Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus up-regulates transcription of human telomerase reverse transcriptase promoter through interaction with transcription factor Sp1.

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Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus up-regulates transcription of human telomerase reverse transcriptase promoter through interaction with transcription factor Sp1. is …
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scholarly articleQ13442814

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P356DOI10.1128/JVI.78.19.10348-10359.2004
P932PMC publication ID516419
P698PubMed publication ID15367601

P50authorSubhash VermaQ57951657
Erle S RobertsonQ88590600
P2093author name stringSumit Borah
P2860cites workThe amino-terminal domains of Epstein-Barr virus nuclear proteins 3A, 3B, and 3C interact with RBPJ(kappa)Q24310605
hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalizationQ24310670
Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcriptionQ24311810
Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2FQ24317554
Carboxy terminus of human herpesvirus 8 latency-associated nuclear antigen mediates dimerization, transcriptional repression, and targeting to nuclear bodies.Q24531182
Protein interactions targeting the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomesQ24538878
A functional YY1 binding site is necessary and sufficient to activate Surf-1 promoter activity in response to serum growth factorsQ24545231
Evidence for physical interaction between the zinc-finger transcription factors YY1 and Sp1Q24562189
Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interactionQ24650233
Association of p107 with Sp1: genetically separable regions of p107 are involved in regulation of E2F- and Sp1-dependent transcriptionQ24651154
The 222- to 234-kilodalton latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear antigenQ24672438
Specific Association of Human Telomerase Activity with Immortal Cells and CancerQ27860801
Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcriptionQ28235557
Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcomaQ28242984
Synergistic activation by the glutamine-rich domains of human transcription factor Sp1Q28245874
KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcomaQ28284765
Telomere length regulationQ28290143
Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma in patients with and without HIV infectionQ28299060
Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomasQ28299069
A survey of telomerase activity in human cancerQ29614858
Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's diseaseQ29619158
Identification of a major latent nuclear antigen, LNA-1, in the human herpesvirus 8 genomeQ30668836
Alternative splicing variants of IkappaB beta establish differential NF-kappaB signal responsiveness in human cellsQ33786480
Latent nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts with RING3, a homolog of the Drosophila female sterile homeotic (fsh) geneQ33824419
Modulation of cellular and viral gene expression by the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirusQ33835021
Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mediates episome persistence through cis-acting terminal repeat (TR) sequence and specifically binds TR DNA.Q33838228
The latency-associated nuclear antigen encoded by Kaposi's sarcoma-associated herpesvirus activates two major essential Epstein-Barr virus latent promotersQ33845947
Close but distinct regions of human herpesvirus 8 latency-associated nuclear antigen 1 are responsible for nuclear targeting and binding to human mitotic chromosomesQ33851443
DNA binding and modulation of gene expression by the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirusQ33853499
Latency-associated nuclear antigen encoded by Kaposi's sarcoma-associated herpesvirus interacts with Tat and activates the long terminal repeat of human immunodeficiency virus type 1 in human cellsQ33854704
Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigenQ33859518
p53 inhibition by the LANA protein of KSHV protects against cell deathQ33885642
Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) binds ATF4/CREB2 and inhibits its transcriptional activation activityQ33922095
K-bZIP of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 (KSHV/HHV-8) binds KSHV/HHV-8 Rta and represses Rta-mediated transactivationQ34180268
Domains of transcription factor Sp1 required for synergistic activation with sterol regulatory element binding protein 1 of low density lipoprotein receptor promoterQ34186131
Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanismQ34235866
Functional dissection of latency-associated nuclear antigen 1 of Kaposi's sarcoma-associated herpesvirus involved in latent DNA replication and transcription of terminal repeats of the viral genome.Q34348453
Chromosome binding site of latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus is essential for persistent episome maintenance and is functionally replaced by histone H1Q34350776
The metastatic suppressor Nm23-H1 interacts with EBNA3C at sequences located between the glutamine- and proline-rich domains and can cooperate in activation of transcriptionQ34362138
The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus): distribution of infection in KS risk groups and evidence for sexual transmissionQ34388952
Functional interactions between the retinoblastoma (Rb) protein and Sp-family members: superactivation by Rb requires amino acids necessary for growth suppressionQ34396889
