| scholarly article | Q13442814 |
| P356 | DOI | 10.1172/JCI31370 |
| P8608 | Fatcat ID | release_cilc3orwobft7aawudynagbb4m |
| P932 | PMC publication ID | 1884690 |
| P698 | PubMed publication ID | 17557118 |
| P5875 | ResearchGate publication ID | 6279999 |
| P50 | author | Victor Nizet | Q7926191 |
| Reto A Schuepbach | Q59507280 | ||
| Carole Peyssonnaux | Q59554852 | ||
| Randall S. Johnson | Q40744820 | ||
| Volker H. Haase | Q41457663 | ||
| Erinn B. Rankin | Q43206012 | ||
| Annelies S. Zinkernagel | Q45437773 | ||
| P2093 | author name string | Sophie Vaulont | |
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| P433 | issue | 7 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | iron | Q677 |
| hypoxia | Q105688 | ||
| P304 | page(s) | 1926-1932 | |
| P577 | publication date | 2007-07-01 | |
| P1433 | published in | Journal of Clinical Investigation | Q3186904 |
| P1476 | title | Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). | |
| P478 | volume | 117 |
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| Q37771336 | Advancements in anemias related to chronic conditions |
| Q38904398 | Advances in understanding the mechanisms of erythropoiesis in homeostasis and disease. |
| Q34308090 | Afebrile Plasmodium falciparum parasitemia decreases absorption of fortification iron but does not affect systemic iron utilization: a double stable-isotope study in young Beninese women |
| Q90266551 | Altered nutrient status reprograms host inflammation and metabolic health via gut microbiota |
| Q38109321 | Alternatives to blood transfusion |
| Q35836904 | Anaemia in kidney disease: harnessing hypoxia responses for therapy |
| Q89631111 | Anaemia, iron homeostasis and pulmonary hypertension: a review |
| Q45382309 | Anemia in heart failure: association of hepcidin levels to iron deficiency in stable outpatients. |
| Q38199176 | Anemia in malignancies: pathogenetic and diagnostic considerations. |
| Q37130139 | Approaches to the treatment of anaemia in patients with chronic heart failure |
| Q35744938 | Aromatase Inhibitor-Induced Erythrocytosis in a Patient Undergoing Hormonal Treatment for Breast Cancer. |
| Q37334987 | Association of hepcidin promoter c.-582 A>G variant and iron overload in thalassemia major |
| Q89761545 | Basic Biology of Hypoxic Responses Mediated by the Transcription Factor HIFs and its Implication for Medicine |
| Q35553601 | Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression |
| Q50677628 | Diseased red blood cells topple iron balance. |
| Q46358235 | Divalent metal transporter 1 is a hypoxia-inducible gene |
| Q46275211 | Does Hypoxia Cause Carcinogenic Iron Accumulation in Alcoholic Liver Disease (ALD)? |
| Q33834771 | Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis |
| Q53264379 | Duodenal cytochrome b (Cybrd 1) and HIF-2α expression during acute hypoxic exposure in mice. |
| Q37701960 | Dynamin 2 along with microRNA-199a reciprocally regulate hypoxia-inducible factors and ovarian cancer metastasis |
| Q90452808 | Dysregulated iron metabolism in polycythemia vera: etiology and consequences |
| Q27343881 | EGL-9 controls C. elegans host defense specificity through prolyl hydroxylation-dependent and -independent HIF-1 pathways |
| Q41486337 | ER Stress and Iron Homeostasis: A New Frontier for the UPR. |
| Q45777680 | Effect of hypoxia on the expression of iron regulatory proteins 1 and the mechanisms involved |
| Q34097890 | Effect of vitamin e supplementation on intestinal barrier function in rats exposed to high altitude hypoxia environment |
| Q36415846 | Effects of Pregnancy and Lactation on Iron Metabolism in Rats |
| Q50002039 | Effects of an Acute Exercise Bout on Serum Hepcidin Levels. |
| Q34114041 | Effects of cellular iron deficiency on the formation of vascular endothelial growth factor and angiogenesis. Iron deficiency and angiogenesis |
| Q40990014 | Elevation of iron storage in humans attenuates the pulmonary vascular response to hypoxia. |
| Q93075404 | Emerging and Dynamic Biomedical Uses of Ferritin |
| Q38930912 | Emerging drugs for the treatment of kidney disease-induced anemia |
| Q35193628 | Endocrine and bone complications in β-thalassemia intermedia: current understanding and treatment |
| Q86260187 | Erythropoietin |
| Q86893314 | Erythropoietin |
| Q37972662 | Essential but toxic: controlling the flux of iron in the body. |
| Q60960606 | Established and Emerging Concepts to Treat Imbalances of Iron Homeostasis in Inflammatory Diseases |
