The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cells

scientific article

The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1010311450
P356DOI10.1038/80459
P698PubMed publication ID11017143
P5875ResearchGate publication ID12306886

P2093author name stringBoshoff C
Kellam P
Radkov SA
P2860cites workIdentification of the gene encoding the major latency-associated nuclear antigen of the Kaposi's sarcoma-associated herpesvirusQ24561400
Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)Q24650427
The 222- to 234-kilodalton latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear antigenQ24672438
Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcomaQ28242984
SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility geneQ28281071
Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomasQ28299069
Regulation of retinoblastoma protein functions by ectopic expression of human cyclinsQ29618320
The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene productQ29618372
Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene productQ29620421
The E7 oncoprotein associates with Mi2 and histone deacetylase activity to promote cell growthQ33292242
Cellular tropism and viral interleukin-6 expression distinguish human herpesvirus 8 involvement in Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's diseaseQ33647676
Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigenQ33859518
p53 inhibition by the LANA protein of KSHV protects against cell deathQ33885642
Timing of cyclin E gene expression depends on the regulated association of a bipartite repressor element with a novel E2F complex.Q33890688
Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphomaQ35131811
Human papillomavirus type 31 oncoproteins E6 and E7 are required for the maintenance of episomes during the viral life cycle in normal human keratinocytesQ35550275
Differential viral protein expression in Kaposi's sarcoma-associated herpesvirus-infected diseases: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease.Q35809792
Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene productQ37016112
Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cellsQ39877852
Epstein-Barr virus EBNA3C represses Cp, the major promoter for EBNA expression, but has no effect on the promoter of the cell gene CD21.Q39882226
Interactions between SV40 large-tumor antigen and the growth suppressor proteins pRB and p53.Q40831461
Deregulation of cell growth by the K1 gene of Kaposi's sarcoma-associated herpesvirusQ41050488
Infection of primary dermal microvascular endothelial cells by Kaposi's sarcoma-associated herpesvirusQ41051439
Expression of K13/v-FLIP gene of human herpesvirus 8 and apoptosis in Kaposi's sarcoma spindle cells.Q42612163
Cyclin encoded by KS herpesvirusQ42633290
G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activatorQ42833351
Kaposi's sarcoma. Coupling herpesvirus to angiogenesisQ42833358
KSHV ORF K9 (vIRF) is an oncogene which inhibits the interferon signaling pathwayQ42834462
Transformation of rat cells by an altered polyoma virus genome expressing only the middle-T proteinQ45801875
Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirusQ47675996
pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.Q54048106
Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cellsQ71563744
The latency-associated nuclear antigen tethers the Kaposi's sarcoma-associated herpesvirus genome to host chromosomes in body cavity-based lymphoma cellsQ73184792
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectretinoblastomaQ500695
P304page(s)1121-1127
P577publication date2000-10-01
P1433published inNature MedicineQ1633234
P1476titleThe latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cells
P478volume6

Reverse relations

cites work (P2860)
Q39756815A Domain in the C-terminal region of latency-associated nuclear antigen 1 of Kaposi's sarcoma-associated Herpesvirus affects transcriptional activation and binding to nuclear heterochromatin
Q27680409A Structural Basis for BRD2/4-Mediated Host Chromatin Interaction and Oligomer Assembly of Kaposi Sarcoma-Associated Herpesvirus and Murine Gammaherpesvirus LANA Proteins
Q33826818A human herpesvirus microRNA inhibits p21 expression and attenuates p21-mediated cell cycle arrest
Q33265370A novel KRAB-Zinc finger protein interacts with latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus and activates transcription via terminal repeat sequences
Q34531461A novel viral mechanism for dysregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency.
Q40106826A potential alpha-helix motif in the amino terminus of LANA encoded by Kaposi's sarcoma-associated herpesvirus is critical for nuclear accumulation of HIF-1alpha in normoxia
Q34179693A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening.
Q35123088Accumulation of heterochromatin components on the terminal repeat sequence of Kaposi's sarcoma-associated herpesvirus mediated by the latency-associated nuclear antigen
Q26743368Activation of DNA Damage Response Induced by the Kaposi's Sarcoma-Associated Herpes Virus
Q33843421Activation of the Kaposi's sarcoma-associated herpesvirus major latency locus by the lytic switch protein RTA (ORF50).
