| scholarly article | Q13442814 |
| P356 | DOI | 10.1038/SJ.CDD.4401688 |
| P698 | PubMed publication ID | 15947788 |
| P2093 | author name string | S J Cook | |
| R Ley | |||
| K Hadfield | |||
| K E Ewings | |||
| P2860 | cites work | The Hallmarks of Cancer | Q221226 |
| JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis | Q24554008 | ||
| Characterization of the c-Jun N-terminal kinase-BimEL signaling pathway in neuronal apoptosis. | Q27919665 | ||
| Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity | Q28138855 | ||
| BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes | Q28203083 | ||
| Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis | Q28212224 | ||
| A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf | Q28263195 | ||
| c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions | Q28298557 | ||
| Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells | Q28505374 | ||
| Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release | Q28567073 | ||
| Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway | Q29616436 | ||
| Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim | Q33715752 | ||
| Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity. | Q37593642 | ||
| Bim is a suppressor of Myc-induced mouse B cell leukemia | Q37647369 | ||
| Genome-wide array-based CGH for mantle cell lymphoma: identification of homozygous deletions of the proapoptotic gene BIM. | Q40479135 | ||
| B cell receptor-mediated apoptosis of human lymphocytes is associated with a new regulatory pathway of Bim isoform expression. | Q40592167 | ||
| Role of Bim in the survival pathway induced by Raf in epithelial cells | Q40607194 | ||
| Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function. | Q40626751 | ||
| Activation of ERK1/2 by deltaRaf-1:ER* represses Bim expression independently of the JNK or PI3K pathways | Q40666435 | ||
| Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim. | Q40717909 | ||
| FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons | Q42918105 | ||
| Dimerization and folding of LC8, a highly conserved light chain of cytoplasmic dynein | Q43591579 | ||
| JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis | Q44485247 | ||
| Selective activation of the c-Jun N-terminal kinase (JNK) pathway fails to elicit Bax activation or apoptosis unless the phosphoinositide 3'-kinase (PI3K) pathway is inhibited | Q44524421 | ||
| Application of proteasomal inhibitors to mouse sympathetic neurons activates the intrinsic apoptotic pathway | Q45039985 | ||
| P433 | issue | 8 | |
| P304 | page(s) | 1008-1014 | |
| P577 | publication date | 2005-08-01 | |
| P1433 | published in | Cell Death & Differentiation | Q2943974 |
| P1476 | title | Regulatory phosphorylation of Bim: sorting out the ERK from the JNK | |
| P478 | volume | 12 |
| Q38508876 | A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2F-dependent apoptosis |
| Q37257665 | A proapoptotic signaling pathway involving RasGRP, Erk, and Bim in B cells |
| Q27691571 | A1/Bfl-1 in leukocyte development and cell death |
| Q37866334 | Aberrantly activated anti‐apoptotic signalling mechanisms in chronic lymphocytic leukaemia cells: clues to the identification of novel therapeutic targets |
| Q37727061 | Acquired and intrinsic BRAF inhibitor resistance in BRAF V600E mutant melanoma |
| Q36271721 | Activation of MAPK/ERK signaling by Burkholderia pseudomallei cycle inhibiting factor (Cif). |
| Q40211075 | Advances towards the development of ATP-competitive small-molecule inhibitors of the insulin-like growth factor receptor (IGF-IR). |
| Q41159379 | Anesthetic Propofol Attenuates Apoptosis, Aβ Accumulation, and Inflammation Induced by Sevoflurane Through NF-κB Pathway in Human Neuroglioma Cells |
| Q35829855 | Anoikis evasion in inflammatory breast cancer cells is mediated by Bim-EL sequestration |
| Q26852158 | Anoikis molecular pathways and its role in cancer progression |
| Q33788708 | Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells. |
| Q42601106 | Apoptosis induced by the fungal pathogen gliotoxin requires a triple phosphorylation of Bim by JNK. |
| Q34545490 | Apoptosis of human melanoma cells induced by inhibition of B-RAFV600E involves preferential splicing of bimS |
| Q36501636 | Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity |
| Q40131183 | Apoptosis-based dual molecular targeting by INNO-406, a second-generation Bcr-Abl inhibitor, and ABT-737, an inhibitor of antiapoptotic Bcl-2 proteins, against Bcr-Abl-positive leukemia |
| Q36472505 | BCR-signaling-induced cell death demonstrates dependency on multiple BH3-only proteins in a murine model of B-cell lymphoma. |
| Q34191999 | BH3-only protein Bmf mediates apoptosis upon inhibition of CAP-dependent protein synthesis |
