HIF-1-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia

scientific article

HIF-1-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1084/JEM.20050177
P932PMC publication ID2213326
P698PubMed publication ID16330813
P5875ResearchGate publication ID7438432

P50authorImogen CoeQ49561445
P2093author name stringHolger K Eltzschig
Sean P Colgan
Karen A Westerman
Andreas Robinson
Caroline Schönfeld
Dionne Daniels
Edgar Hoffman
German Reyes
Jorn Karhausen
Kathryn E Hamilton
Michael Duszenko
Michaela Löffler
Parween Abdulla
P2860cites workCloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugsQ24310832
Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathwayQ24672316
Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptorsQ24672615
Crucial role for ecto-5'-nucleotidase (CD73) in vascular leakage during hypoxiaQ24817161
A new mathematical model for relative quantification in real-time RT-PCRQ27860781
The equilibrative nucleoside transporter family, SLC29Q28184224
Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damageQ28214799
Nucleoside transporter subtype expression and function in rat skeletal muscle microvascular endothelial cellsQ28570384
Oxygen sensing by HIF hydroxylasesQ29617806
Molecular approach to adenosine receptors: receptor-mediated mechanisms of tissue protectionQ30307082
Cell density mediated pericellular hypoxia leads to induction of HIF-1alpha via nitric oxide and Ras/MAP kinase mediated signaling pathwaysQ30308414
Morphological and functional techniques for assessing endothelial integrity: the use of Evans blue dye, silver stains, and endothelial derived relaxing factorQ30458198
Perspectives on oxygen sensingQ33718248
Correction of sickle cell disease in transgenic mouse models by gene therapyQ34105099
Neutrophil-derived glutamate regulates vascular endothelial barrier functionQ34114299
Neutrophil migration across a cultured intestinal epithelium. Dependence on a CD11b/CD18-mediated event and enhanced efficiency in physiological directionQ34209118
Glycine 154 of the equilibrative nucleoside transporter, hENT1, is important for nucleoside transport and for conferring sensitivity to the inhibitors nitrobenzylthioinosine, dipyridamole, and dilazepQ34307816
The adenosine transporter, mENT1, is a target for adenosine receptor signaling and protein kinase Cepsilon in hypoxic and pharmacological preconditioning in the mouse cardiomyocyte cell line, HL-1.Q34319259
Oxygen sensing, HIF-1alpha stabilization and potential therapeutic strategiesQ34573202
Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epitheliaQ34797847
Mammalian nucleoside transportersQ35668173
Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors.Q35698535
Vascular ischaemia and reperfusion injuryQ35923162
Hypoxia-inducible factor 1-dependent induction of intestinal trefoil factor protects barrier function during hypoxiaQ36369318
Neutrophil-derived 5'-adenosine monophosphate promotes endothelial barrier function via CD73-mediated conversion to adenosine and endothelial A2B receptor activationQ36404222
Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expressionQ36672331
Hypoxia-induced exocytosis of endothelial cell Weibel-Palade bodies. A mechanism for rapid neutrophil recruitment after cardiac preservationQ37350527
Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolismQ38337539
Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis.Q40176806
Hypoxia regulates the adenosine transporter, mENT1, in the murine cardiomyocyte cell line, HL-1.Q40585734
Regulation of adenosine receptor engagement by ecto-adenosine deaminaseQ40614831
Hypoxia-inducible factor 1-mediated inhibition of peroxisome proliferator-activated receptor alpha expression during hypoxiaQ40801266
Hypoxia-mediated induction of endothelial cell interleukin-1 alpha. An autocrine mechanism promoting expression of leukocyte adhesion molecules on the vessel surfaceQ41022057
Seeding of vascular grafts with an immortalized human dermal microvascular endothelial cell lineQ41377094
HMEC-1: establishment of an immortalized human microvascular endothelial cell lineQ41592068
Hypoxia-induced inhibition of adenosine kinase potentiates cardiac adenosine releaseQ42442065
In vitro and in vivo properties of novel nucleoside transport inhibitors with improved pharmacological properties that potentiate antifolate activity.Q43670917
Adenosine A2A receptor stimulation increases angiogenesis by down-regulating production of the antiangiogenic matrix protein thrombospondin 1.Q45240162
Intraoperative tissue oximetry in the human gastrointestinal tract.Q45903026
Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1.Q51614218
Plasma concentration of adenosine during normoxia and moderate hypoxia in humans.Q54126699
Measurement of nitrobenzylthioinosine in plasma and erythrocytes: a pharmacokinetic study in miceQ73516086
Protection of perfused lung from oxidant injury by inhibitors of anion exchangeQ73644928
P433issue11
P407language of work or nameEnglishQ1860
P921main subjecthypoxiaQ105688
P304page(s)1493-1505
P577publication date2005-12-01
P1433published inJournal of Experimental MedicineQ3186912
P1476titleHIF-1-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia
P478volume202

Reverse relations

cites work (P2860)
Q342082372,3,7,8-Tetrachlorodibenzo-p-dioxin induced cell-specific drug transporters with acquired cisplatin resistance in cisplatin sensitive cancer cells.
