| scholarly article | Q13442814 |
| P2093 | author name string | Sui Zhang | |
| Edward T H Yeh | |||
| Jinke Cheng | |||
| Xunlei Kang | |||
| P2860 | cites work | Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function | Q22009393 |
| The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis | Q22009936 | ||
| Differential regulation of sentrinized proteins by a novel sentrin-specific protease | Q22011173 | ||
| HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing | Q24291102 | ||
| C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation | Q24291783 | ||
| A conserved family of prolyl-4-hydroxylases that modify HIF | Q24291794 | ||
| Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension | Q24307473 | ||
| Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis | Q24316448 | ||
| HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation | Q24555773 | ||
| SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1 | Q24563640 | ||
| Regulation of hypoxia-inducible factor 1α is mediated by an O 2 -dependent degradation domain via the ubiquitin-proteasome pathway | Q24672316 | ||
| Role of desumoylation in the development of prostate cancer | Q24676101 | ||
| Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation | Q27860876 | ||
| Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3. | Q27863917 | ||
| The SUMO-specific protease SENP5 is required for cell division | Q27863924 | ||
| Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction | Q28140805 | ||
| Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation | Q28188357 | ||
| SUMO: a history of modification | Q28243325 | ||
| Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α | Q28259513 | ||
| Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia | Q28267951 | ||
| Jak2 is essential for signaling through a variety of cytokine receptors | Q28270987 | ||
| SUMO and ubiquitin in the nucleus: different functions, similar mechanisms? | Q28280175 | ||
| Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor | Q28288945 | ||
| Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML/retinoic acid receptor alpha degradation | Q28367104 | ||
| HIF-1 alpha is required for solid tumor formation and embryonic vascularization. | Q28588778 | ||
| Mutation of SENP1/SuPr-2 reveals an essential role for desumoylation in mouse development. | Q28589576 | ||
| Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein | Q28647626 | ||
| BIOLOGY OF HEMATOPOIETIC STEM CELLS AND PROGENITORS: Implications for Clinical Application | Q29397118 | ||
| Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein | Q29615928 | ||
| Regulation of the erythropoietin gene | Q33728925 | ||
| Ubiquitin-like proteins: new wines in new bottles | Q33901542 | ||
| Differential regulation of c-Jun-dependent transcription by SUMO-specific proteases | Q34392520 | ||
| The hare and the tortoise: an embryonic haematopoietic race. | Q34770415 | ||
| Signalling via the hypoxia-inducible factor-1alpha requires multiple posttranslational modifications | Q35903053 | ||
| RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha | Q40179965 | ||
| Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha | Q41843388 | ||
| The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease | Q42399153 | ||
| JunD reduces tumor angiogenesis by protecting cells from oxidative stress | Q45060498 | ||
| Sumoylation increases HIF-1alpha stability and its transcriptional activity | Q45090303 | ||
| Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension | Q71738016 | ||
| The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice | Q81571103 | ||
| P433 | issue | 3 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | hypoxia | Q105688 |
| positive regulation of transcription by RNA polymerase II | Q14818068 | ||
| Erythropoietin | Q14852044 | ||
| Von Hippel-Lindau tumor suppressor | Q14905477 | ||
| SUMO specific peptidase 1 | Q21122812 | ||
| SUMO1/sentrin specific peptidase 1 | Q21991132 | ||
| hypoxia inducible factor 1 subunit alpha | Q5629645 | ||
| P304 | page(s) | 584-95 | |
| P577 | publication date | 2007-11-02 | |
| P1433 | published in | Cell | Q655814 |
| P1476 | title | SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia | |
| P478 | volume | 131 |
| Q39014919 | 15-LOX-1 suppression of hypoxia-induced metastatic phenotype and HIF-1α expression in human colon cancer cells |
