| scholarly article | Q13442814 |
| P356 | DOI | 10.1615/CRITREVEUKARGENEEXPR.V22.I2.40 |
| P953 | full work available at URL | https://dl.begellhouse.com/download/article/3bef5e87592f1e85/CRE-4619.pdf |
| https://europepmc.org/articles/PMC3834587 | ||
| https://europepmc.org/articles/pmc3834587?pdf=render | ||
| https://europepmc.org/articles/PMC3834587?pdf=render | ||
| P932 | PMC publication ID | 3834587 |
| P698 | PubMed publication ID | 22856430 |
| P2093 | author name string | Steven Grant | |
| Hisashi Harada | |||
| P2860 | cites work | Hallmarks of Cancer: The Next Generation | Q22252312 |
| ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL | Q24306894 | ||
| RACK1 and CIS mediate the degradation of BimEL in cancer cells | Q24322936 | ||
| Bim: a novel member of the Bcl-2 family that promotes apoptosis | Q24532974 | ||
| JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis | Q24554008 | ||
| Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy | Q24635408 | ||
| Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters | Q24645192 | ||
| miRiad roles for the miR-17-92 cluster in development and disease | Q24646970 | ||
| Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes | Q24651802 | ||
| BAX activation is initiated at a novel interaction site | Q27652635 | ||
| A microRNA polycistron as a potential human oncogene | Q27860720 | ||
| Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity | Q28138855 | ||
| The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex | Q28141249 | ||
| BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes | Q28203083 | ||
| FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines | Q28207468 | ||
| Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis | Q28212224 | ||
| The proteasome: a novel target for cancer chemotherapy | Q28215095 | ||
| The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2 | Q28216784 | ||
| betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis | Q28306984 | ||
| Androgen-dependent apoptosis in male germ cells is regulated through the proto-oncoprotein Cbl | Q28564996 | ||
| Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release | Q28567073 | ||
| Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis | Q28589263 | ||
| The BCL-2 protein family: opposing activities that mediate cell death | Q29547380 | ||
| An inhibitor of Bcl-2 family proteins induces regression of solid tumours | Q29547595 | ||
| Epidermal growth factor receptor mutations in lung cancer | Q29615474 | ||
| Principles of cancer therapy: oncogene and non-oncogene addiction | Q29616779 | ||
| ER stress triggers apoptosis by activating BH3-only protein Bim | Q29617730 | ||
| MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents | Q30502341 | ||
| 'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737. | Q33266778 | ||
| Frequent loss of expression of the pro-apoptotic protein Bim in renal cell carcinoma: evidence for contribution to apoptosis resistance. | Q33283940 | ||
| Epstein-barr virus latency in B cells leads to epigenetic repression and CpG methylation of the tumour suppressor gene Bim | Q33474807 | ||
| Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim | Q33715752 | ||
| Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim. | Q34115920 | ||
| Glucocorticoid-mediated repression of the oncogenic microRNA cluster miR-17~92 contributes to the induction of Bim and initiation of apoptosis | Q34609961 | ||
| The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis | Q34718167 | ||
| Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic. | Q35075545 | ||
| Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737. | Q35250940 | ||
| The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells | Q35469548 | ||
| The BCL-2 family reunion | Q35568029 | ||
| BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors. | Q35588268 | ||
| Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma | Q35808910 | ||
| Targeting the mitogen-activated protein kinase cascade to treat cancer | Q35968411 | ||
| Bortezomib interacts synergistically with belinostat in human acute myeloid leukaemia and acute lymphoblastic leukaemia cells in association with perturbations in NF-κB and Bim | Q35982670 | ||
| Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas | Q36026392 | ||
| Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants | Q36142180 | ||
| Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis | Q36288687 | ||
| Proapoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody-forming cells | Q36360433 | ||
| Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells | Q36371743 | ||
| Multisite phosphorylation regulates Bim stability and apoptotic activity | Q36756298 | ||
| Vorinostat synergistically potentiates MK-0457 lethality in chronic myelogenous leukemia cells sensitive and resistant to imatinib mesylate | Q36787540 | ||
| Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic | Q36945203 | ||
| Bim and the pro-survival Bcl-2 proteins: opposites attract, ERK repels | Q36946423 | ||
| Runx1 is a co-activator with FOXO3 to mediate transforming growth factor beta (TGFbeta)-induced Bim transcription in hepatic cells | Q37339049 | ||
