KSHV infects a subset of human tonsillar B cells, driving proliferation and plasmablast differentiation

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KSHV infects a subset of human tonsillar B cells, driving proliferation and plasmablast differentiation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI44185
P932PMC publication ID3026728
P698PubMed publication ID21245574

P2093author name stringDean H Kedes
Thomas J Ellison
Lynn M Hassman
P2860cites workCarboxy terminus of human herpesvirus 8 latency-associated nuclear antigen mediates dimerization, transcriptional repression, and targeting to nuclear bodies.Q24531182
Asynchronous progression through the lytic cascade and variations in intracellular viral loads revealed by high-throughput single-cell analysis of Kaposi's sarcoma-associated herpesvirus infectionQ24670607
Marginal-zone B cellsQ28201000
Activation of p21-activated kinase 1-nuclear factor kappaB signaling by Kaposi's sarcoma-associated herpes virus G protein-coupled receptor during cellular transformationQ28236086
Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcomaQ28242984
B cell activation and the establishment of Epstein-Barr virus latencyQ28281625
Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomasQ28299069
Anti-interleukin-6 receptor antibody (tocilizumab) treatment of multicentric Castleman's diseaseQ28304633
Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's diseaseQ29619158
Lytic replication of Kaposi's sarcoma-associated herpesvirus results in the formation of multiple capsid species: isolation and molecular characterization of A, B, and C capsids from a gammaherpesvirusQ30306907
KSHV targets multiple leukocyte lineages during long-term productive infection in NOD/SCID miceQ30440843
Immunoglobulin VH gene mutational analysis suggests that primary effusion lymphomas derive from different stages of B cell maturationQ31977172
KSHV manipulates Notch signaling by DLL4 and JAG1 to alter cell cycle genes in lymphatic endotheliaQ33509506
The role of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in lymphoproliferative diseasesQ33644236
Cellular origin of human B-cell lymphomas.Q33772424
Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigenQ33859518
HHV-8 is associated with a plasmablastic variant of Castleman disease that is linked to HHV-8-positive plasmablastic lymphomaQ33889296
Kaposi sarcoma-associated herpesvirus infects monotypic (IgM lambda) but polyclonal naive B cells in Castleman disease and associated lymphoproliferative disorders.Q33939333
Constitutive NF-kappaB activation, normal Fas-induced apoptosis, and increased incidence of lymphoma in human herpes virus 8 K13 transgenic miceQ33943771
Latency-associated nuclear antigen (LANA) cooperatively binds to two sites within the terminal repeat, and both sites contribute to the ability of LANA to suppress transcription and to facilitate DNA replicationQ34128791
Molecular genetics of immunoglobulins.Q34167300
Dysregulated interleukin 6 expression produces a syndrome resembling Castleman's disease in mice.Q34259037
Patterns of gene expression and a transactivation function exhibited by the vGCR (ORF74) chemokine receptor protein of Kaposi's sarcoma-associated herpesvirusQ34333321
A mouse model for infectious mononucleosisQ34644458
KSHV/HHV8-associated lymphomas.Q34711929
The human marginal zone B cellQ35119920
Differential viral protein expression in Kaposi's sarcoma-associated herpesvirus-infected diseases: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease.Q35809792
Kaposi's sarcoma-associated herpesvirus-infected primary effusion lymphoma has a plasma cell gene expression profileQ35918316
Fifty years of multicentric Castleman's diseaseQ36069611
Human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus is a new transmissible virus that infects B cellsQ36366617
KSHV vFLIP is essential for the survival of infected lymphoma cellsQ36399405
Human herpesvirus 8-encoded proteins with potential roles in virus-associated neoplasiaQ36664300
Regulation of Bcl-2-family proteins in myeloma cells by three myeloma survival factors: interleukin-6, interferon-alpha and insulin-like growth factor 1.Q36711639
The dynamics of the B follicle: understanding the normal counterpart of B-cell-derived malignancies.Q36818916
Human IgM+CD27+ B cells: memory B cells or "memory" B cells?Q36853364
Contribution of viral and cellular cytokines to Kaposi's sarcoma-associated herpesvirus pathogenesisQ36882284
Concurrent expression of latent and a limited number of lytic genes with immune modulation and antiapoptotic function by Kaposi's sarcoma-associated herpesvirus early during infection of primary endothelial and fibroblast cells and subsequent declinQ37010247
Role of Kaposi's sarcoma-associated herpesvirus C-terminal LANA chromosome binding in episome persistenceQ37157253
Key developmental transitions in human germinal center B cells are revealed by differential CD45RB expressionQ37169139
Polyadenylylated nuclear RNA encoded by Kaposi sarcoma-associated herpesvirusQ37273424
Sensitivity of Kaposi's sarcoma-associated herpesvirus replication to antiviral drugs. Implications for potential therapyQ37366303
An in vitro model of differentiation of memory B cells into plasmablasts and plasma cells including detailed phenotypic and molecular characterizationQ38349476
