Loss of Bim results in abnormal accumulation of mature CD4-CD8-CD44-CD25- thymocytes

scientific article

Loss of Bim results in abnormal accumulation of mature CD4-CD8-CD44-CD25- thymocytes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.IMBIO.2007.05.003
P932PMC publication ID2074878
P698PubMed publication ID17869640
P5875ResearchGate publication ID5970787

P50authorJack HutchesonQ47504174
P2093author name stringHarris Perlman
P2860cites workDeficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasisQ52547440
Heterogeneity of the DN4 (CD44-CD25-) subset of CD4-CD8- double negative thymocytes; dependence on CD3 signalingQ74086287
Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis inductionQ24677017
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunityQ28138855
BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytesQ28203083
The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissuesQ28512628
Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosisQ28587336
Mitochondria and apoptosisQ29547905
The Bcl-2 protein family: arbiters of cell survivalQ29618158
Selection of the T cell repertoire.Q33652536
Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein BimQ33715752
Immune responses to adenovirus and adeno-associated virus in humans.Q33874473
The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entryQ33887183
Bim mediates apoptosis of CD127(lo) effector T cells and limits T cell memoryQ34464549
Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteinsQ34471050
Regulation of thymocyte differentiation: pre-TCR signals and beta-selectionQ34831686
Apoptosis in the development and maintenance of the immune systemQ35116684
T-cell development made simpleQ35620087
The role of BH3-only proteins in the immune systemQ36047162
Regulation of cell division cycle progression by bcl-2 expression: a potential mechanism for inhibition of programmed cell deathQ36366587
Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient miceQ36399348
The Role of the Thymus and Recent Thymic Migrants in the Maintenance of the Adult Peripheral Lymphocyte PoolQ36400977
A central role for thymic emigrants in peripheral T cell homeostasisQ36433740
The proto-oncogene Bcl-2 and its role in regulating apoptosisQ41492030
CD3-associated alpha/beta and gamma/delta heterodimeric receptors are expressed by distinct populations of CD4- CD8- thymocytes.Q44268094
New insights into the proliferation and differentiation of early mouse thymocytesQ44936590
Thymic T cell export is not influenced by the peripheral T cell pool.Q52041153
A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.Q52225033
P433issue8
P921main subjectthymocyteQ7799635
P304page(s)629-636
P577publication date2007-06-15
P1433published inImmunobiologyQ15754985
P1476titleLoss of Bim results in abnormal accumulation of mature CD4-CD8-CD44-CD25- thymocytes
P478volume212

Reverse relations

cites work (P2860)
Q33727248BH3-only proteins in rheumatoid arthritis: potential targets for therapeutic intervention.
Q38926368Cell death in the pathogenesis of systemic lupus erythematosus and lupus nephritis
Q61797345Disruption of the FasL/Fas axis protects against inflammation-derived tumorigenesis in chronic liver disease
Q42416539Immunologic and Metabolic Features of Pancreatic Ductal Adenocarcinoma Define Prognostic Subtypes of Disease.
Q43064735Interleukin-7 promotes the survival of human CD4+ effector/memory T cells by up-regulating Bcl-2 proteins and activating the JAK/STAT signalling pathway
Q37808101Shaping the T‐cell repertoire: a matter of life and death
Q90317657T-cell receptor signal strength and epigenetic control of Bim predict memory CD8+ T-cell fate
Q41502539Temporal Expression of Bim Limits the Development of Agonist-Selected Thymocytes and Skews Their TCRβ Repertoire.

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