| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2003PNAS..10014175P |
| P356 | DOI | 10.1073/PNAS.2336198100 |
| P953 | full work available online at | https://europepmc.org/articles/pmc283565?pdf=render |
| https://europepmc.org/articles/PMC283565 | ||
| https://europepmc.org/articles/PMC283565?pdf=render | ||
| https://doi.org/10.1073/pnas.2336198100 | ||
| https://pnas.org/doi/pdf/10.1073/pnas.2336198100 | ||
| P932 | PMC publication ID | 283565 |
| P698 | PubMed publication ID | 14623954 |
| P5875 | ResearchGate publication ID | 9003228 |
| P50 | author | Andreas Strasser | Q38803763 |
| Philippe Bouillet | Q39186694 | ||
| Marc Pellegrini | Q62265701 | ||
| Gabrielle Belz | Q17517003 | ||
| P2860 | cites work | Genes & Development | Q1524533 |
| Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells | Q36371743 | ||
| Expression and function of the interleukin 7 receptor in murine lymphocytes | Q36574038 | ||
| Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors | Q39457731 | ||
| T-lymphocyte downregulation after acute viral infection is not dependent on CD95 (Fas) receptor-ligand interactions. | Q39877053 | ||
| Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim. | Q40717909 | ||
| An evolutionary perspective on apoptosis. | Q40723583 | ||
| Interleukin-2 receptor common gamma-chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: selective induction of anti-apoptotic (bcl-2, bcl-xL) but not pro-apoptotic (bax, bcl-xS) gene expression | Q41234482 | ||
| The fight of viruses against apoptosis | Q41732751 | ||
| Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off | Q41735900 | ||
| Progression of armed CTL from draining lymph node to spleen shortly after localized infection with herpes simplex virus 1. | Q45022725 | ||
| Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally | Q52531761 | ||
| bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship | Q57338704 | ||
| Fas (CD95) participates in peripheral T cell deletion and associated apoptosis in vivo | Q63408405 | ||
| Studies of T cell deletion and T cell anergy following in vivo administration of SEB to normal and lupus-prone mice | Q70527814 | ||
| Implantation of IL-2-containing osmotic pump prolongs the survival of superantigen-reactive T cells expanded in mice injected with bacterial superantigen | Q71403456 | ||
| Mechanisms of peripheral T cell deletion: anergized T cells are Fas resistant but undergo proliferation-associated apoptosis | Q71425875 | ||
| The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice | Q71678868 | ||
| A specific intercellular pathway of apoptotic cell death is defective in the mature peripheral T cells of autoimmune lpr and gld mice | Q72416074 | ||
| Superantigen and endotoxin synergize in the induction of lethal shock | Q73295949 | ||
| Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity | Q28138855 | ||
| Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1 | Q28142184 | ||
| BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes | Q28203083 | ||
| FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis | Q28265012 | ||
| Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1 | Q28265912 | ||
| Death Receptors: Signaling and Modulation | Q28280897 | ||
| Apoptosis by death factor | Q28304002 | ||
| Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim | Q28587387 | ||
| Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis | Q28588677 | ||
| The expanding role of mitochondria in apoptosis | Q28609686 | ||
| The biochemistry of apoptosis | Q29547741 | ||
| BCL-2 family members and the mitochondria in apoptosis | Q29614427 | ||
| Herpes simplex virus type 1-specific cytotoxic T-lymphocyte arming occurs within lymph nodes draining the site of cutaneous infection | Q33799184 | ||
| Fas ligand-induced apoptosis | Q33847658 | ||
| A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes | Q33888184 | ||
| Apoptosis signaling | Q34019359 | ||
| BH3-Only proteins-essential initiators of apoptotic cell death | Q34117362 | ||
| Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome | Q34154044 | ||
| RETRACTED: The Fas/Fas Ligand Pathway and Bcl-2 Regulate T Cell Responses to Model Self and Foreign Antigens | Q34459289 | ||
| Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more | Q34987905 | ||
| Cytokine-induced survival of activated T cells in vitro and in vivo | Q36010639 | ||
| Fas ligand, Bcl-2, granulocyte colony-stimulating factor, and p38 mitogen-activated protein kinase: Regulators of distinct cell death and survival pathways in granulocytes. | Q36368794 | ||
| Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim | Q36371167 | ||
| P433 | issue | 24 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | proto-oncogene protein | Q66020913 |
| P304 | page(s) | 14175-14180 | |
| P577 | publication date | 2003-11-17 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim | |
| P478 | volume | 100 |
| Q36417832 | A CD8+ T cell transcription signature predicts prognosis in autoimmune disease |
| Q47936492 | Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies |
| Q33819643 | An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence |
| Q37815428 | Apoptosis and autophagy in the regulation of T lymphocyte function |
| Q34023771 | Apoptosis and the homeostatic control of immune responses |
| Q27316800 | Apoptosis is essential for neutrophil functional shutdown and determines tissue damage in experimental pneumococcal meningitis |
| Q36501636 | Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity |
| Q42132336 | Apoptosis regulators Fas and Bim synergistically control T-lymphocyte homeostatic proliferation |
| Q36388507 | B7-H1 limits the entry of effector CD8+T cells to the memory pool by upregulating Bim |
| Q100316580 | BATF3 programs CD8+ T cell memory |
| Q36498473 | BH3-only protein Puma contributes to death of antigen-specific T cells during shutdown of an immune response to acute viral infection |
| Q41837676 | BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo. |
| Q35883875 | BH3-only proteins in apoptosis at a glance |
| Q33727248 | BH3-only proteins in rheumatoid arthritis: potential targets for therapeutic intervention. |
| Q36435312 | BH3-only proteins: integrated control point of apoptosis |
| Q42980651 | Bcl-2 allows effector and memory CD8+ T cells to tolerate higher expression of Bim. |
| Q50862969 | Bcl-2 inhibition to overcome memory cell barriers in transplantation. |
| Q34545377 | Bcl-2-regulated cell death signalling in the prevention of autoimmunity |
| Q35173362 | Bid and Bim collaborate during induction of T cell death in persistent infection |
| Q35737865 | Bim and Bmf in tissue homeostasis and malignant disease |
| Q41966864 | Bim controls IL-15 availability and limits engagement of multiple BH3-only proteins |
| Q35824995 | Bim is required for T-cell allogeneic responses and graft-versus-host disease in vivo |
| Q34464549 | Bim mediates apoptosis of CD127(lo) effector T cells and limits T cell memory |
| Q34807146 | Bim mediates the elimination of functionally unfit Th1 responders from the memory pool. |
| Q42284303 | Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infection |
| Q45204023 | CD80 Expressed by CD8+ T Cells Contributes to PD-L1-Induced Apoptosis of Activated CD8+ T Cells. |
| Q37526364 | CD95, BIM and T cell homeostasis |
| Q26999223 | Cell Death in the Maintenance and Abrogation of Tolerance: The Five Ws of Dying Cells |
| Q28587336 | Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis |
| Q34009660 | Contracting the 'mus cells'--does down-sizing suit us for diving into the memory pool? |
| Q38172752 | Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. |
| Q36862396 | Critical role for BIM in T cell receptor restimulation-induced death |
| Q37273230 | Cytokine-dependent regulation of NADPH oxidase activity and the consequences for activated T cell homeostasis |
| Q34474734 | DNA-dependent protein kinase catalytic subunit mediates T-cell loss in rheumatoid arthritis |
| Q36528956 | Development, trafficking, and function of memory T-cell subsets |
| Q34389645 | Dicer in immune cell development and function |
| Q37074146 | Differential tumor necrosis factor receptor 2-mediated editing of virus-specific CD8+ effector T cells |
| Q36632500 | Distinctive Expression of Bcl-2 Factors in Regulatory T Cells Determines a Pharmacological Target to Induce Immunological Tolerance |
| Q37508408 | Diversity in CD8(+) T cell differentiation. |
| Q45226653 | Down-regulation of normal human T cell blast activation: roles of APO2L/TRAIL, FasL, and c- FLIP, Bim, or Bcl-x isoform expression. |
| Q39277476 | Dying to protect: cell death and the control of T-cell homeostasis. |
| Q37260135 | Enhanced T cell apoptosis within Drak2-deficient mice promotes resistance to autoimmunity |
| Q36454649 | Exosomes derived from atorvastatin-modified bone marrow dendritic cells ameliorate experimental autoimmune myasthenia gravis by up-regulated levels of IDO/Treg and partly dependent on FasL/Fas pathway |
| Q36946510 | Exploring regulatory mechanisms of CD8+ T cell contraction |
| Q33388396 | Extreme lymphoproliferative disease and fatal autoimmune thrombocytopenia in FasL and TRAIL double-deficient mice |
