The role of the ubiquitin proteasome system in ischemia and ischemic tolerance

scientific article published on 30 January 2009

The role of the ubiquitin proteasome system in ischemia and ischemic tolerance is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1177/1073858408327809
P932PMC publication ID2946222
P698PubMed publication ID19181875
P5875ResearchGate publication ID23963792

P2093author name stringRobert Meller
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Monoubiquitylation promotes mitochondrial p53 translocationQ24295012
A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrateQ24297635
SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxiaQ24299542
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signallingQ24299573
Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topologyQ24301551
CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activityQ24302505
ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression PathwaysQ24321528
RACK1 and CIS mediate the degradation of BimEL in cancer cellsQ24322936
MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulinQ24323363
Nucleotide sequence analysis of a cDNA encoding human ubiquitin reveals that ubiquitin is synthesized as a precursorQ24328877
Nerve growth factor induced neurite outgrowth from amphibian neuroepithelial precursor cells is prevented by dipeptides inhibiting ubiquitin-mediated proteolysisQ71612479
Rapid alterations in dendrite morphology during sublethal hypoxia or glutamate receptor activationQ71937376
Calpain activation contributes to dendritic remodeling after brief excitotoxic injury in vitroQ71970986
Spreading Depression Induces Tolerance of Cortical Neurons to Ischemia in Rat BrainQ72055404
Rapid preconditioning protects rats against ischemic neuronal damage after 3 but not 7 days of reperfusion following global cerebral ischemiaQ73089277
Ischemic tolerance in the brainQ73089879
CREB phosphorylation promotes nerve cell survivalQ73120719
Distinct roles of synaptic and extrasynaptic NMDA receptors in excitotoxicityQ73338074
Bcl-w expression is increased in brain regions affected by focal cerebral ischemia in the ratQ73477438
Benign focal ischemic preconditioning induces neuronal Hsp70 and prolonged astrogliosis with expression of Hsp27Q73693632
Neurite outgrowth in PC12 cells. Distinguishing the roles of ubiquitylation and ubiquitin-dependent proteolysisQ77336007
Ischemic preconditioning as induction of ischemic tolerance after transient ischemic attacks in human brain: its clinical relevanceQ81497409
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Bim regulation may determine hippocampal vulnerability after injurious seizures and in temporal lobe epilepsyQ37221596
CREB-mediated Bcl-2 protein expression after ischemic preconditioning.Q38332115
Ubiquitin proteasome-mediated synaptic reorganization: a novel mechanism underlying rapid ischemic toleranceQ39274473
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Attenuated stroke severity after prodromal TIA: a role for ischemic tolerance in the brain?Q41604222
Lysosomal localization of ubiquitinated Jun requires multiple determinants in a lysine-27-linked polyubiquitin conjugateQ42044297
Anoxia tolerance of con-familial tiger beetle larvae is associated with differences in energy flow and anaerobiosisQ42047744
Ubiquitin-mediated degradation of the proapoptotic active form of bid. A functional consequence on apoptosis inductionQ42487657
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Solution conformation of Lys63-linked di-ubiquitin chain provides clues to functional diversity of polyubiquitin signalingQ42614287
Structural properties of polyubiquitin chains in solutionQ42689368
c-Cbl is not required for ERK1/2-dependent degradation of BimEL.Q43098314
Dendritic spines lost during glutamate receptor activation reemerge at original sites of synaptic contact.Q43551117
NMDA receptors mediate hypoxic spine loss in cultured neuronsQ43720234
Rapid tolerance to focal cerebral ischemia in rats is attenuated by adenosine A1 receptor antagonistQ43874157
Signal-induced site specific phosphorylation targets Bcl2 to the proteasome pathway.Q44094731
Delayed treatment with MLN519 reduces infarction and associated neurologic deficit caused by focal ischemic brain injury in rats via antiinflammatory mechanisms involving nuclear factor-kappaB activation, gliosis, and leukocyte infiltrationQ44261071
Effects of lipopolysaccharide priming on acute ischemic brain injuryQ44685571
Delayed treatment of ischemia/reperfusion brain injury: extended therapeutic window with the proteosome inhibitor MLN519.Q44827197
Cathepsin B-like proteolysis and MARCKS degradation in sub-lethal NMDA-induced collapse of dendritic spinesQ45086246
A proteasome-sensitive connection between PSD-95 and GluR1 endocytosisQ45086259
