| scholarly article | Q13442814 |
| P356 | DOI | 10.1182/BLOOD-2009-05-189985 |
| P8608 | Fatcat ID | release_bip3ykxl25bh3ia7otnzxnieli |
| P698 | PubMed publication ID | 19494350 |
| P5875 | ResearchGate publication ID | 26264756 |
| P50 | author | Gregg L. Semenza | Q1545025 |
| P2860 | cites work | The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis | Q22009936 |
| HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing | Q24291102 | ||
| C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation | Q24291783 | ||
| A conserved family of prolyl-4-hydroxylases that modify HIF | Q24291794 | ||
| FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity | Q24291819 | ||
| A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation | Q24294741 | ||
| OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha | Q24295172 | ||
| SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia | Q24299542 | ||
| FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor | Q24300161 | ||
| Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension | Q24307473 | ||
| Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells | Q24314526 | ||
| A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis | Q24536498 | ||
| Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2) | Q24550960 | ||
| HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation | Q24555773 | ||
| Novel exon 12 mutations in the HIF2A gene associated with erythrocytosis | Q24649372 | ||
| A gain-of-function mutation in the HIF2A gene in familial erythrocytosis | Q24654396 | ||
| Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay | Q24671869 | ||
| HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia | Q24671941 | ||
| A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development | Q24681396 | ||
| A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove | Q24684178 | ||
| Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation | Q27860876 | ||
| Vascular complications in Chuvash polycythemia | Q28217478 | ||
| Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology | Q28218986 | ||
| Hydroxylation of hypoxia-inducible transcription factors and chemical compounds targeting the HIF-alpha hydroxylases | Q28236323 | ||
| Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α | Q28259513 | ||
| Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha | Q28508120 | ||
| HIF-1 alpha is required for solid tumor formation and embryonic vascularization. | Q28588778 | ||
| Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha | Q28590776 | ||
| The HIF family member EPAS1/HIF-2α is required for normal hematopoiesis in mice | Q28591832 | ||
| Acute postnatal ablation of Hif-2alpha results in anemia | Q28591898 | ||
| Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development | Q28593302 | ||
| Purification and characterization of hypoxia-inducible factor 1 | Q28678375 | ||
| Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes | Q29617594 | ||
| Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia | Q34157665 | ||
| Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha | Q34635842 | ||
| Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). | Q35826597 | ||
| von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis | Q36121776 | ||
| Signalling hypoxia by HIF hydroxylases | Q36247647 | ||
| O2 sensing at the mammalian carotid body: why multiple O2 sensors and multiple transmitters? | Q36292583 | ||
| Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins | Q36491878 | ||
| Control of erythropoietin gene expression and its use in medicine | Q36999068 | ||
| Biology of hypoxia-inducible factor-2alpha in development and disease | Q37079716 | ||
| Genetic mechanisms underlying regulation of hemoglobin mass. | Q37082668 | ||
| Regulation of oxygen homeostasis by hypoxia-inducible factor 1. | Q37443475 | ||
| Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene | Q37541263 | ||
| Functional analysis of an oxygen-regulated transcriptional enhancer lying 3' to the mouse erythropoietin gene | Q37630413 | ||
| HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels | Q38346980 | ||
| Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells | Q40538152 | ||
| Oxygen-regulated Transferrin Expression Is Mediated by Hypoxia-inducible Factor-1 | Q41094584 | ||