| Q47664402 | Estrogen-induced disruption of intracellular iron metabolism leads to oxidative stress, membrane damage, and cell cycle arrest in MCF-7 cells |
| Q28471913 | Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors |
| Q37348699 | Expression of Iron Regulatory Protein 1 Is Regulated not only by HIF-1 but also pCREB under Hypoxia. |
| Q33433700 | Expression of iron-related genes in human brain and brain tumors |
| Q36742479 | Forging a field: the golden age of iron biology |
| Q36746039 | Four-Week Studies of Oral Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor GSK1278863 for Treatment of Anemia |
| Q42619912 | Function of the hemochromatosis protein HFE: Lessons from animal models |
| Q24297889 | Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis |
| Q33659678 | Future alternative therapies for β-thalassemia |
| Q34810044 | Gastrins, iron homeostasis and colorectal cancer |
| Q37626406 | Generating specificity and diversity in the transcriptional response to hypoxia |
| Q33767088 | Genetic study of the hepcidin gene (HAMP) promoter and functional analysis of the c.-582A > G variant. |
| Q37285034 | Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts |
| Q33471093 | HFE mutations modulate the effect of iron on serum hepcidin-25 in chronic hemodialysis patients |
| Q28307377 | HIF prolyl hydroxylase inhibitors for anemia |
| Q38666170 | HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond |
| Q34109802 | HIF-1 regulates iron homeostasis in Caenorhabditis elegans by activation and inhibition of genes involved in iron uptake and storage |
| Q42171228 | HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice. |
| Q34163208 | HIF-independent regulation of thioredoxin reductase 1 contributes to the high levels of reactive oxygen species induced by hypoxia |
| Q33926530 | HIF-prolyl hydroxylases as therapeutic targets in erythropoiesis and iron metabolism |
| Q88273092 | Haemochromatosis |
| Q50615560 | Haemolytic anaemia and alterations in hepatic iron metabolism in aged mice lacking Cu,Zn-superoxide dismutase. |
| Q36006369 | Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis |
| Q39955308 | Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity |
| Q47130083 | Hepatocyte toll-like receptor 4 mediates lipopolysaccharide-induced hepcidin expression |
| Q33559763 | Hepcidin and sports anemia |
| Q34076870 | Hepcidin in beta-thalassemia |
| Q37122273 | Hepcidin modulation in human diseases: from research to clinic. |
| Q41845987 | Hepcidin suppression and defective iron recycling account for dysregulation of iron homeostasis in heme oxygenase-1 deficiency. |
| Q35995909 | Hepcidin-Dependent Regulation of Erythropoiesis during Anemia in a Teleost Fish, Dicentrarchus labrax |
| Q35207617 | Hepcidin: A Critical Regulator of Iron Metabolism during Hypoxia |
| Q37890241 | Hepcidin: clinical utility as a diagnostic tool and therapeutic target |
| Q26800198 | Hepcidin: regulation of the master iron regulator |
| Q24646056 | Hereditary hemochromatosis in the post-HFE era |
| Q51737021 | High-Dose Deferoxamine Treatment Disrupts Intracellular Iron Homeostasis, Reduces Growth, and Induces Apoptosis in Metastatic and Nonmetastatic Breast Cancer Cell Lines. |
| Q57455240 | Histone Deacetylase 3 Inhibitor Suppresses Hepatitis C Virus Replication by Regulating Apo-A1 and LEAP-1 Expression |
| Q41947195 | Hypobaric hypoxia-mediated protein expression in plasma of susceptible & tolerant rats |
| Q34069793 | Hypophosphatemic rickets: revealing novel control points for phosphate homeostasis |
| Q37961603 | Hypoxia and hypoxia inducible factors: diverse roles in liver diseases |
| Q37008513 | Hypoxia and the HIF system in kidney disease |
| Q39914085 | Hypoxia decreases the expression of the two enzymes responsible for producing linear and cyclic tetrapyrroles in the heme biosynthetic pathway |
| Q49833869 | Hypoxia enhances H2O2-mediated upregulation of hepcidin: Evidence for NOX4-mediated iron regulation. |
| Q37009862 | Hypoxia inducible factor (HIF) function in innate immunity and infection |
| Q30273595 | Hypoxia inducible factor-2 α is translationally repressed in response to dietary iron deficiency in Sprague-Dawley rats |
| Q39598794 | Hypoxia inhibits hepcidin expression in HuH7 hepatoma cells via decreased SMAD4 signaling |
| Q35341540 | Hypoxia negatively regulates heparan sulfatase 2 expression in renal cancer cell lines |
| Q38740776 | Hypoxia-Inducible Factor Stabilizers: a New Avenue for Reducing BP While Helping Hemoglobin? |