Q39670043A cell-based luciferase-dependent assay for the quantitative determination of free extracellular adenosine with paracrine signaling activity
Q37373680A(2B) adenosine receptors in immunity and inflammation.
Q64377116A1AR-mediated renal protection against ischemia/reperfusion injury is dependent on HSP27 induction
Q37336475A2B adenosine receptor dampens hypoxia-induced vascular leak
Q34826208A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice
Q47665974ATP induces PAD4 in renal proximal tubule cells via P2X7 receptor activation to exacerbate ischemic AKI.
Q33356018ATP release from vascular endothelia occurs across Cx43 hemichannels and is attenuated during hypoxia
Q36277823Adenosine Attenuates Human Coronary Artery Smooth Muscle Cell Proliferation by Inhibiting Multiple Signaling Pathways That Converge on Cyclin D.
Q24620924Adenosine and hypoxia-inducible factor signaling in intestinal injury and recovery
Q48045032Adenosine production by brain cells
Q33916975Adenosine protected against pulmonary edema through transporter- and receptor A2-mediated endothelial barrier enhancement
Q29346491Adenosine receptors as drug targets--what are the challenges?
Q34211096Adenosine transport by plasma membrane monoamine transporter: reinvestigation and comparison with organic cations
Q37360635Adenosine, adenosine receptors and their role in glucose homeostasis and lipid metabolism
Q33555006Adenosine: an old drug newly discovered
Q34184568Adora2b adenosine receptor engagement enhances regulatory T cell abundance during endotoxin-induced pulmonary inflammation
Q34999682Adverse and protective influences of adenosine on the newborn and embryo: implications for preterm white matter injury and embryo protection
Q36765972Altered Hypoxic-Adenosine Axis and Metabolism in Group III Pulmonary Hypertension
Q36916313Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A.
Q49224586Anti-inflammatory Effects of Heme Oxygenase-1 Depend on Adenosine A2A- and A2B-Receptor Signaling in Acute Pulmonary Inflammation.
Q27006863Attenuating myocardial ischemia by targeting A2B adenosine receptors
Q90183281Bidirectional transport of 2-chloroadenosine by equilibrative nucleoside transporter 4 (hENT4): Evidence for allosteric kinetics at acidic pH
Q37248599Biological implications of extracellular adenosine in hepatic ischemia and reperfusion injury
Q46016040CD73 protects kidney from ischemia-reperfusion injury through reduction of free radicals.
Q52338098Capturing the multifactorial nature of ARDS - "Two-hit" approach to model murine acute lung injury.
Q35140057Cardiac-specific ablation of ARNT leads to lipotoxicity and cardiomyopathy.
Q37039131Central role of Sp1-regulated CD39 in hypoxia/ischemia protection
Q58588096Changes in aortic reactivity associated with the loss of equilibrative nucleoside transporter 1 (ENT1) in mice
Q93161851Control and dysregulation of redox signalling in the gastrointestinal tract
Q58599331Coordination of ENT2-dependent adenosine transport and signaling dampens mucosal inflammation
Q45297840Cross sectional PET study of cerebral adenosine A₁ receptors in premanifest and manifest Huntington's disease
Q98735744Cross-Species Insights Into Genomic Adaptations to Hypoxia
Q37022867Crosstalk between the equilibrative nucleoside transporter ENT2 and alveolar Adora2b adenosine receptors dampens acute lung injury
Q30881980Cytoprotective effects of adenosine and inosine in an in vitro model of acute tubular necrosis
Q34599971Decreased extracellular adenosine levels lead to loss of hypoxia-induced neuroprotection after repeated episodes of exposure to hypoxia
Q37472011Detrimental role of the airway mucin Muc5ac during ventilator-induced lung injury.
