Profound metabolic, functional, and cytolytic differences characterize HIV-specific CD8 T cells in primary and chronic HIV infection

scientific article published on 6 September 2012

Profound metabolic, functional, and cytolytic differences characterize HIV-specific CD8 T cells in primary and chronic HIV infection is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2012-04-422550
P932PMC publication ID3743465
P698PubMed publication ID22955926
P5875ResearchGate publication ID230811236

P50authorNicolas ChomontQ56909197
Lydie TrautmannQ64711548
Rafick-Pierre SékalyQ72643047
P2093author name stringJean-Pierre Routy
Yu Shi
Elias K Haddad
Julien Van Grevenynghe
Yoav Peretz
Jean-Philippe Goulet
Florentin-Martial Mbitikon-Kobo
Francesco Andrea Procopio
Mohamad Rachid Boulassel
P2860cites workPositive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infectionQ24564779
Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infectionQ24645815
Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndromeQ24648628
Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infectionQ24795912
Hypoxia-inducible factors in physiology and medicineQ27013770
Yellow fever vaccine induces integrated multilineage and polyfunctional immune responsesQ27487514
Phenotypic analysis of antigen-specific T lymphocytesQ28290058
Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virusQ28302762
Controlling the false discovery rate in behavior genetics researchQ29614833
Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytesQ29616210
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progressionQ29618956
Why don't CD8+ T cells reduce the lifespan of SIV-infected cells in vivo?Q31032227
CD8+ lymphocytes control viral replication in SIVmac239-infected rhesus macaques without decreasing the lifespan of productively infected cellsQ33618007
Relationship between functional profile of HIV-1 specific CD8 T cells and epitope variability with the selection of escape mutants in acute HIV-1 infectionQ33828583
Weak anti-HIV CD8(+) T-cell effector activity in HIV primary infectionQ33880339
Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cellsQ33981572
Major expansion of CD8+ T cells with a predominant V beta usage during the primary immune response to HIV.Q34060144
Immunologic and virologic events in early HIV infection predict subsequent rate of progressionQ34127870
Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival.Q34151699
Memory CD8 T-cell differentiation during viral infectionQ34152220
A high-throughput single-cell analysis of human CD8⁺ T cell functions reveals discordance for cytokine secretion and cytolysisQ34220876
Dynamics of HIV viremia and antibody seroconversion in plasma donors: implications for diagnosis and staging of primary HIV infectionQ34228730
Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunctionQ34570127
PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status.Q34583193
The immune response during acute HIV-1 infection: clues for vaccine developmentQ34614862
Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairmentQ34857689
Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T-cell exhaustion in HIV infectionQ35001605
Cytokine control of memory T-cell development and survivalQ35096181
Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytesQ35110576
Clonotype and repertoire changes drive the functional improvement of HIV-specific CD8 T cell populations under conditions of limited antigenic stimulationQ35685446
HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic functionQ35834664
Initial HIV-1 antigen-specific CD8+ T cells in acute HIV-1 infection inhibit transmitted/founder virus replicationQ36086631
Metabolic control of T cell activation and death in SLE.Q37187126
The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infectionQ37273195
Decay kinetics of human immunodeficiency virus-specific effector cytotoxic T lymphocytes after combination antiretroviral therapy.Q39549058
CD8(+) T-cell selection, function, and death in the primary immune response in vivoQ40735898
Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory developmentQ40760682
Impaired function of circulating HIV-specific CD8(+) T cells in chronic human immunodeficiency virus infection.Q40846408
Early establishment and antigen dependence of simian immunodeficiency virus-specific CD8+ T-cell defectsQ42071648
Low levels of perforin expression in CD8+ T lymphocyte granules in lymphoid tissue during acute human immunodeficiency virus type 1 infectionQ43986794
Skewed maturation of memory HIV-specific CD8 T lymphocytesQ45284555
Correlation between interferon- gamma secretion and cytotoxicity, in virus-specific memory T cellsQ45567081
Patterns of viral dynamics during primary human immunodeficiency virus type 1 infection. The Sydney Primary HIV Infection Study Group.Q45752836
Ex vivo measurement of the cytotoxic capacity of human primary antigen-specific CD8 T cellsQ45874051
The functional profile of primary human antiviral CD8+ T cell effector activity is dictated by cognate peptide concentrationQ47643908
Immunological and virological impact of highly active antiretroviral therapy initiated during acute HIV-1 infection.Q51979764
Increased CD95/Fas-induced apoptosis of HIV-specific CD8(+) T cells.Q55035589
Most antiviral CD8 T cells during chronic viral infection do not express high levels of perforin and are not directly cytotoxicQ58321599
Dynamics of T cell responses in HIV infectionQ77801088
P4510describes a project that useslimmaQ112236343
P433issue17
P407language of work or nameEnglishQ1860
P304page(s)3466-3477
P577publication date2012-09-06
P1433published inBloodQ885070
P1476titleProfound metabolic, functional, and cytolytic differences characterize HIV-specific CD8 T cells in primary and chronic HIV infection
P478volume120

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cites work (P2860)
Q60914349An altered cytotoxic program of CD8+ T-cells in HIV-infected patients despite HAART-induced viral suppression
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