The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus transactivates the telomerase reverse transcriptase promoter

scientific article published on 19 April 2001

The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus transactivates the telomerase reverse transcriptase promoter is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M101890200
P698PubMed publication ID11313352

P2093author name stringKnight JS
Robertson ES
Cotter MA 2nd
P2860cites workhEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalizationQ24310670
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRTQ24313396
Identification of the gene encoding the major latency-associated nuclear antigen of the Kaposi's sarcoma-associated herpesvirusQ24561400
Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)Q24650427
Specific Association of Human Telomerase Activity with Immortal Cells and CancerQ27860801
Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcomaQ28242984
Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomasQ28258624
The RNA component of human telomeraseQ28288330
Telomere length regulationQ28290143
Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma in patients with and without HIV infectionQ28299060
Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomasQ28299069
TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats familyQ28564535
A mammalian telomerase-associated proteinQ28595030
A survey of telomerase activity in human cancerQ29614858
A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomesQ29617061
Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigenQ33859518
Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) binds ATF4/CREB2 and inhibits its transcriptional activation activityQ33922095
Seroconversion to antibodies against Kaposi's sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi's sarcomaQ34383343
Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytesQ34387542
The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cellsQ34511161
Production by EBV infection of an EBNA-positive subline from an EBNA-negative human lymphoma cell line without detectable EBV DNAQ34571530
Temporal trends of opportunistic infections and malignancies in homosexual men with AIDS.Q34725759
Kaposi's sarcoma among persons with AIDS: a sexually transmitted infection?Q34996973
Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cellsQ36327408
Chromosome first aid.Q37430022
Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT).Q38316509
Identification and characterization of negative regulatory elements of the human telomerase catalytic subunit (hTERT) gene promoter: possible role of MZF-2 in transcriptional repression of hTERT.Q39543159
Kaposi's sarcoma. Epidemiology, pathogenesis, histology, clinical spectrum, staging criteria and therapyQ40882026
Molecular polymorphism of Kaposi's sarcoma-associated herpesvirus (Human herpesvirus 8) latent nuclear antigen: evidence for a large repertoire of viral genotypes and dual infection with different viral genotypes.Q40923894
Distinct patterns of viral antigen expression in Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus coinfected body-cavity-based lymphoma cell lines: potential switches in latent gene expression due to coinfectionQ40928603
Direct activation of TERT transcription by c-MYC.Q40973563
Decrease in amplified telomeric sequences and induction of senescence markers by introduction of human chromosome 7 or its segments in SUSM-1.Q41090781
Replicative senescence and cell immortality: the role of telomeres and telomeraseQ41130848
Propagation of a human herpesvirus from AIDS-associated Kaposi's sarcomaQ41134075
Telomerase and cancer: revisiting the telomere hypothesisQ41211805
Telomerase activation by the E6 gene product of human papillomavirus type 16.Q41218028
Functional characterization and developmental regulation of mouse telomerase RNA.Q41306667
Adenovirus 5 DNA sequences present and RNA sequences transcribed in transformed human embryo kidney cells (HEK-Ad-5 or 293)Q41657050
Kaposi's sarcoma. Retrospective study of 90 cases with particular emphasis on the familial occurrence, ethnic background and prevalence of other diseasesQ44114816
Herpes-Like DNA Sequences in a Body-Cavity–Based Lymphoma in an HIV-Negative PatientQ44541217
Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirusQ47675996
Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformationQ47987665
Neoplastic transformation of human diploid fibroblasts (KMST-6) by treatment with 60Co gamma rays.Q52832421
Sugar and DiseaseQ59060231
Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cellsQ71563744
The latency-associated nuclear antigen tethers the Kaposi's sarcoma-associated herpesvirus genome to host chromosomes in body cavity-based lymphoma cellsQ73184792
The Wilms' tumor 1 tumor suppressor gene represses transcription of the human telomerase reverse transcriptase geneQ73280057
Expression of human telomerase subunits in ovarian malignant, borderline and benign tumorsQ74601071
hTERT is a critical determinant of telomerase activity in renal-cell carcinomaQ77531661
P433issue25
P407language of work or nameEnglishQ1860
P304page(s)22971-22978
P577publication date2001-04-19
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus transactivates the telomerase reverse transcriptase promoter
P478volume276