| Bim upregulation by histone deacetylase inhibitors mediates interactions with the Bcl-2 antagonist ABT-737: evidence for distinct roles for Bcl-2, Bcl-xL, and Mcl-1. | Q37451892 | ||
| Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity. | Q37593642 | ||
| Bim is a suppressor of Myc-induced mouse B cell leukemia | Q37647369 | ||
| Vorinostat-induced apoptosis in mantle cell lymphoma is mediated by acetylation of proapoptotic BH3-only gene promoters | Q39528900 | ||
| Roles of BIM induction and survivin downregulation in lapatinib-induced apoptosis in breast cancer cells with HER2 amplification. | Q39557421 | ||
| PI3K inhibitors prime neuroblastoma cells for chemotherapy by shifting the balance towards pro-apoptotic Bcl-2 proteins and enhanced mitochondrial apoptosis | Q39653523 | ||
| Reversion of epigenetically mediated BIM silencing overcomes chemoresistance in Burkitt lymphoma. | Q39689454 | ||
| Transient potent BCR-ABL inhibition is sufficient to commit chronic myeloid leukemia cells irreversibly to apoptosis | Q39908034 | ||
| Interactions between bortezomib and romidepsin and belinostat in chronic lymphocytic leukemia cells | Q40020174 | ||
| Proteasome inhibition specifically sensitizes leukemic cells to anthracyclin-induced apoptosis through the accumulation of Bim and Bax pro-apoptotic proteins. | Q40156202 | ||
| Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas | Q40234300 | ||
| Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim. | Q40323778 | ||
| Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines. | Q40327522 | ||
| Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells. | Q40462629 | ||
| Genome-wide array-based CGH for mantle cell lymphoma: identification of homozygous deletions of the proapoptotic gene BIM. | Q40479135 | ||
| Roles of Bim in apoptosis of normal and Bcr-Abl-expressing hematopoietic progenitors | Q40540288 | ||
| Role of Bim in the survival pathway induced by Raf in epithelial cells | Q40607194 | ||
| Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function. | Q40626751 | ||
| Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim. | Q40662652 | ||
| Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim. | Q40717909 | ||
| Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts | Q40979308 | ||
| BH3-triggered structural reorganization drives the activation of proapoptotic BAX. | Q41884328 | ||
| FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons | Q42918105 | ||
| Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition. | Q42963571 | ||
| c-Cbl is not required for ERK1/2-dependent degradation of BimEL. | Q43098314 | ||
| JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis | Q44485247 | ||
| Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation | Q44926251 | ||
| Two Epstein-Barr virus (EBV) oncoproteins cooperate to repress expression of the proapoptotic tumour-suppressor Bim: clues to the pathogenesis of Burkitt's lymphoma. | Q45401541 | ||
| Epigenetic down-regulation of BIM expression is associated with reduced optimal responses to imatinib treatment in chronic myeloid leukaemia. | Q46031741 | ||
| Chemical genetics: where genetics and pharmacology meet | Q46192463 | ||
| Cytokines direct the regulation of Bim mRNA stability by heat-shock cognate protein 70. | Q51582241 | ||
| Pro-apoptotic Bim Induction in Response to Nerve Growth Factor Deprivation Requires Simultaneous Activation of Three Different Death Signaling Pathways | Q58287598 | ||
| p38 MAP kinase mediates apoptosis through phosphorylation of BimEL at Ser-65 | Q79833984 | ||
| P433 | issue | 2 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | neoplastic gene expression regulation | Q66660300 |
| P304 | page(s) | 117-129 | |
| P577 | publication date | 2012-01-01 | |
| P1433 | published in | Critical Reviews in Eukaryotic Gene Expression | Q5186666 |
| P1476 | title | Targeting the regulatory machinery of BIM for cancer therapy | |
| Targeting the Regulatory Machinery of BIM for Cancer Therapy | |||
| P478 | volume | 22 |
| Q37281460 | Actinomycin D enhances killing of cancer cells by immunotoxin RG7787 through activation of the extrinsic pathway of apoptosis |
| Q50077375 | An Akt3 Splice Variant Lacking the Serine 472 Phosphorylation Site Promotes Apoptosis and Suppresses Mammary Tumorigenesis |
| Q38261426 | Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM. |
| Q40217765 | Assessment of HTLV-1 proviral load, LAT, BIM, c-FOS and RAD51 gene expression in adult T cell leukemia/lymphoma |
| Q39025727 | C-Abl tyrosine kinase mediates neurotoxic prion peptide-induced neuronal apoptosis via regulating mitochondrial homeostasis |
| Q41921236 | HIV-infected macrophages and microglia that survive acute infection become viral reservoirs by a mechanism involving Bim. |
| Q42283077 | PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation |
| Q27010154 | The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer Therapeutics |
| Q36291106 | miR-491-5p-induced apoptosis in ovarian carcinoma depends on the direct inhibition of both BCL-XL and EGFR leading to BIM activation |
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