| Q48140646 | Hypoxia-Inducible Factor and Its Role in the Management of Anemia in Chronic Kidney Disease. |
| Q42147890 | Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis |
| Q37620078 | Hypoxia-inducible factors link iron homeostasis and erythropoiesis |
| Q35131965 | Hypoxia-inducible transcription factor 2α promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis |
| Q37206879 | Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function |
| Q24609166 | Hypoxic regulation of erythropoiesis and iron metabolism |
| Q33877443 | Identification of Ceruloplasmin as a Gene that Affects Susceptibility to Glomerulonephritis Through Macrophage Function. |
| Q28240988 | Identification of erythroferrone as an erythroid regulator of iron metabolism |
| Q42201402 | Impact of hepcidin antimicrobial peptide on iron overload in tuberculosis patients |
| Q36181276 | Impact of neonatal iron deficiency on hippocampal DNA methylation and gene transcription in a porcine biomedical model of cognitive development |
| Q56489127 | Increased serum hepcidin levels during treatment with deferasirox in iron-overloaded patients with myelodysplastic syndrome |
| Q24602905 | Ineffective erythropoiesis and thalassemias |
| Q36863458 | Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production |
| Q57765548 | Influence of post-exercise hypoxic exposure on hepcidin response in athletes |
| Q37650433 | Insight onto the pathophysiology and clinical complications of thalassemia intermedia. |
| Q27334849 | Insulin/IGF-1 and hypoxia signaling act in concert to regulate iron homeostasis in Caenorhabditis elegans |
| Q40825620 | Integrity of the prolyl hydroxylase domain protein 2:erythropoietin pathway in aging mice |
| Q37174593 | Interrelationships between tissue iron status and erythropoiesis during postweaning development following neonatal iron deficiency in rats |
| Q35010977 | Intestinal hypoxia-inducible factor-2alpha (HIF-2alpha) is critical for efficient erythropoiesis |
| Q37137793 | Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency |
| Q34100135 | Intracellular iron transport and storage: from molecular mechanisms to health implications |
| Q37072151 | Inverse Correlation between IL-10 and HIF-1α in Macrophages Infected with Histoplasma capsulatum |
| Q37506973 | Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis |
| Q38532068 | Iron Homeostasis and Trypanosoma brucei Associated Immunopathogenicity Development: A Battle/Quest for Iron |
| Q33844026 | Iron Loading and Overloading due to Ineffective Erythropoiesis |
| Q60955833 | Iron Regulation: Macrophages in Control |
| Q33677592 | Iron and cancer: more ore to be mined |
| Q35214752 | Iron and immunity: immunological consequences of iron deficiency and overload |
| Q38266801 | Iron and oxygen sensing: a tale of 2 interacting elements? |
| Q28388335 | Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases |
| Q35558693 | Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice. |
| Q37972641 | Iron deficiency syndromes and iron-restricted erythropoiesis (CME). |
| Q45994371 | Iron endowment at birth: maternal iron status and other influences. |
| Q39425760 | Iron facilitator LS081 reduces hypoxia-inducible factor-1α protein and functions as anticancer agent in hepatocellular carcinoma |
| Q37087636 | Iron homeostasis and erythropoiesis |
| Q35024676 | Iron homeostasis and the inflammatory response |
| Q35034547 | Iron homeostasis and tumorigenesis: molecular mechanisms and therapeutic opportunities |
| Q37605754 | Iron homeostasis in the liver |
| Q37036469 | Iron homeostasis: recently identified proteins provide insight into novel control mechanisms |
| Q30835527 | Iron in multiple sclerosis: roles in neurodegeneration and repair |
| Q59808741 | Iron in the Tumor Microenvironment-Connecting the Dots |
| Q52602539 | Iron metabolism in macrophages from HFE hemochromatosis patients |
| Q34549409 | Iron metabolism in thalassemia and sickle cell disease |
| Q37508402 | Iron metabolism: current facts and future directions |
| Q28291718 | Iron regulation by hepcidin |
| Q21129273 | Iron, hepcidin, and the metal connection |
| Q37810273 | Iron-deficiency anemia secondary to mutations in genes controlling hepcidin |
| Q35388676 | Iron-hepcidin dysmetabolism, anemia and renal hypoxia, inflammation and fibrosis in the remnant kidney rat model |
| Q37253813 | Klebsiella pneumoniae Siderophores Induce Inflammation, Bacterial Dissemination, and HIF-1α Stabilization during Pneumonia |
| Q36677136 | Known and potential roles of transferrin in iron biology |