Q22251046Aids-related malignancies
Q37415110Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor
Q36884039An essential role for γ-herpesvirus latency-associated nuclear antigen homolog in an acute lymphoproliferative disease of cattle
Q36098894Analysis of viral cis elements conferring Kaposi's sarcoma-associated herpesvirus episome partitioning and maintenance
Q28750291Angiogenesis, Kaposi's Sarcoma and Kaposi's Sarcoma-Associated Herpesvirus
Q79897199Apoptotic effect of ganciclovir on primary effusion lymphoma cells infected with Kaposi's sarcoma-associated herpesvirus
Q39729318Array-based transcript profiling and limiting-dilution reverse transcription-PCR analysis identify additional latent genes in Kaposi's sarcoma-associated herpesvirus
Q38388893At a crossroads: human DNA tumor viruses and the host DNA damage response.
Q28269301BET domain co-regulators in obesity, inflammation and cancer
Q34092739Brd2/RING3 interacts with a chromatin-binding domain in the Kaposi's Sarcoma-associated herpesvirus latency-associated nuclear antigen 1 (LANA-1) that is required for multiple functions of LANA-1.
Q39675686Bub1 and CENP-F can contribute to Kaposi's sarcoma-associated herpesvirus genome persistence by targeting LANA to kinetochores
Q36086302Bub1 in Complex with LANA Recruits PCNA To Regulate Kaposi's Sarcoma-Associated Herpesvirus Latent Replication and DNA Translesion Synthesis
Q34291968Cancer processes in immunodeficient populations: an introduction
Q36643922Cancers associated with Kaposi's sarcoma (KS) in AIDS: a link between KS herpesvirus and immunoblastic lymphoma
Q35584575Castleman's disease: from basic mechanisms to molecular therapeutics
Q39365643Cdk1 inhibition induces mutually inhibitory apoptosis and reactivation of Kaposi's sarcoma-associated herpesvirus
Q26749612Cell Cycle Regulatory Functions of the KSHV Oncoprotein LANA
Q38218288Cell cycle regulation during viral infection
Q34340317Charting latency transcripts in Kaposi's sarcoma-associated herpesvirus by whole-genome real-time quantitative PCR
Q35237492Chromatinization of the KSHV Genome During the KSHV Life Cycle
Q38475163Claudin-2 downregulation by KSHV infection is involved in the regulation of endothelial barrier function
Q33883910Cloning and identification of a microRNA cluster within the latency-associated region of Kaposi's sarcoma-associated herpesvirus
Q39294399Comparative study of Kaposi's sarcoma-associated herpesvirus serological assays using clinically and serologically defined reference standards and latent class analysis
Q30535717Complex alternative cytoplasmic protein isoforms of the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 generated through noncanonical translation initiation
Q28533244Comprehensive analysis of LANA interacting proteins essential for viral genome tethering and persistence
Q33895240Conservation of complex nuclear localization signals utilizing classical and non-classical nuclear import pathways in LANA homologs of KSHV and RFHV
Q40338623Conserved cell cycle regulatory properties within the amino terminal domain of the Epstein-Barr virus nuclear antigen 3C.
Q34303583Contribution of viral mimics of cellular genes to KSHV infection and disease.
Q38264454Current status of treatment for primary effusion lymphoma
Q33853499DNA binding and modulation of gene expression by the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus
Q40169138Deregulation of c-Myc in primary effusion lymphoma by Kaposi's sarcoma herpesvirus latency-associated nuclear antigen
Q35941628Deregulation of the cell cycle by the Epstein-Barr virus
Q35785433Determination of Kaposi's sarcoma-associated herpesvirus C-terminal latency-associated nuclear antigen residues mediating chromosome association and DNA binding
Q36691938Development of a fluorescence-based assay to screen antiviral drugs against Kaposi's sarcoma associated herpesvirus
Q40163096Disruption of Kaposi's sarcoma-associated herpesvirus latent nuclear antigen leads to abortive episome persistence
Q41891421Disruption of LANA in rhesus rhadinovirus generates a highly lytic recombinant virus
Q39744147Distinct p53, p53:LANA, and LANA complexes in Kaposi's Sarcoma--associated Herpesvirus Lymphomas
Q33673921E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia.
