060 | Challenges in Targeting a Basic Helix-Loop-Helix Transcription Factor with Hydrocarbon-Stapled Peptides |
| Q28480411 | Charge profile analysis reveals that activation of pro-apoptotic regulators Bax and Bak relies on charge transfer mediated allosteric regulation |
| Q28833483 | Chemical synthesis of hydrocarbon-stapled peptides for protein interaction research and therapeutic targeting |
| Q30820760 | Comparative α-helicity of cyclic pentapeptides in water |
| Q37067833 | Conformational Heterogeneity of Bax Helix 9 Dimer for Apoptotic Pore Formation |
| Q36199633 | Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells. |
| Q37258521 | Context-dependent Bcl-2/Bak interactions regulate lymphoid cell apoptosis. |
| Q34009660 | Contracting the 'mus cells'--does down-sizing suit us for diving into the memory pool? |
| Q26751456 | Control of adult neurogenesis by programmed cell death in the mammalian brain |
| Q38172752 | Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. |
| Q37385623 | Control of mitochondrial apoptosis by the Bcl-2 family |
| Q40754542 | Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction |
| Q37466228 | Cytoplasmic functions of the tumour suppressor p53. |
| Q39406288 | Cytosolic Bax: does it require binding proteins to keep its pro-apoptotic activity in check? |
| Q37625507 | Death upon a kiss: mitochondrial outer membrane composition and organelle communication govern sensitivity to BAK/BAX-dependent apoptosis |
| Q37921609 | Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases |
| Q38115674 | Decoding and unlocking the BCL-2 dependency of cancer cells |
| Q40651648 | Di(2-ethylhexyl) phthalate induces apoptosis through mitochondrial pathway in GC-2spd cells |
| Q38942011 | Differential retrotranslocation of mitochondrial Bax and Bak. |
| Q47670493 | Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia. |
| Q30353924 | Direct Activation of Bax Protein for Cancer Therapy |
| Q51015500 | Direct BAKtivation. |
| Q36692849 | Direct activation of full-length proapoptotic BAK |
| Q36741892 | Direct and selective small-molecule activation of proapoptotic BAX |
| Q42087886 | Direct interaction of Bax and Bak proteins with Bcl-2 homology domain 3 (BH3)-only proteins in living cells revealed by fluorescence complementation. |
| Q39028691 | Direct targeting of Rab-GTPase-effector interactions |
| Q38593940 | Discoveries and controversies in BCL-2 protein-mediated apoptosis. |
| Q34039998 | Displacement of Bim by Bmf and Puma rather than increase in Bim level mediates paclitaxel-induced apoptosis in breast cancer cells |
| Q42788323 | Distinct BimBH3 (BimSAHB) stapled peptides for structural and cellular studies. |
| Q37786022 | Drugs targeting Bcl-2 family members as an emerging strategy in cancer |
| Q35938545 | Dynamic Protein Interaction Networks and New Structural Paradigms in Signaling |
| Q38156169 | EBV finds a polycomb-mediated, epigenetic solution to the problem of oncogenic stress responses triggered by infection |
| Q36418705 | Elevated Mcl-1 inhibits thymocyte apoptosis and alters thymic selection. |
| Q38398064 | Emerging understanding of Bcl-2 biology: Implications for neoplastic progression and treatment. |
| Q33474807 | Epstein-barr virus latency in B cells leads to epigenetic repression and CpG methylation of the tumour suppressor gene Bim |
| Q42286702 | Ethanol influences on Bax translocation, mitochondrial membrane potential, and reactive oxygen species generation are modulated by vitamin E and brain-derived neurotrophic factor |
| Q39317652 | Evaluation and Elucidation Studies of Natural Aglycones for Anticancer Potential using Apoptosis-Related Markers: An In silico Study |
| Q37428715 | Evaluation of the BH3-only protein Puma as a direct Bak activator |
| Q28543479 | Evidence of conformational selection driving the formation of ligand binding sites in protein-protein interfaces |
| Q27665695 | Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX |
| Q41460863 | Examining BCL-2 family function with large unilamellar vesicles |
| Q34041550 | Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance |
| Q37400056 | Expression and prognostic significance of bcl-2 and bax in the progression and clinical outcome of transitional bladder cell carcinoma |
| Q36936532 | Flavokawain B, a kava chalcone, induces apoptosis in synovial sarcoma cell lines |
| Q33925625 | Flavokawain B, a kava chalcone, induces apoptosis via up-regulation of death-receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growth |
| Q34541922 | Focal adhesion kinase antagonizes doxorubicin cardiotoxicity via p21(Cip1.). |
