The alternative Epac/cAMP pathway and the MAPK pathway mediate hCG induction of leptin in placental cells

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The alternative Epac/cAMP pathway and the MAPK pathway mediate hCG induction of leptin in placental cells is …
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P819ADS bibcode2012PLoSO...746216M
P356DOI10.1371/JOURNAL.PONE.0046216
P932PMC publication ID3462743
P698PubMed publication ID23056265

P50authorJuan Carlos Ayala CalvoQ86688279
Bernardo MaskinQ114515758
Antonio Pérez-PérezQ82235115
Cecilia VaroneQ42807216
Victor Sánchez-MargaletQ42905868
José L. DueñasQ43059580
P2093author name stringJulieta Lorena Maymó
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Invasion of cytotrophoblastic JEG-3 cells is stimulated by hCG in vitroQ77707588
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Leptin stimulates protein synthesis-activating translation machinery in human trophoblastic cells.Q38352867
Protein kinase A-dependent and -independent signaling pathways contribute to cyclic AMP-stimulated proliferation.Q39446908
Possible role of the exchange protein directly activated by cyclic AMP (Epac) in the cyclic AMP-dependent functional differentiation and syncytialization of human placental BeWo cellsQ39675136
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Cross talk between cAMP and p38 MAPK pathways in the induction of leptin by hCG in human placental syncytiotrophoblastsQ42488099
Identification of a functional Na+/Mg2+ exchanger in human trophoblast cellsQ42522596
Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signallingQ42656809
alpha2- to beta3-Adrenoceptor switch in 3T3-L1 preadipocytes and adipocytes: modulation by testosterone, 17beta-estradiol, and progesteroneQ42818040
Rap1 mediates sustained MAP kinase activation induced by nerve growth factorQ42830846
Regulation of placental leptin expression by cyclic adenosine 5'-monophosphate involves cross talk between protein kinase A and mitogen-activated protein kinase signaling pathwaysQ43059524
Adenosine 3',5'-cyclic monophosphate (cAMP)-dependent inhibition of IL-5 from human T lymphocytes is not mediated by the cAMP-dependent protein kinase A.Q43699062
Effect of cyclic 3',5'-adenosine monophosphate, glucocorticoids, and insulin on leptin messenger RNA levels and leptin secretion in cultured human trophoblastQ43713985
Transcriptional activation of the human leptin gene in response to hypoxia. Involvement of hypoxia-inducible factor 1.Q44041904
Transduction of leptin growth signals in placental cells is independent of JAK-STAT activationQ44376382
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)e46216
P577publication date2012-10-02
P1433published inPLOS OneQ564954
P1476titleThe alternative Epac/cAMP pathway and the MAPK pathway mediate hCG induction of leptin in placental cells
P478volume7