| Q89863761 | A SUMOylation-dependent HIF-1α/CLDN6 negative feedback mitigates hypoxia-induced breast cancer metastasis |
| Q39197245 | A compendium of proteins that interact with HIF-1α. |
| Q39583866 | A comprehensive compilation of SUMO proteomics. |
| Q53206005 | A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity |
| Q35192586 | A novel cyclic AMP/Epac1/CaMKI signaling cascade promotes GCM1 desumoylation and placental cell fusion |
| Q39091679 | A role for paralog-specific sumoylation in histone deacetylase 1 stability |
| Q28535343 | A unique SUMO-2-interacting motif within LANA is essential for KSHV latency |
| Q53182665 | Activating transcription factor 3 SUMOylation is involved in angiotensin II-induced endothelial cell inflammation and dysfunction |
| Q26864235 | Advances in the development of SUMO specific protease (SENP) inhibitors |
| Q37270339 | Allosteric activation of SENP1 by SUMO1 β-grasp domain involves a dock-and-coalesce mechanism. |
| Q37498263 | An additional role for SUMO in ubiquitin-mediated proteolysis |
| Q37563422 | An essential role of small ubiquitin-like modifier (SUMO)-specific Protease 2 in myostatin expression and myogenesis |
| Q39992451 | Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway |
| Q39950016 | Arsenic trioxide stimulates SUMO-2/3 modification leading to RNF4-dependent proteolytic targeting of PML. |
| Q37134534 | Arsenite stabilizes HIF-1α protein through p85α-mediated up-regulation of inducible Hsp70 protein expression |
| Q28678204 | Assays for Investigating deSUMOylation Enzymes |
| Q38263173 | Balancing Act during Development: Lessons from a SUMO-less SF-1 |
| Q89583690 | Bclaf1 is a direct target of HIF-1 and critically regulates the stability of HIF-1α under hypoxia |
| Q30505393 | BubR1 is modified by sumoylation during mitotic progression |
| Q64950795 | CD34+KLF4+ Stromal Stem Cells Contribute to Endometrial Regeneration and Repair. |
| Q46792119 | CHFR is negatively regulated by SUMOylation-mediated ubiquitylation |
| Q35032636 | Cardiac function and disease: emerging role of small ubiquitin‐related modifier |
| Q24320715 | Cbx4 governs HIF-1α to potentiate angiogenesis of hepatocellular carcinoma by its SUMO E3 ligase activity |
| Q38214442 | Cell cycle progression in response to oxygen levels. |
| Q42969031 | Cezanne paints inflammation by regulating ubiquitination |
| Q60921574 | Chloramphenicol Induces Autophagy and Inhibits the Hypoxia Inducible Factor-1 Alpha Pathway in Non-Small Cell Lung Cancer Cells |
| Q39535553 | Computational Investigation of SENP:SUMO Protein-Protein Interaction for Structure Based Drug Design |
| Q41874525 | Conformational flexibility and changes underlying activation of the SUMO-specific protease SENP1 by remote substrate binding |
| Q24301429 | Control of adipogenesis by the SUMO-specific protease SENP2 |
| Q34464956 | Covalent NEDD8 Conjugation Increases RCAN1 Protein Stability and Potentiates Its Inhibitory Action on Calcineurin |
| Q98735744 | Cross-Species Insights Into Genomic Adaptations to Hypoxia |
| Q88337377 | DNA damage-induced nuclear factor-kappa B activation and its roles in cancer progression |
| Q35874536 | De-SUMOylation of CCCTC Binding Factor (CTCF) in Hypoxic Stress-induced Human Corneal Epithelial Cells |
| Q49911371 | DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages |
| Q64989029 | Deciphering the SUMO code in the kidney. |
| Q34626922 | Decreased plasma soluble erythropoietin receptor in high-altitude excessive erythrocytosis and Chronic Mountain Sickness |
| Q36994911 | Decreased recognition of SUMO-sensitive target genes following modification of SF-1 (NR5A1). |
| Q37407152 | Deficiency of SUMO-specific protease 1 induces arsenic trioxide-mediated apoptosis by regulating XBP1 activity in human acute promyelocytic leukemia |
| Q39471731 | Design, synthesis, and biological evaluation of benzodiazepine-based SUMO-specific protease 1 inhibitors |
| Q47972130 | Detection of SUMOylation in Plasmodium falciparum |
| Q39505892 | Detection of differentially expressed genes and association with clinicopathological features in laryngeal squamous cell carcinoma |
| Q93199945 | Deubiquitylase OTUD6B Governs pVHL Stability in an Enzyme-Independent Manner and Suppresses Hepatocellular Carcinoma Metastasis |