| Q33558259 | Functional cooperation of the proapoptotic Bcl2 family proteins Bmf and Bim in vivo |
| Q30370004 | GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death |
| Q42576111 | Genetically defining the mechanism of Puma- and Bim-induced apoptosis |
| Q33988143 | Genome-wide gene expression analysis suggests an important role of hypoxia in the pathogenesis of endemic osteochondropathy Kashin-Beck disease |
| Q37783548 | Genomic profiles in B cell lymphoma |
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| Q52684466 | Grouper iridovirus GIV66 is a Bcl-2 protein that inhibits apoptosis by exclusively sequestering Bim. |
| Q34059078 | Heightened mitochondrial priming is the basis for apoptotic hypersensitivity of CD4+ CD8+ thymocytes. |
| Q34809043 | Hepatic deficiency of COP9 signalosome subunit 8 induces ubiquitin-proteasome system impairment and Bim-mediated apoptosis in murine livers. |
| Q37169993 | Histone deacetylase inhibitors prevent p53-dependent and p53-independent Bax-mediated neuronal apoptosis through two distinct mechanisms |
| Q38367375 | How do viruses control mitochondria-mediated apoptosis? |
| Q37563700 | How does Epstein-Barr virus (EBV) complement the activation of Myc in the pathogenesis of Burkitt's lymphoma? |
| Q28542025 | Hydrocarbon-stapled peptides: principles, practice, and progress |
| Q41933434 | IKKγ-Mimetic Peptides Block the Resistance to Apoptosis Associated with Kaposi's Sarcoma-Associated Herpesvirus Infection |
| Q24648348 | Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters |
| Q36960198 | Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies |
| Q35187080 | IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe-/- mice |
| Q36823954 | Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane |
| Q35644274 | Inflammation-inducing Th1 and Th17 cells differ in their expression patterns of apoptosis-related molecules |
| Q27676390 | Inhibition of Apoptosis and NF-κB Activation by Vaccinia Protein N1 Occur via Distinct Binding Surfaces and Make Different Contributions to Virulence |
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| Q27674587 | Inhibition of oncogenic Wnt signaling through direct targeting of -catenin |
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| Q27314915 | Integration and oligomerization of Bax protein in lipid bilayers characterized by single molecule fluorescence study |
| Q39357641 | Inter-organellar communication with mitochondria regulates both the intrinsic and extrinsic pathways of apoptosis |
| Q37383229 | Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis |
| Q88693653 | Intrinsic Instability of BOK Enables Membrane Permeabilization in Apoptosis |
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| Q90396260 | Isolation of Synthetic Antibodies Against BCL-2-Associated X Protein (BAX) |
| Q47564485 | Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells. |
| Q28550350 | Knockout Serum Replacement Promotes Cell Survival by Preventing BIM from Inducing Mitochondrial Cytochrome C Release |
| Q35712841 | Ligand binding and membrane insertion compete with oligomerization of the BclXL apoptotic repressor |
| Q33432478 | Loss of PUMA (BBC3) does not prevent thrombocytopenia caused by the loss of BCL-XL (BCL2L1). |
| Q35102064 | MK-STYX, a catalytically inactive phosphatase regulating mitochondrially dependent apoptosis |
| Q37564773 | Mantle cell lymphoma in cyclin D1 transgenic mice with Bim-deficient B cells |
| Q38185804 | Many players in BCL-2 family affairs |
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| Q37389520 | Mapping the interaction of pro-apoptotic tBID with pro-survival BCL-XL. |
| Q34135298 | Maturation stage of T-cell acute lymphoblastic leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199 |
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| Q38451839 | Mcl-1 is vital for neutrophil survival. |
| Q36932838 | Mechanisms of action of Bcl-2 family proteins |
| Q24300125 | Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization |
| Q39644070 | MicroRNA miR-886-5p inhibits apoptosis by down-regulating Bax expression in human cervical carcinoma cells |
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| Q35659301 | Mitochondria and apoptosis: emerging concepts. |
| Q29615459 | Mitochondria and cell death: outer membrane permeabilization and beyond |
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| Q50550781 | Mitochondria in cell death. |
| Q36723084 | Mitochondria in human pluripotent stem cell apoptosis |
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| Q38820532 | Mitochondrial Function, Biology, and Role in Disease: A Scientific Statement From the American Heart Association. |