| Q34085370 | BH3-only proteins in apoptosis and beyond: an overview |
| Q33727248 | BH3-only proteins in rheumatoid arthritis: potential targets for therapeutic intervention. |
| Q39726300 | BIM induction of apoptosis triggered by EGFR-sensitive and resistance cell lines of non-small-cell lung cancer |
| Q28756824 | BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations |
| Q37317126 | BIM mediates oncogene inactivation-induced apoptosis in multiple transgenic mouse models of acute lymphoblastic leukemia |
| Q38093430 | BIM, PUMA, and the Achilles’ Heel of Oncogene Addiction |
| Q42980651 | Bcl-2 allows effector and memory CD8+ T cells to tolerate higher expression of Bim. |
| Q37373448 | Bcl2 family proteins in carcinogenesis and the treatment of cancer. |
| Q35063113 | Bim Protein Degradation Contributes to Cisplatin Resistance |
| Q35737865 | Bim and Bmf in tissue homeostasis and malignant disease |
| Q38818046 | Bim gene dosage is critical in modulating nephron progenitor survival in the absence of microRNAs during kidney development |
| Q34007843 | Bim is a crucial regulator of apoptosis induced by Mycobacterium tuberculosis. |
| Q28910218 | Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets |
| Q34097076 | BimEL as a possible molecular link between proteasome dysfunction and cell death induced by mutant huntingtin |
| Q24309169 | BimL directly neutralizes Bcl-xL to promote Bax activation during UV-induced apoptosis |
| Q37146087 | Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival |
| Q37942464 | Cell death pathology: The war against cancer |
| Q37412481 | Chemotherapy resistance and metastasis-promoting effects of thyroid hormone in hepatocarcinoma cells are mediated by suppression of FoxO1 and Bim pathway |
| Q41836780 | Colorectal cancer cells with the BRAF(V600E) mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM. |
| Q33812112 | Combination treatment with doxorubicin and gamitrinib synergistically augments anticancer activity through enhanced activation of Bim. |
| Q34009660 | Contracting the 'mus cells'--does down-sizing suit us for diving into the memory pool? |
| Q39112089 | Contribution of microRNA 24-3p and Erk1/2 to interleukin-6-mediated plasma cell survival |
| Q39332546 | Control of cell death and mitochondrial fission by ERK1/2 MAP kinase signalling. |
| Q54584941 | Critical role of acidic sphingomyelinase in murine hepatic ischemia-reperfusion injury. |
| Q36580838 | Current strategies in overcoming resistance of cancer cells to apoptosis melanoma as a model. |
| Q28591851 | Cyclic-AMP-dependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein Bim |
| Q37745522 | Cysteine-linked dimerization of BST-2 confers anoikis resistance to breast cancer cells by negating proapoptotic activities to promote tumor cell survival and growth |
| Q46178162 | Cytoplasmic inclusions of Htt exon1 containing an expanded polyglutamine tract suppress execution of apoptosis in sympathetic neurons. |
| Q37921609 | Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases |
| Q35102284 | Destruction of tumor vasculature and abated tumor growth upon VEGF blockade is driven by proapoptotic protein Bim in endothelial cells. |
| Q41988767 | Differentiation-related gene-1 decreases Bim stability by proteasome-mediated degradation |
| Q38961040 | Downregulation of proapoptotic Bim augments IL-2-independent T-cell transformation by human T-cell leukemia virus type-1 Tax. |
| Q93155378 | Dual role of Endoplasmic Reticulum Stress-Mediated Unfolded Protein Response Signaling Pathway in Carcinogenesis |
| Q89682691 | Dynamics and Regulations of BimEL Ser65 and Thr112 Phosphorylation in Porcine Granulosa Cells during Follicular Atresia |
| Q92690890 | Dynein light chain binding determines complex formation and posttranslational stability of the Bcl-2 family members Bmf and Bim |
| Q39431690 | ERK1/2 and Akt pathway activated during (3R, 6R)‐bassiatin(1)‐induced apoptosis in MCF‐7 cells |
| Q24306894 | ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL |
| Q33789562 | ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events |
| Q37140816 | Early cellular signaling responses to axonal injury |
| Q33888764 | Erythropoietin drives breast cancer progression by activation of its receptor EPOR |
| Q37129282 | Erythropoietin-induced phosphorylation/degradation of BIM contributes to survival of erythroid cells |
| Q24676637 | FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal |
| Q34349363 | Foxp3 Transcription Factor Is Proapoptotic and Lethal to Developing Regulatory T Cells unless Counterbalanced by Cytokine Survival Signals |
| Q28571413 | GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim |
| Q28469345 | Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics |
| Q39309415 | Glucocorticoid-mediated BIM induction and apoptosis are regulated by Runx2 and c-Jun in leukemia cells |
| Q39718208 | Glycogen synthase kinase-3 plays a central role in mediating glucocorticoid-induced apoptosis |
| Q33533399 | Grb10 interacts with Bim L and inhibits apoptosis |
| Q42358226 | HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis. |
| Q28484877 | Hypoxia-Induced Modulation of Apoptosis and BCL-2 Family Proteins in Different Cancer Cell Types |
| Q41344802 | IER3IP1 deficiency leads to increased β-cell death and decreased β-cell proliferation |
| Q37521988 | Immune cell-mediated liver injury |
| Q50998106 | Impaired removal of Vβ8+ lymphocytes aggravates colitis in mice deficient for B cell lymphoma-2-interacting mediator of cell death (Bim) |
| Q54379896 | In vivo activation of the PI3K-Akt pathway in mouse beta cells by the EGFR mutation L858R protects against diabetes |
| Q34192011 | Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development |
| Q27469052 | Induction of Apoptosis by the Nonstructural Protein 4 and 10 of Porcine Reproductive and Respiratory Syndrome Virus |
| Q36026392 | Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas |
| Q43485482 | Induction of Bim limits cytokine-mediated prolonged survival of neutrophils |
| Q80513465 | Inhibition of apoptosis can be accompanied by increased Bim levels in T lymphocytes and neutrophil granulocytes |
| Q30479990 | Inositol 1,3,4,5-tetrakisphosphate controls proapoptotic Bim gene expression and survival in B cells |
| Q94452467 | JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD induction |
| Q36294226 | Life in the balance: how BH3-only proteins induce apoptosis. |
| Q41951300 | Lineage-specific transcriptional regulation of DICER by MITF in melanocytes. |
| Q49905672 | MAPK and PI3K Signaling: at the Crossroads of Neural Crest Development. |
| Q39858584 | MEK inhibitors potentiate dexamethasone lethality in acute lymphoblastic leukemia cells through the pro-apoptotic molecule BIM. |
| Q42413848 | MEK/ERK-mediated phosphorylation of Bim is required to ensure survival of T and B lymphocytes during mitogenic stimulation. |
| Q35990714 | MEK1/2 inhibitors potentiate UCN-01 lethality in human multiple myeloma cells through a Bim-dependent mechanism |
| Q37341018 | Mechanisms regulating the susceptibility of hematopoietic malignancies to glucocorticoid-induced apoptosis |
| Q36546659 | Mitochondrial ATF2 translocation contributes to apoptosis induction and BRAF inhibitor resistance in melanoma through the interaction of Bim with VDAC1. |
| Q28388183 | Mitochondrial adaptations to oxidative stress confer resistance to apoptosis in lymphoma cells |
| Q37109684 | Mitotic cell death caused by follistatin-like 1 inhibition is associated with up-regulated Bim by inactivated Erk1/2 in human lung cancer cells |
| Q37323332 | Modulation of vascular cell function by bim expression |
| Q37801270 | Molecular and genetic parameters defining T-cell clonal selection |
| Q36756298 | Multisite phosphorylation regulates Bim stability and apoptotic activity |
| Q38739256 | Mutant BRAF Upregulates MCL-1 to Confer Apoptosis Resistance that Is Reversed by MCL-1 Antagonism and Cobimetinib in Colorectal Cancer. |
| Q36104876 | NF-kappaB1 and c-Rel cooperate to promote the survival of TLR4-activated B cells by neutralizing Bim via distinct mechanisms |
| Q35829141 | NRAS mutation causes a human autoimmune lymphoproliferative syndrome. |
| Q28578213 | Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion via regulation of Bim |
| Q37028555 | Oncogenic BRAF(V600E) inhibits BIM expression to promote melanoma cell survival |
| Q47814631 | Overcoming Acquired Resistance to AZD9291, A Third-Generation EGFR Inhibitor, through Modulation of MEK/ERK-Dependent Bim and Mcl-1 Degradation |
| Q93062391 | Overcoming acquired resistance of epidermal growth factor receptor-mutant non-small cell lung cancer cells to osimertinib by combining osimertinib with the histone deacetylase inhibitor panobinostat (LBH589) |
| Q34761941 | PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression |
| Q37121933 | PUMA and BIM are required for oncogene inactivation-induced apoptosis. |
| Q38706500 | Partial p53-dependence of anisomycin-induced apoptosis in PC12 cells |
| Q47868110 | Peripheral Deletion of CD8 T Cells Requires p38 MAPK in Cross-Presenting Dendritic Cells. |
| Q37778022 | Permeabilization of the Outer Mitochondrial Membrane by Bcl-2 Proteins |
| Q58544078 | Priming stem cells with protein kinase C activator enhances early stem cell-chondrocyte interaction by increasing adhesion molecules |
| Q38207459 | Programmed cell death during neuronal development: the sympathetic neuron model |