| A novel heterozygous HIF2AM535I mutation reinforces the role of oxygen sensing pathway disturbances in the pathogenesis of familial erythrocytosis. | Q46570730 | ||
| Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury | Q47849035 | ||
| Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia | Q48420875 | ||
| Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs. | Q48422889 | ||
| Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. | Q51614218 | ||
| Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. | Q52195684 | ||
| Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension | Q71738016 | ||
| Transferrin receptor induction by hypoxia. HIF-1-mediated transcriptional activation and cell-specific post-transcriptional regulation | Q78122332 | ||
| Identification of a hypoxia response element in the transferrin receptor gene | Q78122337 | ||
| P433 | issue | 10 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | oxygen sensing | Q69984017 |
| P304 | page(s) | 2015-2019 | |
| P577 | publication date | 2009-06-03 | |
| P13046 | publication type of scholarly work | review article | Q7318358 |
| P1433 | published in | Blood | Q885070 |
| P1476 | title | Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis | |
| P478 | volume | 114 |
| Q52657647 | A novel splicing site IRP1 somatic mutation in a patient with pheochromocytoma and JAK2V617F positive polycythemia vera: a case report. |
| Q36290223 | Adipocyte iron regulates adiponectin and insulin sensitivity |
| Q38904398 | Advances in understanding the mechanisms of erythropoiesis in homeostasis and disease. |
| Q34156703 | An acetate switch regulates stress erythropoiesis |
| Q38107279 | Anaemia in chronic obstructive pulmonary disease. Does it really matter? |
| Q34024015 | Analysis of Hypoxia and Hypoxia-Like States through Metabolite Profiling |
| Q35683322 | Association of the von Hippel–Lindau Protein with AUF1 and Posttranscriptional Regulation of VEGFA mRNA |
| Q37276012 | Blood gas analysis and cooximetry in retired racing Greyhounds |
| Q54428734 | Cellular and molecular mechanisms regulating the hepatic erythropoietin expression during acute-phase response: a role for IL-6. |
| Q94553053 | Detecting anaemia at high altitude |
| Q34672190 | Development of Lymphoproliferative Diseases by Hypoxia Inducible Factor-1alpha Is Associated with Prolonged Lymphocyte Survival |
| Q33916552 | Dietary iron restriction or iron chelation protects from diabetes and loss of beta-cell function in the obese (ob/ob lep-/-) mouse |
| Q38989123 | Direct phosphorylation events involved in HIF-α regulation: the role of GSK-3β. |
| Q34614742 | Distinct regulatory mechanisms of the human ferritin gene by hypoxia and hypoxia mimetic cobalt chloride at the transcriptional and post-transcriptional levels |
| Q50036957 | Does Renal Tubular Injury-Induced Local Tissue Hypoxia Involve Post-Transplantation Erythrocytosis? |
| Q43623723 | Dose-related Differences in the Pharmacodynamic and Toxicologic Response to a Novel Hyperglycosylated Analog of Recombinant Human Erythropoietin in Sprague-Dawley Rats with Similarly High Hematocrit |
| Q35585864 | Duodenal cytochrome b (DCYTB) in iron metabolism: an update on function and regulation. |
| Q92391500 | Dynamics of Prolyl Hydroxylases Levels During Disease Progression in Experimental Colitis |
| Q38672565 | Effect of hypoxia-inducible factors in normal and leukemic stem cell regulation and their potential therapeutic impact. |
| Q33907747 | Erythropoietin action in stress response, tissue maintenance and metabolism |
| Q35909929 | Erythropoietin in Brain Development and Beyond |
| Q45267182 | Erythropoietin production in neuroepithelial and neural crest cells during primitive erythropoiesis |
| Q33789378 | Erythropoietin signaling: a novel regulator of white adipose tissue inflammation during diet-induced obesity |
| Q33721268 | Ethnically Tibetan women in Nepal with low hemoglobin concentration have better reproductive outcomes |
| Q39516088 | Evaluation of the Combined Effect of 2ME2 and (60)Co on the Inducement of DNA Damage by IUdR in a Spheroid Model of the U87MG Glioblastoma Cancer Cell Line Using Alkaline Comet Assay |
| Q34230954 | Genetic determinants of Tibetan high-altitude adaptation. |
