pVHL acts as a downstream target of E2F1 to suppress E2F1 activity

scientific article

pVHL acts as a downstream target of E2F1 to suppress E2F1 activity is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1042/BJ20130793
P698PubMed publication ID24112038

P2093author name stringWei Zhang
Jing Wang
Wei Ji
Xing Liu
Wuhan Xiao
Gang Ouyang
P2860cites workThe tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysisQ22009936
Hypoxia and cell cycle regulation of the von Hippel-Lindau tumor suppressorQ24298032
Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damageQ24299098
Chk2 activates E2F-1 in response to DNA damageQ24300634
Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activationQ24318303
TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survivalQ24627319
Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complexQ24654714
A system for stable expression of short interfering RNAs in mammalian cellsQ27860875
Retinoblastoma protein recruits histone deacetylase to repress transcriptionQ28262144
Rb Interacts with Histone Deacetylase to Repress TranscriptionQ28263985
Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor proteinQ29615931
E2f1-3 switch from activators in progenitor cells to repressors in differentiating cellsQ33589421
E2F-1 Directly Regulates Thrombospondin 1 ExpressionQ33728451
Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27.Q33837015
p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death.Q33972469
Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.Q34091273
Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL.Q34530199
p53 stabilization and transactivation by a von Hippel-Lindau proteinQ34567288
E2F1 pathways to apoptosisQ34922303
Emerging roles of E2Fs in cancer: an exit from cell cycle controlQ35009182
The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis.Q35036600
The E2F family: specific functions and overlapping interestsQ35945854
Regulation of E2F through ubiquitin-proteasome-dependent degradation: stabilization by the pRB tumor suppressor proteinQ36034460
Defective placental vasculogenesis causes embryonic lethality in VHL-deficient miceQ36551258
Transcriptional and Nontranscriptional Functions of E2F1 in Response to DNA DamageQ36584712
The von hippel-lindau tumor suppressor protein: an updateQ36999097
Multitasking by pVHL in tumour suppressionQ37002154
Cellular mechanisms of tumour suppression by the retinoblastoma gene.Q37225340
Conserved functions of the pRB and E2F familiesQ37249375
Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesisQ37506973
Translating DNA damage into cancer cell death-A roadmap for E2F1 apoptotic signalling and opportunities for new drug combinations to overcome chemoresistanceQ37776932
Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysisQ38299703
Expression analysis using DNA microarrays demonstrates that E2F-1 up-regulates expression of DNA replication genes including replication protein A2.Q38301658
E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis.Q38304702
Lysine methylation regulates E2F1-induced cell deathQ39684254
Regulation of E2F1 activity by acetylationQ40387087
Regulation of E2F-1 after DNA damage by p300-mediated acetylation and ubiquitinationQ40416938
Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma proteinQ40656395
Genetic and functional analysis of the von Hippel-Lindau (VHL) tumour suppressor gene promoterQ40718800
The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathwayQ41148875
Elongation factor ELL (Eleven-Nineteen Lysine-rich Leukemia) acts as a transcription factor for direct thrombospondin-1 regulationQ43099231
VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400.Q43455466
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau proteinQ44043145
The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinomaQ44043146
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)185-195
P577publication date2014-01-01
P1433published inBiochemical JournalQ864221
P1476titlepVHL acts as a downstream target of E2F1 to suppress E2F1 activity
P478volume457

Reverse relations

cites work (P2860)
Q36173567Forkhead Transcription Factor 3a (FOXO3a) Modulates Hypoxia Signaling via Up-regulation of the von Hippel-Lindau Gene (VHL).
Q37391494Oxalomalate reduces expression and secretion of vascular endothelial growth factor in the retinal pigment epithelium and inhibits angiogenesis: Implications for age-related macular degeneration
Q49405081Suppression of homology-dependent DNA double-strand break repair induces PARP inhibitor sensitivity in VHL-deficient human renal cell carcinoma.
Q34660062The multifaceted von Hippel-Lindau tumour suppressor protein