Clonotype and repertoire changes drive the functional improvement of HIV-specific CD8 T cell populations under conditions of limited antigenic stimulation

scientific article published on 30 December 2011

Clonotype and repertoire changes drive the functional improvement of HIV-specific CD8 T cell populations under conditions of limited antigenic stimulation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1102610
P932PMC publication ID3262882
P698PubMed publication ID22210916
P5875ResearchGate publication ID51974217

P50authorPhillip ScheinbergQ55136109
David A PriceQ61139603
Lydie TrautmannQ64711548
Rafick-Pierre SékalyQ72643047
Richard A KoupQ97635775
David R. AmbrozakQ114519295
P2093author name stringJean-Pierre Routy
Daniel C Douek
Tedi E Asher
Abdelali Filali-Mouhim
Glenda Canderan
Mohamad Rachid Boulassel
Loury Janbazian
P2860cites workVirus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infectionQ24645815
Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndromeQ24648628
High-programmed death-1 levels on hepatitis C virus-specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infectionQ27490345
A human memory T cell subset with stem cell-like propertiesQ28248395
Phenotypic analysis of antigen-specific T lymphocytesQ28290058
Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cellsQ28754733
HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cellsQ29616205
Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytesQ29616210
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progressionQ29618956
In vivo induction of a high-avidity, high-frequency cytotoxic T-lymphocyte response is associated with antiviral protective immunityQ33806244
Decay kinetics of human immunodeficiency virus-specific CD8+ T cells in peripheral blood after initiation of highly active antiretroviral therapyQ33843388
De novo generation of escape variant-specific CD8+ T-cell responses following cytotoxic T-lymphocyte escape in chronic human immunodeficiency virus type 1 infectionQ34045616
HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoirQ34097573
Memory CD8 T-cell differentiation during viral infectionQ34152220
New approaches to design HIV-1 T-cell vaccinesQ34274849
Hierarchies in cytokine expression profiles for acute and resolving influenza virus-specific CD8+ T cell responses: correlation of cytokine profile and TCR avidityQ45649608
Persistent survival of prevalent clonotypes within an immunodominant HIV gag-specific CD8+ T cell response.Q46705263
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A novel approach to the analysis of specificity, clonality, and frequency of HIV-specific T cell responses reveals a potential mechanism for control of viral escape.Q49022303
A mechanism for TCR sharing between T cell subsets and individuals revealed by pyrosequencing.Q51017634
Induction and evolution of cytomegalovirus-specific CD4+ T cell clonotypes in rhesus macaques.Q51968503
Method for assessing the similarity between subsets of the T cell receptor repertoire.Q51969816
Reversion of CTL escape–variant immunodeficiency viruses in vivoQ56427919
Evolution and transmission of stable CTL escape mutations in HIV infectionQ56880602
Impact of changes in antigen level on CD38/PD-1 co-expression on HIV-specific CD8 T cells in chronic, untreated HIV-1 infectionQ58674139
Changes in thymic function with age and during the treatment of HIV infectionQ59066353
HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressorsQ78342521
Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunctionQ34570127
PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status.Q34583193
Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnoverQ34692601
SPICE: exploration and analysis of post-cytometric complex multivariate datasetsQ34769778
Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairmentQ34857689
The clonal composition of human CD4+CD25+Foxp3+ cells determined by a comprehensive DNA-based multiplex PCR for TCRB gene rearrangementsQ35471742
The many important facets of T-cell repertoire diversityQ35709655
Selective depletion of high-avidity human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells after early HIV-1 infectionQ35785225
HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic functionQ35834664
SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infectionQ35901710
Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection.Q36228011
CD8 single-cell gene coexpression reveals three different effector types present at distinct phases of the immune responseQ36229371
Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques.Q36368095
Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection.Q36369035
Repertoire, diversity, and differentiation of specific CD8 T cells are associated with immune protection against human cytomegalovirus diseaseQ36399914
Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA virusesQ36403141
An inverse relationship between T cell receptor affinity and antigen dose during CD4(+) T cell responses in vivo and in vitroQ36433369
Emergence of polyfunctional CD8+ T cells after prolonged suppression of human immunodeficiency virus replication by antiretroviral therapyQ36498230
Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapyQ36499290
Virological outcome after structured interruption of antiretroviral therapy for human immunodeficiency virus infection is associated with the functional profile of virus-specific CD8+ T cellsQ36540008
Structural determinants of T-cell receptor bias in immunityQ36655911
The T cell repertoire in infection and vaccination: implications for control of persistent virusesQ36791454
The molecular basis for public T-cell responses?Q37095250
Impact of epitope escape on PD-1 expression and CD8 T-cell exhaustion during chronic infectionQ37157206
Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activityQ37262408
Ultradeep pyrosequencing detects complex patterns of CD8+ T-lymphocyte escape in simian immunodeficiency virus-infected macaquesQ37275022
Functional implications of T cell receptor diversityQ37518497
Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy.Q37629901
Decay kinetics of human immunodeficiency virus-specific effector cytotoxic T lymphocytes after combination antiretroviral therapy.Q39549058
High-avidity CTL exploit two complementary mechanisms to provide better protection against viral infection than low-avidity CTL.Q40830770
Impaired function of circulating HIV-specific CD8(+) T cells in chronic human immunodeficiency virus infection.Q40846408
Dominant clonotypes within HIV-specific T cell responses are programmed death-1high and CD127low and display reduced variant cross-reactivity.Q42035290
Primary infection of a male plasma donor with divergent HIV variants from the same source followed by rapid fluctuations in their relative frequency and viral recombinationQ45208588
Skewed maturation of memory HIV-specific CD8 T lymphocytesQ45284555
Rapid CD8+ T cell repertoire focusing and selection of high-affinity clones into memory following primary infection with a persistent human virus: human cytomegalovirusQ45401027
Heterogeneity of effector phenotype for acute phase and memory influenza A virus-specific CTL.Q45402819
Impact of HLA-B alleles, epitope binding affinity, functional avidity, and viral coinfection on the immunodominance of virus-specific CTL responsesQ45418704
Dynamic immune responses maintain cytotoxic T lymphocyte epitope mutations in transmitted simian immunodeficiency virus variantsQ45516005
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)1156-1167
P577publication date2011-12-30
P1433published inJournal of ImmunologyQ3521441
P1476titleClonotype and repertoire changes drive the functional improvement of HIV-specific CD8 T cell populations under conditions of limited antigenic stimulation
P478volume188

Reverse relations

cites work (P2860)
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Q34819446Rapid perturbation in viremia levels drives increases in functional avidity of HIV-specific CD8 T cells
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