Activation of DNA Damage Response Induced by the Kaposi's Sarcoma-Associated Herpes Virus

scientific article

Activation of DNA Damage Response Induced by the Kaposi's Sarcoma-Associated Herpes Virus is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3390/IJMS17060854
P3181OpenCitations bibliographic resource ID1160000
P932PMC publication ID4926388
P698PubMed publication ID27258263

P50authorFabrizio EnsoliQ55069671
Valentina BordignonQ56450971
Luigi TomaQ62664887
Enea Gino Di DomenicoQ42838379
P2093author name stringElisabetta Trento
Giovanna D'Agosto
Paola Cordiali-Fei
P2860cites workThe cancer burden attributable to biologic agentsQ38293923
Kaposi's sarcoma-associated herpesvirus latent and lytic gene expression as revealed by DNA arraysQ38305362
Kaposi's sarcoma-associated herpesvirus induces the ATM and H2AX DNA damage response early during de novo infection of primary endothelial cells, which play roles in latency establishmentQ38329562
Therapeutic opportunities within the DNA damage responseQ38364665
Identification of Kaposi Sarcoma Herpesvirus (KSHV) vIRF1 Protein as a Novel Interaction Partner of Human Deubiquitinase USP7.Q38801652
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathwayQ22065419
Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiationQ24298255
The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cellsQ24305557
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damageQ24306743
Kaposi's sarcoma-associated herpesvirus ORF57 protein interacts with PYM to enhance translation of viral intronless mRNAsQ24309306
Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replicationQ24310689
Autophagy mediates the mitotic senescence transitionQ24320401
Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cellsQ24527215
Protein interactions targeting the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomesQ24538878
Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen modulates K1 expression through its cis-acting elements within the terminal repeatsQ24543014
Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cellsQ24555724
Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitorsQ24597269
Megabase chromatin domains involved in DNA double-strand breaks in vivoQ24680284
Co-infections and Pathogenesis of KSHV-Associated MalignanciesQ26766493
Modulation of DNA damage and repair pathways by human tumour virusesQ26825783
The crystal structure of the DNA-binding domain of vIRF-1 from the oncogenic KSHV reveals a conserved fold for DNA binding and reinforces its role as a transcription factorQ27676606
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexesQ27860662
The DNA Damage Response: Making It Safe to Play with KnivesQ27861055
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139Q28131715
A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATMQ28270543
DNA damage and the balance between survival and death in cancer biologyQ28271163
H2AX: the histone guardian of the genomeQ28274279
The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancerQ28297155
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damageQ28364113
KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANAQ28474913
Kaposi sarcoma herpes virus latency associated nuclear antigen protein release the G2/M cell cycle blocks by modulating ATM/ATR mediated checkpoint pathwayQ28540116
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damageQ29614218
GammaH2AX and cancerQ29614974
DNA repair pathways as targets for cancer therapyQ29615572
Identification of microRNAs of the herpesvirus familyQ29618671
Global burden of cancers attributable to infections in 2008: a review and synthetic analysisQ29620303
Kaposi's sarcoma-associated herpesvirus-encoded LANA can interact with the nuclear mitotic apparatus protein to regulate genome maintenance and segregationQ30482603
The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaksQ33286997
Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesisQ33301012
Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latencyQ33545232
Kinetics of Kaposi's sarcoma-associated herpesvirus gene expressionQ33653424
Glycyrrhizic acid alters Kaposi sarcoma-associated herpesvirus latency, triggering p53-mediated apoptosis in transformed B lymphocytes.Q33683742
Kaposi's sarcoma-associated herpesvirus reactivation is regulated by interaction of latency-associated nuclear antigen with recombination signal sequence-binding protein Jkappa, the major downstream effector of the Notch signaling pathwayQ33737793
A cluster of latently expressed genes in Kaposi's sarcoma-associated herpesvirusQ33784966
A complex translational program generates multiple novel proteins from the latently expressed kaposin (K12) locus of Kaposi's sarcoma-associated herpesvirus.Q33815534
Latent nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts with RING3, a homolog of the Drosophila female sterile homeotic (fsh) geneQ33824419
CREB-binding protein and histone deacetylase regulate the transcriptional activity of Kaposi's sarcoma-associated herpesvirus open reading frame 50Q33854980
Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigenQ33859518
Cloning and identification of a microRNA cluster within the latency-associated region of Kaposi's sarcoma-associated herpesvirusQ33883910