Q33261811EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressors
Q78860218Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes
Q33772234Epidemiology and pathogenesis of Kaposi's sarcoma-associated herpesvirus
Q90702448Epigenetic control in Kaposi sarcoma-associated herpesvirus infection and associated disease
Q24535609Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase
Q40637962Epstein-Barr virus nuclear antigen 1 (EBNA1) induced cytotoxicity in epithelial cells is associated with EBNA1 degradation and processing
Q40135893Epstein-Barr virus-encoded EBNA1 regulates cellular gene transcription and modulates the STAT1 and TGFbeta signaling pathways
Q40252446Ets-1-dependent expression of vascular endothelial growth factor receptors is activated by latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus through interaction with Daxx
Q42665921Expression of p53 and human herpesvirus-8 (HHV-8)-encoded latency-associated nuclear antigen with inhibition of apoptosis in HHV-8-associated malignancies
Q57029061FUS Negatively Regulates Kaposi's Sarcoma-Associated Herpesvirus Gene Expression
Q41924146Full-Length Isoforms of Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Accumulate in the Cytoplasm of Cells Undergoing the Lytic Cycle of Replication
Q34348453Functional dissection of latency-associated nuclear antigen 1 of Kaposi's sarcoma-associated herpesvirus involved in latent DNA replication and transcription of terminal repeats of the viral genome.
Q36192668Functional genomics and the development of pathogenesis-targeted therapies for Kaposi's sarcoma
Q37865141Gammaherpesvirus and lymphoproliferative disorders in immunocompromised patients
Q37060535Genetic disruption of KSHV major latent nuclear antigen LANA enhances viral lytic transcriptional program
Q34554716Genetic requirements for the episomal maintenance of oncogenic herpesvirus genomes
Q30479353HHV-8 encoded LANA-1 alters the higher organization of the cell nucleus
Q38346932HIV TAT basic peptide is not a high-affinity ligand for VEGF receptor 2.
Q34572946HIV-associated Kaposi sarcoma: pathogenic mechanisms
Q34597442HIV/AIDS: epidemiology, pathophysiology, and treatment of Kaposi sarcoma-associated herpesvirus disease: Kaposi sarcoma, primary effusion lymphoma, and multicentric Castleman disease
Q33917901Hepatitis C virus NS5B protein delays s phase progression in human hepatocyte-derived cells by relocalizing cyclin-dependent kinase 2-interacting protein (CINP).
Q89783184Herpesviral Latency-Common Themes
Q34383861Human DNA tumor viruses generate alternative reading frame proteins through repeat sequence recoding
Q47552231Human Herpesvirus 8 Interferon Regulatory Factors 1 and 3 Mediate Replication and Latency Activities via Interactions with USP7 Deubiquitinase
Q37831159Human Herpesvirus-8 Infection Associated with Kaposi Sarcoma, Multicentric Castleman's Disease, and Plasmablastic Microlymphoma in a Man with AIDS: A Case Report with Review of Pathophysiologic Processes
Q55239038Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
Q34614394Human tumor-associated viruses and new insights into the molecular mechanisms of cancer
Q37711147Human viral oncogenesis: a cancer hallmarks analysis
Q34423461Human viruses and cancer.
Q27001095Hypoxia-inducible factor 1 and its role in viral carcinogenesis
Q39882833Identification and characterization of a new Kaposi's sarcoma-associated herpesvirus replication and transcription activator (RTA)-responsive element involved in RTA-mediated transactivation
Q89621489Identification of AIDS-Associated Kaposi Sarcoma: A Functional Genomics Approach
Q24646461Identification of a novel cellular transcriptional repressor interacting with the latent nuclear antigen of Kaposi's sarcoma-associated herpesvirus
Q21131610Identification of cellular genes targeted by KSHV-encoded microRNAs
Q37307209Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis
Q92340148In Vivo Models of Oncoproteins Encoded by Kaposi's Sarcoma-Associated Herpesvirus
Q40589924Inflammatory cytokines inhibit Kaposi's sarcoma-associated herpesvirus lytic gene transcription in in vitro-infected endothelial cells
Q39794624Inhibition of KSHV-infected primary effusion lymphomas in NOD/SCID mice by gamma-secretase inhibitor.
