| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2010PLoSO...5.9720C |
| P356 | DOI | 10.1371/JOURNAL.PONE.0009720 |
| P932 | PMC publication ID | 2838797 |
| P698 | PubMed publication ID | 20300531 |
| P5875 | ResearchGate publication ID | 42346079 |
| P50 | author | Subhash Verma | Q57951657 |
| Qiliang Cai | Q88570720 | ||
| Erle S Robertson | Q88590600 | ||
| P2093 | author name string | Pankaj Kumar | |
| Michelle Ma | |||
| P2860 | cites work | Von Hippel-Lindau disease | Q51971299 |
| SUMOylation of hypoxia-inducible factor-1alpha reduces its transcriptional activity | Q51981644 | ||
| Ser80Ile mutation and a concurrent Pro25Leu variant of the VHL gene in an extended Hungarian von Hippel-Lindau family | Q59823105 | ||
| pVHL: a multipurpose adaptor protein | Q81470388 | ||
| Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function | Q22009393 | ||
| The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis | Q22009936 | ||
| A conserved family of prolyl-4-hydroxylases that modify HIF | Q24291794 | ||
| Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking | Q24295186 | ||
| RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia | Q24298480 | ||
| SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia | Q24299542 | ||
| NEDD8 acts as a 'molecular switch' defining the functional selectivity of VHL | Q24321579 | ||
| Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity | Q24531180 | ||
| Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL | Q24634352 | ||
| pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2 | Q24684757 | ||
| Function and regulation of cullin-RING ubiquitin ligases | Q28131707 | ||
| HIF-1 and human disease: one highly involved factor | Q28144179 | ||
| SUMO: a history of modification | Q28243325 | ||
| The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosis | Q28247891 | ||
| Specific Inhibition of Stat3 Signal Transduction by PIAS3 | Q28255665 | ||
| SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation | Q28282094 | ||
| MG53 nucleates assembly of cell membrane repair machinery. | Q28511885 | ||
| Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein | Q29615928 | ||
| Identification of the von Hippel-Lindau disease tumor suppressor gene | Q29618644 | ||
| SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting | Q29619527 | ||
| EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressors | Q33261811 | ||
| Increase of SUMO-1 expression in response to hypoxia: direct interaction with HIF-1alpha in adult mouse brain and heart in vivo | Q33289386 | ||
| ATM activates p53 by regulating MDM2 oligomerization and E3 processivity | Q33552958 | ||
| The role of oxygen availability in embryonic development and stem cell function | Q33876311 | ||
| A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking | Q33890625 | ||
| SP-RING for SUMO: new functions bloom for a ubiquitin-like protein | Q34094595 | ||
| HIF-1 and mechanisms of hypoxia sensing | Q34180645 | ||
| Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL. | Q34530199 | ||
| p53 stabilization and transactivation by a von Hippel-Lindau protein | Q34567288 | ||
| The von Hippel-Lindau Tumor Suppressor Protein Is Required for Proper Assembly of an Extracellular Fibronectin Matrix | Q34748818 | ||
| pVHL 19 is a biologically active product of the von Hippel–Lindau gene arising from internal translation initiation | Q34753344 | ||
| A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor. | Q36222472 | ||
| Ubiquitylation and cell signaling | Q36251951 | ||
| Hypoxia signalling in cancer and approaches to enforce tumour regression | Q36488739 | ||
| The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress | Q36540303 | ||
| Oligomerization of BAK by p53 utilizes conserved residues of the p53 DNA binding domain | Q36777990 | ||
| pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development | Q37275211 | ||
| PIAS proteins modulate transcription factors by functioning as SUMO-1 ligases. | Q39695522 | ||
| RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2alpha. | Q39843528 | ||
| p53 Oligomerization is essential for its C-terminal lysine acetylation | Q39902123 | ||
| A potential alpha-helix motif in the amino terminus of LANA encoded by Kaposi's sarcoma-associated herpesvirus is critical for nuclear accumulation of HIF-1alpha in normoxia | Q40106826 | ||
| Sumoylation of Oct4 enhances its stability, DNA binding, and transactivation. | Q40128108 | ||
| C-terminal modifications regulate MDM2 dissociation and nuclear export of p53. | Q40157263 | ||
| PIASy mediates NEMO sumoylation and NF-kappaB activation in response to genotoxic stress. | Q40244068 | ||
| von Hippel-Lindau gene-mediated growth suppression and induction of differentiation in renal cell carcinoma cells grown as multicellular tumor spheroids. | Q40995797 | ||
| Tumour suppression by the human von Hippel-Lindau gene product | Q41320477 | ||
| Mutations of the VHL tumour suppressor gene in renal carcinoma | Q42806703 | ||