p53 inhibition by the LANA protein of KSHV protects against cell deathQ33885642
Viral cyclinsQ33920746
Regulation of homologous recombination in eukaryotesQ33966065
Inhibition of p300 histone acetyltransferase by viral interferon regulatory factorQ33966269
Kaposi's sarcoma-associated herpesvirus: a new DNA tumor virusQ34132022
Update on KSHV epidemiology, Kaposi Sarcoma pathogenesis, and treatment of Kaposi SarcomaQ34168712
Multifunctional role of ATM/Tel1 kinase in genome stability: from the DNA damage response to telomere maintenanceQ34176919
Mechanism of action of antitumor drugs that interact with microtubules and tubulinQ34188643
The DNA damage response in viral-induced cellular transformationQ34246710
Kaposi's Sarcoma-Associated Herpesvirus microRNAsQ34273195
The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus supports latent DNA replication in dividing cellsQ34355092
Selenomethionine regulation of p53 by a ref1-dependent redox mechanismQ34394902
Inhibition of the ATM/p53 signal transduction pathway by Kaposi's sarcoma-associated herpesvirus interferon regulatory factor 1.Q34434681
The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cellsQ34511161
Virus-encoded microRNAs: an overview and a look to the futureQ34544400
Molecular and cellular mechanisms of KSHV oncogenesis of Kaposi's sarcoma associated with HIV/AIDSQ34663095
KSHV LANA--the master regulator of KSHV latencyQ34774797
Lytic infection of Kaposi's sarcoma-associated herpesvirus induces DNA double-strand breaks and impairs non-homologous end joining.Q50990735
Targeting mitotic chromosomes: a conserved mechanism to ensure viral genome persistence.Q51831648
Familial Kaposi's Sarcoma in HHV8 infected subjects presenting the G-174C allele of the IL-6 promoter: a possible role for EBV?Q51846023
Transient activation of p53 in G2 phase is sufficient to induce senescence.Q53043642
The Transcriptional Activity of cAMP Response Element-binding Protein-binding Protein Is Modulated by the Latency Associated Nuclear Antigen of Kaposi's Sarcoma-associated HerpesvirusQ57662902
Associations of Classic Kaposi Sarcoma with Common Variants in Genes that Modulate Host ImmunityQ57665241
Three-Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on DNA and Its Implications for DNA DSB RepairQ58660114
Transcription profile of Kaposi's sarcoma-associated herpesvirus in primary Kaposi's sarcoma lesions as determined by real-time PCR arraysQ73344152
Electrochemotherapy-induced virus disappearance in HHV-8-positive skin nodules of Kaposi sarcoma: first histological and immunohistochemical demonstration of efficacyQ84584664
A seroprevalence study of human herpesvirus type 8 (HHV8) in eastern and Central Africa and in the Mediterranean area.Q38884285
Prevalence and risk factors for human herpesvirus 8 infection in northern CameroonQ39395409
Characterization of human herpesvirus 8 ORF59 protein (PF-8) and mapping of the processivity and viral DNA polymerase-interacting domainsQ39597623
Differential regulation of the overlapping Kaposi's sarcoma-associated herpesvirus vGCR (orf74) and LANA (orf73) promotersQ39602154
Octamer-binding sequence is a key element for the autoregulation of Kaposi's sarcoma-associated herpesvirus ORF50/Lyta gene expressionQ39603733
Transcripts encoding K12, v-FLIP, v-cyclin, and the microRNA cluster of Kaposi's sarcoma-associated herpesvirus originate from a common promoter.Q39612221
Bub1 and CENP-F can contribute to Kaposi's sarcoma-associated herpesvirus genome persistence by targeting LANA to kinetochoresQ39675686
DNA-PK/Ku complex binds to latency-associated nuclear antigen and negatively regulates Kaposi's sarcoma-associated herpesvirus latent replication.Q39725564
Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cellsQ39877852
Kaposi's sarcoma-associated herpesvirus encodes a functional cyclin.Q39878517
The cyclin encoded by Kaposi's sarcoma-associated herpesvirus stimulates cdk6 to phosphorylate the retinoblastoma protein and histone H1.Q39879780
Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus up-regulates transcription of human telomerase reverse transcriptase promoter through interaction with transcription factor Sp1.Q39992257
Disruption of Kaposi's sarcoma-associated herpesvirus latent nuclear antigen leads to abortive episome persistenceQ40163096
Ets-1-dependent expression of vascular endothelial growth factor receptors is activated by latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus through interaction with DaxxQ40252446
The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA.Q40318272
Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen induces chromosomal instability through inhibition of p53 functionQ40335991
Constitutively active K-cyclin/cdk6 kinase in Kaposi sarcoma-associated herpesvirus-infected cellsQ40426996
The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.Q40461940
Interferon-Induced Antiviral Actions and Their RegulationQ40484830
The Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen binds to specific sequences at the left end of the viral genome through its carboxy-terminusQ40746913
Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in cultureQ41225141