Q35702343Inhibition of infection and replication of human herpesvirus 8 in microvascular endothelial cells by alpha interferon and phosphonoformic acid
Q27486093Inhibition of replication and transcription activator and latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus by morpholino oligomers
Q36296882Integrated systems biology analysis of KSHV latent infection reveals viral induction and reliance on peroxisome mediated lipid metabolism.
Q42407453Interleukin-6 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension
Q39610285Internal ribosome entry site regulates translation of Kaposi's sarcoma-associated herpesvirus FLICE inhibitory protein
Q38107828Interplay between DNA tumor viruses and the host DNA damage response.
Q33221441Intrabodies targeting the Kaposi sarcoma-associated herpesvirus latency antigen inhibit viral persistence in lymphoma cells.
Q40267803Intracellular activated Notch1 is critical for proliferation of Kaposi's sarcoma-associated herpesvirus-associated B-lymphoma cell lines in vitro
Q37410861Involvement of SSRP1 in latent replication of Kaposi's sarcoma-associated herpesvirus
Q43764140Is KSHV lytic growth induced by a methylation-sensitive switch?
Q26766437KSHV Genome Replication and Maintenance
Q36591375KSHV LANA inhibits TGF-beta signaling through epigenetic silencing of the TGF-beta type II receptor
Q34774797KSHV LANA--the master regulator of KSHV latency
Q41662283KSHV and the Role of Notch Receptor Dysregulation in Disease Progression
Q33761091KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine
Q38418556KSHV downregulation of galectin-3 in Kaposi's sarcoma
Q37237030KSHV encoded LANA recruits Nucleosome Assembly Protein NAP1L1 for regulating viral DNA replication and transcription
Q40286016KSHV encoded LANA upregulates Pim-1 and is a substrate for its kinase activity
Q38692823KSHV encoded ORF59 modulates histone arginine methylation of the viral genome to promote viral reactivation
Q35079842KSHV microRNAs mediate cellular transformation and tumorigenesis by redundantly targeting cell growth and survival pathways
Q26742030KSHV-Mediated Angiogenesis in Tumor Progression
Q35642220KSHV/HHV-8 and HIV infection in Kaposi's sarcoma development.
Q34711929KSHV/HHV8-associated lymphomas.
Q34291982KSHV/HHV8-associated lymphoproliferations in the AIDS setting
Q27026000KSHV: pathways to tumorigenesis and persistent infection
Q36731435Kaposi sarcoma as a model of oncogenesis and cancer treatment.
Q28540116Kaposi sarcoma herpes virus latency associated nuclear antigen protein release the G2/M cell cycle blocks by modulating ATM/ATR mediated checkpoint pathway
Q40046587Kaposi sarcoma herpesvirus pathogenesis.
Q35127940Kaposi sarcoma-associated herpesvirus (KSHV): molecular biology and oncogenesis
Q33748042Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen inhibits interferon (IFN) beta expression by competing with IFN regulatory factor-3 for binding to IFNB promoter
Q34470355Kaposi sarcoma-associated herpesvirus-associated malignancies: epidemiology, pathogenesis, and advances in treatment.
Q37016504Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 and lymphoproliferative disorders
Q43813237Kaposi virus scores cancer coup
Q35691156Kaposi's Sarcoma-Associated Herpesvirus Genome Replication, Partitioning, and Maintenance in Latency
Q34976840Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Induces Expression of the Helix-Loop-Helix Protein Id-1 in Human Endothelial Cells
Q34997083Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Prolongs the Life Span of Primary Human Umbilical Vein Endothelial Cells
Q47606321Kaposi's Sarcoma-Associated Herpesvirus: Epidemiology and Molecular Biology
Q29394711Kaposi's Sarcoma–Associated Herpesvirus Immunoevasion and Tumorigenesis: Two Sides of the Same Coin?
Q36487309Kaposi's sarcoma and its associated herpesvirus
Q34556281Kaposi's sarcoma associated herpesvirus (KSHV) or human herpesvirus 8 (HHV8).
Q44277985Kaposi's sarcoma associated herpesvirus G protein-coupled receptor immortalizes human endothelial cells by activation of the VEGF receptor-2/ KDR.