| Q36433762 | Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system. |
| Q39751672 | Down-regulation of HIF-1alpha by oncolytic reovirus infection independently of VHL and p53. |
| Q51468159 | Downregulation of AIF by HIF-1 contributes to hypoxia-induced epithelial-mesenchymal transition of colon cancer |
| Q24646355 | Dual modification of BMAL1 by SUMO2/3 and ubiquitin promotes circadian activation of the CLOCK/BMAL1 complex |
| Q38129554 | Dynamic regulation of innate immunity by ubiquitin and ubiquitin-like proteins |
| Q35840967 | Effects of High Intensity Interval Training on Pregnant Rats, and the Placenta, Heart and Liver of Their Fetuses |
| Q42005821 | Electrophilic lipid mediator 15-deoxy-Δ12,14-prostaglandin j2 modifies glucocorticoid signaling via receptor SUMOylation |
| Q28513287 | Eliminating SF-1 (NR5A1) Sumoylation In Vivo Results in Ectopic Hedgehog Signaling and Disruption of Endocrine Development |
| Q34108064 | Emerging roles of SUMO modification in arthritis |
| Q37926562 | Emerging roles of the SUMO pathway in development |
| Q42270282 | Enhanced HOXA10 sumoylation inhibits embryo implantation in women with recurrent implantation failure |
| Q35803643 | Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction |
| Q36980048 | Enhanceosomes as integrators of hypoxia inducible factor (HIF) and other transcription factors in the hypoxic transcriptional response. |
| Q38065482 | Erythropoietin in cancer: a dilemma in risk therapy |
| Q44976387 | Escherichia coli succinic thiolinase. Stoichiometry of phosphorylation and coenzyme A binding |
| Q44323392 | Exploring the Desumoylation Process of SENP1: A Study Combined MD Simulations with QM/MM Calculations on SENP1-SUMO1-RanGAP1 |
| Q37192018 | Extracellular signal-regulated kinase mitogen-activated protein kinase signaling initiates a dynamic interplay between sumoylation and ubiquitination to regulate the activity of the transcriptional activator PEA3. |
| Q49211105 | Factor inhibiting HIF1-A novel target of SUMOylation in the human placenta |
| Q26991707 | Function and regulation of SUMO proteases |
| Q40043380 | Functional Insights into ANP32A-Dependent Influenza A Virus Polymerase Host Restriction. |
| Q39591089 | Further insights into the mechanism of hypoxia-induced NFκB. [corrected]. |
| Q37626406 | Generating specificity and diversity in the transcriptional response to hypoxia |
| Q89762376 | Generation of a Quantitative Luciferase Reporter for Sox9 SUMOylation |
| Q28248051 | Genetic variation in SENP1 and ANP32D as predictors of chronic mountain sickness |
| Q37450692 | HAF : the new player in oxygen-independent HIF-1alpha degradation |
| Q38112399 | HIF expression and the role of hypoxic microenvironments within primary tumours as protective sites driving cancer stem cell renewal and metastatic progression |
| Q38332215 | HIF-1α induction, proliferation and glycolysis of Theileria-infected leukocytes |
| Q27025886 | HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression |
| Q33685018 | Heme oxygenase-1 plays a pro-life role in experimental brain stem death via nitric oxide synthase I/protein kinase G signaling at rostral ventrolateral medulla |
| Q46659572 | High-altitude adaptation in humans: from genomics to integrative physiology |
| Q42220579 | High-risk HPV16E6 stimulates hADA3 degradation by enhancing its SUMOylation |
| Q38256197 | Higher androgen bioactivity is associated with excessive erythrocytosis and chronic mountain sickness in Andean Highlanders: a review. |
| Q44045526 | How can we realize the promise of personalized antidepressant medicines? |
| Q27306560 | Hyper-SUMOylation of the Kv7 potassium channel diminishes the M-current leading to seizures and sudden death |
| Q90788856 | Hypermethylated gene ANKDD1A is a candidate tumor suppressor that interacts with FIH1 and decreases HIF1α stability to inhibit cell autophagy in the glioblastoma multiforme hypoxia microenvironment |
| Q37921345 | Hypoxia Inducible Factor-1 as a Target for Neurodegenerative Diseases |
| Q52689280 | Hypoxia Triggers SENP1 (Sentrin-Specific Protease 1) Modulation of KLF15 (Kruppel-Like Factor 15) and Transcriptional Regulation of Arg2 (Arginase 2) in Pulmonary Endothelium. |
| Q64086693 | Hypoxia and Hypoxia-Inducible Factors in Kidney Injury and Repair |
| Q92918176 | Hypoxia and aging |
| Q33543092 | Hypoxia inactivates the VHL tumor suppressor through PIASy-mediated SUMO modification |