| Sumoylation increases HIF-1alpha stability and its transcriptional activity | Q45090303 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 3 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | hypoxia | Q105688 |
| P304 | page(s) | e9720 | |
| P577 | publication date | 2010-03-16 | |
| P1433 | published in | PLOS One | Q564954 |
| P1476 | title | Hypoxia inactivates the VHL tumor suppressor through PIASy-mediated SUMO modification | |
| P478 | volume | 5 |
| Q36089988 | A novel VHLα isoform inhibits Warburg effect via modulation of PKM splicing |
| Q39091679 | A role for paralog-specific sumoylation in histone deacetylase 1 stability |
| Q28535343 | A unique SUMO-2-interacting motif within LANA is essential for KSHV latency |
| Q38459546 | Computational genomic analysis of PARK7 interactome reveals high BBS1 gene expression as a prognostic factor favoring survival in malignant pleural mesothelioma. |
| Q91208644 | DUBs, Hypoxia, and Cancer |
| Q64081971 | Genotype-phenotype relations of the von Hippel-Lindau tumor suppressor inferred from a large-scale analysis of disease mutations and interactors |
| Q37026526 | Global SUMOylation facilitates the multimodal neuroprotection afforded by quercetin against the deleterious effects of oxygen/glucose deprivation and the restoration of oxygen/glucose. |
| Q38112399 | HIF expression and the role of hypoxic microenvironments within primary tumours as protective sites driving cancer stem cell renewal and metastatic progression |
| Q38886697 | HIF-1α SUMOylation affects the stability and transcriptional activity of HIF-1α in human lens epithelial cells. |
| Q38844323 | Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis |
| Q38938089 | Hypoxia-induced SUMOylation of E3 ligase HAF determines specific activation of HIF2 in clear-cell renal cell carcinoma. |
| Q36347178 | ING1b negatively regulates HIF1α protein levels in adipose-derived stromal cells by a SUMOylation-dependent mechanism |
| Q33743831 | Inhibition of KAP1 enhances hypoxia-induced Kaposi's sarcoma-associated herpesvirus reactivation through RBP-Jκ. |
| Q41242833 | Interaction between von Hippel-Lindau Protein and Fatty Acid Synthase Modulates Hypoxia Target Gene Expression. |
| Q34233804 | Microtubular Stability Affects pVHL-Mediated Regulation of HIF-1alpha via the p38/MAPK Pathway in Hypoxic Cardiomyocytes |
| Q35124404 | Molecular Biology of Kaposi's Sarcoma-associated Herpesvirus and Related Oncogenesis |
| Q38115818 | Molecular targets underlying SUMO‐mediated neuroprotection in brain ischemia |
| Q56860538 | PIAS4 SUMOylates VHL with SUMO1 |
| Q37214337 | PIAS4 is an activator of hypoxia signalling via VHL suppression during growth of pancreatic cancer cells. |
| Q35101075 | Proline-hydroxylated hypoxia-inducible factor 1α (HIF-1α) upregulation in human tumours |
| Q21261281 | Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition |
| Q42358402 | Protein inhibitor of activated STAT 4 (PIAS4) regulates liver fibrosis through modulating SMAD3 activity |
| Q37536430 | Protein inhibitor of activated STAT 4 (PIAS4) regulates pro-inflammatory transcription in hepatocytes by repressing SIRT1. |
| Q53670511 | RSUME inhibits VHL and regulates its tumor suppressor function |
| Q27010433 | Regulation of epithelial-mesenchymal transition through SUMOylation of transcription factors |
| Q37697020 | SENP1 promotes proliferation of clear cell renal cell carcinoma through activation of glycolysis |
| Q39108925 | SUMO and the robustness of cancer |
| Q38132691 | SUMO rules: regulatory concepts and their implication in neurologic functions. |
| Q33988687 | SUMOylation of DEC1 protein regulates its transcriptional activity and enhances its stability |
| Q63884152 | SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer |
| Q47969789 | Sumoylation regulates nuclear localization and function of zinc finger transcription factor ZIC3 |
| Q36432039 | TLX controls angiogenesis through interaction with the von Hippel-Lindau protein |
| Q39768470 | The activity of the glucocorticoid receptor is regulated by SUMO conjugation to FKBP51. |
| Q39149819 | The sumoylation of zinc-fingers and homeoboxes 1 (ZHX1) by ubc9 regulates its stability and transcriptional repression activity |
| Q31153788 | Tomosyn interacts with the SUMO E3 ligase PIASγ. |
| Q41287854 | Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming. |
| Q36264188 | Towards standardization of next-generation sequencing of FFPE samples for clinical oncology: intrinsic obstacles and possible solutions. |
| Q51327165 | Tuberous sclerosis complex protein 1 expression is affected by VHL Gene alterations and HIF-1α production in sporadic clear-cell renal cell carcinoma |
| Q34115236 | Ubiquitin/SUMO Modification Regulates VHL Protein Stability and Nucleocytoplasmic Localization |
| Q90728665 | VHL Dependent Expression of REDD1 and PDK3 Proteins in Clear-cell Renal Cell Carcinoma |
| Q36905755 | Wogonin inhibits multiple myeloma-stimulated angiogenesis via c-Myc/VHL/HIF-1α signaling axis |
| Q64074421 | von Hippel-Lindau mutants in renal cell carcinoma are regulated by increased expression of RSUME |
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