Our cells get stressed too! Implications for human diseaseQ41693676
Kaposi's sarcoma-associated herpesvirus LANA protein downregulates nuclear glycogen synthase kinase 3 activity and consequently blocks differentiationQ41846091
Regulation of the interaction between glycogen synthase kinase 3 and the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigenQ41849965
The latency-associated nuclear antigen interacts with MeCP2 and nucleosomes through separate domainsQ41860564
Kaposi's sarcoma-associated herpesvirus latent protein LANA interacts with HIF-1 alpha to upregulate RTA expression during hypoxia: Latency control under low oxygen conditionsQ42049779
Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppressionQ42062886
ATM is a target for positive regulation by E2F-1.Q42806424
FLIP-mediated autophagy regulation in cell death controlQ42832950
A mitotic role for the DNA damage-responsive CHK2 kinaseQ44178226
MDM2 and CDKN1A gene polymorphisms and risk of Kaposi's sarcoma in African and Caucasian patientsQ44248155
Recruitment of the tumour suppressor protein p73 by Kaposi's Sarcoma Herpesvirus latent nuclear antigen contributes to the survival of primary effusion lymphoma cellsQ44703163
Antibodies to human herpesvirus type 8 in the general population and in Kaposi's sarcoma patients.Q45878585
The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivoQ46725222
Subversion of autophagy by Kaposi's sarcoma-associated herpesvirus impairs oncogene-induced senescenceQ46798265
Effective treatment of Kaposi's sarcoma by electrochemotherapy and intravenous bleomycin administrationQ47443263
Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Induces Expression of the Helix-Loop-Helix Protein Id-1 in Human Endothelial CellsQ34976840
Molecular biology of KSHV lytic reactivationQ35014918
Stimulus-dependent dynamics of p53 in single cellsQ35088876
The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus manipulates the activity of glycogen synthase kinase-3betaQ35104781
Molecular Biology of Kaposi's Sarcoma-associated Herpesvirus and Related OncogenesisQ35124404
Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphomaQ35131811
A novel mechanism inducing genome instability in Kaposi's sarcoma-associated herpesvirus infected cellsQ35161728
Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas.Q35664106
The cell cycle and how it is steered by Kaposi's sarcoma-associated herpesvirus cyclin.Q35786023
Interactions of viruses with the cellular DNA repair machineryQ35848546
Treatment of Kaposi sarcoma-associated herpesvirus-associated cancersQ35895560
Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic ReplicationQ35927487
The viral interferon regulatory factors of KSHV: immunosuppressors or oncogenes?Q35927496
Nutlin-3 induces apoptosis, disrupts viral latency and inhibits expression of angiopoietin-2 in Kaposi sarcoma tumor cells.Q35954902
Regulation of growth signalling and cell cycle by Kaposi's sarcoma-associated herpesvirus genes.Q35964857
Global chromatin compaction limits the strength of the DNA damage responseQ36119310
TREX, SR proteins and export of mRNA.Q36131499
HIV and human herpesvirus 8 co-infection across the globe: Systematic review and meta-analysisQ36167185
KSHV vFLIP is essential for the survival of infected lymphoma cellsQ36399405
Kaposi's sarcoma and its associated herpesvirusQ36487309
Cell signaling pathways engaged by KSHV.Q36531004
H2AX phosphorylation is important for LANA-mediated Kaposi's sarcoma-associated herpesvirus episome persistenceQ36760020
Lytic cycle switches of oncogenic human gammaherpesvirusesQ36786043
KSHV infection and the pathogenesis of Kaposi's sarcomaQ37014777
Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage responseQ37497709
Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcomaQ37535731
mRNA export and cancerQ37907202
Pegylated liposomal doxorubicin: a review of its use in metastatic breast cancer, ovarian cancer, multiple myeloma and AIDS-related Kaposi's sarcomaQ37964713
New clues to understand the role of THO and other functionally related factors in mRNP biogenesisQ37972238
Cellular origin of Kaposi's sarcoma and Kaposi's sarcoma-associated herpesvirus-induced cell reprogrammingQ38107726
Kaposi's sarcoma-associated herpesvirus ORF57 protein: exploiting all stages of viral mRNA processing.Q38125077
The role of Kaposi sarcoma-associated herpesvirus in the pathogenesis of Kaposi sarcomaQ38248404
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectvirusQ808
catalysisQ82264
DNA damageQ5205747
organic chemistryQ11351
Herpesviridae infectious diseaseQ18975237
P304page(s)854
P577publication date2016-06-01
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleActivation of DNA Damage Response Induced by the Kaposi's Sarcoma-Associated Herpes Virus
P478volume17

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cites work (P2860)
Q42323202DNA Damage and Repair in Degenerative Diseases 2016
Q41674995Resveratrol inhibits Extranodal NK/T cell lymphoma through activation of DNA damage response pathway
Q38716372The DNA damage response promotes polyomavirus JC infection by nucleus to cytoplasm NF- kappaB activation.
Q59357194Virus DNA Replication and the Host DNA Damage Response

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