| scholarly article | Q13442814 |
| review article | Q7318358 |
| P2093 | author name string | Michael Ohh | |
| Claire M Robinson | |||
| P2860 | cites work | The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis | Q22009936 |
| HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing | Q24291102 | ||
| C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation | Q24291783 | ||
| FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity | Q24291819 | ||
| Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C | Q24336712 | ||
| Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma | Q24337664 | ||
| von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination | Q24554216 | ||
| The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins | Q24564802 | ||
| Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein | Q24599442 | ||
| Mutation and cancer: statistical study of retinoblastoma | Q24618185 | ||
| Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex | Q24654714 | ||
| pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2 | Q24684757 | ||
| Prevalence of von Hippel-Lindau gene mutations in sporadic renal cell carcinoma: results from The Netherlands cohort study | Q24813050 | ||
| Comprehensive molecular characterization of clear cell renal cell carcinoma | Q27852374 | ||
| On the Origin of Cancer Cells | Q27861025 | ||
| Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer | Q28267037 | ||
| Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells | Q28504716 | ||
| An essential role for p300/CBP in the cellular response to hypoxia | Q28678439 | ||
| Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes | Q29615757 | ||
| Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein | Q29615928 | ||
| Identification of the von Hippel-Lindau disease tumor suppressor gene | Q29618644 | ||
| The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth | Q30480543 | ||
| Deciphering von Hippel-Lindau (VHL/Vhl)-associated pancreatic manifestations by inactivating Vhl in specific pancreatic cell populations | Q33425920 | ||
| The von hippel-lindau protein suppresses androgen receptor activity | Q33669695 | ||
| Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. | Q33863055 | ||
| Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer | Q33865946 | ||
| Von Hippel-Lindau (VHL) inactivation in sporadic clear cell renal cancer: associations with germline VHL polymorphisms and etiologic risk factors | Q34055338 | ||
| Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. | Q34091273 | ||
| Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia | Q34157665 | ||
| von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF. | Q34514928 | ||
| The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C. | Q34517945 | ||
| Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL. | Q34530199 | ||
| The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix | Q34748818 | ||
| pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation | Q34753344 | ||
| Expression of hypoxic marker CA IX is regulated by site-specific DNA methylation and is associated with the histology of gastric cancer | Q34756174 | ||
| pVHL acts as a downstream target of E2F1 to suppress E2F1 activity | Q35013339 | ||
| Role of VHL gene mutation in human cancer | Q35990141 | ||
| High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq. | Q36029877 | ||
| Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy | Q36220497 | ||
| Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor | Q36446896 | ||
| Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression | Q36471184 | ||
| Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer. | Q36518228 | ||
| Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice | Q36551258 | ||
| The positive regulation of p53 by the tumor suppressor VHL. | Q36592019 | ||
| Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis | Q37132758 | ||
| CpG methylation profiling in VHL related and VHL unrelated renal cell carcinoma. | Q37233603 | ||
| Epigenetics, the epicenter of the hypoxic response | Q37737004 | ||
| Chromatin as an oxygen sensor and active player in the hypoxia response. | Q37933611 | ||
| 5-Methylcytosine DNA demethylation: more than losing a methyl group | Q38043063 | ||
| DCNL1 functions as a substrate sensor and activator of cullin 2-RING ligase | Q39196067 | ||
| Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia. | Q39273902 | ||
| Hypoxia-induced DNA hypermethylation in human pulmonary fibroblasts is associated with Thy-1 promoter methylation and the development of a pro-fibrotic phenotype | Q39287669 | ||
| Suppression of hypoxia-inducible factor 2alpha restores p53 activity via Hdm2 and reverses chemoresistance of renal carcinoma cells | Q39773550 | ||
| VHL loss causes spindle misorientation and chromosome instability. | Q39822734 | ||
| Generation of an epigenetic signature by chronic hypoxia in prostate cells | Q39827986 | ||
| SWI/SNF regulates the cellular response to hypoxia. | Q39903276 | ||
| Regulation of renal epithelial tight junctions by the von Hippel-Lindau tumor suppressor gene involves occludin and claudin 1 and is independent of E-cadherin | Q39906454 | ||
| Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha | Q39949245 | ||
| Inadequate activation of the GTPase RhoA contributes to the lack of fibronectin matrix assembly in von Hippel-Lindau protein-defective renal cancer cells | Q39970146 | ||
| Induction of DNA hypomethylation by tumor hypoxia. | Q40061058 | ||
| Interaction of hydroxylated collagen IV with the von hippel-lindau tumor suppressor. | Q40163119 | ||
| 5-hydroxymethylcytosine and its potential roles in development and cancer. | Q40453448 | ||
| Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. | Q40633683 | ||
