Latency-associated nuclear antigen (LANA) cooperatively binds to two sites within the terminal repeat, and both sites contribute to the ability of LANA to suppress transcription and to facilitate DNA replication

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Latency-associated nuclear antigen (LANA) cooperatively binds to two sites within the terminal repeat, and both sites contribute to the ability of LANA to suppress transcription and to facilitate DNA replication is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M203489200
P698PubMed publication ID12015325

P50authorRolf RenneQ74933237
P2093author name stringJianhong Hu
Alexander C Garber
P2860cites workHuman herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cellsQ24527215
Carboxy terminus of human herpesvirus 8 latency-associated nuclear antigen mediates dimerization, transcriptional repression, and targeting to nuclear bodies.Q24531182
Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)Q24650427
57 Sequencing end-labeled DNA with base-specific chemical cleavagesQ27860479
Epstein-Barr nuclear antigen 1 mediates a DNA loop within the latent replication origin of Epstein-Barr virusQ37637247
Differential regulation of the overlapping Kaposi's sarcoma-associated herpesvirus vGCR (orf74) and LANA (orf73) promotersQ39602154
Interactions of USF and Ku antigen with a human DNA region containing a replication originQ40408378
The Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen binds to specific sequences at the left end of the viral genome through its carboxy-terminusQ40746913
The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus transactivates the telomerase reverse transcriptase promoterQ40811288
The DNA segregation mechanism of Epstein-Barr virus nuclear antigen 1Q40818766
Human herpesvirus-8-encoded LNA-1 accumulates in heterochromatin- associated nuclear bodiesQ40914940
The Structure and Coding Organization of the Genomic Termini of Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8)Q41090568
Comparison of the EBNA1 proteins of Epstein-Barr virus and herpesvirus papio in sequence and functionQ41179765
Replication-deficient vaccinia virus encoding bacteriophage T7 RNA polymerase for transient gene expression in mammalian cellsQ41334221
Deletion analysis of minimal sequence requirements for autonomous replication of ors8, a monkey early-replicating DNA sequenceQ41375438
Targeting the E1 replication protein to the papillomavirus origin of replication by complex formation with the E2 transactivatorQ41710155
SV40 gene expression is modulated by the cooperative binding of T antigen to DNAQ43915434
A common function for polyoma virus large-T and papillomavirus E1 proteins?Q45807494
Transactivation of a bovine papilloma virus transcriptional regulatory element by the E2 gene productQ45838465
Association of the Origin Recognition Complex with Heterochromatin and HP1 in Higher EukaryotesQ46408897
Aberrant replication timing induces defective chromosome condensation in Drosophila ORC2 mutantsQ47071017
The Transcriptional Activity of cAMP Response Element-binding Protein-binding Protein Is Modulated by the Latency Associated Nuclear Antigen of Kaposi's Sarcoma-associated HerpesvirusQ57662902
Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cellsQ71563744
Replication from oriP of Epstein-Barr virus requires human ORC and is inhibited by gemininQ28213116
Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcomaQ28242984
KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcomaQ28284765
Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomasQ28299069
A yeast chromosomal origin of DNA replication defined by multiple functional elementsQ28679255
Product review. New mammalian expression vectorsQ29620743
Stimulation of DNA replication in Saccharomyces cerevisiae by a glutamine- and proline-rich transcriptional activation domainQ30304323
The minimal replicator of Epstein-Barr virus oriP.Q33804269
Modulation of cellular and viral gene expression by the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirusQ33835021
Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mediates episome persistence through cis-acting terminal repeat (TR) sequence and specifically binds TR DNA.Q33838228
DNA replication efficiency depends on transcription factor-binding sitesQ33842004
The replicator of the Epstein-Barr virus latent cycle origin of DNA replication, oriP, is composed of multiple functional elementsQ33848552
Close but distinct regions of human herpesvirus 8 latency-associated nuclear antigen 1 are responsible for nuclear targeting and binding to human mitotic chromosomesQ33851443
DNA binding and modulation of gene expression by the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirusQ33853499
Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigenQ33859518
Cellular transcription factors recruit viral replication proteins to activate the Epstein-Barr virus origin of lytic DNA replication, oriLytQ33891311
Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) binds ATF4/CREB2 and inhibits its transcriptional activation activityQ33922095
Human DNA replication initiation factors, ORC and MCM, associate with oriP of Epstein-Barr virusQ33942957
Human origin recognition complex binds to the region of the latent origin of DNA replication of Epstein-Barr virusQ34081126
Maintenance of Epstein-Barr virus (EBV) oriP-based episomes requires EBV-encoded nuclear antigen-1 chromosome-binding domains, which can be replaced by high-mobility group-I or histone H1.Q34107917
The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus): distribution of infection in KS risk groups and evidence for sexual transmissionQ34388952
The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cellsQ34511161
Stable replication of plasmids derived from Epstein-Barr virus in various mammalian cellsQ34564031
Simian virus 40 (SV40) DNA replication: SV40 large T antigen unwinds DNA containing the SV40 origin of replication.Q34583809
Control of HPV 18 DNA replication by cellular and viral transcription factors.Q34782217
Bovine papilloma virus (BPV)-encoded E1 protein contains multiple activities required for BPV DNA replicationQ36068854
Fas-induced proteolytic activation and intracellular redistribution of the stress-signaling kinase MEKK1Q36092884
The E1 protein of bovine papilloma virus 1 is an ATP-dependent DNA helicaseQ36336279
Transcription inhibits the replication of autonomously replicating plasmids in human cellsQ36650272
A mammalian origin of bidirectional DNA replication within the Chinese hamster RPS14 locusQ36664334
Isolation of human sequences that replicate autonomously in human cellsQ36767535
A putative origin of replication of plasmids derived from Epstein-Barr virus is composed of two cis-acting componentsQ36891387
trans activation of an Epstein-Barr viral transcriptional enhancer by the Epstein-Barr viral nuclear antigen 1.Q36899288
Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcomaQ37535731
P433issue30
P407language of work or nameEnglishQ1860
P304page(s)27401-27411
P577publication date2002-05-15
P1433published inJournal of Biological ChemistryQ867727
P1476titleLatency-associated nuclear antigen (LANA) cooperatively binds to two sites within the terminal repeat, and both sites contribute to the ability of LANA to suppress transcription and to facilitate DNA replication
P478volume277

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cites work (P2860)
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