| Q38201407 | Mitochondrial channels: ion fluxes and more |
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| Q42910802 | Molecular details of Bax activation, oligomerization, and membrane insertion. |
| Q35578787 | Molecular mechanism of local drug delivery with Paclitaxel-eluting membranes in biliary and pancreatic cancer: new application for an old drug |
| Q47843948 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. |
| Q33819193 | Mst1 promotes cardiac myocyte apoptosis through phosphorylation and inhibition of Bcl-xL |
| Q37192687 | Multimodal interaction with BCL-2 family proteins underlies the proapoptotic activity of PUMA BH3 |
| Q52886186 | Multivalent design of apoptosis-inducing bid-BH3 peptide-oligosaccharides boosts the intracellular activity at identical overall peptide concentrations. |
| Q39979970 | Musings on genome medicine: cancer genetics and the promise of effective treatment |
| Q35149107 | Mutation of a putative S-nitrosylation site of TRPV4 protein facilitates the channel activates |
| Q24322798 | Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis |
| Q40326792 | Myeloid leukemia factor 1 interfered with Bcl-XL to promote apoptosis and its function was regulated by 14-3-3. |
| Q35668914 | Natural diterpenoid compound elevates expression of Bim protein, which interacts with antiapoptotic protein Bcl-2, converting it to proapoptotic Bax-like molecule. |
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| Q38289100 | New Modalities for Challenging Targets in Drug Discovery |
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| Q48162021 | Oligomerization process of Bcl-2 associated X protein revealed from intermediate structures in solution. |
| Q38067023 | On the binding affinity of macromolecular interactions: daring to ask why proteins interact |
| Q54398821 | PP1γ functionally augments the alternative splicing of CaMKIIδ through interaction with ASF. |
| Q37121933 | PUMA and BIM are required for oncogene inactivation-induced apoptosis. |
| Q37571324 | PUMA cooperates with direct activator proteins to promote mitochondrial outer membrane permeabilization and apoptosis |
| Q38045794 | PUMA, a critical mediator of cell death--one decade on from its discovery. |
| Q47661789 | Paclitaxel Reduces Axonal Bclw to Initiate IP3R1-Dependent Axon Degeneration |
| Q37034373 | Pancreatic β-Cell Death due to Pdx-1 Deficiency Requires Multi-BH Domain Protein Bax but Not Bak. |
| Q38068571 | Peptide scanning for studying structure-activity relationships in drug discovery |
| Q37778022 | Permeabilization of the Outer Mitochondrial Membrane by Bcl-2 Proteins |
| Q33832757 | Perturbation of the Bcl-2 network and an induced Noxa/Bcl-xL interaction trigger mitochondrial dysfunction after DNA damage |
| Q34621121 | Photoreactive stapled BH3 peptides to dissect the BCL-2 family interactome. |
| Q26853192 | Photoreceptor cell death and rescue in retinal detachment and degenerations |
| Q35987570 | Pin1-Induced Proline Isomerization in Cytosolic p53 Mediates BAX Activation and Apoptosis |
| Q34044638 | Platelet-derived growth factor primes cancer-associated fibroblasts for apoptosis. |
| Q35170975 | Potent and specific peptide inhibitors of human pro-survival protein Bcl-xL. |
| Q26771601 | Potential of apoptotic pathway-targeted cancer therapeutic research: Where do we stand? |
| Q92542011 | Predisposition to Apoptosis in Hepatocellular Carcinoma: From Mechanistic Insights to Therapeutic Strategies |
| Q38064278 | Prevention of cellular suicide by cytomegaloviruses |
| Q34545350 | Pro-apoptotic Bax is the major and Bak an auxiliary effector in cytokine deprivation-induced mast cell apoptosis |
| Q30388868 | Pro-apoptotic Bax molecules densely populate the edges of membrane pores |
| Q39452441 | Progress in targeting the BCL-2 family of proteins. |
| Q39641222 | Prostaglandins antagonistically control Bax activation during apoptosis |
| Q37789771 | Protein kinase networks regulating glucocorticoid-induced apoptosis of hematopoietic cancer cells: fundamental aspects and practical considerations |
| Q55234523 | Pulling the BAX trigger for tumor cell death. |
| Q43107803 | Puma strikes Bax. |
| Q28085240 | Putting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy? |
| Q41009828 | Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of complexes for apoptosis regulation. |
| Q42371495 | RNAi targeting Nogo Receptor enhanced survival and proliferation of murine retinal ganglion cells during N-methyl-D-aspartate-induced optic nerve crush |