Sumoylation increases HIF-1alpha stability and its transcriptional activityQ45090303
Sequential E2s drive polyubiquitin chain assembly on APC targetsQ46225392
Protective role of autophagy in neonatal hypoxia-ischemia induced brain injuryQ46400463
Geldanamycin treatment reduces delayed CA1 damage in mouse hippocampal organotypic cultures subjected to oxygen glucose deprivationQ46464959
Recovery from ischemic brain injury in the rat following a 10 h delayed injection with MLN519.Q46490706
Diverse polyubiquitin interaction properties of ubiquitin-associated domainsQ46592679
Isoflurane tolerance against focal cerebral ischemia is attenuated by adenosine A1 receptor antagonistsQ46910242
Excitotoxic loss of post-synaptic sites is distinct temporally and mechanistically from neuronal deathQ46943480
The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemiaQ46953900
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Opening of ATP-sensitive potassium channels by cromakalim confers tolerance against chemical ischemia in rat neuronal culturesQ47712610
Prevention from hypoxia-induced apoptosis by pre-conditioning: a mechanistic approach in cultured neurons from fetal rat forebrainQ47759766
Hypoxia stabilizes type 2 deiodinase activity in rat astrocytesQ48113477
Focal ischemic preconditioning induces rapid tolerance to middle cerebral artery occlusion in miceQ48158714
Local cerebral blood flow during hibernation, a model of natural tolerance to "cerebral ischemia".Q48164910
Effect of ischaemic preconditioning on genomic response to cerebral ischaemia: similarity to neuroprotective strategies in hibernation and hypoxia-tolerant statesQ48182556
Evidence from cultured rat cortical neurons of differences in the mechanism of ischemic preconditioning of brain and heartQ48215599
Endotoxin preconditioning protects against the cytotoxic effects of TNFalpha after stroke: a novel role for TNFalpha in LPS-ischemic toleranceQ48258831
Rapid preconditioning neuroprotection following anoxia in hippocampal slices: role of the K+ ATP channel and protein kinase C.Q48264329
Adaptation of adult brain tissue to anoxia and hypoxia in vitroQ48342251
A balance of protein synthesis and proteasome-dependent degradation determines the maintenance of LTP.Q48394969
Ubiquitin immunoreactivity of multiple polypeptides in rat brain synaptic membranesQ48490108
Hibernation in Ground Squirrels Induces State and Species-Specific Tolerance to Hypoxia and Aglycemia: An In Vitro Study in Hippocampal SlicesQ48532413
Activity-dependent ubiquitination of GABA(A) receptors regulates their accumulation at synaptic sitesQ48542489
Anoxic preconditioning in hippocampal slices: role of adenosineQ48853526
Preconditioning of primary rat neuronal cultures against ischemic injury: characterization of the "time window of protection'.Q48858502
Rapid reversible changes in dendritic spine structure in vivo gated by the degree of ischemia.Q48874149
'Ischemic tolerance' phenomenon found in the brainQ48895274
ALTERATIONS IN LYSOSOMES (INTRACELLULAR ENZYMES) DURING SHOCK; EFFECTS OF PRECONDITIONING (TOLERANCE) AND PROTECTIVE DRUGSQ50268727
Proteasome inhibitors induce cytochrome c-caspase-3-like protease-mediated apoptosis in cultured cortical neurons.Q52537613
Genomics of preconditioningQ53633445
E3-independent monoubiquitination of ubiquitin-binding proteins.Q55044113
Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85Q70212185
Recognition of the polyubiquitin proteolytic signalQ24530006
Bim: a novel member of the Bcl-2 family that promotes apoptosisQ24532974
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Mechanisms underlying ubiquitinationQ27860656
Ubc9p Is the Conjugating Enzyme for the Ubiquitin-like Protein Smt3pQ27930030
Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities.Q27933653
A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.Q27935265
Pathobiology of ischaemic stroke: an integrated viewQ28141682
Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl‐2 family1Q28208950
Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosisQ28212224
CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylationQ28216253
Back to the future with ubiquitinQ28240711
Modification of proteins by ubiquitin and ubiquitin-like proteinsQ28244250
The MARCKS family of phospholipid binding proteins: regulation of phospholipase D and other cellular componentsQ28253543
Concepts in sumoylation: a decade onQ28257220
The ubiquitin-proteasome system in Alzheimer's diseaseQ28268311
Proteasome-independent functions of ubiquitin in endocytosis and signalingQ28282959
Rapid hypoxia preconditioning protects cortical neurons from glutamate toxicity through delta-opioid receptorQ28300145
Activity-dependent dynamics and sequestration of proteasomes in dendritic spinesQ28507040
Androgen-dependent apoptosis in male germ cells is regulated through the proto-oncoprotein CblQ28564996
Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expressionQ28566984
Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: evidence from an in vitro modelQ28575710
Protein kinase C-gamma and calcium/calmodulin-dependent protein kinase II-alpha are persistently translocated to cell membranes of the rat brain during and after middle cerebral artery occlusionQ28576827
Role of ubiquitin carboxy terminal hydrolase-L1 in neural cell apoptosis induced by ischemic retinal injury in vivoQ28585083
Proteolysis of AKAP121 regulates mitochondrial activity during cellular hypoxia and brain ischaemiaQ28590290
Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85Q28591666
Proteasomes and their kin: proteases in the machine ageQ29614359
The Proteasome: Paradigm of a Self-Compartmentalizing ProteaseQ29615187
BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectlyQ29617135
Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome systemQ29617400
Histone ubiquitination: triggering gene activityQ29617523
Protein regulation by monoubiquitinQ29620221
Protection by rapid chemical preconditioning of stressed hippocampal slice: a study of cellular swelling using optical scatter imaging.Q30836232
Rapid cerebral ischemic preconditioning in mice deficient in endothelial and neuronal nitric oxide synthases.Q31137380
Ischemic Preconditioning and Brain Tolerance: Temporal Histological and Functional Outcomes, Protein Synthesis Requirement, and Interleukin-1 Receptor Antagonist and Early Gene ExpressionQ32024563
Involvement of the ubiquitin-proteasome system in the early stages of wallerian degenerationQ33187817
Treatment of embolic stroke in rats with bortezomib and recombinant human tissue plasminogen activatorQ33236872
Anoxia tolerance in turtles: metabolic regulation and gene expressionQ33260127
The role of the ubiquitin-proteasome pathway in apoptosisQ33669467
Cerebral ischemia-hypoxia induces intravascular coagulation and autophagyQ33998182
Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene.Q34107309
Proteasomes in apoptosis: villains or guardians?Q34158571
Polyubiquitination of p53 by a ubiquitin ligase activity of p300.Q34190044
The role of bim, a proapoptotic BH3-only member of the Bcl-2 family in cell-death controlQ34194899
Rapid degradation of Bim by the ubiquitin-proteasome pathway mediates short-term ischemic tolerance in cultured neuronsQ34446404
Caspase 3 activation is essential for neuroprotection in preconditioningQ34470616
Cerebral ischemic preconditioning. An experimental phenomenon or a clinical important entity of stroke prevention?Q34990903
Animal models of focal and global cerebral ischemiaQ35090269
Ischemic tolerance and endogenous neuroprotectionQ35126696
Mammalian hibernation. Transcriptional and translational controls.Q35624297
Bax degradation by the ubiquitin/proteasome-dependent pathway: involvement in tumor survival and progressionQ35663874
Ischemic preconditioning: nearly two decades of research. A comprehensive reviewQ35690601
Ubiquitin-proteasome system and proteasome inhibition: new strategies in stroke therapy.Q35760480
Multiubiquitylation by E4 enzymes: 'one size' doesn't fit all.Q36092032
Co-translational protein aggregation after transient cerebral ischemiaQ36180631
Lingering mysteries of ubiquitin-chain assemblyQ36368593
The ARF tumour suppressorQ36442822
The complexity of p53 stabilization and activationQ36443523
Ischemic preconditioning prevents protein aggregation after transient cerebral ischemiaQ36455545
Protein ubiquitination in postsynaptic densities after transient cerebral ischemiaQ36455548
Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injuryQ36559658
Proteasome inhibition enhances the induction and impairs the maintenance of late-phase long-term potentiationQ36625561
Ischaemic preconditioning of the brain, mechanisms and applicationsQ36676111
Protein SUMOylation is massively increased in hibernation torpor and is critical for the cytoprotection provided by ischemic preconditioning and hypothermia in SHSY5Y cellsQ36676352
Preconditioning reprograms the response to ischemic injury and primes the emergence of unique endogenous neuroprotective phenotypes: a speculative synthesisQ36721626
Emerging roles for ubiquitin and protein degradation in neuronal functionQ36747899
Ubiquitin-proteasome system dysfunction in Parkinson's disease: current evidence and controversiesQ37027500
The age of crosstalk: phosphorylation, ubiquitination, and beyondQ37033138
P433issue3
P921main subjectubiquitin-proteasome systemQ47175589
P304page(s)243-260
P577publication date2009-01-30
P13046publication type of scholarly workreview articleQ7318358
P1433published inThe NeuroscientistQ7753449
P1476titleThe role of the ubiquitin proteasome system in ischemia and ischemic tolerance
P478volume15

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