Hypoxia-inducible factor 1 and its role in viral carcinogenesis

scientific article

Hypoxia-inducible factor 1 and its role in viral carcinogenesis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.VIROL.2014.02.027
P3181OpenCitations bibliographic resource ID5083753
P698PubMed publication ID24698149
P5875ResearchGate publication ID261370085

P50authorRobert JacksonQ85237127
Ingeborg ZehbeQ109301855
Sean CuninghameQ117231623
P2860cites workHallmarks of Cancer: The Next GenerationQ22252312
Structures and Proton-Pumping Strategies of Mitochondrial Respiratory EnzymesQ22255650
A conserved family of prolyl-4-hydroxylases that modify HIFQ24291794
Epstein-Barr virus immortalization of human B-cells leads to stabilization of hypoxia-induced factor 1 alpha, congruent with the Warburg effectQ24294513
Twist and epithelial-mesenchymal transition are induced by the EBV oncoprotein latent membrane protein 1 and are associated with metastatic nasopharyngeal carcinomaQ24298635
SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxiaQ24299542
Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1.Q24306316
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tensionQ24307473
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1Q24316075
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53Q24317677
IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathwayQ24337225
Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alphaQ24338422
Lysosomal cysteine proteases: facts and opportunitiesQ24535678
Understanding the Warburg effect: the metabolic requirements of cell proliferationQ24604760
miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasisQ24613599
HIF-1: upstream and downstream of cancer metabolismQ24647482
Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)Q24650427
Why do viruses cause cancer? Highlights of the first century of human tumour virologyQ37811898
Diverse roles of hepatitis B virus in liver cancerQ38020667
Oxygen-independent regulation of HIF-1: novel involvement of PI3K/AKT/mTOR pathway in cancerQ38072462
Disrupting proton dynamics and energy metabolism for cancer therapyQ38130850
bHLH-PAS proteins in cancerQ38164994
The transcription factor Egr1 regulates the HIF-1alpha gene during hypoxia.Q38290578
Nucleotide sequence, chromosomal assignment and mRNA expression of mouse hypoxia-inducible factor-1 alphaQ38356865
Hepatitis B virus X protein induces angiogenesis by stabilizing hypoxia-inducible factor-1alphaQ38518574
A dual role for hypoxia inducible factor-1α in the hepatitis C virus lifecycle and hepatoma migrationQ39426654
Overexpression of MMP-9 and HIF-1α in Breast Cancer Cells under Hypoxic ConditionsQ39716859
Role of the HBx oncoprotein in carbonic anhydrase 9 inductionQ39768872
Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma.Q39788635
Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH.Q39899643
Epstein-Barr virus-encoded EBNA1 modulates the AP-1 transcription factor pathway in nasopharyngeal carcinoma cells and enhances angiogenesis in vitroQ39927855
Kaposi's sarcoma-associated herpesvirus viral IFN regulatory factor 3 stabilizes hypoxia-inducible factor-1 alpha to induce vascular endothelial growth factor expressionQ40002571
Roles for hypoxia-regulated genes during cervical carcinogenesis: somatic evolution during the hypoxia-glycolysis-acidosis sequenceQ40041397
A potential alpha-helix motif in the amino terminus of LANA encoded by Kaposi's sarcoma-associated herpesvirus is critical for nuclear accumulation of HIF-1alpha in normoxiaQ40106826
Activation of hypoxia-inducible factor 1 in human T-cell leukaemia virus type 1-infected cell lines and primary adult T-cell leukaemia cellsQ40118264
Higher expression and activity of metalloproteinases in human cervical carcinoma cell lines is associated with HPV presence.Q40196754
EBV latent membrane protein 1 up-regulates hypoxia-inducible factor 1alpha through Siah1-mediated down-regulation of prolyl hydroxylases 1 and 3 in nasopharyngeal epithelial cellsQ40219046
Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasisQ36584906
Glucose metabolism and cancerQ36625786
Virus-specific mechanisms of carcinogenesis in hepatitis C virus associated liver cancerQ36812745
HIF-1 mediates the Warburg effect in clear cell renal carcinomaQ36841614
Papillomavirus E6 and E7 proteins and their cellular targetsQ36992007
NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alphaQ37158836
Hypoxia-specific stabilization of HIF-1alpha by human papillomavirusesQ37171664
Increased expression of ErbB-2 in liver is associated with hepatitis B x antigen and shorter survival in patients with liver cancerQ37349973
Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-associated myeloid cellsQ37417836
Regulation of hypoxia-inducible factor-1alpha by NF-kappaBQ24657260
Clonal integration of a polyomavirus in human Merkel cell carcinomaQ24657675
Hepatitis C Virus Stabilizes Hypoxia-Inducible Factor 1 and Stimulates the Synthesis of Vascular Endothelial Growth FactorQ27481487
Temporal Proteome and Lipidome Profiles Reveal Hepatitis C Virus-Associated Reprogramming of Hepatocellular Metabolism and BioenergeticsQ27490520
Hepatitis C Virus-Linked Mitochondrial Dysfunction Promotes Hypoxia-Inducible Factor 1 -Mediated Glycolytic AdaptationQ27490543
Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancerQ27824855
Targeting HIF-1 for cancer therapyQ27860504
Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of functionQ28140184
HIF1A gene transcription is dependent on a core promoter sequence encompassing activating and inhibiting sequences located upstream from the transcription initiation site and cis elements located within the 5'UTRQ28140700
HIF-1: mediator of physiological and pathophysiological responses to hypoxiaQ28140835
HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleusQ28191456
Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancerQ28206439
Asparagine hydroxylation of the HIF transactivation domain a hypoxic switchQ28217194
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1αQ28259513
Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activityQ28274440
Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinomaQ28284012
In vivo expression of mRNAs encoding hypoxia-inducible factor 1Q28286675
Energy boost: the Warburg effect returns in a new theory of cancerQ28298486
Hypoxia-inducible factor-1 alpha is regulated at the post-mRNA levelQ28303316
Molecular mechanisms and clinical applications of angiogenesisQ29547314
Microenvironmental regulation of metastasisQ29547660
Papillomaviruses and cancer: from basic studies to clinical applicationQ29614745
Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathwaysQ29615855
THE METABOLISM OF TUMORS IN THE BODYQ29616202
Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensingQ29617570
Tumor metastasis: mechanistic insights and clinical challengesQ29617676
Epidemiology of Viral Hepatitis and Hepatocellular CarcinomaQ29617918
Epstein-Barr virus: 40 years onQ29617969
Global burden of cancers attributable to infections in 2008: a review and synthetic analysisQ29620303
The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic miceQ29620765
EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressorsQ33261811
The role of NF-kappaB in Hepatitis b virus X protein-mediated upregulation of VEGF and MMPsQ33523861
Bicarbonate increases tumor pH and inhibits spontaneous metastasesQ33711068
MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesisQ33744153
Hepatitis B virus HBx protein deregulates cell cycle checkpoint controlsQ33765576
Kaposi's sarcoma-associated herpesvirus LANA2 is a B-cell-specific latent viral protein that inhibits p53Q33834993
p53 inhibition by the LANA protein of KSHV protects against cell deathQ33885642
Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1 alphaQ40236336
NF-kappaB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2.Q40252191
Role for Akt/protein kinase B and activator protein-1 in cellular proliferation induced by the human T-cell leukemia virus type 1 tax oncoproteinQ40325197