Q41094641Dietary obesity-associated Hif1α activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system.
Q35410561Direct or indirect stimulation of adenosine A2A receptors enhances bone regeneration as well as bone morphogenetic protein-2.
Q42234787Disruption of spatiotemporal hypoxic signaling causes congenital heart disease in mice
Q38980570Downregulation of duodenal SLC transporters and activation of proinflammatory signaling constitute the early response to high altitude in humans
Q27343881EGL-9 controls C. elegans host defense specificity through prolyl hydroxylation-dependent and -independent HIF-1 pathways
Q39531156Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity.
Q24323818Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26
Q46026239Environmental triggers in IBD: a review of progress and evidence.
Q36724467Epigenetic changes within the promoter region of the HLA-G gene in ovarian tumors
Q38526404Equilibrative Nucleoside Transporters 1 and 4: Which One Is a Better Target for Cardioprotection Against Ischemia-Reperfusion Injury?
Q35698980Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice
Q37174112Equilibrative nucleoside transporter 1 plays an essential role in cardioprotection
Q30244329Equilibrative nucleoside transporters-A review
Q33613207Excess adenosine A2B receptor signaling contributes to priapism through HIF-1α mediated reduction of PDE5 gene expression
Q37157213Exercise training and peripheral arterial disease
Q36585539Extracellular adenosine signaling in molecular medicine
Q35193886Extracellular adenosine: a safety signal that dampens hypoxia-induced inflammation during ischemia
Q36699593Extracellular guanosine regulates extracellular adenosine levels
Q34047834Extracellular nucleotide and nucleoside signaling in vascular and blood disease
Q36217312Functional importance of Dicer protein in the adaptive cellular response to hypoxia
Q39694952Gemcitabine intercellular diffusion mediated by gap junctions: new implications for cancer therapy.
Q37618228Genetic factors influencing cytarabine therapy
Q34109802HIF-1 regulates iron homeostasis in Caenorhabditis elegans by activation and inhibition of genes involved in iron uptake and storage
Q38565092High altitude journeys and flights are associated with an increased risk of flares in inflammatory bowel disease patients
Q48895948Hypoxia and HIF-1 suppress SERCA2a expression in embryonic cardiac myocytes through two interdependent hypoxia response elements.
Q39131639Hypoxia and P1 receptor activation regulate the high-affinity concentrative adenosine transporter CNT2 in differentiated neuronal PC12 cells
Q37842498Hypoxia and inflammation
Q34087018Hypoxia increases the expression of stem-cell markers and promotes clonogenicity in glioblastoma neurospheres
Q33312383Hypoxia inducible factor (HIF)-1 coordinates induction of Toll-like receptors TLR2 and TLR6 during hypoxia
Q37061658Hypoxia inducible factor-1 (HIF-1)-mediated repression of cystic fibrosis transmembrane conductance regulator (CFTR) in the intestinal epithelium
Q34001111Hypoxia signaling controls postnatal changes in cardiac mitochondrial morphology and function
Q36752391Hypoxia signaling during acute lung injury
Q37373524Hypoxia signaling during intestinal ischemia and inflammation
Q33713383Hypoxia-induced deoxycytidine kinase expression contributes to apoptosis in chronic lung disease.
Q35998064Hypoxia-inducible factor 1 protects hypoxic astrocytes against glutamate toxicity
Q37448566Hypoxia-inducible factor-1α-dependent protection from intestinal ischemia/reperfusion injury involves ecto-5'-nucleotidase (CD73) and the A2B adenosine receptor
Q46175545Hypoxia-inducible factor-dependent induction of netrin-1 dampens inflammation caused by hypoxia.