Q34186981Kaposi's sarcoma herpesvirus upregulates Aurora A expression to promote p53 phosphorylation and ubiquitylation
Q36019173Kaposi's sarcoma herpesvirus-encoded latency-associated nuclear antigen stabilizes intracellular activated Notch by targeting the Sel10 protein
Q36911800Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen regulates the KSHV epigenome by association with the histone demethylase KDM3A.
Q37424480Kaposi's sarcoma-associated herpesvirus K7 protein targets a ubiquitin-like/ubiquitin-associated domain-containing protein to promote protein degradation
Q41846091Kaposi's sarcoma-associated herpesvirus LANA protein downregulates nuclear glycogen synthase kinase 3 activity and consequently blocks differentiation
Q35139294Kaposi's sarcoma-associated herpesvirus LANA-1 interacts with the short variant of BRD4 and releases cells from a BRD4- and BRD2/RING3-induced G1 cell cycle arrest
Q39860632Kaposi's sarcoma-associated herpesvirus RTA promotes degradation of the Hey1 repressor protein through the ubiquitin proteasome pathway
Q42328529Kaposi's sarcoma-associated herpesvirus induction of chromosome instability in primary human endothelial cells
Q39665994Kaposi's sarcoma-associated herpesvirus inhibits interleukin-4-mediated STAT6 phosphorylation to regulate apoptosis and maintain latency
Q39210824Kaposi's sarcoma-associated herpesvirus lana2 protein interacts with the pocket proteins and inhibits their sumoylation.
Q33838228Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mediates episome persistence through cis-acting terminal repeat (TR) sequence and specifically binds TR DNA.
Q40128647Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mimics Epstein-Barr virus EBNA1 immune evasion through central repeat domain effects on protein processing
Q35689577Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen and angiogenin interact with common host proteins, including annexin A2, which is essential for survival of latently infected cells
Q35665756Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen induction by hypoxia and hypoxia-inducible factors
Q24673761Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes
Q36023151Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with multifunctional angiogenin to utilize its antiapoptotic functions.
Q38305362Kaposi's sarcoma-associated herpesvirus latent and lytic gene expression as revealed by DNA arrays
Q36540187Kaposi's sarcoma-associated herpesvirus latent gene vFLIP inhibits viral lytic replication through NF-kappaB-mediated suppression of the AP-1 pathway: a novel mechanism of virus control of latency
Q42049779Kaposi's sarcoma-associated herpesvirus latent protein LANA interacts with HIF-1 alpha to upregulate RTA expression during hypoxia: Latency control under low oxygen conditions
Q33737793Kaposi's sarcoma-associated herpesvirus reactivation is regulated by interaction of latency-associated nuclear antigen with recombination signal sequence-binding protein Jkappa, the major downstream effector of the Notch signaling pathway
Q40607781Kaposi's sarcoma-associated herpesvirus-encoded LANA can induce chromosomal instability through targeted degradation of the mitotic checkpoint kinase Bub1
Q30482603Kaposi's sarcoma-associated herpesvirus-encoded LANA can interact with the nuclear mitotic apparatus protein to regulate genome maintenance and segregation
Q33744019Kaposi's sarcoma-associated herpesvirus-encoded LANA interacts with host KAP1 to facilitate establishment of viral latency
Q39320195Kaposi's sarcoma-associated herpesvirus-encoded LANA recruits topoisomerase IIβ for latent DNA replication of the terminal repeats
Q40335991Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen induces chromosomal instability through inhibition of p53 function
Q34194120Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen inhibits lytic replication by targeting Rta: a potential mechanism for virus-mediated control of latency
Q24543014Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen modulates K1 expression through its cis-acting elements within the terminal repeats
Q35192868Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen reduces interleukin-8 expression in endothelial cells and impairs neutrophil chemotaxis by degrading nuclear p65.
Q36154559Kaposi's sarcoma-associated herpesvirus: clinical, diagnostic, and epidemiological aspects
Q82344523Kaposi’s sarcoma-associated herpesvirus-encoded LANA positively affects on ubiquitylation of p53
Q24314650LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription
Q34128791Latency-associated nuclear antigen (LANA) cooperatively binds to two sites within the terminal repeat, and both sites contribute to the ability of LANA to suppress transcription and to facilitate DNA replication
Q33854704Latency-associated nuclear antigen encoded by Kaposi's sarcoma-associated herpesvirus interacts with Tat and activates the long terminal repeat of human immunodeficiency virus type 1 in human cells
Q34553088Latency-associated nuclear antigen expression and human herpesvirus-8 polymerase chain reaction in the evaluation of Kaposi sarcoma and other vascular tumors in HIV-positive patients
Q39852047Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (KSHV) upregulates survivin expression in KSHV-Associated B-lymphoma cells and contributes to their proliferation
Q40682995Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus functionally interacts with heterochromatin protein 1.
