Heterogeneity of effector phenotype for acute phase and memory influenza A virus-specific CTL.

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Heterogeneity of effector phenotype for acute phase and memory influenza A virus-specific CTL. is …
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scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.179.1.64
P698PubMed publication ID17579022
P5875ResearchGate publication ID6258248

P50authorPeter C. DohertyQ309814
Katherine KedzierskaQ28355204
Stephen J. TurnerQ47502192
P2093author name stringMisty R Jenkins
P2860cites workThe epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptidesQ24339477
Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactionsQ24675072
Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymesQ24675937
Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient miceQ28594763
Activation, differentiation, and migration of naive virus-specific CD8+ T cells during pulmonary influenza virus infectionQ30433912
Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysisQ30480387
Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunctionQ30670293
Effector CD8+ T cells recovered from an influenza pneumonia differentiate to a state of focused gene expressionQ33771135
Herpes simplex virus type 1-specific cytotoxic T-lymphocyte arming occurs within lymph nodes draining the site of cutaneous infectionQ33799184
A previously unrecognized H-2D(b)-restricted peptide prominent in the primary influenza A virus-specific CD8(+) T-cell response is much less apparent following secondary challengeQ33801952
Preferential localization of effector memory cells in nonlymphoid tissueQ34514330
Early establishment of diverse T cell receptor profiles for influenza-specific CD8(+)CD62L(hi) memory T cellsQ34694947
Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8+ T cells in influenza virus-infected mice.Q34807777
In vivo proliferation of naïve and memory influenza-specific CD8(+) T cellsQ35557069
Measuring the diaspora for virus-specific CD8+ T cells.Q35941203
Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysisQ36322609
Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.Q36368577
Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cellsQ36369731
Differential antigen presentation regulates the changing patterns of CD8+ T cell immunodominance in primary and secondary influenza virus infectionsQ36371363
In vitro- and ex vivo-derived cytolytic leukocytes from granzyme A x B double knockout mice are defective in granule-mediated apoptosis but not lysis of target cellsQ36380903
Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cellsQ37139786
Conserved T cell receptor usage in primary and recall responses to an immunodominant influenza virus nucleoprotein epitopeQ37415551
Diversity of epitope and cytokine profiles for primary and secondary influenza a virus-specific CD8+ T cell responsesQ40820376
Effector CD4+ and CD8+ T-cell mechanisms in the control of respiratory virus infections.Q41672951
Interleukin 15 controls both proliferation and survival of a subset of memory-phenotype CD8(+) T cellsQ41773432
Rapid effector function in CD8+ memory T cellsQ41847748
Differential expression of the granzymes A, K and M and perforin in human peripheral blood lymphocytesQ42803361
The genes for perforin, granzymes A-C and IFN-gamma are differentially expressed in single CD8(+) T cells during primary activationQ44012083
Progression of armed CTL from draining lymph node to spleen shortly after localized infection with herpes simplex virus 1.Q45022725
Crystal structures of murine MHC Class I H-2 D(b) and K(b) molecules in complex with CTL epitopes from influenza A virus: implications for TCR repertoire selection and immunodominanceQ45219745
Hierarchies in cytokine expression profiles for acute and resolving influenza virus-specific CD8+ T cell responses: correlation of cytokine profile and TCR avidityQ45649608
Analysis of clonotype distribution and persistence for an influenza virus-specific CD8+ T cell responseQ45724232
Virus-specific CD8+ T cells in primary and secondary influenza pneumoniaQ45755057
Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A.Q45785971
IL-2 regulates perforin and granzyme gene expression in CD8+ T cells independently of its effects on survival and proliferationQ46844014
Cutting edge: rapid in vivo killing by memory CD8 T cellsQ47817073
Accelerated CD8+ T-cell memory and prime-boost response after dendritic-cell vaccination.Q51991275
Molecular and functional profiling of memory CD8 T cell differentiation.Q52008481
Early acquisition of cytolytic function and transcriptional changes in a primary CD8+ T-cell response in vivo.Q54579906
Dynamic programming of CD8+ T lymphocyte responsesQ63408380
Interleukin-15 induces the expression of mRNAs of cytolytic mediators and augments cytotoxic activities in primary murine lymphocytesQ71801993
Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiationQ73808233
Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activationQ77879079
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectinfluenza A virusQ834390
P304page(s)64-70
P577publication date2007-07-01
P1433published inJournal of ImmunologyQ3521441
P1476titleHeterogeneity of effector phenotype for acute phase and memory influenza A virus-specific CTL.
P478volume179

Reverse relations

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Q46167518Visualizing CTL activity for different CD8+ effector T cells supports the idea that lower TCR/epitope avidity may be advantageous for target cell killing.

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