| Q26765316 | Laboratory use of hepcidin in renal transplant recipients |
| Q53164836 | Live high, train low - influence on resting and post-exercise hepcidin levels. |
| Q37618839 | Maintaining Mammalian iron and oxygen homeostasis: sensors, regulation, and cross-talk |
| Q42074898 | Maintenance of mitochondrial genomic integrity in the absence of manganese superoxide dismutase in mouse liver hepatocytes. |
| Q37502811 | Mammalian iron transport. |
| Q35659768 | Management of Iron-Deficiency Anemia in Inflammatory Bowel Disease: A Systematic Review |
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| Q38932625 | Mechanisms of transcription factor acetylation and consequences in hearts. |
| Q26861531 | Mechanistic and regulatory aspects of intestinal iron absorption |
| Q40065267 | Metabolism in Immune Cell Differentiation and Function. |
| Q36298344 | Micromanaging Iron Homeostasis: hypoxia-inducible micro-RNA-210 suppresses iron homeostasis-related proteins |
| Q36847852 | Modulation of hepcidin to treat iron deregulation: potential clinical applications |
| Q37737808 | Molecular basis of hereditary iron homeostasis defects |
| Q37807528 | Molecular basis of iron-loading disorders. |
| Q33999246 | Molecular mechanisms of hepcidin regulation: implications for the anemia of CKD. |
| Q37653179 | Molecular mechanisms of normal iron homeostasis |
| Q102388789 | Multiple myeloma hinders erythropoiesis and causes anaemia owing to high levels of CCL3 in the bone marrow microenvironment |
| Q27009565 | Murine mutants in the study of systemic iron metabolism and its disorders: an update on recent advances |
| Q37017901 | Neuronal-specific iron deficiency dysregulates mammalian target of rapamycin signaling during hippocampal development in nonanemic genetic mouse models |
| Q27026399 | New advances in molecular mechanisms and emerging therapeutic targets in alcoholic liver diseases |
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| Q51325271 | Parenteral iron polymaltose changes i:c-terminal FGF23 ratios in iron deficiency, but not in dialysis patients. |
| Q48247015 | Pathophysiology and treatment of patients with beta-thalassemia - an update. |
| Q28577508 | Pathways for the regulation of hepcidin expression in anemia of chronic disease and iron deficiency anemia in vivo |
| Q36066325 | Physiologic hypoxia and oxygen homeostasis in the healthy intestine. A Review in the Theme: Cellular Responses to Hypoxia. |
| Q50234877 | Physiological focus on the erythropoietin-hepcidin-ferroportin axis. |
| Q34255058 | Polarization dictates iron handling by inflammatory and alternatively activated macrophages |
| Q93192934 | Potential role of iron in repair of inflammatory demyelinating lesions |
| Q36282985 | Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells |
| Q39198116 | Prohepcidin binds to the HAMP promoter and autoregulates its own expression. |
| Q37779100 | Prolyl hydroxylase domain-containing protein inhibitors as stabilizers of hypoxia-inducible factor: small molecule-based therapeutics for anemia |
| Q30413289 | Protein degradation and iron homeostasis |
| Q28289283 | Pseudomonas aeruginosa disrupts Caenorhabditis elegans iron homeostasis, causing a hypoxic response and death |
| Q55237927 | Pulmonary Arterial Hypertension: Iron Matters. |
| Q36058555 | Randomized placebo-controlled dose-ranging and pharmacodynamics study of roxadustat (FG-4592) to treat anemia in nondialysis-dependent chronic kidney disease (NDD-CKD) patients |
| Q48225857 | Rational Management of Iron-Deficiency Anaemia in Inflammatory Bowel Disease |
| Q37598376 | Reduction of hepatic fibrosis by overexpression of von Hippel-Lindau protein in experimental models of chronic liver disease |
| Q92889691 | Regulation of Fibroblast Growth Factor 23 by Iron, EPO, and HIF |
| Q37063716 | Regulation of erythropoiesis by hypoxia-inducible factors |
| Q37320318 | Regulation of iron absorption in hemoglobinopathies. |
| Q36995110 | Regulation of iron acquisition and storage: consequences for iron-linked disorders |
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| Q39641301 | Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis |
| Q37990051 | Review article: the iron overload syndromes |
| Q36761787 | Role of hepcidin in the pathophysiology and diagnosis of anemia |
| Q39608341 | Role of hypoxia-inducible factors in the dexrazoxane-mediated protection of cardiomyocytes from doxorubicin-induced toxicity. |
| Q64111741 | Roxadustat Treatment of Chronic Kidney Disease-Associated Anemia in Japanese Patients Not on Dialysis: A Phase 2, Randomized, Double-Blind, Placebo-Controlled Trial |