| Q39696500 | Hypoxia inducible factor-1 mediates expression of galectin-1: the potential role in migration/invasion of colorectal cancer cells |
| Q37980646 | Hypoxia inducible factor-1: its potential role in cerebral ischemia |
| Q37464073 | Hypoxia-Inducible Factor Signaling in Pheochromocytoma: Turning the Rudder in the Right Direction |
| Q64070655 | Hypoxia-Inducible Factors and the Regulation of Lipid Metabolism |
| Q24629323 | Hypoxia-Inducible Factors and the Response to Hypoxic Stress |
| Q39669709 | Hypoxia-Inducible Factors: Post-translational Crosstalk of Signaling Pathways |
| Q36994805 | Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation |
| Q38938089 | Hypoxia-induced SUMOylation of E3 ligase HAF determines specific activation of HIF2 in clear-cell renal cell carcinoma. |
| Q27001095 | Hypoxia-inducible factor 1 and its role in viral carcinogenesis |
| Q35535109 | Hypoxia-inducible factor as an angiogenic master switch |
| Q37206879 | Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function |
| Q37837986 | Hypoxia‐inducible factors – regulation, role and comparative aspects in tumourigenesis |
| Q24609166 | Hypoxic regulation of erythropoiesis and iron metabolism |
| Q37636729 | IGF-II induced by hepatitis B virus X protein regulates EMT via SUMO mediated loss of E-cadherin in mice |
| Q36347178 | ING1b negatively regulates HIF1α protein levels in adipose-derived stromal cells by a SUMOylation-dependent mechanism |
| Q37341772 | Identification and Characterization of a New Chemotype of Noncovalent SENP Inhibitors |
| Q24651502 | Identification of an alternative mechanism of degradation of the hypoxia-inducible factor-1alpha |
| Q50631183 | Identification of gene variants associated with hypoxia pathway in acute coronary syndrome: a pilot study |
| Q90741939 | Increased hypoxic proliferative response and gene expression in erythroid progenitor cells of Andean highlanders with chronic mountain sickness |
| Q34299153 | Induction of SENP1 in Endothelial Cells Contributes to Hypoxia-driven VEGF Expression and Angiogenesis |
| Q41759672 | Induction of SENP1 in myocardium contributes to abnormities of mitochondria and cardiomyopathy |
| Q42002257 | Inhibition of SENP1 induces radiosensitization in lung cancer cells |
| Q34566270 | Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1α by inhibiting prolyl-4-hydroxylase PHD2. |
| Q37876539 | Interplay of Hypoxia and A2B Adenosine Receptors in Tissue Protection |
| Q37506973 | Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis |
| Q34348693 | Kainate receptor activation induces glycine receptor endocytosis through PKC deSUMOylation |
| Q39833667 | Kaposi's sarcoma-associated herpesvirus protein LANA2 disrupts PML oncogenic domains and inhibits PML-mediated transcriptional repression of the survivin gene |
| Q37579929 | Kinase-SUMO networks in diabetes-mediated cardiovascular disease |
| Q40189675 | LSD1 demethylates HIF1α to inhibit hydroxylation and ubiquitin-mediated degradation in tumor angiogenesis |
| Q93134158 | Mechanisms of hypoxia signalling: new implications for nephrology |
| Q36527578 | Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis. |
| Q52760987 | MiR-133a-3p Targets SUMO-Specific Protease 1 to Inhibit Cell Proliferation and Cell Cycle Progress in Colorectal Cancer |
| Q36492395 | MicroRNA-146a-mediated downregulation of IRAK1 protects mouse and human small intestine against ischemia/reperfusion injury |
| Q83174357 | Microphthalmia‐associated transcription factor, melanoma, and renal carcinoma: the small ubiquitin‐like modifier connection |
| Q41846179 | Modification of Akt by SUMO conjugation regulates alternative splicing and cell cycle |
| Q34485197 | Modification of Nonstructural Protein 1 of Influenza A Virus by SUMO1 |
| Q38008339 | Molecular mechanisms regulating macrophage response to hypoxia |
| Q38115818 | Molecular targets underlying SUMO‐mediated neuroprotection in brain ischemia |
| Q37644806 | Momordin Ic, a new natural SENP1 inhibitor, inhibits prostate cancer cell proliferation |
| Q52715671 | Montelukast inhibits hypoxia inducible factor-1α translation in prostate cancer cells. |
| Q38811321 | Mps1 is SUMO-modified during the cell cycle |
| Q34790185 | Multiscale modeling of the causal functional roles of nsSNPs in a genome-wide association study: application to hypoxia |
