Possible role of the exchange protein directly activated by cyclic AMP (Epac) in the cyclic AMP-dependent functional differentiation and syncytialization of human placental BeWo cells

scientific article published on July 27, 2010

Possible role of the exchange protein directly activated by cyclic AMP (Epac) in the cyclic AMP-dependent functional differentiation and syncytialization of human placental BeWo cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/HUMREP/DEQ190
P953full work available at URLhttp://humrep.oxfordjournals.org/cgi/content/abstract/25/9/2229
P698PubMed publication ID20663796
P5875ResearchGate publication ID45388758

P50authorKazuya KusamaQ59692284
Mikihiro YoshieQ73588311
P2093author name stringKazuhiro Tamura
Hirotaka Nishi
Keiichi Isaka
Chinatsu Higuma
Kei Kaneyama
P2860cites workMolecular and Cellular BiologyQ3319478
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMPQ22008544
A family of cAMP-binding proteins that directly activate Rap1Q22008551
Metabolites of an Epac-selective cAMP analog induce cortisol synthesis by adrenocortical cells through a cAMP-independent pathwayQ28475669
Epac1 is upregulated during neointima formation and promotes vascular smooth muscle cell migrationQ28570215
Direct spatial control of Epac1 by cyclic AMP.Q30487622
Enhanced expression of uterine stathmin during the process of implantation and decidualization in ratsQ30724730
GCMa regulates the syncytin-mediated trophoblastic fusionQ31115381
Requirement of gap junctional intercellular communication for human villous trophoblast differentiation.Q34208959
Stimulation of GCMa and syncytin via cAMP mediated PKA signaling in human trophoblastic cells under normoxic and hypoxic conditionsQ34432383
Epac proteins: multi-purpose cAMP targetsQ34579147
Syncytin-2 plays an important role in the fusion of human trophoblast cellsQ34992874
Apoptosis in the trophoblast--role of apoptosis in placental morphogenesisQ35879137
Endocrine cell lines from the placentaQ35947568
Rap1: a key regulator in cell-cell junction formationQ36689667
Cyclic AMP (cAMP)-mediated stimulation of adipocyte differentiation requires the synergistic action of Epac- and cAMP-dependent protein kinase-dependent processesQ36711265
Epac: effectors and biological functionsQ37051159
Epac increases melanoma cell migration by a heparan sulfate-related mechanismQ37406239
Expression of stathmin, a microtubule regulatory protein, is associated with the migration and differentiation of cultured early trophoblastsQ39948498
cAMP-induced Epac-Rap activation inhibits epithelial cell migration by modulating focal adhesion and leading edge dynamics.Q40001607
8-bromo-cyclicAMP stimulates glucose transporter-1 expression in a human choriocarcinoma cell lineQ40902322
8-Bromo-3',5'-adenosine monophosphate stimulates the endocrine activity of human cytotrophoblasts in cultureQ42217199
Progesterone secretion by luteinizing human granulosa cells: a possible cAMP-dependent but PKA-independent mechanism involved in its regulationQ42470119
Effects of 8-bromo-cAMP on expression of endocrine functions by cultured human trophoblast cells. Regulation of specific mRNAsQ42498735
Protein kinase A suppresses the differentiation of 3T3-L1 preadipocytesQ42818146
Effect of IPs, cAMP, and cGMP on the hPL and hCG secretion from human term placentaQ46754292
Structural dynamics in the activation of Epac.Q54695888
Involvement of connexin 43 in human trophoblast cell fusion and differentiationQ59344565
Basic fibroblast growth factor in rat corpus luteum stimulates prostaglandin F2-alpha productionQ70227951
Enhanced functional gap junction neoformation by protein kinase A-dependent and Epac-dependent signals downstream of cAMP in cardiac myocytesQ81118444
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectcell differentiationQ210861
signal transductionQ828130
P304page(s)2229-2238
P577publication date2010-07-27
P1433published inHuman ReproductionQ5937357
P1476titlePossible role of the exchange protein directly activated by cyclic AMP (Epac) in the cyclic AMP-dependent functional differentiation and syncytialization of human placental BeWo cells
P478volume25

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cites work (P2860)
Q35192586A novel cyclic AMP/Epac1/CaMKI signaling cascade promotes GCM1 desumoylation and placental cell fusion
Q39598613Fibulin-5 expression in the human placenta
Q52656382Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.
Q28482150Involvement of membrane GRP78 in trophoblastic cell fusion
Q92812919Placenta-Specific Genes, Their Regulation During Villous Trophoblast Differentiation and Dysregulation in Preterm Preeclampsia
Q33728187Placental villous mesenchymal cells trigger trophoblast invasion
Q28117720Role of the vasohibin family in the regulation of fetoplacental vascularization and syncytiotrophoblast formation
Q40964114Spatiotemporal regulation of cAMP signaling controls the human trophoblast fusion
Q34441228The alternative Epac/cAMP pathway and the MAPK pathway mediate hCG induction of leptin in placental cells