EGL-9 controls C. elegans host defense specificity through prolyl hydroxylation-dependent and -independent HIF-1 pathways

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EGL-9 controls C. elegans host defense specificity through prolyl hydroxylation-dependent and -independent HIF-1 pathways is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1002798
P8608Fatcat IDrelease_arzlyyfkdrdm5hxesejgx6k6c4
P3181OpenCitations bibliographic resource ID2387312
P932PMC publication ID3390412
P698PubMed publication ID22792069
P5875ResearchGate publication ID229083068

P50authorOrane VisvikisQ57321424
Javier E. IrazoquiQ41590501
Adam Lacy-HulbertQ41770819
P2093author name stringLynda M Stuart
Amanda C Wollenberg
Lyly G Luhachack
P2860cites workHIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensingQ24291102
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylationQ24291783
Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responsesQ24602140
Evolution of host innate defence: insights from Caenorhabditis elegans and primitive invertebratesQ24623064
Transcriptional repression of human cad gene by hypoxia inducible factor-1alphaQ24814445
Dissection of the inflammatory bowel disease transcriptome using genome-wide cDNA microarraysQ24814806
Models of Caenorhabditis elegans infection by bacterial and fungal pathogens.Q52689855
Treatment response and colonic gene expression in patients with Crohn's diseaseQ61757235
Characterization of Burkholderia pseudomallei infection and identification of novel virulence factors using a Caenorhabditis elegans host systemQ74311679
Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitisQ37308981
Two distinct roles for EGL-9 in the regulation of HIF-1-mediated gene expression in Caenorhabditis elegansQ37425018
Hypoxia signaling and resistance in C. elegansQ37718363
Diagnostic mRNA expression patterns of inflamed, benign, and malignant colorectal biopsy specimen and their correlation with peripheral blood resultsQ38360197
Hypoxia-inducible factor-dependent repression of equilibrative nucleoside transporter 2 attenuates mucosal inflammation during intestinal hypoxiaQ39902165
Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis.Q40176806
Gene expression signature and the prediction of ulcerative colitis-associated colorectal cancer by DNA microarrayQ40248468
Transcriptional repression of Na-K-2Cl cotransporter NKCC1 by hypoxia-inducible factor-1.Q40298393
Molecular classification of Crohn's disease and ulcerative colitis patients using transcriptional profiles in peripheral blood mononuclear cellsQ42793741
HIF-1alpha expression regulates the bactericidal capacity of phagocytesQ42876119
Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier functionQ42989196
Neuroimmune regulation of antimicrobial peptide expression by a noncanonical TGF-beta signaling pathway in Caenorhabditis elegans epidermisQ43415018
Pharmacologic augmentation of hypoxia-inducible factor-1alpha with mimosine boosts the bactericidal capacity of phagocytesQ46351580
Cutting edge: Essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsisQ46377120
Paralysis and killing of Caenorhabditis elegans by enteropathogenic Escherichia coli requires the bacterial tryptophanase geneQ46642599
HIF-1-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leakQ46726814
The ERK MAP kinase cascade mediates tail swelling and a protective response to rectal infection in C. elegansQ47068982
HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegansQ27312348
Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureusQ27313965
p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegansQ27315174
Insulin/IGF-1 and hypoxia signaling act in concert to regulate iron homeostasis in Caenorhabditis elegansQ27334849
Hypoxia: an alarm signal during intestinal inflammationQ27691319
A new mathematical model for relative quantification in real-time RT-PCRQ27860781
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylationQ27860876
HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleusQ28191456
Plant and animal sensors of conserved microbial signaturesQ28298959
Lethal paralysis of Caenorhabditis elegans by Pseudomonas aeruginosaQ28776408
Killing of Caenorhabditis elegans by Pseudomonas aeruginosa used to model mammalian bacterial pathogenesisQ28776658
Crosstalk in NF-κB signaling pathwaysQ29617418
HIF-1alpha is essential for myeloid cell-mediated inflammationQ29617581
A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunityQ29617874
Genome-wide RNAi screening in Caenorhabditis elegansQ29617900
Mucosal gene expression of antimicrobial peptides in inflammatory bowel disease before and after first infliximab treatmentQ30945619
Hypoxia and the hypoxic response pathway protect against pore-forming toxins in C. elegansQ33518501
C. elegans SWAN-1 Binds to EGL-9 and regulates HIF-1-mediated resistance to the bacterial pathogen Pseudomonas aeruginosa PAO1.Q33701707
Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogensQ33996240
HIF-1 regulates iron homeostasis in Caenorhabditis elegans by activation and inhibition of genes involved in iron uptake and storageQ34109802
Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activityQ34683601
Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal injuryQ34717238
Caenorhabditis elegans as a model host for Staphylococcus aureus pathogenesisQ34855656
Caenorhabditis elegans: an emerging genetic model for the study of innate immunityQ35120183
Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs).Q35826597
Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition.Q36372667
HIF-1-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxiaQ36403983
A conserved Toll-like receptor is required for Caenorhabditis elegans innate immunityQ36466393
Genome-wide investigation reveals pathogen-specific and shared signatures in the response of Caenorhabditis elegans to infectionQ36643300
Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade.Q36871728
Role for beta-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactionsQ36970836
The DAF-2 insulin-like signaling pathway independently regulates aging and immunity in C. elegansQ37071632
Community-associated methicillin-resistant Staphylococcus aureus skin infections: advances toward identifying the key virulence factorsQ37100936
NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alphaQ37158836
Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcriptsQ37285034
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectCaenorhabditis elegansQ91703
P304page(s)e1002798
P577publication date2012-01-01
P1433published inPLOS PathogensQ283209
P1476titleEGL-9 controls C. elegans host defense specificity through prolyl hydroxylation-dependent and -independent HIF-1 pathways
P478volume8

Reverse relations

cites work (P2860)
Q57281291A comparative transcriptome approach for identification of molecular changes in Aphanomyces invadans infected Channa striatus
Q35986214Contrasting invertebrate immune defense behaviors caused by a single gene, the Caenorhabditis elegans neuropeptide receptor gene npr-1
Q38589862Current advances in the novel functions of hypoxia-inducible factor and prolyl hydroxylase in invertebrates
Q47143523Interrelated Roles for the Aryl Hydrocarbon Receptor and Hypoxia Inducible Factor-1α in the Immune Response to Infection.
Q44159799Loss of the Birt-Hogg-Dubé gene product folliculin induces longevity in a hypoxia-inducible factor-dependent manner
Q33658871Mechanisms of iron metabolism in Caenorhabditis elegans
Q92085329Microbial Colonization Activates an Immune Fight-and-Flight Response via Neuroendocrine Signaling
Q38280768Microbial pathogenesis and host defense in the nematode C. elegans
Q58796449Non-proteolytic activity of 19S proteasome subunit RPT-6 regulates GATA transcription during response to infection
Q28289283Pseudomonas aeruginosa disrupts Caenorhabditis elegans iron homeostasis, causing a hypoxic response and death
Q52727060Reconstructing a metazoan genetic pathway with transcriptome-wide epistasis measurements.
Q27312208The Invertebrate Lysozyme Effector ILYS-3 Is Systemically Activated in Response to Danger Signals and Confers Antimicrobial Protection in C. elegans
Q38383051The impact of hypoxia on bacterial infection

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