Q26752304Hypoxia-inducible factors as molecular targets for liver diseases
Q38109802Hypoxia: a master regulator of microRNA biogenesis and activity
Q33569829Hypoxic repression of endothelial nitric-oxide synthase transcription is coupled with eviction of promoter histones
Q37625454Identification of hypoxia-inducible factor HIF-1A as transcriptional regulator of the A2B adenosine receptor during acute lung injury.
Q33725755Identification of vasodilator-stimulated phosphoprotein (VASP) as an HIF-regulated tissue permeability factor during hypoxia
Q90639932Inhibition of CXCR4 and CXCR7 Is Protective in Acute Peritoneal Inflammation
Q43111428Inhibition of neutrophil apoptosis by ATP is mediated by the P2Y11 receptor.
Q64108225Intestinal Epithelial Cells-Derived Hypoxia-Inducible Factor-1α Is Essential for the Homeostasis of Intestinal Intraepithelial Lymphocytes
Q46260887Intestinal hypoxia and hypoxia-induced signalling as therapeutic targets for IBD.
Q63977060Invited Lectures : Overviews Purinergic signalling: past, present and future
Q50849347Involvement of CD73, equilibrative nucleoside transporters and inosine in rhythm and conduction disturbances mediated by adenosine A1 and A2A receptors in the developing heart.
Q36430733Loss of CD73-mediated actin polymerization promotes endometrial tumor progression
Q39361006Mechanisms of attenuation of abdominal sepsis induced acute lung injury by ascorbic acid
Q91779682Metabolic Regulation of Macrophage Polarization in Cancer
Q90073357Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors
Q39923834Microarray analyses of hypoxia-regulated genes in an aryl hydrocarbon receptor nuclear translocator (Arnt)-dependent manner
Q28080772Molecular mechanisms of ischemic preconditioning in the kidney
Q39250668Molecular predictors of gemcitabine response in pancreatic cancer
Q64103114NR3C1 gene polymorphisms are associated with high-altitude pulmonary edema in Han Chinese
Q34011327Neutrophils as sources of extracellular nucleotides: functional consequences at the vascular interface
Q39523639New role of the human equilibrative nucleoside transporter 1 (hENT1) in epithelial-to-mesenchymal transition in renal tubular cells.
Q36127152Nickel-induced epithelial-mesenchymal transition by reactive oxygen species generation and E-cadherin promoter hypermethylation
Q38031634Nucleoside transporters: biological insights and therapeutic applications
Q37855808Nucleoside/nucleobase transporters: drug targets of the future?
Q33374284Oxygen-independent stabilization of hypoxia inducible factor (HIF)-1 during RSV infection
Q89839805P2X4 receptor exacerbates ischemic AKI and induces renal proximal tubular NLRP3 inflammasome signaling
Q91940114PAK inhibition by PF-3758309 enhanced the sensitivity of multiple chemotherapeutic reagents in patient-derived pancreatic cancer cell lines
Q33916670Partial netrin-1 deficiency aggravates acute kidney injury
Q37593569Perioperative organ injury
Q37082372Physiology of nucleoside transporters: back to the future. . . .
Q33890909Protection against acute kidney injury via A(1) adenosine receptor-mediated Akt activation reduces liver injury after liver ischemia and reperfusion in mice
Q41112476Protocol for a prospective, controlled, observational study to evaluate the influence of hypoxia on healthy volunteers and patients with inflammatory bowel disease: the Altitude IBD Study
Q92404916Purinergic Signaling in Pulmonary Inflammation
Q37139591Purinergic dysregulation in pulmonary hypertension
Q38034108Quintessential risk factors: their role in promoting cognitive dysfunction and Alzheimer's disease
Q39621896Regulation of ENT1 expression and ENT1-dependent nucleoside transport by c-Jun N-terminal kinase
Q24620317Regulation of neutrophil function by adenosine
Q39165553Repression of the equilibrative nucleoside transporters dampens inflammatory lung injury
Q37227567Retracted: Equilibrative nucleoside transporter (ENT)-1-dependent elevation of extracellular adenosine protects the liver during ischemia and reperfusion
Q37108355Role of adenosine A(2B) receptors in inflammation
Q36804999Role of extracellular nucleotide phosphohydrolysis in intestinal ischemia-reperfusion injury
Q33496725Selective deletion of the A1 adenosine receptor abolishes heart-rate slowing effects of intravascular adenosine in vivo
Q34707637Selective induction of endothelial P2Y6 nucleotide receptor promotes vascular inflammation
Q55263042Sequencing the exons of human glucocorticoid receptor (NR3C1) gene in Han Chinese with high-altitude pulmonary edema.