| Q91330018 | NER-factor DDB2 regulates HIF1α and hypoxia-response genes in HNSCC |
| Q38392308 | NF-κB induction of the SUMO protease SENP2: A negative feedback loop to attenuate cell survival response to genotoxic stress. |
| Q34795504 | Negative Regulation of TLR Inflammatory Signaling by the SUMO-deconjugating Enzyme SENP6 |
| Q36382218 | New genetic and physiological factors for excessive erythrocytosis and Chronic Mountain Sickness |
| Q47160346 | Non-Canonical Mechanisms Regulating Hypoxia-Inducible Factor 1 Alpha in Cancer |
| Q37375988 | Nonrenal regulation of EPO synthesis |
| Q54405532 | Normoxic Expression of Hypoxia‐Inducible Factor 1 in Rat Leydig Cells In Vivo and In Vitro |
| Q38599294 | Novel Stat1 Mutation Disrupts Small Ubiquitin-Related Modifier (Sumo) Conjugation Causing Gain Of Function |
| Q27022880 | Novel mechanisms of endothelial mechanotransduction |
| Q64065200 | Nuclear FGFR2 negatively regulates hypoxia-induced cell invasion in prostate cancer by interacting with HIF-1 and HIF-2 |
| Q47701879 | Off-tumor targets compromise antiangiogenic drug sensitivity by inducing kidney erythropoietin production. |
| Q39589034 | Oncogenic Ras abrogates MEK SUMOylation that suppresses the ERK pathway and cell transformation |
| Q49631372 | Osteopontin-integrin engagement induces HIF-1α-TCF12-mediated endothelial-mesenchymal transition to exacerbate colorectal cancer. |
| Q36858606 | Overexpression of SENP3 in oral squamous cell carcinoma and its association with differentiation |
| Q37788021 | Oxygen homeostasis |
| Q29617805 | Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway |
| Q98623257 | PAX6, modified by SUMOylation, plays a protective role in corneal endothelial injury |
| Q24293208 | PIASy stimulates HIF1α SUMOylation and negatively regulates HIF1α activity in response to hypoxia |
| Q37977513 | Perspective in Chronic Kidney Disease: Targeting Hypoxia-Inducible Factor (HIF) as Potential Therapeutic Approach |
| Q47164861 | Plasminogen kringle 5 suppresses gastric cancer via regulating HIF-1α and GRP78. |
| Q39254961 | Prognostic impact of SUMO-specific protease 1 (SENP1) in prostate cancer patients undergoing radical prostatectomy |
| Q21261281 | Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition |
| Q47903181 | Protein Modifications with Ubiquitin as Response to Cerebral Ischemia-Reperfusion Injury |
| Q47099041 | Protein SUMOylation modification and its associations with disease |
| Q38071685 | Protein SUMOylation, an emerging pathway in amyotrophic lateral sclerosis |
| Q38125942 | Protein sumoylation in brain development, neuronal morphology and spinogenesis. |
| Q33636343 | RNAi screen for telomerase reverse transcriptase transcriptional regulators identifies HIF1alpha as critical for telomerase function in murine embryonic stem cells |
| Q39843528 | RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2alpha. |
| Q38879546 | RSRC1 SUMOylation enhances SUMOylation and inhibits transcriptional activity of estrogen receptor β. |
| Q53670511 | RSUME inhibits VHL and regulates its tumor suppressor function |
| Q33655773 | Regulation of DNA repair through deSUMOylation and SUMOylation of replication protein A complex. |
| Q34899616 | Regulation of REGγ cellular distribution and function by SUMO modification |
| Q47145510 | Regulation of Smoothened Trafficking and Hedgehog Signaling by the SUMO Pathway |
| Q37063716 | Regulation of erythropoiesis by hypoxia-inducible factors |
| Q37879983 | Regulation of hypoxia-inducible factor 1 and the loss of the cellular response to hypoxia in diabetes. |
| Q37866139 | Regulation of mammalian target of rapamycin complex 1 (mTORC1) by hypoxia: causes and consequences |
| Q64085901 | Regulation of post-translational modification in breast cancer treatment |
| Q36808685 | Regulation of the sumoylation system in gene expression |
| Q51595101 | Regulators of the hypoxic response: a growing family. |
| Q48333559 | Regulatory mechanisms of hypoxia-inducible factor 1 activity: Two decades of knowledge. |
| Q35610555 | Repression of hypoxia-inducible factor α signaling by Set7-mediated methylation |
| Q33644391 | Retracted: Bcl-2 Regulates HIF-1α Protein Stabilization in Hypoxic Melanoma Cells via the Molecular Chaperone HSP90 |
| Q38950514 | Review and Literature Mining on Proteostasis Factors and Cancer. |