| Q49649941 | Roxadustat in the treatment of anaemia in chronic kidney disease. |
| Q44390505 | Serum prohepcidin reflects the degree of liver function impairment in liver cirrhosis |
| Q35803702 | Severe microcytic anemia but increased erythropoiesis in mice lacking Hfe or Tfr2 and Tmprss6 |
| Q37730645 | Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2. |
| Q35067405 | Skeletal muscle hemojuvelin is dispensable for systemic iron homeostasis |
| Q24630685 | State of the science: an update on renal cell carcinoma |
| Q38103912 | Structure-based drug design for hypoxia-inducible factor prolyl-hydroxylase inhibitors and its therapeutic potential for the treatment of erythropoiesis-stimulating agent-resistant anemia: raising expectations for exploratory clinical trials |
| Q33782058 | Successful antiviral therapy is associated with a decrease of serum prohepcidin in chronic hepatitis C. |
| Q37224564 | Suppression of HIF-1α by Valproic Acid Sustains Self-Renewal of Mouse Embryonic Stem Cells under Hypoxia In Vitro. |
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| Q33757232 | Targeting iron metabolism in drug discovery and delivery |
| Q33559201 | Targeting the hepcidin-ferroportin axis in the diagnosis and treatment of anemias |
| Q34549431 | Thalassaemia intermedia: an update. |
| Q38609375 | The Iron age of host-microbe interactions |
| Q37543492 | The Regulation of Iron Absorption and Homeostasis |
| Q91872236 | The Role of Iron Regulation in Immunometabolism and Immune-Related Disease |
| Q50422095 | The ST6Gal-I sialyltransferase protects tumor cells against hypoxia by enhancing HIF-1α signaling. |
| Q37064867 | The VHL tumor suppressor and HIF: insights from genetic studies in mice |
| Q33945163 | The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism |
| Q36736806 | The effect of altitude on dosing and response to erythropoietin in ESRD |
| Q37592830 | The essential nature of iron usage and regulation |
| Q36631296 | The genetics of essential metal homeostasis during development |
| Q26823465 | The hepcidin-ferroportin system as a therapeutic target in anemias and iron overload disorders |
| Q24646951 | The human side of hypoxia-inducible factor |
| Q39301385 | The hypoxia-inducible factor-C/EBPα axis controls ethanol-mediated hepcidin repression. |
| Q37464105 | The liver: conductor of systemic iron balance |
| Q38153305 | The regulation of iron transport. |
| Q47096795 | The relationship between systemic iron homeostasis and erythropoiesis. |
| Q33792105 | The role of hepcidin in iron metabolism |
| Q34729887 | The role of iron in learning and memory |
| Q28278593 | The serine protease TMPRSS6 is required to sense iron deficiency |
| Q28115763 | The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin |
| Q41512201 | Transferrin receptor-1 and ferritin heavy and light chains in astrocytic brain tumors: Expression and prognostic value |
| Q36206440 | Treatment of erythropoietin deficiency in mice with systemically administered siRNA. |
| Q37701609 | Tumor-initiating cells of breast and prostate origin show alterations in the expression of genes related to iron metabolism. |
| Q37623547 | Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling |
| Q41765603 | Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic death. |
| Q36471843 | Understanding and exploiting hepcidin as an indicator of anemia due to chronic kidney disease |
| Q90446620 | Unfolded protein response (UPR) integrated signaling networks determine cell fate during hypoxia |
| Q36828496 | Unraveling mechanisms regulating systemic iron homeostasis |
| Q36123826 | Von Hippel-Lindau disease (VHL): a need for a murine model with retinal hemangioblastoma |
| Q47885433 | What can we learn from ineffective erythropoiesis in thalassemia? |
| Q36483828 | When less is more: novel mechanisms of iron conservation |
| Q89494287 | Zinc Inhibits HIF-Prolyl Hydroxylase Inhibitor-Aggravated VSMC Calcification Induced by High Phosphate |
| Q40659209 | beta-Thalassemia: HiJAKing Ineffective Erythropoiesis and Iron Overload |
| Q64975929 | mRNA-binding protein tristetraprolin is essential for cardiac response to iron deficiency by regulating mitochondrial function. |
| Q92217601 | β Cell Hypoxia-Inducible Factor-1α Is Required for the Prevention of Type 1 Diabetes |
| Q49588086 | β-Thalassemia intermedia: a comprehensive overview and novel approaches. |
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