Q42003221Severe hypoxia induces complete antifolate resistance in carcinoma cells due to cell cycle arrest.
Q64900575Short-Term Hypoxia Dampens Inflammation in vivo via Enhanced Adenosine Release and Adenosine 2B Receptor Stimulation.
Q33807056Signaling through the A2B adenosine receptor dampens endotoxin-induced acute lung injury
Q33844658Signalling pathways involved in hypoxia-induced renal fibrosis
Q36539636Sustained adenosine exposure causes lung endothelial barrier dysfunction via nucleoside transporter-mediated signaling
Q55259961Switching-Off Adora2b in Vascular Smooth Muscle Cells Halts the Development of Pulmonary Hypertension.
Q33297014Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival
Q93062525Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function
Q38209586Targeting CD73 and downstream adenosine receptor signaling in triple-negative breast cancer
Q34657382Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases
Q33830064Targeting the A2B adenosine receptor during gastrointestinal ischemia and inflammation
Q35601599The 2',3'-cAMP-adenosine pathway
Q38686607The Adenosinergic System as a Therapeutic Target in the Vasculature: New Ligands and Challenges.
Q99565422The Association of FLT3-ITD Gene Mutation with Bone Marrow Blast Cell Count, CD34, Cyclin D1, Bcl-xL and hENT1 Expression in Acute Myeloid Leukemia Patients
Q38063159The CD39-adenosinergic axis in the pathogenesis of renal ischemia-reperfusion injury
Q38644137The Hypoxia-Adenosine Link during Inflammation.
Q48191363The Hypoxia-Adenosine Link during Intestinal Inflammation.
Q37440360The Janus-faced effects of hypoxia on astrocyte function
Q96230894The adenosine pathway in immuno-oncology
Q33692620The adenosine transporter, ENT1, in cardiomyocytes is sensitive to inhibition by ethanol in a kinase-dependent manner: implications for ethanol-dependent cardioprotection and nucleoside analog drug cytotoxicity
Q27014790The clinically relevant pharmacogenomic changes in acute myelogenous leukemia
Q90608608The failure of DAC to induce OCT2 expression and its remission by hemoglobin-based nanocarriers under hypoxia in renal cell carcinoma
Q35676172The hypoxia-inflammation link and potential drug targets
Q41678839The impact of hypoxia on tumor-associated macrophages
Q28473410The reno-vascular A2B adenosine receptor protects the kidney from ischemia
Q34307284The resurgence of A2B adenosine receptor signaling
Q36575943Transcriptional control of adenosine signaling by hypoxia-inducible transcription factors during ischemic or inflammatory disease
Q41871477Transgenic overexpression of CD39 protects against renal ischemia-reperfusion and transplant vascular injury
Q36593052Tubuloglomerular feedback and renal function in mice with targeted deletion of the type 1 equilibrative nucleoside transporter
Q48284423Unfolding Role of a Danger Molecule Adenosine Signaling in Modulation of Microbial Infection and Host Cell Response.
Q104491993Upregulated Hif-1α signaling pathway in high risk myelodysplastic syndrome and acute myeloid leukemia patients is associated with better response to 5-azacytidine - Data from the Hellenic MDS study group
Q35203103Use of a hanging weight system for coronary artery occlusion in mice
Q46626898Use of a hanging-weight system for liver ischemic preconditioning in mice
Q35859147Vasodilator phosphostimulated protein (VASP) protects endothelial barrier function during hypoxia
Q37593531miR-205 hinders the malignant interplay between prostate cancer cells and associated fibroblasts
Q58760423p21-activated kinase signalling in pancreatic cancer: New insights into tumour biology and immune modulation

Search more.