| Q39669659 | FOXO3 is differentially required for CD8(+) T-cell death during tolerance versus immunity. |
| Q42183270 | Foxo-mediated Bim transcription is dispensable for the apoptosis of hematopoietic cells that is mediated by this BH3-only protein |
| Q33862447 | Functional Role of Kallikrein 6 in Regulating Immune Cell Survival |
| Q41891187 | Gammaherpesvirus latency differentially impacts the generation of primary versus secondary memory CD8+ T cells during subsequent infection |
| Q37773428 | Generation of effector CD8+ T cells and their conversion to memory T cells |
| Q43101017 | Guarding effector T-cell survival: all for one, Mcl-1 for all? |
| Q24633207 | How I treat autoimmune lymphoproliferative syndrome |
| Q36986709 | How apoptosis got the immune system in shape |
| Q36394994 | How the Bcl-2 family of proteins interact to regulate apoptosis. |
| Q36867809 | IFN-gamma acts directly on activated CD4+ T cells during mycobacterial infection to promote apoptosis by inducing components of the intracellular apoptosis machinery and by inducing extracellular proapoptotic signals |
| Q42017438 | Id2 Influences Differentiation of Killer Cell Lectin-like Receptor G1hi Short-Lived CD8+ Effector T Cells |
| Q51983656 | Impact of cellular lifespan on the T cell receptor repertoire |
| Q39116343 | Impact of conditional deletion of the pro-apoptotic BCL-2 family member BIM in mice |
| Q34192011 | Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development |
| Q34571341 | Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection |
| Q33614042 | Interleukin-7 regulates Bim proapoptotic activity in peripheral T-cell survival |
| Q37383229 | Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis |
| Q35108580 | Intertwined pathways of programmed cell death in immunity |
| Q43913993 | Intracellular pathways of pancreatic β‐cell apoptosis in type 1 diabetes |
| Q42409140 | Intrahepatic murine CD8 T-cell activation associates with a distinct phenotype leading to Bim-dependent death |
| Q37273739 | Intrinsic Role of FoxO3a in the Development of CD8+ T Cell Memory |
| Q37217375 | Intrinsic and extrinsic control of effector T cell survival and memory T cell development |
| Q58657741 | Inverse correlation between IL-7 receptor expression and CD8 T cell exhaustion during persistent antigen stimulation |
| Q37947994 | It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival |
| Q35729822 | Killer T cells regulate antigen presentation for early expansion of memory, but not naive, CD8+ T cell |
| Q49636303 | Life and Death of Activated T Cells: How Are They Different from Naïve T Cells? |
| Q36294226 | Life in the balance: how BH3-only proteins induce apoptosis. |
| Q36843709 | Locally produced C5a binds to T cell-expressed C5aR to enhance effector T-cell expansion by limiting antigen-induced apoptosis |
| Q36399348 | Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice |
| Q36136644 | Loss of Bim results in abnormal accumulation of mature CD4-CD8-CD44-CD25- thymocytes |
| Q36509870 | Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development |
| Q42563511 | Lymphocyte apoptosis in murine Pneumocystis pneumonia |
| Q42413848 | MEK/ERK-mediated phosphorylation of Bim is required to ensure survival of T and B lymphocytes during mitogenic stimulation. |
| Q37341018 | Mechanisms regulating the susceptibility of hematopoietic malignancies to glucocorticoid-induced apoptosis |
| Q38129084 | Multipronged CD4+ T‐cell effector and memory responses cooperate to provide potent immunity against respiratory virus |
| Q36756298 | Multisite phosphorylation regulates Bim stability and apoptotic activity |
| Q37922581 | NK cell development, homeostasis and function: parallels with CD8⁺ T cells |
| Q34333607 | NKT cell stimulation with glycolipid antigen in vivo: costimulation-dependent expansion, Bim-dependent contraction, and hyporesponsiveness to further antigenic challenge |
| Q38090202 | Natural killer cells: walking three paths down memory lane |
| Q37782409 | Nature and nurture: T-cell receptor-dependent and T-cell receptor-independent differentiation cues in the selection of the memory T-cell pool. |
| Q40219501 | Network Analysis of the Systemic Response to Fasciola hepatica Infection in Sheep Reveals Changes in Fibrosis, Apoptosis, Toll-Like Receptors 3/4, and B Cell Function |
| Q41911200 | Opposing effects of TGF-beta and IL-15 cytokines control the number of short-lived effector CD8+ T cells |
| Q37691426 | Overexpression of Mcl-1 exacerbates lymphocyte accumulation and autoimmune kidney disease in lpr mice. |
