c-Cbl is not required for ERK1/2-dependent degradation of BimEL.

scientific article published on 23 August 2007

c-Cbl is not required for ERK1/2-dependent degradation of BimEL. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.CELLSIG.2007.08.008
P932PMC publication ID2707770
P698PubMed publication ID17884340
P5875ResearchGate publication ID5959515

P2093author name stringHamid Band
Simon J Cook
Ceri M Wiggins
P2860cites workProteolysis: from the lysosome to ubiquitin and the proteasomeQ81354981
Regulatory phosphorylation of Bim: sorting out the ERK from the JNKQ81833475
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic functionQ24293924
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or BakQ24296478
ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xLQ24306894
Bim: a novel member of the Bcl-2 family that promotes apoptosisQ24532974
v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomasQ24624849
Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinaseQ27617539
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunityQ28138855
Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1Q28142184
The Cbl interactome and its functionsQ28277251
Androgen-dependent apoptosis in male germ cells is regulated through the proto-oncoprotein CblQ28564996
Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c releaseQ28567073
The Bcl2 family: regulators of the cellular life-or-death switchQ29614982
A hitchhiker's guide to the cullin ubiquitin ligases: SCF and its kinQ29618006
The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradationQ30175273
Altered thymic positive selection and intracellular signals in Cbl-deficient miceQ33596728
Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient miceQ33776192
The proteasome as a target for cancer therapy.Q34286144
Proteasome inhibitors: from research tools to drug candidatesQ34341985
Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteinsQ34612753
c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responsesQ36280423
Life in the balance: how BH3-only proteins induce apoptosis.Q36294226
Bim is a suppressor of Myc-induced mouse B cell leukemiaQ37647369
Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitorQ40164535
Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim.Q40323778
Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy.Q40446996
Identification of a DEF-type docking domain for extracellular signal-regulated kinases 1/2 that directs phosphorylation and turnover of the BH3-only protein BimEL.Q40454938
Genome-wide array-based CGH for mantle cell lymphoma: identification of homozygous deletions of the proapoptotic gene BIM.Q40479135
Bim is an apoptosis sensor that responds to loss of survival signals delivered by epidermal growth factor but not those provided by integrinsQ40528952
Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnoverQ40606380
Role of Bim in the survival pathway induced by Raf in epithelial cellsQ40607194
Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.Q40626751
Cbl-mediated Ubiquitinylation Is Required for Lysosomal Sorting of Epidermal Growth Factor Receptor but Is Dispensable for EndocytosisQ40646939
Phosphorylation of the pro-apoptotic protein Bim in lymphocytes is associated with protection from apoptosisQ40647484
Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.Q40662652
Activation of ERK1/2 by deltaRaf-1:ER* represses Bim expression independently of the JNK or PI3K pathwaysQ40666435
FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neuronsQ42918105
Nucleotide-binding Oligomerization Domain-1 and Epidermal Growth Factor ReceptorQ61398472
P433issue12
P1104number of pages7
P304page(s)2605-2611
P577publication date2007-08-23
P1433published inCellular SignallingQ1524097
P1476titlec-Cbl is not required for ERK1/2-dependent degradation of BimEL.
P478volume19

Reverse relations

cites work (P2860)
Q37605160Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics
Q33797357Bim and Mcl-1 exert key roles in regulating JAK2V617F cell survival
Q37883974Bim: Guardian of Tissue Homeostasis and Critical Regulator of the Immune System, Tumorigenesis and Bone Biology
Q34009660Contracting the 'mus cells'--does down-sizing suit us for diving into the memory pool?
Q50316561Delineating Crosstalk Mechanisms of the Ubiquitin Proteasome System That Regulate Apoptosis
Q24299252Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection
Q35137787Potential roles of Centipede Scolopendra extracts as a strategy against EGFR-dependent cancers
Q35688708Targeting Cdc20 as a novel cancer therapeutic strategy
Q39575518Targeting the Regulatory Machinery of BIM for Cancer Therapy
Q27010154The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer Therapeutics
Q37381217The role of the ubiquitin proteasome system in ischemia and ischemic tolerance
Q35320797Transforming growth factor beta (TGFbeta)-induced apoptosis: the rise & fall of Bim
Q37290943Tumour cell survival signalling by the ERK1/2 pathway
Q28306984betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis

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