The role of epigenetics in the acquisition and maintenance of effector function in virus-specific CD8 T cells

scientific article published on July 2010

The role of epigenetics in the acquisition and maintenance of effector function in virus-specific CD8 T cells is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1002/IUB.351
P698PubMed publication ID20552633
P5875ResearchGate publication ID44677589

P50authorPeter C. DohertyQ309814
Stephen J. TurnerQ47502192
Matthew R. OlsonQ51022230
P2093author name stringBrendan E Russ
P2860cites workA novel transcription factor, T-bet, directs Th1 lineage commitmentQ22253874
The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptidesQ24339477
An endotoxin-induced serum factor that causes necrosis of tumorsQ24564406
Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulationQ24680549
Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibitionQ24682546
Chromatin modifications and their functionQ27861067
T-cell priming by dendritic cells in lymph nodes occurs in three distinct phasesQ28237805
Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene lociQ28256853
An in vivo cytotoxicity threshold for influenza A virus-specific effector and memory CD8(+) T cellsQ28284174
Activation, differentiation, and migration of naive virus-specific CD8+ T cells during pulmonary influenza virus infectionQ30433912
Fas ligand is required for the development of respiratory syncytial virus vaccine-enhanced diseaseQ30436942
A role for TNF in limiting the duration of CTL effector phase and magnitude of CD8 T cell memory.Q51972635
Rapid demethylation of the IFN-gamma gene occurs in memory but not naive CD8 T cells.Q52022962
Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.Q52111650
Granzyme A initiates an alternative pathway for granule-mediated apoptosis.Q54013097
Early acquisition of cytolytic function and transcriptional changes in a primary CD8+ T-cell response in vivo.Q54579906
Fas ligand costimulates the in vivo proliferation of CD8+ T cellsQ73163098
Viral infection results in massive CD8+ T cell expansion and mortality in vaccinated perforin-deficient miceQ73296821
Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin levelQ73835273
Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activationQ77879079
Cutting edge: the differential involvement of the N-finger of GATA-3 in chromatin remodeling and transactivation during Th2 developmentQ78346665
Cutting edge: re-evaluating the in vivo cytokine responses of CD8+ T cells during primary and secondary viral infectionsQ81724300
Granzyme A- and B-cluster deficiency delays acute lung injury in pneumovirus-infected miceQ33578226
Plasmacytoid dendritic cells enhance mortality during lethal influenza infections by eliminating virus-specific CD8 T cellsQ33776501
ATP-dependent chromatin-remodeling complexes.Q33786898
A previously unrecognized H-2D(b)-restricted peptide prominent in the primary influenza A virus-specific CD8(+) T-cell response is much less apparent following secondary challengeQ33801952
Perforin and Fas cytolytic pathways coordinately shape the selection and diversity of CD8+-T-cell escape variants of influenza virusQ33843485
Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma.Q33925554
Death by a thousand cuts: granzyme pathways of programmed cell deathQ34588821
Delivering the kiss of death: progress on understanding how perforin worksQ34653872
Histone acetylation facilitates rapid and robust memory CD8 T cell response through differential expression of effector molecules (eomesodermin and its targets: perforin and granzyme B).Q34784615
The interaction of transcription factors with nucleosomal DNAQ35284105
TRAIL and viral infectionQ35756895
Mitochondria-dependent and -independent regulation of Granzyme B-induced apoptosisQ35834606
GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cellsQ35834668
Maximal proliferation of cytotoxic T lymphocytes requires reverse signaling through Fas ligandQ36381058
Distinct methylation of the interferon gamma (IFN-gamma) and interleukin 3 (IL-3) genes in newly activated primary CD8+ T lymphocytes: regional IFN-gamma promoter demethylation and mRNA expression are heritable in CD44(high)CD8+ T cellsQ36851717
CD8 T cells utilize TRAIL to control influenza virus infectionQ37029404
The dual functions of fas ligand in the regulation of peripheral CD8+ and CD4+ T cellsQ37114374
Distinct profiles of cytotoxic granules in memory CD8 T cells correlate with function, differentiation stage, and antigen exposureQ37127942
Molecular mechanisms of IFN-gamma to up-regulate MHC class I antigen processing and presentationQ37610453
Role of tumor necrosis factor receptors in regulating CD8 T-cell responses during acute lymphocytic choriomeningitis virus infectionQ37747298
A novel domain in adenovirus L4-100K is required for stable binding and efficient inhibition of human granzyme B: possible interaction with a species-specific exositeQ39852886
Rapid production of TNF-alpha following TCR engagement of naive CD8 T cellsQ40364726
Adaptive immunity and enhanced CD8+ T cell response to Listeria monocytogenes in the absence of perforin and IFN-gammaQ40875268
Effects of DNA methylation on DNA-binding proteins and gene expression.Q40912883
Cytokines and immunity to viral infectionsQ41672958
The genes for perforin, granzymes A-C and IFN-gamma are differentially expressed in single CD8(+) T cells during primary activationQ44012083
Transient familial haemophagocytic lymphohistiocytosis reactivation post-CD34 haematopoietic stem cell transplantationQ44020636
The roles of perforin- and Fas-dependent cytotoxicity in protection against cytopathic and noncytopathic virusesQ44152234
Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejectionQ44504164
Granzyme A expression reveals distinct cytolytic CTL subsets following influenza A virus infectionQ44721618
Granzyme K expressing cytotoxic T lymphocytes protects against influenza virus in granzyme AB-/- miceQ45391089
Cell cycle-related acquisition of cytotoxic mediators defines the progressive differentiation to effector status for virus-specific CD8+ T cellsQ45391522
Heterogeneity of effector phenotype for acute phase and memory influenza A virus-specific CTL.Q45402819
Prolonged production of TNF-alpha exacerbates illness during respiratory syncytial virus infectionQ45598082
Hierarchies in cytokine expression profiles for acute and resolving influenza virus-specific CD8+ T cell responses: correlation of cytokine profile and TCR avidityQ45649608
Granzyme K displays highly restricted substrate specificity that only partially overlaps with granzyme A.Q46211971
Cutting edge: chromatin remodeling as a molecular basis for the enhanced functionality of memory CD8 T cellsQ46497457
Lymph node dendritic cells control CD8+ T cell responses through regulated FasL expressionQ46852881
Interplay between chromatin remodeling and epigenetic changes during lineage-specific commitment to granzyme B expression.Q50720592
P433issue7
P921main subjectepigeneticsQ26939
P304page(s)519-526
P577publication date2010-07-01
P1433published inIUBMB LifeQ15764029
P1476titleThe role of epigenetics in the acquisition and maintenance of effector function in virus-specific CD8 T cells
P478volume62

Reverse relations

cites work (P2860)
Q37374912Interferon regulatory factor 4 sustains CD8(+) T cell expansion and effector differentiation
Q36585832Maintenance of CMV-specific CD8+ T cell responses and the relationship of IL-27 to IFN-γ levels with aging

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