| Q46045421 | Redox regulation of anoikis resistance of metastatic prostate cancer cells: key role for Src and EGFR-mediated pro-survival signals |
| Q40015294 | Redox regulation of anoikis: reactive oxygen species as essential mediators of cell survival. |
| Q26781203 | Regulation of Bim in Health and Disease |
| Q79412060 | Regulation of the proapoptotic BH3-only protein BIM by glucocorticoids, survival signals and proteasome in chronic lymphocytic leukemia cells |
| Q34963434 | Restoration of Transforming Growth Factor-β Receptor II Expression in Colon Cancer Cells with Microsatellite Instability Increases Metastatic Potential in Vivo |
| Q37865381 | Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy. |
| Q54514060 | SV40 T/t-common polypeptide enhances the sensitivity of HER2-overexpressing human cancer cells to anticancer drugs cisplatin and doxorubicin |
| Q35653078 | Silence of MACC1 expression by RNA interference inhibits proliferation, invasion and metastasis, and promotes apoptosis in U251 human malignant glioma cells |
| Q38871853 | Silencing SOX2 Expression by RNA Interference Inhibits Proliferation, Invasion and Metastasis, and Induces Apoptosis through MAP4K4/JNK Signaling Pathway in Human Laryngeal Cancer TU212 Cells |
| Q36072016 | Suppression of PP2A is critical for protection of melanoma cells upon endoplasmic reticulum stress |
| Q35920997 | TP53 Silencing Bypasses Growth Arrest of BRAFV600E-Induced Lung Tumor Cells in a Two-Switch Model of Lung Tumorigenesis |
| Q92372864 | Targeting Degradation of EGFR through the Allosteric Site Leads to Cancer Cell Detachment-Promoted Death |
| Q36546429 | Targeting ERK1/2-bim signaling cascades by BH3-mimetic ABT-737 as an alternative therapeutic strategy for oral cancer |
| Q34173253 | Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway |
| Q29547380 | The BCL-2 protein family: opposing activities that mediate cell death |
| Q33763059 | The Erk2 MAPK regulates CD8 T cell proliferation and survival |
| Q34165045 | The HSP90 inhibitor XL888 overcomes BRAF inhibitor resistance mediated through diverse mechanisms |
| Q35691278 | The Novel ATP-Competitive MEK/Aurora Kinase Inhibitor BI-847325 Overcomes Acquired BRAF Inhibitor Resistance through Suppression of Mcl-1 and MEK Expression |
| Q37729932 | The Roles of Histone Demethylase Jmjd3 in Osteoblast Differentiation and Apoptosis |
| Q39664652 | The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program |
| Q35619447 | The expanding spectrum of the autoimmune lymphoproliferative syndromes |
| Q37306641 | The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease |
| Q35602342 | The pro-apoptotic BH3-only protein Bim interacts with components of the translocase of the outer mitochondrial membrane (TOM) |
| Q40985170 | The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE(2) signalling in colorectal adenoma cells. |
| Q37381217 | The role of the ubiquitin proteasome system in ischemia and ischemic tolerance |
| Q42062961 | The sphingolipid degradation product trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner |
| Q37240022 | The von Hippel-Lindau protein sensitizes renal carcinoma cells to apoptotic stimuli through stabilization of BIM(EL). |
| Q28534603 | Transcriptional repression of Bim by a novel YY1-RelA complex is essential for the survival and growth of Multiple Myeloma |
| Q36945203 | Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic |
| Q37290943 | Tumour cell survival signalling by the ERK1/2 pathway |
| Q42461336 | Tumour-suppression function of KLF12 through regulation of anoikis. |
| Q35640196 | Using quantitative proteomic analysis to understand genotype specific intrinsic drug resistance in melanoma |
| Q37008257 | What do we know about the mechanisms of elimination of autoreactive T and B cells and what challenges remain |
| Q33304557 | Why do cancer cells become "addicted" to oncogenic epidermal growth factor receptor? |
| Q43098314 | c-Cbl is not required for ERK1/2-dependent degradation of BimEL. |
| Q89018067 | cIAP2 Is an Independent Signaling and Survival Factor during Mammary Lactational Involution and Tumorigenesis |
| Q35676981 | miR-155 Controls Lymphoproliferation in LAT Mutant Mice by Restraining T-Cell Apoptosis via SHIP-1/mTOR and PAK1/FOXO3/BIM Pathways |
| Q34681377 | miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes |
| Q40274693 | p38-MAP kinase activation followed by BIM induction is essential for glucocorticoid-induced apoptosis in lymphoblastic leukemia cells |
| Q35588465 | p38α Signaling Induces Anoikis and Lumen Formation During Mammary Morphogenesis. |
| Q38817198 | uPAR peptide antagonist alters regulation of MAP kinases and Bcl-2 family members in favor of apoptosis in MDA-MB-231 cell line |
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