Reverse relations

cites work (P2860)
Q38073761AKTivation of PI3K/AKT/mTOR signaling pathway by KSHV.
Q34648229Acetylation of the latency-associated nuclear antigen regulates repression of Kaposi's sarcoma-associated herpesvirus lytic transcription.
Q39675686Bub1 and CENP-F can contribute to Kaposi's sarcoma-associated herpesvirus genome persistence by targeting LANA to kinetochores
Q35943718Carboxyl-terminal amino acids 1052 to 1082 of the latency-associated nuclear antigen (LANA) interact with RBP-Jκ and are responsible for LANA-mediated RTA repression.
Q39365643Cdk1 inhibition induces mutually inhibitory apoptosis and reactivation of Kaposi's sarcoma-associated herpesvirus
Q26749612Cell Cycle Regulatory Functions of the KSHV Oncoprotein LANA
Q40169138Deregulation of c-Myc in primary effusion lymphoma by Kaposi's sarcoma herpesvirus latency-associated nuclear antigen
Q40163096Disruption of Kaposi's sarcoma-associated herpesvirus latent nuclear antigen leads to abortive episome persistence
Q41891421Disruption of LANA in rhesus rhadinovirus generates a highly lytic recombinant virus
Q39744147Distinct p53, p53:LANA, and LANA complexes in Kaposi's Sarcoma--associated Herpesvirus Lymphomas
Q92664567Diverse regulatory manners of human telomerase reverse transcriptase
Q39629572Epstein-Barr Virus nuclear antigen 1 (EBNA1) confers resistance to apoptosis in EBV-positive B-lymphoma cells through up-regulation of survivin
Q36099024Epstein-Barr virus latent nuclear antigens can induce metastasis in a nude mouse model
Q24311421Epstein-Barr virus nuclear antigen 3C interacts with and enhances the stability of the c-Myc oncoprotein
Q34302223Epstein-Barr virus protein can upregulate cyclo-oxygenase-2 expression through association with the suppressor of metastasis Nm23-H1
Q40288802Expression of alpha V integrin is modulated by Epstein-Barr virus nuclear antigen 3C and the metastasis suppressor Nm23-H1 through interaction with the GATA-1 and Sp1 transcription factors
Q34348453Functional dissection of latency-associated nuclear antigen 1 of Kaposi's sarcoma-associated herpesvirus involved in latent DNA replication and transcription of terminal repeats of the viral genome.
Q30479353HHV-8 encoded LANA-1 alters the higher organization of the cell nucleus
Q37867038Horizontal gene transfers with or without cell fusions in all categories of the living matter
Q40730661Human papillomavirus E2 down-regulates the human telomerase reverse transcriptase promoter
Q37905799Human telomerase expression regulation
Q24646461Identification of a novel cellular transcriptional repressor interacting with the latent nuclear antigen of Kaposi's sarcoma-associated herpesvirus
Q41839438In vivo-restricted and reversible malignancy induced by human herpesvirus-8 KSHV: a cell and animal model of virally induced Kaposi's sarcoma.
Q47840799Inactivation of hTERT transcription by Tax.
Q33843211Induction of Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen by the lytic transactivator RTA: a novel mechanism for establishment of latency
Q39794624Inhibition of KSHV-infected primary effusion lymphomas in NOD/SCID mice by gamma-secretase inhibitor.
Q40267803Intracellular activated Notch1 is critical for proliferation of Kaposi's sarcoma-associated herpesvirus-associated B-lymphoma cell lines in vitro
Q28540116Kaposi sarcoma herpes virus latency associated nuclear antigen protein release the G2/M cell cycle blocks by modulating ATM/ATR mediated checkpoint pathway
Q44277985Kaposi's sarcoma associated herpesvirus G protein-coupled receptor immortalizes human endothelial cells by activation of the VEGF receptor-2/ KDR.
Q36019173Kaposi's sarcoma herpesvirus-encoded latency-associated nuclear antigen stabilizes intracellular activated Notch by targeting the Sel10 protein
Q35665756Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen induction by hypoxia and hypoxia-inducible factors
Q42049779Kaposi's sarcoma-associated herpesvirus latent protein LANA interacts with HIF-1 alpha to upregulate RTA expression during hypoxia: Latency control under low oxygen conditions
Q33737793Kaposi's sarcoma-associated herpesvirus reactivation is regulated by interaction of latency-associated nuclear antigen with recombination signal sequence-binding protein Jkappa, the major downstream effector of the Notch signaling pathway
Q40607781Kaposi's sarcoma-associated herpesvirus-encoded LANA can induce chromosomal instability through targeted degradation of the mitotic checkpoint kinase Bub1
Q34841987Kaposi's sarcoma-associated herpesvirus-encoded LANA down-regulates IL-22R1 expression through a cis-acting element within the promoter region