Q24670086Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus recruits uracil DNA glycosylase 2 at the terminal repeats and is important for latent persistence of the virus
Q39992257Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus up-regulates transcription of human telomerase reverse transcriptase promoter through interaction with transcription factor Sp1.
Q91637326Latent infection with Kaposi's sarcoma-associated herpesvirus enhances retrotransposition of long interspersed element-1
Q44486355Learning old tricks from new viruses
Q36223625Linking KSHV to human cancer
Q40287215Long-term-infected telomerase-immortalized endothelial cells: a model for Kaposi's sarcoma-associated herpesvirus latency in vitro and in vivo
Q40578287Lytic KSHV infection inhibits host gene expression by accelerating global mRNA turnover
Q35168476Lytic but not latent infection by Kaposi's sarcoma-associated herpesvirus requires host CSL protein, the mediator of Notch signaling
Q33482148Malignant catarrhal fever of cattle is associated with low abundance of IL-2 transcript and a predominantly latent profile of ovine herpesvirus 2 gene expression
Q35678361Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers
Q39602182Mechanisms governing expression of the v-FLIP gene of Kaposi's sarcoma-associated herpesvirus
Q35010647Mechanisms of Kaposi's Sarcoma-Associated Herpesvirus Latency and Reactivation
Q36550916Messenger RNA turnover and its regulation in herpesviral infection
Q38674284Metabolic reprogramming: a hallmark of viral oncogenesis.
Q34437977Mitotic chromosome-binding activity of latency-associated nuclear antigen 1 is required for DNA replication from terminal repeat sequence of Kaposi's sarcoma-associated herpesvirus
Q47547495Modified cross-linking, ligation, and sequencing of hybrids (qCLASH) identifies KSHV microRNA targets in endothelial cells
Q90319823Molecular Biology of KSHV in Relation to HIV/AIDS-Associated Oncogenesis
Q35124404Molecular Biology of Kaposi's Sarcoma-associated Herpesvirus and Related Oncogenesis
Q34663095Molecular and cellular mechanisms of KSHV oncogenesis of Kaposi's sarcoma associated with HIV/AIDS
Q35138059Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus
Q35110891Molecular biology of Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus
Q33560572Molecular biology of KSHV in relation to AIDS-associated oncogenesis
Q34013830Molecular biology of human herpesvirus 8: novel functions and virus-host interactions implicated in viral pathogenesis and replication
Q35026060Molecular genetics of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) epidemiology and pathogenesis
Q38863770Multicentric Castleman disease: Where are we now?
Q81505199Multiplex PCR-based DNA array for simultaneous detection of three human herpesviruses, EVB, CMV and KSHV
Q34022999Murine gamma-herpesvirus immortalization of fetal liver-derived B cells requires both the viral cyclin D homolog and latency-associated nuclear antigen
Q37252928Nuclear Innate Immune DNA Sensor IFI16 Is Degraded during Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus (KSHV): Role of IFI16 in Maintenance of KSHV Latency.
Q40066566ORF73 LANA homologs of RRV and MneRV2 contain an extended RGG/RG-rich nuclear and nucleolar localization signal that interacts directly with importin β1 for non-classical nuclear import
Q40173321ORF73 of Herpesvirus Saimiri Strain C488 Tethers the Viral Genome to Metaphase Chromosomes and Binds to cis -Acting DNA Sequences in the Terminal Repeats
Q37511491ORF73 of herpesvirus saimiri, a viral homolog of Kaposi's sarcoma-associated herpesvirus, modulates the two cellular tumor suppressor proteins p53 and pRb.