| Q34731201 | Role of SUMO-specific protease 2 in reprogramming cellular glucose metabolism. |
| Q92175147 | Roles and mechanisms of SUMOylation on key proteins in myocardial ischemia/reperfusion injury |
| Q37278125 | SENP1 Is a Crucial Regulator for Cell Senescence through DeSUMOylation of Bmi1. |
| Q54986544 | SENP1 and SENP2 regulate SUMOylation of amyloid precursor protein. |
| Q37281470 | SENP1 deSUMOylates and Regulates Pin1 Protein Activity and Cellular Function |
| Q36262399 | SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α. |
| Q34056043 | SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms |
| Q92859711 | SENP1 is a crucial promotor for hepatocellular carcinoma through deSUMOylation of UBE2T |
| Q34741221 | SENP1 mediates TNF-induced desumoylation and cytoplasmic translocation of HIPK1 to enhance ASK1-dependent apoptosis |
| Q39722920 | SENP1 participates in the dynamic regulation of Elk-1 SUMOylation |
| Q47960028 | SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop |
| Q37697020 | SENP1 promotes proliferation of clear cell renal cell carcinoma through activation of glycolysis |
| Q40476483 | SENP1 regulates IFN-γ-STAT1 signaling through STAT3-SOCS3 negative feedback loop. |
| Q42109613 | SENP1 regulates PTEN stability to dictate prostate cancer development. |
| Q36784044 | SENP1-Mediated Desumoylation of DBC1 Inhibits Apoptosis Induced by High Glucose in Bovine Retinal Pericytes |
| Q33902403 | SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis |
| Q36325236 | SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression |
| Q60921421 | SENP1-mediated deSUMOylation of USP28 regulated HIF-1α accumulation and activation during hypoxia response |
| Q48260130 | SENP1/HIF-1α feedback loop modulates hypoxia-induced cell proliferation, invasion, and EMT in human osteosarcoma cells. |
| Q54286128 | SENP2 Regulates Hepatocellular Carcinoma Cell Growth by Modulating the Stability of β-catenin |
| Q24294664 | SENP2 negatively regulates cellular antiviral response by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation |
| Q39229777 | SENP2 regulates MEF2A de-SUMOylation in an activity dependent manner |
| Q24328747 | SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation |
| Q58795966 | SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation |
| Q50641117 | SENP5, a SUMO isopeptidase, induces apoptosis and cardiomyopathy |
| Q36722154 | SENP‑1 enhances hypoxia‑induced proliferation of rat pulmonary artery smooth muscle cells by regulating hypoxia‑inducible factor‑1α. |
| Q24293305 | SIRT2 regulates tumour hypoxia response by promoting HIF-1α hydroxylation |
| Q38177821 | STAT5 acetylation: Mechanisms and consequences for immunological control and leukemogenesis |
| Q90356763 | STUB1 is targeted by the SUMO-interacting motif of EBNA1 to maintain Epstein-Barr Virus latency |
| Q37820200 | SUMO Losing Balance: SUMO Proteases Disrupt SUMO Homeostasis to Facilitate Cancer Development and Progression |
| Q37415451 | SUMO Modification Stabilizes Enterovirus 71 Polymerase 3D To Facilitate Viral Replication. |
| Q38131751 | SUMO and Parkinson's disease |
| Q39108925 | SUMO and the robustness of cancer |
| Q57286305 | SUMO protease SENP1 deSUMOylates and stabilizes c-Myc |
| Q38132691 | SUMO rules: regulatory concepts and their implication in neurologic functions. |
| Q51758915 | SUMO suppresses and MYC amplifies transcription globally by regulating CDK9 sumoylation. |
| Q34400369 | SUMO--a post-translational modification with therapeutic potential? |
| Q35714635 | SUMO-Specific Protease 1 Is Critical for Early Lymphoid Development through Regulation of STAT5 Activation |
| Q35769614 | SUMO-Specific Protease 2 (SENP2) Is an Important Regulator of Fatty Acid Metabolism in Skeletal Muscle |
| Q39325271 | SUMO-specific protease 1 promotes prostate cancer progression and metastasis |
| Q37603287 | SUMO-specific protease 1 protects neurons from apoptotic death during transient brain ischemia/reperfusion |
| Q36492834 | SUMO-specific protease 1 regulates mitochondrial biogenesis through PGC-1α. |
| Q38956991 | SUMO-specific protease 1 regulates pancreatic cancer cell proliferation and invasion by targeting MMP-9. |
| Q39525345 | SUMO-specific protease 1 regulates the in vitro and in vivo growth of colon cancer cells with the upregulated expression of CDK inhibitors |