Q34128791Latency-associated nuclear antigen (LANA) cooperatively binds to two sites within the terminal repeat, and both sites contribute to the ability of LANA to suppress transcription and to facilitate DNA replication
Q40317413Latency-associated nuclear antigen (LANA) of Kaposi's sarcoma-associated herpesvirus interacts with origin recognition complexes at the LANA binding sequence within the terminal repeats
Q40682995Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus functionally interacts with heterochromatin protein 1.
Q24670086Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus recruits uracil DNA glycosylase 2 at the terminal repeats and is important for latent persistence of the virus
Q39992257Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus up-regulates transcription of human telomerase reverse transcriptase promoter through interaction with transcription factor Sp1.
Q34437977Mitotic chromosome-binding activity of latency-associated nuclear antigen 1 is required for DNA replication from terminal repeat sequence of Kaposi's sarcoma-associated herpesvirus
Q26860203Modeling human endothelial cell transformation in vascular neoplasias
Q35138059Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus
Q35026060Molecular genetics of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) epidemiology and pathogenesis
Q37355889Nuclear translocated Ehrlichia chaffeensis ankyrin protein interacts with a specific adenine-rich motif of host promoter and intronic Alu elements
Q40173321ORF73 of Herpesvirus Saimiri Strain C488 Tethers the Viral Genome to Metaphase Chromosomes and Binds to cis -Acting DNA Sequences in the Terminal Repeats
Q37511491ORF73 of herpesvirus saimiri, a viral homolog of Kaposi's sarcoma-associated herpesvirus, modulates the two cellular tumor suppressor proteins p53 and pRb.
Q28257238On the road to immortality: hTERT upregulation in cancer cells
Q35174136Pathogenesis of Kaposi's sarcoma
Q33282107Protein complexes associated with the Kaposi's sarcoma-associated herpesvirus-encoded LANA.
Q24538878Protein interactions targeting the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomes
Q34292265Regulation and autoregulation of the promoter for the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus
Q40398026Regulation of matrix metalloproteinase 9 expression by Epstein-Barr virus nuclear antigen 3C and the suppressor of metastasis Nm23-H1.
Q34535621Regulation of the human telomerase reverse transcriptase gene
Q38144129Review of latent and lytic phase biomarkers in Kaposi's sarcoma
Q35192690Ribosomal protein S6 interacts with the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus
Q99616354Role of DNA methylation and CpG sites in the viral telomerase RNA promoter during Gallid herpesvirus 2 pathogenesis
Q37157253Role of Kaposi's sarcoma-associated herpesvirus C-terminal LANA chromosome binding in episome persistence
Q38267908Sp1 and the 'hallmarks of cancer'.
Q35124429Structure and function of latency-associated nuclear antigen
Q36868580Telomerase as a useful target in cancer fighting-the breast cancer case
Q37765230Telomere/telomerase interplay in virus-driven and virus-independent lymphomagenesis: pathogenic and clinical implications
Q35857290The ATM/ATR signaling effector Chk2 is targeted by Epstein-Barr virus nuclear antigen 3C to release the G2/M cell cycle block
Q36301221The Kaposi Sarcoma Herpesvirus Latency-associated Nuclear Antigen DNA Binding Domain Dorsal Positive Electrostatic Patch Facilitates DNA Replication and Episome Persistence.
Q26767186The Role of Gammaherpesviruses in Cancer Pathogenesis
Q36080884The Telomerase Inhibitor MST-312 Interferes with Multiple Steps in the Herpes Simplex Virus Life Cycle
Q34178308The Viral Latency-Associated Nuclear Antigen Augments the B-Cell Response to AntigenIn Vivo
Q34391203The latency-associated nuclear antigen of Kaposi sarcoma-associated herpesvirus induces B cell hyperplasia and lymphoma
Q35104781The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus manipulates the activity of glycogen synthase kinase-3beta
Q40496132The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus modulates cellular gene expression and protects lymphoid cells from p16 INK4A-induced cell cycle arrest
Q33834414The latency-associated nuclear antigen of rhesus monkey rhadinovirus inhibits viral replication through repression of Orf50/Rta transcriptional activation
Q35077558The single RBP-Jkappa site within the LANA promoter is crucial for establishing Kaposi's sarcoma-associated herpesvirus latency during primary infection
Q26739925Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene
Q39960021Transcriptional activation by the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen is facilitated by an N-terminal chromatin-binding motif.

Search more.