| Q37121662 | Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. |
| Q89511610 | Reconstituting the Mammalian Apoptotic Switch in Yeast |
| Q41975085 | Reconstitution of proapoptotic BAK function in liposomes reveals a dual role for mitochondrial lipids in the BAK-driven membrane permeabilization process |
| Q26781203 | Regulation of Bim in Health and Disease |
| Q91100188 | Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins |
| Q33990989 | Regulation of mitochondrial apoptotic events by p53-mediated disruption of complexes between antiapoptotic Bcl-2 members and Bim. |
| Q28384330 | Regulation of mitochondrial ceramide distribution by members of the BCL-2 family |
| Q38369733 | Regulation of mitochondrial nutrient and energy metabolism by BCL-2 family proteins |
| Q39260268 | Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML |
| Q34071295 | Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia. |
| Q93195699 | Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target |
| Q37826384 | Role of Bcl-2 family proteins and caspases in the regulation of apoptosis. |
| Q41374031 | Selective Covalent Targeting of Anti-Apoptotic BFL-1 by Cysteine-Reactive Stapled Peptide Inhibitors. |
| Q42317568 | Self-regulation of BAX-induced cell death. |
| Q42790829 | Single-point mutations of a lysine residue change function of Bax and Bcl-xL expressed in Bax- and Bak-less mouse embryonic fibroblasts: novel insights into the molecular mechanisms of Bax-induced apoptosis. |
| Q90239351 | Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX |
| Q35876252 | Small-Molecule and Peptide Inhibitors of the Pro-Survival Protein Mcl-1 |
| Q91341224 | Small-molecule allosteric inhibitors of BAX |
| Q37799747 | Small-molecule inhibitors reveal a new function for Bcl-2 as a proangiogenic signaling molecule. |
| Q36422392 | Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis |
| Q38014489 | Stabilized helical peptides: overview of the technologies and therapeutic promises. |
| Q38268983 | Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis. |
| Q37773789 | Still embedded together binding to membranes regulates Bcl-2 protein interactions. |
| Q27680461 | Structural Insights of tBid, the Caspase-8-activated Bid, and Its BH3 Domain |
| Q37357054 | Structural biology of the Bcl-2 family and its mimicry by viral proteins |
| Q37654859 | Structural biology of the intrinsic cell death pathway: what do we know and what is missing? |
| Q27675369 | Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA |
| Q42166522 | Structural model of active Bax at the membrane. |
| Q38539666 | Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes. |
| Q47632574 | Synthesis and inhibitory effect of 10-chlorocanthin-6-one on ovarian cancer HO8910PM cells |
| Q84261511 | Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis |
| Q34670518 | Synthesis of cell-permeable stapled peptide dual inhibitors of the p53-Mdm2/Mdmx interactions via photoinduced cycloaddition |
| Q30381337 | Synthetic Antibodies Inhibit Bcl-2-associated X Protein (BAX) through Blockade of the N-terminal Activation Site. |
| Q92826559 | Targeting BAX to drug death directly |
| Q39456786 | Targeting BCL-2-like Proteins to Kill Cancer Cells |
| Q39197893 | Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation. |
| Q34115304 | Targeting mitochondria for cancer therapy |
| Q83158104 | Targeting mitochondria for cancer therapy |
| Q39575518 | Targeting the regulatory machinery of BIM for cancer therapy |
| Q47166330 | The BCL-2 arbiters of apoptosis and their growing role as cancer targets |
| Q35568029 | The BCL-2 family reunion |
| Q36067778 | The BCL-2 protein family, BH3-mimetics and cancer therapy |
| Q27010154 | The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer Therapeutics |
| Q34685414 | The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner |
| Q41922877 | The Bcl-2 Family in Host-Virus Interactions. |
| Q92662243 | The Bcl-2 Family: Ancient Origins, Conserved Structures, and Divergent Mechanisms |
| Q38268329 | The Bcl-2 family: structures, interactions and targets for drug discovery |
| Q37131896 | The Epstein-Barr virus Bcl-2 homolog, BHRF1, blocks apoptosis by binding to a limited amount of Bim |
| Q90383179 | The Incomplete Puzzle of the BCL2 Proteins |
| Q27662487 | The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer |
| Q36033113 | The MUC1-C oncoprotein binds to the BH3 domain of the pro-apoptotic BAX protein and blocks BAX function |
| Q30387749 | The N Terminus of the Vaccinia Virus Protein F1L Is an Intrinsically Unstructured Region That Is Not Involved in Apoptosis Regulation |