| Q37679350 | HIF and pulmonary vascular responses to hypoxia |
| Q28583933 | HIF-1 inhibition decreases systemic vascular remodelling diseases by promoting apoptosis through a hexokinase 2-dependent mechanism |
| Q33404963 | HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis |
| Q36006369 | Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis |
| Q35207617 | Hepcidin: A Critical Regulator of Iron Metabolism during Hypoxia |
| Q42938320 | Hereditary myeloproliferative disorders |
| Q46659572 | High-altitude adaptation in humans: from genomics to integrative physiology |
| Q58394252 | Human Adaptation to Climate: Temperature, Ultraviolet Radiation, and Altitude |
| Q36594429 | Human prolyl hydroxylase expression in uterine leiomyoma during the menstrual cycle |
| Q24298032 | Hypoxia and cell cycle regulation of the von Hippel-Lindau tumor suppressor |
| Q92002424 | Hypoxia inducible factor 1α in vascular smooth muscle cells promotes angiotensin II-induced vascular remodeling via activation of CCL7-mediated macrophage recruitment |
| Q33619166 | Hypoxia regulates BMP4 expression in the murine spleen during the recovery from acute anemia |
| Q92767464 | Hypoxia-induced human deoxyribonuclease I is a cellular restriction factor of hepatitis B virus |
| Q38104118 | Hypoxia-inducible factor pathway and diseases of the vascular wall |
| Q37306773 | Hypoxia-inducible factor-1α(Pro-582-Ser) polymorphism prevents iron deprivation in healthy blood donors. |
| Q93015669 | Impaired Neovascularization in Aging |
| Q39433660 | Inactivation of prolyl hydroxylase domain (PHD) protein by epigallocatechin (EGCG) stabilizes hypoxia-inducible factor (HIF-1α) and induces hepcidin (Hamp) in rat kidney |
| Q53677192 | Increased activation of the hypoxia-inducible factor pathway in varicose veins |
| Q39545175 | Induction of hypoxia inducible factor (HIF-1α) in rat kidneys by iron chelation with the hydroxypyridinone, CP94 |
| Q35907071 | Integrating physiological regulation with stem cell and tissue homeostasis |
| Q33844026 | Iron Loading and Overloading due to Ineffective Erythropoiesis |
| Q41939471 | Isolated erythrocytosis: study of 67 patients and identification of three novel germ-line mutations in the prolyl hydroxylase domain protein 2 (PHD2) gene |
| Q27317145 | Isolation and Characterization of Renal Erythropoietin-Producing Cells from Genetically Produced Anemia Mice |
| Q21133953 | Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells |
| Q50991360 | Leukemia kidney infiltration can cause secondary polycythemia by activating hypoxia-inducible factor (HIF) pathway |
| Q57749735 | Long-term oxygen therapy |
| Q35607284 | Maxi- and Mini-Ferritins: Minerals and Protein Nanocages |
| Q38520206 | Metabolic aspects of high-altitude adaptation in Tibetans. |
| Q24601095 | MicroRNA-210: a unique and pleiotropic hypoxamir |
| Q35787451 | Middle cerebral artery alterations in a rat chronic hypoperfusion model |
| Q26781641 | Mitochondria-controlled signaling mechanisms of brain protection in hypoxia |
| Q37737808 | Molecular basis of hereditary iron homeostasis defects |
| Q28297656 | Molecular mechanisms of action and therapeutic uses of pharmacological inhibitors of HIF-prolyl 4-hydroxylases for treatment of ischemic diseases |
| Q52406843 | Mouse models of gallstone disease |
| Q54337878 | Mutations profile of polycythemia vera and essential thrombocythemia among Japanese children |
| Q34377146 | NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment |
| Q33961430 | Negative autoregulation by Fas stabilizes adult erythropoiesis and accelerates its stress response |
| Q37399954 | Nickel-free stainless steel avoids neointima formation following coronary stent implantation |
| Q33993973 | Novel approach to reactive oxygen species in nontransfusion-dependent thalassemia |
| Q39642324 | Old proteins - new locations: myoglobin, haemoglobin, neuroglobin and cytoglobin in solid tumours and cancer cells. |
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| Q92702306 | Pheochromocytomas and Paragangliomas: From Genetic Diversity to Targeted Therapies |
| Q52921858 | Polycythemia following allogeneic hematopoietic progenitor cell transplantation occurring during iron chelation therapy |
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