p53 Oligomerization is essential for its C-terminal lysine acetylation

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p53 Oligomerization is essential for its C-terminal lysine acetylation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M805696200
P932PMC publication ID2643511
P698PubMed publication ID19106109

P50authorHengming KeQ61519113
P2093author name stringYanping Zhang
Yoko Itahana
P2860cites workSynergistic activation of transcription by CBP and p53Q24311979
Binding and modulation of p53 by p300/CBP coactivatorsQ24312018
Acetylation is indispensable for p53 activationQ24313477
p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damageQ24530584
Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53Q24681065
Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstromsQ27730393
High-resolution structure of the oligomerization domain of p53 by multidimensional NMRQ27730817
Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domainQ27860534
Surfing the p53 networkQ28032484
Deacetylation of p53 modulates its effect on cell growth and apoptosisQ28138967
p53 Transcriptional activity is mediated through the SRC1-interacting domain of CBP/p300Q28215076
Recruitment of p300/CBP in p53-dependent signal pathwaysQ28243213
Identification of p53 as a sequence-specific DNA-binding proteinQ28282745
p300/MDM2 complexes participate in MDM2-mediated p53 degradationQ28288274
Identification of a signal for rapid export of proteins from the nucleusQ29547742
DNA damage activates p53 through a phosphorylation-acetylation cascadeQ29616294
A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES maskingQ33890625
p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.Q34585107
Sequence-specific transcriptional activation is essential for growth suppression by p53.Q35086763
Nucleocytoplasmic shuttling of p53 is essential for MDM2-mediated cytoplasmic degradation but not ubiquitinationQ35920894
Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivoQ36601373
Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitinationQ39540284
C-terminal modifications regulate MDM2 dissociation and nuclear export of p53.Q40157263
A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylationQ40800224
A bipartite nuclear localization signal is required for p53 nuclear import regulated by a carboxyl-terminal domainQ40919270
A previously undescribed mutation within the tetramerisation domain of TP53 in a family with Li-Fraumeni syndrome.Q41192792
Acetylation of the p53 DNA-binding domain regulates apoptosis inductionQ43019120
Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosisQ45345472
Binding of p53 to the KIX domain of CREB binding protein. A potential link to human T-cell leukemia virus, type I-associated leukemogenesisQ45747438
Mechanistic insights into maintenance of high p53 acetylation by PTEN.Q46035699
Ubiquitin-dependent distribution of the transcriptional coactivator p300 in cytoplasmic inclusion bodiesQ46927285
Li-Fraumeni and related syndromes: correlation between tumor type, family structure, and TP53 genotypeQ47418527
High levels of cytoplasmic HTLV-1 Tax mutant proteins retain a Tax-NF-kappaB-CBP ternary complex in the cytoplasm.Q55239504
Phosphorylation of serine 392 stabilizes the tetramer formation of tumor suppressor protein p53Q73581630
Mechanism of folding and assembly of a small tetrameric protein domain from tumor suppressor p53Q74523797
Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferasesQ77456357
Murine double minute (MDM2) blocks p53-coactivator interaction, a new mechanism for inhibition of p53-dependent gene expressionQ77726350
Tandem dimerization of the human p53 tetramerization domain stabilizes a primary dimer intermediate and dramatically enhances its oligomeric stabilityQ79368912
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)5158-5164
P577publication date2008-12-23
P1433published inJournal of Biological ChemistryQ867727
P1476titlep53 Oligomerization is essential for its C-terminal lysine acetylation
P478volume284

Reverse relations

cites work (P2860)
Q41596857A new era of studying p53-mediated transcription activation
Q61798584A new technique for predicting intrinsically disordered regions based on average distance map constructed with inter-residue average distance statistics
Q35050674An acetyl-methyl switch drives a conformational change in p53.
Q51524331Analysis of Protein Oligomerization by Electrophoresis.
Q36486911Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress
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Q28510522Deacetylation of p53 induces autophagy by suppressing Bmf expression
Q37636699Delphinidin induces apoptosis via cleaved HDAC3-mediated p53 acetylation and oligomerization in prostate cancer cells
Q37697035Evaluation of potential interactions between the metastasis-associated protein S100A4 and the tumor suppressor protein p53.
Q37428803Extensive post-translational modification of active and inactivated forms of endogenous p53.
Q38250144Further evidence for pathogenicity of the TP53 tetramerization domain mutation p.Arg342Pro in Li-Fraumeni syndrome
Q34968621Fuse binding protein antagonizes the transcription activity of tumor suppressor protein p53.
Q36207381Genomic profiling of multiple sequentially acquired tumor metastatic sites from an "exceptional responder" lung adenocarcinoma patient reveals extensive genomic heterogeneity and novel somatic variants driving treatment response
Q33543092Hypoxia inactivates the VHL tumor suppressor through PIASy-mediated SUMO modification
Q38769335Lysines in the tetramerization domain of p53 selectively modulate G1 arrest
Q45302322Modifications of p53 and the DNA damage response in cells expressing mutant form of the protein huntingtin
Q91626701Mutant and Wild-Type Tumor Suppressor p53 Induces p300 Autoacetylation
Q41993999NEURL4 regulates the transcriptional activity of tumor suppressor protein p53 by modulating its oligomerization.
Q51636057Planck-Benzinger thermal work function: thermodynamic characterization of the carboxy-terminus of p53 peptide fragments.
Q36075403Regulation of p53 oligomerization by Ras superfamily protein RBEL1A
Q24294804S100A4 interacts with p53 in the nucleus and promotes p53 degradation
Q41768808Single-Molecule characterization of oligomerization kinetics and equilibria of the tumor suppressor p53
Q27657730Structural evolution of p53, p63, and p73: Implication for heterotetramer formation
Q35967111Surf the post-translational modification network of p53 regulation
Q39005319The E3 ubiquitin protein ligase HERC2 modulates the activity of tumor protein p53 by regulating its oligomerization
Q42322261The HERC2 ubiquitin ligase is essential for embryonic development and regulates motor coordination.
Q40649350The Protein Acetyltransferase PatZ from Escherichia coli Is Regulated by Autoacetylation-induced Oligomerization
Q37596345The nucleolar protein Myb-binding protein 1A (MYBBP1A) enhances p53 tetramerization and acetylation in response to nucleolar disruption
Q39495822The pathogenic Escherichia coli type III secreted protease NleC degrades the host acetyltransferase p300.
Q47742599Therapeutic targeting of p53: all mutants are equal, but some mutants are more equal than others
Q38804776Tris-acetate polyacrylamide gradient gel electrophoresis for the analysis of protein oligomerization.
Q37318326Ultraslow oligomerization equilibria of p53 and its implications
Q52651294Wild-type and cancer-related p53 proteins are preferentially degraded by MDM2 as dimers rather than tetramers.
Q34384524p53 Dimers associate with a head-to-tail response element to repress cyclin B transcription
Q28079390p53 Proteoforms and Intrinsic Disorder: An Illustration of the Protein Structure-Function Continuum Concept
Q38740246p53 oligomerization status modulates cell fate decisions between growth, arrest and apoptosis.
Q36567469p53 sumoylation: mechanistic insights from reconstitution studies

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