A novel cyclic AMP/Epac1/CaMKI signaling cascade promotes GCM1 desumoylation and placental cell fusion

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A novel cyclic AMP/Epac1/CaMKI signaling cascade promotes GCM1 desumoylation and placental cell fusion is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.05582-11
P932PMC publication ID3165715
P698PubMed publication ID21791615
P5875ResearchGate publication ID51523424

P2093author name stringChing-Wen Chang
Hungwen Chen
Geen-Dong Chang
P2860cites workA family of cAMP-binding proteins that directly activate Rap1Q22008551
Cyclic AMP-dependent protein kinases and human trophoblast cell differentiation in vitroQ74270155
Epac-mediated activation of phospholipase C(epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytesQ79441381
Syncytin is a captive retroviral envelope protein involved in human placental morphogenesisQ22253248
Mechanism of regulation of the Epac family of cAMP-dependent RapGEFsQ22253953
SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxiaQ24299542
Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMaQ24534839
Structure of the GCM domain-DNA complex: a DNA-binding domain with a novel fold and mode of target site recognitionQ24676230
Mechanisms, regulation and consequences of protein SUMOylationQ27865251
The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognitionQ27865256
SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineagesQ28508647
SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic developmentQ28589417
Mutation of SENP1/SuPr-2 reveals an essential role for desumoylation in mouse development.Q28589576
The glial cells missing-1 protein is essential for branching morphogenesis in the chorioallantoic placentaQ28589631
Glial cell missing-1 transcription factor is required for the differentiation of the human trophoblastQ29147541
Protein modification by SUMOQ29547919
GCMa regulates the syncytin-mediated trophoblastic fusionQ31115381
Protein stability and domain topology determine the transcriptional activity of the mammalian glial cells missing homolog, GCMbQ33889706
Epac: defining a new mechanism for cAMP actionQ34091443
FBW2 targets GCMa to the ubiquitin-proteasome degradation systemQ34382959
Stimulation of GCMa and syncytin via cAMP mediated PKA signaling in human trophoblastic cells under normoxic and hypoxic conditionsQ34432383
Dual-specificity phosphatase 23 mediates GCM1 dephosphorylation and activationQ34559644
Small ubiquitin-like modifier modification regulates the DNA binding activity of glial cell missing Drosophila homolog a.Q34655191
Cyclic AMP (cAMP)-mediated stimulation of adipocyte differentiation requires the synergistic action of Epac- and cAMP-dependent protein kinase-dependent processesQ36711265
bZIP-Type transcription factors CREB and OASIS bind and stimulate the promoter of the mammalian transcription factor GCMa/Gcm1 in trophoblast cellsQ36740143
Mechanism of hypoxia-induced GCM1 degradation: implications for the pathogenesis of preeclampsiaQ37285199
Emerging roles of desumoylating enzymesQ37375239
Interplay of cAMP and MAPK pathways in hCG secretion and fusogenic gene expression in a trophoblast cell line.Q39638147
Possible role of the exchange protein directly activated by cyclic AMP (Epac) in the cyclic AMP-dependent functional differentiation and syncytialization of human placental BeWo cellsQ39675136
GCM1 regulation of the expression of syncytin 2 and its cognate receptor MFSD2A in human placentaQ39702263
Functional characterization of the human placental fusogenic membrane protein syncytin 2.Q39957954
Epac, in synergy with cAMP-dependent protein kinase (PKA), is required for cAMP-mediated mitogenesisQ40038631
Modulators of cyclic AMP metabolism induce syncytiotrophoblast formation in vitroQ41746072
Epac and phospholipase Cepsilon regulate Ca2+ release in the heart by activation of protein kinase Cepsilon and calcium-calmodulin kinase II.Q42443922
Regulation of axonal extension and growth cone motility by calmodulin-dependent protein kinase I.Q44844953
Cytoplasmic localization of calcium/calmodulin-dependent protein kinase I-alpha depends on a nuclear export signal in its regulatory domainQ47591894
The cAMP binding protein Epac modulates Ca2+ sparks by a Ca2+/calmodulin kinase signalling pathway in rat cardiac myocytesQ64377082
Active intracellular domain of Notch enhances transcriptional activation of CCAAT/enhancer binding protein beta on a rat pregnancy-specific glycoprotein geneQ73454474
P4510describes a project that usesImageJQ1659584
P433issue18
P407language of work or nameEnglishQ1860
P1104number of pages12
P304page(s)3820-3831
P577publication date2011-07-26
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleA novel cyclic AMP/Epac1/CaMKI signaling cascade promotes GCM1 desumoylation and placental cell fusion
P478volume31

Reverse relations

cites work (P2860)
Q36434039A Positive Feedback Loop between Glial Cells Missing 1 and Human Chorionic Gonadotropin (hCG) Regulates Placental hCGβ Expression and Cell Differentiation
Q33707949A Rho-associated coiled-coil containing kinases (ROCK) inhibitor, Y-27632, enhances adhesion, viability and differentiation of human term placenta-derived trophoblasts in vitro
Q36751530ADAM12-directed ectodomain shedding of E-cadherin potentiates trophoblast fusion.
Q38613609Cell Signaling Pathways Involved During Invasion and Syncytialization of Trophoblast Cells.
Q44657493Context-specific transcriptional regulatory network inference from global gene expression maps using double two-way t-tests
Q53385845Cooperation of Epac1/Rap1/Akt and PKA in prostaglandin E(2) -induced proliferation of human umbilical cord blood derived mesenchymal stem cells: involvement of c-Myc and VEGF expression
Q27673945Crystal Structures of Human CaMKIα Reveal Insights into the Regulation Mechanism of CaMKI
Q45719205Emerging role of SUMOylation in placental pathology
Q30234675Endogenous Retroviruses: With Us and against Us
Q33685872Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses
Q38714215Expression and function of endogenous retroviruses in the placenta
Q36227415Gene targeting in primary human trophoblasts
Q34580891Implication of human endogenous retrovirus envelope proteins in placental functions.
Q52656382Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.
Q24309957Involvement of Epac1/Rap1/CaMKI/HDAC5 signaling cascade in the regulation of placental cell fusion
Q64933769New insights into the regulation of placental growth factor gene expression by the transcription factors GCM1 and DLX3 in human placenta.
Q33728187Placental villous mesenchymal cells trigger trophoblast invasion
Q40964114Spatiotemporal regulation of cAMP signaling controls the human trophoblast fusion
Q37596354Transglutaminase 2-dependent deamidation of glyceraldehyde-3-phosphate dehydrogenase promotes trophoblastic cell fusion
Q33815861p45 NF-E2 regulates syncytiotrophoblast differentiation by post-translational GCM1 modifications in human intrauterine growth restriction

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