| Q46405006 | Parenchymal cells critically curtail cytotoxic T-cell responses by inducing Bim-mediated apoptosis |
| Q36483578 | Proapoptotic Bcl-2 family member Bim promotes persistent infection and limits protective immunity |
| Q38076413 | Protecting and rescuing the effectors: roles of differentiation and survival in the control of memory T cell development |
| Q27490311 | Protective Role of Fas-FasL Signaling in Lethal Infection with Herpes Simplex Virus Type 2 in Mice |
| Q41006403 | Pseudorabies virus glycoprotein gE triggers ERK1/2 phosphorylation and degradation of the pro-apoptotic protein Bim in epithelial cells |
| Q24677017 | Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction |
| Q37272067 | RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice. |
| Q38574697 | Rapid culling of the CD4+ T cell repertoire in the transition from effector to memory |
| Q26781203 | Regulation of Bim in Health and Disease |
| Q37773424 | Regulation of CD4+ T-cell contraction during pathogen challenge |
| Q38165191 | Regulation of antiviral CD8 T-cell responses |
| Q81833475 | Regulatory phosphorylation of Bim: sorting out the ERK from the JNK |
| Q41838113 | Role of Bim in regulating CD8+ T-cell responses during chronic viral infection. |
| Q37747298 | Role of tumor necrosis factor receptors in regulating CD8 T-cell responses during acute lymphocytic choriomeningitis virus infection |
| Q36488905 | SDF-1α degrades whereas glycoprotein 120 upregulates Bcl-2 interacting mediator of death extralong isoform: implications for the development of T cell memory |
| Q37064861 | Shaping and reshaping CD8+ T-cell memory. |
| Q40474396 | Short-Lived Antigen Recognition but Not Viral Infection at a Defined Checkpoint Programs Effector CD4 T Cells To Become Protective Memory. |
| Q30433067 | Stimulation of naive CD8+ T cells by a variant viral epitope induces activation and enhanced apoptosis |
| Q24673771 | Structural and mechanistic features of protein O glycosylation linked to CD8+ T-cell apoptosis |
| Q50930237 | Subversion of the Bcl-2 life/death switch in cancer development and therapy. |
| Q34958560 | Surviving the crash: transitioning from effector to memory CD8+ T cell |
| Q35073666 | T helper lymphocytes rescue CTL from activation-induced cell death |
| Q37002795 | T-cell death and cancer immune tolerance |
| Q36605397 | T-cell intrinsic and extrinsic mechanisms of p27Kip1 in the regulation of CD8 T-cell memory. |
| Q90317657 | T-cell receptor signal strength and epigenetic control of Bim predict memory CD8+ T-cell fate |
| Q41942006 | T-cell tolerance: central and peripheral |
| Q39575518 | Targeting the Regulatory Machinery of BIM for Cancer Therapy |
| Q38193997 | Targeting the mitochondrial apoptotic pathway: a preferred approach in hematologic malignancies? |
| Q29547380 | The BCL-2 protein family: opposing activities that mediate cell death |
| Q24620437 | The Bcl-2 apoptotic switch in cancer development and therapy |
| Q33763059 | The Erk2 MAPK regulates CD8 T cell proliferation and survival |
| Q24676636 | The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells |
| Q39636098 | The Pim Kinase Pathway Contributes to Survival Signaling in Primed CD8+ T Cells upon CD27 Costimulation |
| Q45361185 | The Proapoptotic Bcl-2 Family Member Bim Plays a Central Role during the Development of Virus-Induced Hepatitis |
| Q36673657 | The Requirement of Linker for Activation of T Cells in the Primary and Memory Responses of CD8 T Cells |
| Q35083049 | The essential role of evasion from cell death in cancer |
| Q38034268 | The fourth dimension in immunological space: how the struggle for nutrients selects high-affinity lymphocytes. |
| Q37619069 | The linker histone h1.2 is an intermediate in the apoptotic response to cytokine deprivation in T-effectors |
| Q34205697 | The many roles of FAS receptor signaling in the immune system |
| Q37773430 | The metabolic life and times of a T-cell |
| Q37187520 | The molecular signature of CD8+ T cells undergoing deletional tolerance |
| Q34009654 | The power and the promise of restimulation-induced cell death in human immune diseases |
| Q36047162 | The role of BH3-only proteins in the immune system |
| Q36295655 | The role of apoptosis in the development and function of T lymphocytes |
| Q37948129 | T‐cell intrinsic effects of GITR and 4‐1BB during viral infection and cancer immunotherapy |
| Q37008257 | What do we know about the mechanisms of elimination of autoreactive T and B cells and what challenges remain |
| Q39865491 | miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim. |
Search more.