Q40094006ORF73-null murine gammaherpesvirus 68 reveals roles for mLANA and p53 in virus replication
Q35841060Oncogenic gamma-herpesviruses: comparison of viral proteins involved in tumorigenesis
Q35110909Pathogenesis and manifestations of human herpesvirus-8-associated disorders
Q35174136Pathogenesis of Kaposi's sarcoma
Q34456086Phosphorylation of the chromatin binding domain of KSHV LANA
Q24299259Physical and functional interactions between STAT3 and Kaposi's sarcoma-associated herpesvirus-encoded LANA
Q39959766Poly(ADP-ribose) polymerase 1 binds to Kaposi's sarcoma-associated herpesvirus (KSHV) terminal repeat sequence and modulates KSHV replication in latency
Q35755464Post-Translational Modifications of Kaposi's Sarcoma-Associated Herpesvirus Regulatory Proteins - SUMO and KSHV
Q55518093Primary effusion lymphoma: current perspectives.
Q39271443Primary lymphocyte infection models for KSHV and its putative tumorigenesis mechanisms in B cell lymphomas
Q38010467Prognosis in primary effusion lymphoma is associated with the number of body cavities involved
Q40292424Promoter switching allows simultaneous transcription of LANA and K14/vGPCR of Kaposi's sarcoma-associated herpesvirus
Q35774091Protein arginine methyltransferase 1-directed methylation of Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen
Q33282107Protein complexes associated with the Kaposi's sarcoma-associated herpesvirus-encoded LANA.
Q24538878Protein interactions targeting the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomes
Q41866484Proteomic analysis of the Kaposi's sarcoma-associated herpesvirus terminal repeat element binding proteins
Q42693319RFHVMn ORF73 is structurally related to the KSHV ORF73 latency-associated nuclear antigen (LANA) and is expressed in retroperitoneal fibromatosis (RF) tumor cells
Q34295807Reactivation and role of HHV-8 in Kaposi's sarcoma initiation
Q35080754Recruitment of the de novo DNA methyltransferase Dnmt3a by Kaposi's sarcoma-associated herpesvirus LANA
Q64375144Reduction of Kaposi's Sarcoma-Associated Herpesvirus Latency Using CRISPR-Cas9 To Edit the Latency-Associated Nuclear Antigen Gene
Q34292265Regulation and autoregulation of the promoter for the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus
Q37590325Regulation of angiogenesis in malignancies associated with Epstein-Barr virus and Kaposi's sarcoma-associated herpes virus
Q35964857Regulation of growth signalling and cell cycle by Kaposi's sarcoma-associated herpesvirus genes.
Q41849965Regulation of the interaction between glycogen synthase kinase 3 and the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen
Q37085853Regulation of the retinoblastoma proteins by the human herpesviruses.
Q38144129Review of latent and lytic phase biomarkers in Kaposi's sarcoma
Q35192690Ribosomal protein S6 interacts with the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus
Q37157253Role of Kaposi's sarcoma-associated herpesvirus C-terminal LANA chromosome binding in episome persistence
Q55338587Role of Pattern Recognition Receptors in KSHV Infection.
Q36060662Role of infectious diseases in human carcinogenesis
Q90368251Serological Assessment of 18 Pathogens and Risk of AIDS-Associated Non-Hodgkin Lymphoma
Q34071388Single molecule analysis of replicated DNA reveals the usage of multiple KSHV genome regions for latent replication
Q40605206Site-specific association with host and viral chromatin by Kaposi's sarcoma-associated herpesvirus LANA and its reversal during lytic reactivation.
Q33906970Spectrum of Kaposi's sarcoma-associated herpesvirus, or human herpesvirus 8, diseases
Q37164834TRIP-Br2 promotes oncogenesis in nude mice and is frequently overexpressed in multiple human tumors
Q51831648Targeting mitotic chromosomes: a conserved mechanism to ensure viral genome persistence.
Q61449826The Critical Role of Genome Maintenance Proteins in Immune Evasion During Gammaherpesvirus Latency
Q34355898The Herpesvirus Saimiri open reading frame 73 gene product interacts with the cellular protein p32.
Q41932132The Kaposi's sarcoma-associated herpesvirus (KSHV) non-structural membrane protein K15 is required for viral lytic replication and may represent a therapeutic target.
