Inositol 1,3,4,5-tetrakisphosphate controls proapoptotic Bim gene expression and survival in B cells (scientific article)

The three isoenzymes of human inositol-1,4,5-trisphosphate 3-kinase show specific intracellular localization but comparable Ca2+ responses on transfection in COS-7 cells

Q24530164

Structure of the binding site for inositol phosphates in a PH domain

Q27729737

Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain

Q27732194

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

Q28138855

Back in the water: the return of the inositol phosphates

Q28186774

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

Q28506206

Inositol 1,3,4,5-tetrakisphosphate is essential for T lymphocyte development

Q28511412

Inositol (1,4,5) trisphosphate 3 kinase B controls positive selection of T cells and modulates Erk activity

Q28512312

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

Q28587387

BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis

Q29620466

Nicotinamide inhibits B lymphocyte activation by disrupting MAPK signal transduction

Q33267569

Tissue-specific expression and endogenous subcellular distribution of the inositol 1,3,4,5-tetrakisphosphate-binding proteins GAP1(IP4BP) and GAP1(m).

Q33853458

GAP1IP4BP contains a novel group I pleckstrin homology domain that directs constitutive plasma membrane association.

Q33907044

The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane

Q34253544

Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more

Q34987905

Cytokine-mediated cell survival

Q35947238

BAFF regulates B cell survival by downregulating the BH3-only family member Bim via the ERK pathway

Q36403102

Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity.

Q37593642

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease

Q37600558

Structural and functional analysis of the putative inositol 1,3,4, 5-tetrakisphosphate receptors GAP1(IP4BP) and GAP1(m).

Q38333429

TLR-dependent Bim phosphorylation in macrophages is mediated by ERK and is connected to proteasomal degradation of the protein

Q40208439

Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim.

Q40323778

The endoplasmic reticulum gateway to apoptosis by Bcl-X(L) modulation of the InsP3R

Q40369800

A molecular basis for inositol polyphosphate synthesis in Drosophila melanogaster

Q40523601

Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnover

Q40606380

Molecular modelling and site-directed mutagenesis of the inositol 1,3,4,5-tetrakisphosphate-binding pleckstrin homology domain from the Ras GTPase-activating protein GAP1IP4BP

Q41764505

Specificity of inositol trisphosphate-induced calcium release from permeabilized Swiss-mouse 3T3 cells

Q41774120

How much TCR does a T cell need?

Q43695965

Production of Ins(1,3,4,5)P4 mediated by the kinase Itpkb inhibits store-operated calcium channels and regulates B cell selection and activation.

Q46019984

The regulation of membrane to cytosol partitioning of signalling proteins by phosphoinositides and their soluble headgroups

Q46771498

Role of the forkhead transcription family member, FKHR, in thymocyte differentiation.

Q52163167

The versatility of inositol phosphates as cellular signals

Q77631236

Positive regulation of Itk PH domain function by soluble IP4

Q80108134

Regulatory phosphorylation of Bim: sorting out the ERK from the JNK

Q81833475

P433

issue

P407

language of work or name

English

Q1860

P304

page(s)

13978-13983

P577

publication date

2007-08-20

P1433

published in

Proceedings of the National Academy of Sciences of the United States of America

Q1146531

P1476

title

Inositol 1,3,4,5-tetrakisphosphate controls proapoptotic Bim gene expression and survival in B cells

P478

volume

104

Reverse relations

cites work (P2860)

Q38260410	A novel retroviral mutagenesis screen identifies prognostic genes in RUNX1 mediated myeloid leukemogenesis
Q41780823	BLNK binds active H-Ras to promote B cell receptor-mediated capping and ERK activation
Q39303549	Calcium Signaling: From Normal B Cell Development to Tolerance Breakdown and Autoimmunity.
Q36526501	Common variable immunodeficiency associated with microdeletion of chromosome 1q42.1-q42.3 and inositol 1,4,5-trisphosphate kinase B (ITPKB) deficiency
Q37989042	Defining signal transduction by inositol phosphates
Q41814062	Human inositol 1,4,5-trisphosphate 3-kinase isoform B (IP3KB) is a nucleocytoplasmic shuttling protein specifically enriched at cortical actin filaments and at invaginations of the nuclear envelope.
Q35560031	IP3 3-kinase B controls hematopoietic stem cell homeostasis and prevents lethal hematopoietic failure in mice
Q28731851	IP3 3-kinase opposes NGF driven neurite outgrowth
Q35926503	ITPKA expression is a novel prognostic factor in hepatocellular carcinoma
Q35677341	Inhibition of the Inositol Kinase Itpkb Augments Calcium Signaling in Lymphocytes and Reveals a Novel Strategy to Treat Autoimmune Disease
Q37820689	Inhibitor and activator: dual functions for SHIP in immunity and cancer
Q36529486	Inositol tetrakisphosphate limits NK cell effector functions by controlling PI3K signaling
Q28586246	Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis
Q39036400	Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology
Q37672405	Inositol trisphosphate 3-kinases: focus on immune and neuronal signaling
Q91971712	Inositol-triphosphate 3-kinase B confers cisplatin resistance by regulating NOX4-dependent redox balance
Q37390487	Leukocyte transcriptome from chickens infected with avian pathogenic Escherichia coli identifies pathways associated with resistance
Q34241131	Lipid Signaling in T-Cell Development and Function
Q38395493	Lipid and Protein Co-Regulation of PI3K Effectors Akt and Itk in Lymphocytes
Q36509008	Micro-scale flow cytometry-based and biochemical analysis of lipid signaling in primary B cell subpopulations
Q41883939	Modulation of Epidermal Growth Factor Stimulated ERK Phosphorylation and Cell Motility by Inositol Trisphosphate Kinase.
Q38313393	Molecular control of PtdIns(3,4,5)P3 signaling in neutrophils
Q57201013	New therapeutic targets in immune disorders: ItpkB, Orai1 and UNC93B
Q37596231	PPIP5K1 modulates ligand competition between diphosphoinositol polyphosphates and PtdIns(3,4,5)P3 for polyphosphoinositide-binding domains
Q35846615	Phosphoinositide and inositol phosphate analysis in lymphocyte activation
Q37657049	Receptor-dependent compartmentalization of PPIP5K1, a kinase with a cryptic polyphosphoinositide binding domain
Q37256980	Regulation of B-cell entry into the cell cycle
Q54108534	Regulation of Hematopoietic Cell Development and Function Through Phosphoinositides.
Q41041969	Regulation of NGF-driven neurite outgrowth by Ins(1,4,5)P3 kinase is specifically associated with the two isoenzymes Itpka and Itpkb in a model of PC12 cells
Q24631587	Regulation of immune cell development through soluble inositol-1,3,4,5-tetrakisphosphate
Q92824866	Role of miRNAs in Alzheimer's Disease and Possible Fields of Application
Q91644762	Role of rat sarcoma virus mutations in cancer and potential target for cancer therapy
Q35320797	Transforming growth factor beta (TGFbeta)-induced apoptosis: the rise & fall of Bim
Q61053563	Whole exome sequencing of relapsed/refractory patients expands the repertoire of somatic mutations in diffuse large B-cell lymphoma
Q41005799	miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain

P819	ADS bibcode	2007PNAS..10413978M
P356	DOI	10.1073/PNAS.0704312104
P932	PMC publication ID	1955816
P698	PubMed publication ID	17709751
P5875	ResearchGate publication ID	6129717