Hepatitis C virus, ER stress, and oxidative stressQ40432170
Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH.Q40489574
The carboxy-terminus of the hepatitis B virus X protein is necessary and sufficient for the activation of hypoxia-inducible factor-1alphaQ40495822
Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potentialQ40558090
Suppression of the dual-specificity phosphatase MKP-1 enhances HIF-1 trans-activation and increases expression of EPO.Q40606498
Hypoxia up-regulates hypoxia-inducible factor-1alpha transcription by involving phosphatidylinositol 3-kinase and nuclear factor kappaB in pulmonary artery smooth muscle cellsQ40725245
Association of latent membrane protein 1 and matrix metalloproteinase 9 with metastasis in nasopharyngeal carcinomaQ40860124
Telomerase activation by the E6 gene product of human papillomavirus type 16.Q41218028
Mitogen-Activated Protein Kinases and Reactive Oxygen Species: How Can ROS Activate MAPK Pathways?Q41786663
Degradation of extracellular-matrix proteins by human cathepsin B from normal and tumour tissuesQ41849893
The physiology and pathology of the EMT. Meeting on the epithelial-mesenchymal transition.Q41987639
Kaposi's sarcoma-associated herpesvirus latent protein LANA interacts with HIF-1 alpha to upregulate RTA expression during hypoxia: Latency control under low oxygen conditionsQ42049779
HIF-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxiaQ42512319
Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)-dependent signalingQ42814573
The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survivalQ42828483
G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activatorQ42833351
Expression and coordinated regulation of matrix metalloproteinases in chronic hepatitis C and hepatitis C virus-induced liver cirrhosisQ43048487
Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxiaQ43761426
Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesisQ43954468
Overexpression of human papillomavirus (HPV) type 16 oncoproteins promotes angiogenesis via enhancing HIF-1α and VEGF expression in non-small cell lung cancer cellsQ44066614
Kaposi's sarcoma associated herpesvirus G protein-coupled receptor immortalizes human endothelial cells by activation of the VEGF receptor-2/ KDR.Q44277985
Hepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1alpha through activation of mitogen-activated protein kinase pathwayQ44509761
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathwaysQ44905183
Angiogenesis soluble factors as hepatocellular carcinoma noninvasive markers for monitoring hepatitis C virus cirrhotic patients awaiting liver transplantation.Q44934094
Hepatitis C virus core protein upregulates the expression of vascular endothelial growth factor via the nuclear factor‐κB/hypoxia‐inducible factor‐1α axis under hypoxic conditionsQ45360614
Hepatitis B virus X protein induces the expression of MTA1 and HDAC1, which enhances hypoxia signaling in hepatocellular carcinoma cellsQ45397229
Human hepatitis B virus X protein is a possible mediator of hypoxia-induced angiogenesis in hepatocarcinogenesisQ45744352
HBx gene of hepatitis B virus induces liver cancer in transgenic miceQ45852802
Overexpression of human papillomavirus type 16 oncoproteins enhances hypoxia-inducible factor 1 alpha protein accumulation and vascular endothelial growth factor expression in human cervical carcinoma cellsQ46198800
The potential of angiogenesis soluble markers in chronic hepatitis C.Q46653289
The Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) K1 protein induces expression of angiogenic and invasion factorsQ47755368
HPV-16 E7 but not E6 oncogenic protein triggers both cellular immunosuppression and angiogenic processesQ50757084
TWIST activation by hypoxia inducible factor-1 (HIF-1): implications in metastasis and developmentQ51952297
p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.Q52173333