Adenovirus E1A: remodelling the host cell, a life or death experienceQ34468761
The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cellsQ34511161
A novel viral mechanism for dysregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency.Q34531461
A glutamine-rich hydrophobic patch in transcription factor Sp1 contacts the dTAFII110 component of the Drosophila TFIID complex and mediates transcriptional activationQ34920038
Erythroid Kruppel-like factor is recruited to the CACCC box in the beta-globin promoter but not to the CACCC box in the gamma-globin promoter: the role of the neighboring promoter elementsQ35074726
The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus manipulates the activity of glycogen synthase kinase-3betaQ35104781
Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphomaQ35131811
Sp1 and the subfamily of zinc finger proteins with guanine-rich binding sitesQ35555749
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family membersQ36486862
Species-specific interaction of the glutamine-rich activation domains of Sp1 with the TATA box-binding proteinQ36647515
Chromosome first aid.Q37430022
The retinoblastoma gene product RB stimulates Sp1-mediated transcription by liberating Sp1 from a negative regulatorQ38306731
Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT).Q38316509
Functional interference of Sp1 and NF-kappaB through the same DNA binding siteQ38339684
Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiationQ38345845
The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus permits replication of terminal repeat-containing plasmids.Q39700420
Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus functionally interacts with heterochromatin protein 1.Q40682995
Human papillomavirus E2 down-regulates the human telomerase reverse transcriptase promoterQ40730661
The Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen binds to specific sequences at the left end of the viral genome through its carboxy-terminusQ40746913
The hinge region of the human papillomavirus type 8 E2 protein activates the human p21(WAF1/CIP1) promoter via interaction with Sp1.Q40751180
The Kaposi sarcoma-associated herpesvirus (KSHV) induces cellular interleukin 6 expression: role of the KSHV latency-associated nuclear antigen and the AP1 response elementQ40758382
The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus transactivates the telomerase reverse transcriptase promoterQ40811288
Protein phosphatase 2A and phosphatidylinositol 3-kinase regulate the activity of Sp1-responsive promotersQ40891345
Molecular polymorphism of Kaposi's sarcoma-associated herpesvirus (Human herpesvirus 8) latent nuclear antigen: evidence for a large repertoire of viral genotypes and dual infection with different viral genotypes.Q40923894
In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequencesQ40971183
Protein phosphatase 2A is a critical regulator of protein kinase C zeta signaling targeted by SV40 small t to promote cell growth and NF-kappaB activationQ41089273
Functional analysis of the transforming growth factor beta responsive elements in the WAF1/Cip1/p21 promoterQ41267630
Transcriptional regulation by the Sp family proteins.Q41756422
A role of the TATA box and the general co-activator hTAF(II)130/135 in promoter-specific trans-activation by simian virus 40 small t antigen.Q42800510
Inhibition of NF-kappaB-dependent transcription of human immunodeficiency virus 1 promoter by a phosphodiester compound of vitamin C and vitamin E, EPC-K1.Q45754797
Tumor-specific activation of hTERT-derived promoters by tumor suppressive E1A-mutants involves recruitment of p300/CBP/HAT and suppression of HDAC-1 and defines a combined tumor targeting and suppression systemQ45856536
The adenoviral E1A induces p21WAF1/CIP1 expression in cancer cellsQ45862463
Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirusQ47675996
Cloning and characterization of the promoter region of human telomerase reverse transcriptase geneQ47986055
c-Jun transactivates the promoter of the human p21(WAF1/Cip1) gene by acting as a superactivator of the ubiquitous transcription factor Sp1.Q52573384
Expression of human telomerase subunits and correlation with telomerase activity in cervical cancer.Q53435668
The Transcriptional Activity of cAMP Response Element-binding Protein-binding Protein Is Modulated by the Latency Associated Nuclear Antigen of Kaposi's Sarcoma-associated HerpesvirusQ57662902
The latency-associated nuclear antigen tethers the Kaposi's sarcoma-associated herpesvirus genome to host chromosomes in body cavity-based lymphoma cellsQ73184792
Structure and function analysis of the human myeloid cell nuclear differentiation antigen promoter: evidence for the role of Sp1 and not of c-Myb or PU.1 in myelomonocytic lineage-specific expressionQ73308150
Human telomerase reverse transcriptase as a critical determinant of telomerase activity in normal and malignant endometrial tissuesQ77959517
Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cellsQ78109137
P433issue19
P407language of work or nameEnglishQ1860
P304page(s)10348-10359
P577publication date2004-10-01
P1433published inJournal of VirologyQ1251128
P1476titleLatency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus up-regulates transcription of human telomerase reverse transcriptase promoter through interaction with transcription factor Sp1.
P478volume78

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