Regulation of CD4+ T-cell contraction during pathogen challenge

scientific article published on July 2010

Regulation of CD4+ T-cell contraction during pathogen challenge is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1111/J.1600-065X.2010.00921.X
P932PMC publication ID2908916
P698PubMed publication ID20636812
P5875ResearchGate publication ID45269286

P50authorSusan L. SwainQ56754956
P2093author name stringK Kai McKinstry
Tara M Strutt
P2860cites workThe immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell deathQ24643456
Follicular helper T cells: lineage and locationQ24647274
Antiviral CD4+ memory T cells are IL-15 dependentQ24676283
The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cellsQ24676636
Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis inductionQ24677017
Alveolar epithelial type II cell: defender of the alveolus revisitedQ24791750
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunityQ28138855
The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathwaysQ28145665
Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansionQ28250811
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and deathQ28363890
Bmi1 regulates memory CD4 T cell survival via repression of the Noxa geneQ28588527
TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional propertiesQ29547848
TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaBQ29614706
An essential role for NF-kappaB in preventing TNF-alpha-induced cell deathQ29614707
Cellular responses to interferon-gammaQ29618567
Suppression of TNF-alpha-induced apoptosis by NF-kappaBQ29618717
Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania majorQ29619125
Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell deathQ29620021
T-cell quality in memory and protection: implications for vaccine designQ30014840
Multiple dendritic cell populations activate CD4+ T cells after viral stimulationQ33321258
bcl-2 transgene inhibits T cell death and perturbs thymic self-censorshipQ57338704
Quality and Vaccine Efficacy of CD4+ T Cell Responses Directed to Dominant and Subdominant Epitopes in ESAT-6 from Mycobacterium tuberculosisQ58827803
Bax and Bak: back-bone of T cell deathQ62817758
Naive and effector CD4 T cells differ in their requirements for T cell receptor versus costimulatory signalsQ71687726
Lack of interferon gamma receptor beta chain and the prevention of interferon gamma signaling in TH1 cellsQ71902890
A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunityQ72628270
Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control pointsQ72628282
CD44 supports T cell proliferation and apoptosis by apposition of protein kinasesQ73166201
FasL promoter activation by IL-2 through SP1 and NFAT but not Egr-2 and Egr-3Q73170394
Activation-induced T cell death occurs at G1A phase of the cell cycleQ73228067
Broad programming by IL-2 receptor signaling for extended growth to multiple cytokines and functional maturation of antigen-activated T cellsQ73400763
Mechanisms of CD95 (APO-1/Fas)-mediated apoptosisQ77485539
Withdrawal of stimulation may initiate the transition of effector to memory CD4 cellsQ77522350
Granzyme B is critical for T cell receptor-induced cell death of type 2 helper T cellsQ80092770
From vanilla to 28 flavors: multiple varieties of T regulatory cellsQ80141724
CD4 T cell-mediated protection from lethal influenza: perforin and antibody-mediated mechanisms give a one-two punchQ80142432
Persistent depots of influenza antigen fail to induce a cytotoxic CD8 T cell responseQ80427869
Direct interferon-gamma signaling dramatically enhances CD4+ and CD8+ T cell memoryQ80582310
CD8+ T cells responding to influenza infection reach and persist at higher numbers than CD4+ T cells independently of precursor frequencyQ80591535
IL-6 increases primed cell expansion and survivalQ81621879
Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytesQ39912633
CD44 regulates survival and memory development in Th1 cellsQ40157095
Antigen-specific and non-specific CD4+ T cell recruitment and proliferation during influenza infectionQ40391424
Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.Q40717909
Diversity of epitope and cytokine profiles for primary and secondary influenza a virus-specific CD8+ T cell responsesQ40820376
Engagement of CD4 before TCR triggering regulates both Bax- and Fas (CD95)-mediated apoptosisQ40881618
Establishment and persistence of virus-specific CD4+ and CD8+ T cell memoryQ41091825
From naive to memory T cellsQ41091863
Th1 and Th2 subsets equally undergo Fas-dependent and -independent activation-induced cell deathQ41096065
Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environmentQ33652471
Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein BimQ33715752
Lymphocyte survival--the struggle against deathQ33804304
Autophagy is induced in CD4+ T cells and important for the growth factor-withdrawal cell deathQ33999904
Cutting Edge: Limiting amounts of IL-7 do not control contraction of CD4+ T cell responsesQ34023803
In vivo activation of antigen-specific CD4 T cells.Q34178091
The many roles of FAS receptor signaling in the immune systemQ34205697