| Q28589417 | SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development |
| Q39328325 | SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane |
| Q39598389 | SUMO2 and SUMO3 transcription is differentially regulated by oxidative stress in an Sp1-dependent manner |
| Q34338850 | SUMO2 is essential while SUMO3 is dispensable for mouse embryonic development |
| Q48007300 | SUMOylation Negatively Regulates Angiogenesis by Targeting Endothelial NOTCH Signaling |
| Q37325310 | SUMOylation and De-SUMOylation: wrestling with life's processes |
| Q35961999 | SUMOylation and Ubiquitylation Circuitry Controls Pregnane X Receptor Biology in Hepatocytes |
| Q35002768 | SUMOylation attenuates human β-arrestin 2 inhibition of IL-1R/TRAF6 signaling |
| Q37964361 | SUMOylation in carcinogenesis |
| Q37616739 | SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons. |
| Q58097712 | SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2 |
| Q58771413 | SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis |
| Q36635942 | SUMOylation of pancreatic glucokinase regulates its cellular stability and activity |
| Q35838903 | SUMOylation of sPRDM16 promotes the progression of acute myeloid leukemia |
| Q41299145 | SUMOylation of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 Increases Surface Expression and the Maximal Conductance of the Hyperpolarization-Activated Current |
| Q37216682 | SUMOylation participates in induction of ischemic tolerance |
| Q34505683 | SUMOylation regulates the transcriptional repression activity of FOG-2 and its association with GATA-4. |
| Q26776081 | SUMOylation-Mediated Regulation of Cell Cycle Progression and Cancer |
| Q37415199 | Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease |
| Q37178230 | Senp1 is essential for desumoylating Sumo1-modified proteins but dispensable for Sumo2 and Sumo3 deconjugation in the mouse embryo |
| Q34070458 | Small ubiquitin-like modifier (SUMO) protein-specific protease 1 de-SUMOylates Sharp-1 protein and controls adipocyte differentiation |
| Q36717273 | Small ubiquitin-like modifier 1-3 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival |
| Q37074734 | Small ubiquitin-like modifier protein-specific protease 1 and prostate cancer |
| Q37392596 | Small ubiquitin-like modifiers in cellular malignancy and metastasis |
| Q42604248 | Small ubiquitin-related modifier (SUMO)-1 promotes glycolysis in hypoxia |
| Q43286701 | Small ubiquitin-related modifier paralogs are indispensable but functionally redundant during early development of zebrafish |
| Q37039583 | Stabilization of HIF-1alpha is critical to improve wound healing in diabetic mice |
| Q35178418 | Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells. |
| Q27865263 | Strategies to Identify Recognition Signals and Targets of SUMOylation. |
| Q55100253 | Streptonigrin Inhibits SENP1 and Reduces the Protein Level of Hypoxia-Inducible Factor 1α (HIF1α) in Cells. |
| Q38645482 | Stromal Senp1 promotes mouse early folliculogenesis by regulating BMP4 expression |
| Q27652201 | Structure of the Human SENP7 Catalytic Domain and Poly-SUMO Deconjugation Activities for SENP6 and SENP7 |
| Q39107046 | Sub-cellular localization specific SUMOylation in the heart |
| Q30512526 | Sumoylated BubR1 plays an important role in chromosome segregation and mitotic timing |
| Q27318485 | Sumoylated NHR-25/NR5A regulates cell fate during C. elegans vulval development |
| Q37097348 | Sumoylation and regulation of cardiac gene expression |
| Q38757476 | Sumoylation in Craniofacial Disorders |
| Q39271257 | Sumoylation is important for stability, subcellular localization, and transcriptional activity of SALL4, an essential stem cell transcription factor. |
| Q28477335 | Sumoylation of Hypoxia-Inducible Factor-1α Ameliorates Failure of Brain Stem Cardiovascular Regulation in Experimental Brain Death |
| Q30636955 | Sumoylation of Kif18A plays a role in regulating mitotic progression |
| Q38219255 | Sumoylation of hypoxia inducible factor-1α and its significance in cancer |
| Q34107383 | Sumoylation regulates interaction of FOG1 with C-terminal-binding protein (CTBP) |
| Q37744859 | Sumoylation-deficient Prdx6 gains protective function by amplifying enzymatic activity and stability and escapes oxidative stress-induced aberrant Sumoylation |