| Q33838271 | The Rubella virus capsid is an anti-apoptotic protein that attenuates the pore-forming ability of Bax. |
| Q64897378 | The Structural Biology of Bcl-xL. |
| Q42587755 | The anti-apoptotic function of human αA-crystallin is directly related to its chaperone activity |
| Q33717586 | The apoptotic response in HCT116 BAX-/- cancer cells becomes rapidly saturated with increasing expression of a GFP-BAX fusion protein |
| Q92906324 | The carboxyl-terminal sequence of bim enables bax activation and killing of unprimed cells |
| Q24300635 | The cytosolic domain of human Tom22 modulates human Bax mitochondrial translocation and conformation in yeast |
| Q38668186 | The deadly landscape of pro-apoptotic BCL-2 proteins in the outer mitochondrial membrane |
| Q36150746 | The dynamics of Bax channel formation: influence of ionic strength |
| Q37247956 | The fowlpox virus BCL-2 homologue, FPV039, interacts with activated Bax and a discrete subset of BH3-only proteins to inhibit apoptosis |
| Q30368405 | The functional differences between pro-survival and pro-apoptotic B cell lymphoma 2 (Bcl-2) proteins depend on structural differences in their Bcl-2 homology 3 (BH3) domains. |
| Q47953846 | The functional domains for Bax∆2 aggregate-mediated caspase 8-dependent cell death |
| Q42723851 | The liver's dance with death: two Bcl-2 guardian proteins from the abyss |
| Q38331196 | The mystery of BCL2 family: Bcl-2 proteins and apoptosis: an update. |
| Q40985170 | The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE(2) signalling in colorectal adenoma cells. |
| Q27675459 | The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist |
| Q36850417 | The retinoblastoma protein induces apoptosis directly at the mitochondria |
| Q34038716 | The rheostat in the membrane: BCL-2 family proteins and apoptosis |
| Q37309119 | The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins |
| Q26853329 | The role of BH3-only proteins in apoptosis within the ovary |
| Q48359369 | The role of conformational heterogeneity in regulating the apoptotic activity of BAX protein. |
| Q39028789 | The use of a neutral peptide aptamer scaffold to anchor BH3 peptides constitutes a viable approach to studying their function |
| Q36865196 | Therapeutic development in targeting protein-protein interactions with synthetic topological mimetics |
| Q36005445 | Therapeutic potential of a peptide targeting BCL-2 cell guardians in cancer |
| Q38715430 | Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies |
| Q91691705 | Tightening a deadly pore former |
| Q91304407 | Topology of active, membrane-embedded Bax in the context of a toroidal pore |
| Q42738412 | Tracking BAX once its trigger is pulled |
| Q99548871 | Transient Unfolding and Long-Range Interactions in Viral BCL2 M11 Enable Binding to the BECN1 BH3 Domain |
| Q42800693 | Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization |
| Q37803120 | Translating p53 into the clinic. |
| Q35839831 | Translocation of a Bak C-terminus mutant from cytosol to mitochondria to mediate cytochrome C release: implications for Bak and Bax apoptotic function |
| Q36097989 | Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein-induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic cluster sorting protein-2 (PACS-2) |
| Q39642126 | Tyrosine dephosphorylation is required for Bak activation in apoptosis |
| Q38609449 | Unlatched BAX pairs for death |
| Q35909630 | Unraveling the Tissue-Specific Gene Signatures of Gilthead Sea Bream (Sparus aurata L.) after Hyper- and Hypo-Osmotic Challenges. |
| Q28507255 | Upregulation of Bcl2 inhibits apoptosis-driven BAX insertion but favors BAX relocalization in mitochondria |
| Q34382986 | VSV Oncolysis in Combination With the BCL-2 Inhibitor Obatoclax Overcomes Apoptosis Resistance in Chronic Lymphocytic Leukemia |
| Q33914559 | Variations in the rheostat model of apoptosis: what studies of retinal ganglion cell death tell us about the functions of the Bcl2 family proteins |
| Q34960771 | Visual and functional demonstration of growing Bax-induced pores in mitochondrial outer membranes |
| Q84702792 | WITHDRAWN: Reprint of: Variations in the rheostat model of apoptosis: What studies of retinal ganglion cell death tell us about the functions of the Bcl2 family proteins |
| Q36629743 | Where killers meet--permeabilization of the outer mitochondrial membrane during apoptosis |
| Q55043889 | cAMP signalling of Bordetella adenylate cyclase toxin through the SHP-1 phosphatase activates the BimEL-Bax pro-apoptotic cascade in phagocytes. |
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