| Oxygen-regulated erythropoietin gene expression is dependent on a CpG methylation-free hypoxia-inducible factor-1 DNA-binding site | Q41027829 | ||
| Tumour suppression by the human von Hippel-Lindau gene product | Q41320477 | ||
| Alternate choice of initiation codon produces a biologically active product of the von Hippel Lindau gene with tumor suppressor activity | Q42469993 | ||
| Ischemia dysregulates DNA methyltransferases and p16INK4a methylation in human colorectal cancer cells | Q42552522 | ||
| Effects of HIF-1alpha and HIF2alpha on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts | Q42726487 | ||
| The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF. | Q43154570 | ||
| Deletions of chromosomes 3p and 14q molecularly subclassify clear cell renal cell carcinoma | Q46208481 | ||
| Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. | Q51256046 | ||
| von Hippel-Lindau protein promotes Skp2 destabilization on DNA damage. | Q54609264 | ||
| Overproduction of vascular endothelial growth factor related to von Hippel-Lindau tumor suppressor gene mutations and hypoxia-inducible factor-1 alpha expression in renal cell carcinomas. | Q54765102 | ||
| Über eine sehr seltene Erkrankung der Netzhaut | Q56068022 | ||
| ZUR FRAGE DER ANGIOMATOSIS RETINae UND IHRER HIRNKOMPLIKATIONEN | Q56068023 | ||
| P433 | issue | 16 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 2704-2711 | |
| P577 | publication date | 2014-02-25 | |
| P1433 | published in | FEBS Letters | Q1388051 |
| P1476 | title | The multifaceted von Hippel-Lindau tumour suppressor protein | |
| P478 | volume | 588 |
| Q51271668 | A Late G1 Lipid Checkpoint That Is Dysregulated in Clear Cell Renal Carcinoma Cells. |
| Q36274373 | Beluga whale pVHL enhances HIF-2α activity via inducing HIF-2α proteasomal degradation under hypoxia |
| Q34103385 | Chromatin and oxygen sensing in the context of JmjC histone demethylases |
| Q49789775 | Consequences of VHL Loss on Global DNA Methylome |
| Q93199945 | Deubiquitylase OTUD6B Governs pVHL Stability in an Enzyme-Independent Manner and Suppresses Hepatocellular Carcinoma Metastasis |
| Q34312452 | Disease pathways at the Rat Genome Database Pathway Portal: genes in context-a network approach to understanding the molecular mechanisms of disease |
| Q41574276 | Epigenome Aberrations: Emerging Driving Factors of the Clear Cell Renal Cell Carcinoma |
| Q64081971 | Genotype-phenotype relations of the von Hippel-Lindau tumor suppressor inferred from a large-scale analysis of disease mutations and interactors |
| Q35897966 | Global 5-Hydroxymethylcytosine Levels Are Profoundly Reduced in Multiple Genitourinary Malignancies |
| Q58721805 | HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease |
| Q42217007 | Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. |
| Q55689936 | Hypoxia and Chromatin: A Focus on Transcriptional Repression Mechanisms. |
| Q36882394 | Hypoxia as a therapy for mitochondrial disease. |
| Q38714028 | Intrinsic gene changes determine the successful establishment of stable renal cancer cell lines from tumor tissue. |
| Q92816840 | Involvement of E3 Ligases and Deubiquitinases in the Control of HIF-α Subunit Abundance |
| Q35891379 | Isoform-specific interactions of the von Hippel-Lindau tumor suppressor protein |
| Q42074689 | KDM2 Family Members are Regulated by HIF-1 in Hypoxia |
| Q35888073 | Macrophage Migration Inhibitory Factor Secretion Is Induced by Ionizing Radiation and Oxidative Stress in Cancer Cells |
| Q53653503 | Metastatic phaeochromocytoma in a 23-year-old woman with an unclassified variant in the von Hippel Lindau disease gene: how can the pathogenicity of this variant be determined? |
| Q38841735 | NETs: organ-related epigenetic derangements and potential clinical applications |
| Q26801253 | New and emerging factors in tumorigenesis: an overview |
| Q37093230 | Over-expression of DNA-PKcs in renal cell carcinoma regulates mTORC2 activation, HIF-2α expression and cell proliferation |
| Q38932099 | Overexpression of HOXC11 homeobox gene in clear cell renal cell carcinoma induces cellular proliferation and is associated with poor prognosis |
| Q41198110 | Profiling of the metabolic transcriptome via single molecule molecular inversion probes. |
| Q48169059 | Quantitative proteomics to study a small molecule targeting the loss of von Hippel-Lindau in renal cell carcinomas |
| Q46219895 | Remodeling of the Extracellular Matrix by Endothelial Cell-Targeting siRNA Improves the EPR-Based Delivery of 100 nm Particles |
| Q38509463 | Rethinking pheochromocytomas and paragangliomas from a genomic perspective. |
| Q92661639 | Role of Cytosolic 2-Cys Prx1 and Prx2 in Redox Signaling |
| Q49405081 | Suppression of homology-dependent DNA double-strand break repair induces PARP inhibitor sensitivity in VHL-deficient human renal cell carcinoma. |
| Q26753176 | Targeting Protein-Protein Interactions in the HIF System |
| Q50026055 | The HIF and other quandaries in VHL disease |
| Q48295398 | The Treatment Landscape and New Opportunities of Molecular Targeted Therapies in Gastroenteropancreatic Neuroendocrine Tumors. |
| Q28079015 | The ever-expanding role of HIF in tumour and stromal biology |
| Q39185765 | The functional interplay between the HIF pathway and the ubiquitin system - more than a one-way road. |
| Q33728258 | The preclinical assessment of XL388, a mTOR kinase inhibitor, as a promising anti-renal cell carcinoma agent |
| Q26852080 | The unfolded protein response in retinal vascular diseases: implications and therapeutic potential beyond protein folding |
| Q35863138 | The von Hippel-Lindau tumour suppressor gene: uncovering the expression of the pVHL172 isoform |
| Q38418649 | Tumour and patient factors in renal cell carcinoma-towards personalized therapy |
| Q26740274 | WSB1: from homeostasis to hypoxia |
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