Unlike Th1, Th17 cells mediate sustained autoimmune inflammation and are highly resistant to restimulation-induced cell deathQ34217243
CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.Q34300766
A role for antigen in the maintenance of immunological memoryQ34572241
The biology of interleukin-2.Q34585827
Differentiation and function of Th17 T cellsQ34618966
Plasticity of CD4+ T cell lineage differentiation.Q34982725
Overview: apoptotic signaling pathways in the immune systemQ35129689
Activation-induced cell death in T cellsQ35129715
Similarities and differences in CD4+ and CD8+ effector and memory T cell generationQ35207085
Aberrant contraction of antigen-specific CD4 T cells after infection in the absence of gamma interferon or its receptor.Q35217552
IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic miceQ35296962
Persistent antigen presentation after acute vesicular stomatitis virus infectionQ35635383
Control of T cell viabilityQ35698562
Virus-specific antigen presentation by different subsets of cells from lung and mediastinal lymph node tissues of influenza virus-infected miceQ35848499
T-lymphocyte death during shutdown of an immune responseQ35920529
Multiple-cytokine-producing antiviral CD4 T cells are functionally superior to single-cytokine-producing cellsQ35947812
Convergence of TCR and cytokine signaling leads to FOXO3a phosphorylation and drives the survival of CD4+ central memory T cellsQ36228932
Rapid default transition of CD4 T cell effectors to functional memory cellsQ36229656
T cell memory is short-lived in the absence of antigenQ36230537
Response of naive antigen-specific CD4+ T cells in vitro: characteristics and antigen-presenting cell requirementsQ36231963
Interleukin-2 enhances CD4+ T cell memory by promoting the generation of IL-7R alpha-expressing cellsQ36267169
Type I interferons keep activated T cells aliveQ36367751
Transforming growth factor beta1 inhibits Fas ligand expression and subsequent activation-induced cell death in T cells via downregulation of c-MycQ36367920
Antigen-specific T helper cell function: differential cytokine expression in primary and memory responsesQ36369065
Protection from respiratory virus infections can be mediated by antigen-specific CD4(+) T cells that persist in the lungsQ36369221
CD4 effector T cell subsets in the response to influenza: heterogeneity, migration, and functionQ36371144
Ligand-induced autoregulation of IFN-gamma receptor beta chain expression in T helper cell subsetsQ41270009
Costimulatory requirements of naive CD4+ T cells. ICAM-1 or B7-1 can costimulate naive CD4 T cell activation but both are required for optimum response.Q41332813
Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)Q41371079
Interleukin 15 controls both proliferation and survival of a subset of memory-phenotype CD8(+) T cellsQ41773432
Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populationsQ41840721
Functionally diverse subsets in CD4 T cell responses against influenza.Q42282182
IL-15 and IL-2: a matter of life and death for T cells in vivoQ42639989
Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation.Q42830166
Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killingQ42951871
Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosisQ43539775
High antigen density and IL-2 are required for generation of CD4 effectors secreting Th1 rather than Th0 cytokines.Q44959196
Termination of antigen-specific immunity by CD95 ligand (Fas ligand) and IL-10.Q44987433
Heterogeneity of effector phenotype for acute phase and memory influenza A virus-specific CTL.Q45402819
Different Dynamics of CD4+ and CD8+ T Cell Responses During and After Acute Lymphocytic Choriomeningitis Virus InfectionQ45710912
Virus-specific CD8 T cells in peripheral tissues are more resistant to apoptosis than those in lymphoid organs.Q45723560
TNF receptor 1 (TNFR1) and CD95 are not required for T cell deletion after virus infection but contribute to peptide-induced deletion under limited conditionsQ45744528
Bystander virus infection prolongs activated T cell survivalQ45750055
Functionally distinct T cells in three compartments of the respiratory tract after influenza virus infection.Q45768117
Influenza virus RNA in the lung and lymphoid tissue of immunologically intact and CD4-depleted miceQ45860583
The roles of Fas/APO-1 (CD95) and TNF in antigen-induced programmed cell death in T cell receptor transgenic mice.Q46110412
Differential regulation of antiviral T-cell immunity results in stable CD8+ but declining CD4+ T-cell memoryQ46347403
IL-2 induces a competitive survival advantage in T lymphocytesQ46466198
Lymphoid reservoirs of antigen-specific memory T helper cellsQ46609740
Granzyme B, a new player in activation-induced cell death, is down-regulated by vasoactive intestinal peptide in Th2 but not Th1 effectorsQ46859572
Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk.Q46862843
Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas.Q46925453
Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosisQ47992184
IL-4 potentiates activated T cell apoptosis via an IL-2-dependent mechanismQ48024933
Immunological adjuvants promote activated T cell survival via induction of Bcl-3.Q48367905
Memory CD4 T cells emerge from effector T-cell progenitorsQ48887186