| Q47799714 | Sumoylation: Implications for Neurodegenerative Diseases |
| Q55039544 | TRPV1 SUMOylation regulates nociceptive signaling in models of inflammatory pain. |
| Q34286796 | Targeted genes and interacting proteins of hypoxia inducible factor-1 |
| Q34620966 | The Bmi‐1/NF‐κB/VEGF story: another hint for proteasome involvement in glioma angiogenesis? |
| Q42759370 | The In Vivo Functions of Desumoylating Enzymes |
| Q36866696 | The Local HIF-2α/EPO Pathway in the Bone Marrow is Associated with Excessive Erythrocytosis and the Increase in Bone Marrow Microvessel Density in Chronic Mountain Sickness |
| Q58799984 | The Protein Phosphatase PPM1G Destabilizes HIF-1α Expression |
| Q33649507 | The Role of the Small Ubiquitin-Related Modifier (SUMO) Pathway in Prostate Cancer |
| Q57022065 | The SUMO protease SENP1 and the chromatin remodeler CHD3 interact and jointly affect chromatin accessibility and gene expression |
| Q28593689 | The Small Ubiquitin-like Modifier-Deconjugating Enzyme Sentrin-Specific Peptidase 1 Switches IFN Regulatory Factor 8 from a Repressor to an Activator during Macrophage Activation |
| Q38060406 | The Warburg effect: Insights from the past decade |
| Q38122985 | The complexity of recognition of ubiquitinated substrates by the 26S proteasome |
| Q33770904 | The critical role of SENP1-mediated GATA2 deSUMOylation in promoting endothelial activation in graft arteriosclerosis |
| Q43079289 | The expanding universe of hypoxia |
| Q30397629 | The expression of hypoxia-inducible factor-1α gene is not affected by low-oxygen conditions in yellow perch (Perca flavescens) juveniles. |
| Q35543918 | The hypoxia signaling pathway and hypoxic adaptation in fishes |
| Q38057666 | The lysine48-based polyubiquitin chain proteasomal signal: not a single child anymore |
| Q35706611 | The prognostic value of SUMO1/Sentrin specific peptidase 1 (SENP1) in prostate cancer is limited to ERG-fusion positive tumors lacking PTEN deletion |
| Q33914603 | The role of hypoxia inducible factor-1 in hepatocellular carcinoma |
| Q37381217 | The role of the ubiquitin proteasome system in ischemia and ischemic tolerance |
| Q33813039 | The ubiquitin ligase Siah2 and the hypoxia response |
| Q37807639 | The ubiquitous role of ubiquitin in the DNA damage response |
| Q36001994 | The updated biology of hypoxia-inducible factor |
| Q36355518 | Transcriptional Profile and Structural Conservation of SUMO-Specific Proteases inSchistosoma mansoni |
| Q37660872 | Transcriptional repression of estrogen receptor α signaling by SENP2 in breast cancer cells. |
| Q28484018 | Triptolide Inhibits the Proliferation of Prostate Cancer Cells and Down-Regulates SUMO-Specific Protease 1 Expression |
| Q53276128 | Tumor strengths and frailties: Cancer SUMmOns Otto's metabolism |
| Q37059658 | Turn me on: regulating HIF transcriptional activity. |
| Q36920252 | Two distinct sites in Nup153 mediate interaction with the SUMO proteases SENP1 and SENP2. |
| Q24315889 | Ubc9 acetylation modulates distinct SUMO target modification and hypoxia response |
| Q38663141 | Ubiquitin and ubiquitin-like proteins in cardiac disease and protection |
| Q42535352 | Ubiquitin, infinitely seductive: symposium on the many faces of ubiquitin. |
| Q88792005 | Ultrasound-Enhanced Protective Effect of Tetramethylpyrazine via the ROS/HIF-1A Signaling Pathway in an in Vitro Cerebral Ischemia/Reperfusion Injury Model |
| Q24625492 | Whole-genome sequencing uncovers the genetic basis of chronic mountain sickness in Andean highlanders |
| Q38182534 | Wrestling with stress: roles of protein SUMOylation and deSUMOylation in cell stress response |
| Q91940275 | Writing and erasing MYC ubiquitination and SUMOylation |
| Q34489192 | Xanthine oxidoreductase promotes the inflammatory state of mononuclear phagocytes through effects on chemokine expression, peroxisome proliferator-activated receptor-{gamma} sumoylation, and HIF-1{alpha} |
| Q50080229 | deSUMOylation signaling: a novel mechanism of liver CSC properties and hepatocarcinogenesis in hypoxia |
| Q64100298 | mRNA-to-protein translation in hypoxia |
| Q34418791 | mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α |
| Q64074421 | von Hippel-Lindau mutants in renal cell carcinoma are regulated by increased expression of RSUME |
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