Expression of the bcl-2 family of pro- and anti-apoptotic genes in multiple myeloma and normal plasma cells: regulation during interleukin-6(IL-6)-induced growth and survival

scientific article published on 01 August 2002

Expression of the bcl-2 family of pro- and anti-apoptotic genes in multiple myeloma and normal plasma cells: regulation during interleukin-6(IL-6)-induced growth and survival is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1034/J.1600-0609.2002.01549.X
P698PubMed publication ID12366710

P2093author name stringKenneth Nilsson
Patrik Georgii-Hemming
Thomas Strömberg
Helena Jernberg-Wiklund
Helena Spets
Jan Siljason
P2860cites workThe effects on growth and survival of IL-6 can be dissociated in the U-266-1970/U-266-1984 and HL407E/HL407L human multiple myeloma cell linesQ73535726
Dexamethasone induces apoptosis of multiple myeloma cells in a JNK/SAP kinase independent mechanismQ73615079
The Bcl-2 protein family: arbiters of cell survivalQ29618158
The assessment of cellular proliferation by immunohistochemistry: a review of currently available methods and their applicationsQ35254984
Hexamethylene bisacetamide induces programmed cell death (apoptosis) and down-regulates BCL-2 expression in human myeloma cellsQ35670634
Regulation of Bcl-2-family proteins in myeloma cells by three myeloma survival factors: interleukin-6, interferon-alpha and insulin-like growth factor 1.Q36711639
Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cellsQ40972355
Insulin/IGF-I Rescues Immortalized Brown Adipocytes from Apoptosis Down-Regulating Bcl-xS Expression, in a PI 3-Kinase- and Map Kinase-Dependent MannerQ41007767
Immunoglobulin synthesis in the human myeloma cell line U-266; expression of two immunoglobulin heavy chain isotypes (epsilon and alpha) after long-term cultivation in vitroQ42820941
Interleukin-6 is expressed by plasma cells from patients with multiple myeloma and monoclonal gammopathy of undetermined significance.Q48020559
Mcl-1 and Bcl-xL are co-regulated by IL-6 in human myeloma cellsQ52826978
Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomasQ59077136
Type I insulin-like growth factor receptor activation regulates apoptotic proteinsQ71833567
Interleukin-6 inhibits apoptosis of malignant plasma cellsQ72220182
Fas antigen/APO-1 (CD95) expression on myeloma cellsQ73068666
Insulin-like growth factor-1 inhibition of apoptosis is associated with increased expression of the bcl-xL gene productQ73106933
Expression of Apo-1/Fas (CD95), Bcl-2, Bax and Bcl-x in myeloma cell lines: relationship between responsiveness to anti-Fas mab and p53 functional statusQ73367164
Interferon alpha extends the survival of human myeloma cells through an upregulation of the Mcl-1 anti-apoptotic moleculeQ73416734
P433issue2
P921main subjectmultiple myelomaQ467635
apoptotic processQ14599311
P1104number of pages14
P304page(s)76-89
P577publication date2002-08-01
P1433published inEuropean Journal of HaematologyQ15765799
P1476titleExpression of the bcl-2 family of pro- and anti-apoptotic genes in multiple myeloma and normal plasma cells: regulation during interleukin-6(IL-6)-induced growth and survival
P478volume69

Reverse relations

cites work (P2860)
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Q28587037BCMA is essential for the survival of long-lived bone marrow plasma cells
Q43626781Bortezomib mitigates adverse prognosis conferred by Bcl-2 overexpression in patients with relapsed/refractory multiple myeloma
Q34029221Bortezomib-based chemotherapy regimens can improve response in newly diagnosed multiple myeloma patients with bcl-2 and survivin overexpression
Q55281764Celastrol Attenuates the Invasion and Migration and Augments the Anticancer Effects of Bortezomib in a Xenograft Mouse Model of Multiple Myeloma.
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Q36786053Control of apoptosis in human multiple myeloma by insulin-like growth factor I (IGF-I).
Q41767963CpG DNA activation and plasma-cell differentiation of CD27- naive human B cells
Q53294841Cutaneous HPV5 E6 causes increased expression of Osteoprotegerin and Interleukin 6 which contribute to evasion of UV-induced apoptosis
Q30436741Deregulation of c-Myc Confers distinct survival requirements for memory B cells, plasma cells, and their progenitors
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Q40291972Inhibition of p38alpha MAPK enhances proteasome inhibitor-induced apoptosis of myeloma cells by modulating Hsp27, Bcl-X(L), Mcl-1 and p53 levels in vitro and inhibits tumor growth in vivo
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Q40560316Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage.
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Q101137057Venetoclax or placebo in combination with bortezomib and dexamethasone in patients with relapsed or refractory multiple myeloma (BELLINI): a randomised, double-blind, multicentre, phase 3 trial

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