IFN-gamma mediates the death of Th1 cells in a paracrine manner.Q51968174
Asymmetric T lymphocyte division in the initiation of adaptive immune responses.Q51977375
Anatomical heterogeneity of memory CD4+ T cells due to reversible adaptation to the microenvironment.Q51995867
High numbers of IL-2-producing CD8+ T cells during viral infection: correlation with stable memory development.Q52011061
Distinct lineages of T(H)1 cells have differential capacities for memory cell generation in vivo.Q52011176
CD4(+) T cell effectors can become memory cells with high efficiency and without further division.Q52018427
Class II-independent generation of CD4 memory T cells from effectors.Q52031200
Following the development of a CD4 T cell response in vivo: from activation to memory formation.Q52032084
OX-40: life beyond the effector T cell stage.Q52036718
Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo.Q52057633
IFNgamma sensitizes for apoptosis by upregulating caspase-8 expression through the Stat1 pathway.Q52545841
Soluble TNF-alpha but not transmembrane TNF-alpha sensitizes T cells for enhanced activation-induced cell death.Q53377749
CD28 engagement and proinflammatory cytokines contribute to T cell expansion and long-term survival in vivoQ56908416
CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferationQ56908745
Reactive Oxygen Species Regulate Activation-Induced T Cell ApoptosisQ56922123
T-cell survivalQ56922138
IL-6 rescues resting mouse T cells from apoptosisQ56922159
Experimental Models to Study Molecular Mechanisms Underlying Intestinal InflammationQ57197678
Minimal activation of memory CD8+ T cell by tissue-derived dendritic cells favors the stimulation of naive CD8+ T cellsQ57227696
Interferon gamma is required for activation-induced death of T lymphocytesQ36371148
Interleukin 7 regulates the survival and generation of memory CD4 cellsQ36371578
IL-7 promotes the transition of CD4 effectors to persistent memory cellsQ36371590
Interleukin 2, but not other common gamma chain-binding cytokines, can reverse the defect in generation of CD4 effector T cells from naive T cells of aged miceQ36375375
High level expression of CD43 inhibits T cell receptor/CD3-mediated apoptosisQ36375645
Unequal death in T helper cell (Th)1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosisQ36377260
CD4 regulates susceptibility to Fas ligand- and tumor necrosis factor-mediated apoptosisQ36400376
Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generationQ36402838
Repeated stimulation of CD4 effector T cells can limit their protective functionQ36403433
cFLIP regulation of lymphocyte activation and developmentQ36405075
Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors.Q36446889
CD4+ T-cell memory: generation and multi-faceted roles for CD4+ T cells in protective immunity to influenza.Q36494486
The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccineQ36497412
Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunityQ36501636
Control of CD4+ T-cell memory by cytokines and costimulatorsQ36528927
Not all CD4+ memory T cells are long livedQ36528938
Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4+ memory T lymphocyte populationsQ36628376
Protective influenza-specific CD8 T cell responses require interactions with dendritic cells in the lungsQ36742280
Life and death in peripheral T cellsQ36858872
IFN-gamma acts directly on activated CD4+ T cells during mycobacterial infection to promote apoptosis by inducing components of the intracellular apoptosis machinery and by inducing extracellular proapoptotic signalsQ36867809
CD8 T cell dysfunction during chronic viral infection.Q36893050
Type II collagen autoimmunity in a mouse model of human rheumatoid arthritisQ36984686
The effector to memory transition of CD4 T cells.Q37063091
Concepts of activated T cell deathQ37090795
Antigen-experienced T cells limit the priming of naive T cells during infection with Leishmania majorQ37227400
Abundant c-Fas-associated death domain-like interleukin-1-converting enzyme inhibitory protein expression determines resistance of T helper 17 cells to activation-induced cell deathQ37291626
IL-10 deficiency unleashes an influenza-specific Th17 response and enhances survival against high-dose challengeQ37297787
Plasmodium falciparum apical membrane antigen 1 vaccine elicits multifunctional CD4 cytokine-producing and memory T cellsQ37349074
Interleukin-2 in the development and control of inflammatory diseaseQ37374918
Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cellsQ37483184
Heterogeneity of CD4+ memory T cells: functional modules for tailored immunityQ37578374
The T lymphocyte in experimental allergic encephalomyelitisQ37925549
Rapid culling of the CD4+ T cell repertoire in the transition from effector to memoryQ38574697
Interleukin-2: inception, impact, and implicationsQ39603037
T-lymphocyte downregulation after acute viral infection is not dependent on CD95 (Fas) receptor-ligand interactions.Q39877053
P304page(s)110-124
P577publication date2010-07-01
P1433published inImmunological ReviewsQ15724582
P1476titleRegulation of CD4+ T-cell contraction during pathogen challenge
P478volume236