p38alpha MAP kinase as a sensor of reactive oxygen species in tumorigenesisQ53336933
The purpose of the HIF-1/PHD feedback loop: To limit mTOR-induced HIF-1αQ53427469
Expression of VEGF as prognosticator in primary nasopharyngeal cancer and its relation to EBV statusQ53658719
Epstein–Barr Virus in Burkitt's Lymphoma and Nasopharyngeal Carcinoma: EBV DNA in Biopsies of Burkitt Tumours and Anaplastic Carcinomas of the NasopharynxQ56689988
Oncogenes and tumor angiogenesis: the HPV-16 E6 oncoprotein activates the vascular endothelial growth factor (VEGF) gene promoter in a p53 independent mannerQ62566479
Angiogenesis Modulators Expression in Culture Cell Lines Positives for HPV-16 OncoproteinsQ62566482
Significant differences in serum activities of matrix metalloproteinase-2 and -9 between HCV- and HBV-infected patients and carriersQ73571853
Asian-American variants of human papillomavirus 16 and risk for cervical cancer: a case-control studyQ74459615
Expression profiles associated with aggressive behavior in Merkel cell carcinomaQ79370590
Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude miceQ79834386
MAP kinase pathwaysQ81074052
Amplification of the angiogenic signal through the activation of the TSC/mTOR/HIF axis by the KSHV vGPCR in Kaposi's sarcomaQ33895137
HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expressionQ33968465
HIV, EBV and KSHV: Viral cooperation in the pathogenesis of human malignanciesQ34170639
Epstein-Barr virus and cancerQ34297027
Acidity generated by the tumor microenvironment drives local invasionQ34320819
Epstein-Barr virus latent membrane protein 1 induces synthesis of hypoxia-inducible factor 1 alphaQ34346992
Hepatitis B Virus X Protein Upregulates mTOR Signaling through IKKβ to Increase Cell Proliferation and VEGF Production in Hepatocellular CarcinomaQ34359262
Aerobic glycolysis by proliferating cells: a protective strategy against reactive oxygen species.Q34425171
Molecular mechanisms of cellular transformation by HTLV-1 Tax.Q34450092
Transcriptional repression of E-cadherin by human papillomavirus type 16 E6.Q34493735
The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cellsQ34511161
Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alphaQ34519869
Cancer's molecular sweet tooth and the Warburg effect.Q34566915
Transcriptional repression of p53 promoter by hepatitis C virus core proteinQ34739314
Epstein-Barr Virus latent membrane protein 1 induces Snail and epithelial–mesenchymal transition in metastatic nasopharyngeal carcinomaQ34745799
Human papillomavirus E7 enhances hypoxia-inducible factor 1-mediated transcription by inhibiting binding of histone deacetylasesQ34799489
Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) contains hypoxia response elements: relevance to lytic induction by hypoxiaQ35019982
Kaposi sarcoma-associated herpesvirus (KSHV): molecular biology and oncogenesisQ35127940
Latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells activates hypoxia-induced factorsQ35139228
Depletion of Langerhans cells in human papillomavirus type 16-infected skin is associated with E6-mediated down regulation of E-cadherinQ35155315
Increased intrahepatic cyclooxygenase 2, matrix metalloproteinase 2, and matrix metalloproteinase 9 expression is associated with progressive liver disease in chronic hepatitis C virus infection: role of viral core and NS5A proteinsQ35596979
Oncogenic Viruses and Tumor Glucose Metabolism: Like Kids in a Candy StoreQ35671327
Aberrant expression of VEGF-C is related to grade of cervical intraepithelial neoplasia (CIN) and high risk HPV, but does not predict virus clearance after treatment of CIN or prognosis of cervical cancer.Q35769502
Kaposi's sarcoma-associated herpesvirus infection promotes invasion of primary human umbilical vein endothelial cells by inducing matrix metalloproteinasesQ35914351
Hypoxia-inducible factor-1 facilitates cervical cancer progression in human papillomavirus type 16 transgenic miceQ35916052
Vascular endothelial growth factor/vascular permeability factor is an autocrine growth factor for AIDS-Kaposi sarcomaQ35967211