Q36099076The Kaposi's sarcoma-associated herpesvirus LANA protein stabilizes and activates c-Myc
Q38725485The Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Inhibits Expression of SUMO/Sentrin-Specific Peptidase 6 To Facilitate Establishment of Latency
Q26747452The Modulation of Apoptotic Pathways by Gammaherpesviruses
Q26767186The Role of Gammaherpesviruses in Cancer Pathogenesis
Q37989143The Ubiquitin System and Kaposi's Sarcoma-Associated Herpesvirus
Q37157234The interaction of the gammaherpesvirus 68 orf73 protein with cellular BET proteins affects the activation of cell cycle promoters
Q35140238The internal Kaposi's sarcoma-associated herpesvirus LANA regions exert a critical role on episome persistence
Q33845947The latency-associated nuclear antigen encoded by Kaposi's sarcoma-associated herpesvirus activates two major essential Epstein-Barr virus latent promoters
Q41860564The latency-associated nuclear antigen interacts with MeCP2 and nucleosomes through separate domains
Q34391203The latency-associated nuclear antigen of Kaposi sarcoma-associated herpesvirus induces B cell hyperplasia and lymphoma
Q35104781The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus manipulates the activity of glycogen synthase kinase-3beta
Q40496132The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus modulates cellular gene expression and protects lymphoid cells from p16 INK4A-induced cell cycle arrest
Q34355092The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus supports latent DNA replication in dividing cells
Q40811288The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus transactivates the telomerase reverse transcriptase promoter
Q33834414The latency-associated nuclear antigen of rhesus monkey rhadinovirus inhibits viral replication through repression of Orf50/Rta transcriptional activation
Q37380228The latency-associated nuclear antigen, a multifunctional protein central to Kaposi's sarcoma-associated herpesvirus latency
Q40199723The minimal replicator element of the Kaposi's sarcoma-associated herpesvirus terminal repeat supports replication in a semiconservative and cell-cycle-dependent manner
Q26995410The modulation of apoptosis by oncogenic viruses
Q34605505The molecular pathology of Kaposi's sarcoma-associated herpesvirus
Q38248404The role of Kaposi sarcoma-associated herpesvirus in the pathogenesis of Kaposi sarcoma
Q41692241The seroprevalence of Kaposi's sarcoma associated herpes virus and human herpes virus-6 in pediatric patients with cancer and healthy children in a Turkish pediatric oncology center
Q35847738The targeting of primary effusion lymphoma cells for apoptosis by inducing lytic replication of human herpesvirus 8 while blocking virus production
Q36086767The ubiquitin-specific protease USP7 modulates the replication of Kaposi's sarcoma-associated herpesvirus latent episomal DNA
Q24685892The viral etiology of AIDS-associated malignancies
Q35917368Therapeutic options for human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus-related disorders
Q34349469Tissue specificity of the Kaposi's sarcoma-associated herpesvirus latent nuclear antigen (LANA/orf73) promoter in transgenic mice
Q64247511Towards Better Understanding of KSHV Life Cycle: from Transcription and Posttranscriptional Regulations to Pathogenesis
Q33841257Transcription program of human herpesvirus 8 (kaposi's sarcoma-associated herpesvirus).
Q39960021Transcriptional activation by the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen is facilitated by an N-terminal chromatin-binding motif.
Q39683497Transcriptional downregulation of ORF50/Rta by methotrexate inhibits the switch of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 from latency to lytic replication.
Q39612221Transcripts encoding K12, v-FLIP, v-cyclin, and the microRNA cluster of Kaposi's sarcoma-associated herpesvirus originate from a common promoter.
Q33947132Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6.
Q93108742Tumor-Associated Protein Profiles in Kaposi Sarcoma and Mimicking Vascular Tumors, and Their Pathological Implications
Q34764819Update on Kaposi's sarcoma and other HHV8 associated diseases. Part 2: pathogenesis, Castleman's disease, and pleural effusion lymphoma
Q37692599Viral cyclin promotes KSHV-induced cellular transformation and tumorigenesis by overriding contact inhibition
Q37681282Viral epigenomes in human tumorigenesis.
Q37301053Viral manipulation of DNA repair and cell cycle checkpoints
Q33301012Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis
Q38106958Virus-associated lymphomagenesis
Q34308884Viruses and apoptosis
Q30384388Viruses and human cancers: a long road of discovery of molecular paradigms.
Q37811898Why do viruses cause cancer? Highlights of the first century of human tumour virology
Q43919089p16INK4a loss and sensitivity in KSHV associated primary effusion lymphoma

Search more.