Prevalence and transmission of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in Ugandan children and adolescentsQ38887194
X-box binding protein 1 contributes to induction of the Kaposi's sarcoma-associated herpesvirus lytic cycle under hypoxic conditionsQ39858771
Transmissible Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in saliva of men with a history of Kaposi's sarcomaQ39881065
Human herpesvirus 8 infects and replicates in primary cultures of activated B lymphocytes through DC-SIGN.Q40002946
B cell terminal differentiation factor XBP-1 induces reactivation of Kaposi's sarcoma-associated herpesvirusQ40110061
The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts preferentially with the terminal repeats of the genome in vivo and this complex is sufficient for episomal DNA replicationQ40644381
The Kaposi sarcoma–associated herpesvirus (KSHV) induces cellular interleukin 6 expression: role of the KSHV latency-associated nuclear antigen and the AP1 response elementQ40758382
Human herpesvirus 8 envelope-associated glycoprotein B interacts with heparan sulfate-like moietiesQ40802330
Ki67: from antibody to molecule to understanding?Q40848762
Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoireQ41505077
CpG DNA activation and plasma-cell differentiation of CD27- naive human B cellsQ41767963
Isolation and characterization of human tonsil dendritic cellsQ42608616
Herpes-like sequences in HIV-infected and uninfected Kaposi's sarcoma patientsQ43823829
Human primary and memory cytotoxic T lymphocyte responses are efficiently induced by means of CD40-activated B cells as antigen-presenting cells: potential for clinical applicationQ43966225
Human tonsillar tissue block cultures differ from autologous tonsillar cell suspension cultures in lymphocyte subset activation and cytokine gene expression.Q44060550
High levels of human herpesvirus 8 viral load, human interleukin-6, interleukin-10, and C reactive protein correlate with exacerbation of multicentric castleman disease in HIV-infected patients.Q44424254
Regulatory role of CD19 molecules in B-cell activation and differentiationQ44925493
Atypical marginal zone hyperplasia of mucosa-associated lymphoid tissue: a reactive condition of childhood showing immunoglobulin lambda light-chain restrictionQ44980755
Comparison of virus reactivation, DNA base damage, and cell cycle effects in autologous human melanoma cells resistant to methylating agentsQ45794791
Tocilizumab is effective for pulmonary hypertension associated with multicentric Castleman's disease.Q45953695
Moraxella catarrhalis-dependent tonsillar B cell activation does not lead to apoptosis but to vigorous proliferation resulting in nonspecific IgM productionQ46677350
Interleukin-6 is a growth factor for nonmalignant human plasmablastsQ52021179
B-cell neoplasia in man.Q53596983
Maxiprep genomic DNA extractions for molecular epidemiology studies and biorepositories.Q54473077
Monoclonality or Oligoclonality of Human Herpesvirus 8 Terminal Repeat Sequences in Kaposi's Sarcoma and Other DiseasesQ57952920
Picogram per cell determination of DNA by flow cytofluorometryQ71381146
Assessment of cell viability by flow cytometric analysis using DNase exclusionQ71706005
Lymphocyte Subsets in Normal Human Lymphoid TissuesQ72700201
Anti-interleukin 6 (IL-6) receptor antibody suppresses Castleman's disease like symptoms emerged in IL-6 transgenic miceQ73118585
The latency-associated nuclear antigen tethers the Kaposi's sarcoma-associated herpesvirus genome to host chromosomes in body cavity-based lymphoma cellsQ73184792
Anti-tumour activity of interferon-alpha in multiple myeloma: role of interleukin 6 and tumor cell differentiationQ73267742
CD154/CD40 and CD70/CD27 interactions have different and sequential functions in T cell-dependent B cell responses: enhancement of plasma cell differentiation by CD27 signalingQ73705592
Association of Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma with expression of the CD138/syndecan-1 antigenQ73923367
Generation of polyclonal plasmablasts from peripheral blood B cells: a normal counterpart of malignant plasmablastsQ74541237
Expression of the bcl-2 family of pro- and anti-apoptotic genes in multiple myeloma and normal plasma cells: regulation during interleukin-6(IL-6)-induced growth and survivalQ78336747
Role of tonsillar IgD+CD27+ memory B cells in humoral immunity against pneumococcal infectionQ79438364
Extended depth of field imaging for high speed cell analysisQ79722363
Immunophenotypic analysis of the Kaposi sarcoma herpesvirus (KSHV; HHV-8)-infected B cells in HIV+ multicentric Castleman disease (MCD)Q79786222
Anti-interleukin 6 receptor antibody tocilizumab reduces the level of serum hepcidin in patients with multicentric Castleman's diseaseQ80432988
CD5+ B cells with the features of subepithelial B cells found in human tonsilsQ80577042
Detection of herpesvirus type 8 (HHV8) in children's tonsils and adenoids by immunohistochemistry and in situ hybridizationQ81889435
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectplasmablastQ66590834
P304page(s)752-768
P577publication date2011-01-18
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleKSHV infects a subset of human tonsillar B cells, driving proliferation and plasmablast differentiation
P478volume121

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cites work (P2860)
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