The expression of matrix metalloproteinase 9 is enhanced by Epstein–Barr virus latent membrane protein 1Q36006767
Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapyQ36220497
Induction of cyclooxygenase-2 by Epstein-Barr virus latent membrane protein 1 is involved in vascular endothelial growth factor production in nasopharyngeal carcinoma cellsQ36242117
PI3K/AKT inhibition induces caspase-dependent apoptosis in HTLV-1-transformed cellsQ36358632
The Asian-American E6 Variant Protein of Human Papillomavirus 16 Alone Is Sufficient To Promote Immortalization, Transformation, and Migration of Primary Human Foreskin KeratinocytesQ36363871
Kaposi sarcoma herpesvirus promotes endothelial-to-mesenchymal transition through Notch-dependent signaling.Q36439695
Kaposi's sarcoma and its associated herpesvirusQ36487309
P407language of work or nameEnglishQ1860
P921main subjecthypoxiaQ105688
carcinogenesisQ1637543
P304page(s)370-383
P577publication date2014-04-01
P1433published inVirologyQ7934867
P1476titleHypoxia-inducible factor 1 and its role in viral carcinogenesis
P478volume456-457

Reverse relations

cites work (P2860)
Q39426973Abnormalities in alternative splicing of angiogenesis-related genes and their role in HIV-related cancers
Q28082569Angiogenesis and liver fibrosis
Q36177999Ankyrin Repeat Proteins of Orf Virus Influence the Cellular Hypoxia Response Pathway
Q58740348Delta-like ligand 4 in hepatocellular carcinoma intrinsically promotes tumour growth and suppresses hepatitis B virus replication
Q55272984Epstein–Barr Virus-Induced Metabolic Rearrangements in Human B-Cell Lymphomas.
Q92702749Evaluation of Hypoxia-Inducible Factor-1 Alpha (HIF-1α) in Equine Sarcoid: An Immunohistochemical and Biochemical Study
Q34856882Functional implications of mitochondrial reactive oxygen species generated by oncogenic viruses
Q33688459HIF-1α activates hypoxia-induced BCL-9 expression in human colorectal cancer cells
Q58089566Hepatitis C virus downregulates ubiquitin conjugating enzyme E2S expression to prevent proteasomal degradation of NS5A, leading to host cells more sensitive to DNA damage
Q37578788Hypoxia activates Wnt/β-catenin signaling by regulating the expression of BCL9 in human hepatocellular carcinoma
Q47120363Hypoxia-inducible factor-1α activation in HPV-positive head and neck squamous cell carcinoma cell lines.
Q33842381Hypoxia-inducible factor-1α plays roles in Epstein-Barr virus's natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter.
Q93074235KSHV-encoded LANA protects the cellular replication machinery from hypoxia induced degradation
Q37706218LHBs can elevate the expression of MDR1 through HIF-1α in patients with CHB infection: a comparative proteomic study
Q28828484Loss of HIF-1α in macrophages attenuates AhR/ARNT-mediated tumorigenesis in a PAH-driven tumor model
Q53781024Metabolic reprogramming of Kaposi's sarcoma associated herpes virus infected B-cells in hypoxia
Q38765329MicroRNA-138 suppresses proliferation, invasion and glycolysis in malignant melanoma cells by targeting HIF-1α.
Q38768815MicroRNA-18b inhibits the growth of malignant melanoma via inhibition of HIF-1α-mediated glycolysis
Q47286778Modulation of the Tumor Microenvironment by Epstein-Barr virus Latent Membrane Protein-1 in Nasopharyngeal Carcinoma.
Q58555606Oncogenic virus-induced aerobic glycolysis and tumorigenesis
Q33617085Papillomaviruses: a systematic review.
Q58612094Poly(ADP-ribose) polymerase 1 is necessary for coactivating hypoxia-inducible factor-1-dependent gene expression by Epstein-Barr virus latent membrane protein 1
Q36238539RNA Sequencing Reveals that Kaposi Sarcoma-Associated Herpesvirus Infection Mimics Hypoxia Gene Expression Signature.
Q39329214The role of metabolic reprogramming in γ-herpesvirus-associated oncogenesis.
Q64979501[HPV - A different view on Head and Neck Cancer].
Q45805029microRNA-33a-5p increases radiosensitivity by inhibiting glycolysis in melanoma.

Search more.